I am a postdoctoral researcher in the hepatology group in the Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre.
Current projects include:
- Serum and tissue markers of disease progression in NAFLD and ALD
- Circulating microRNAs and bacterial translocation in liver disease
- Links between diet, genetics and NAFLD risk, particularly in South Asians
- Effects of genetic variation of hepatitis B virus on infection & diagnosis
- Viral deep sequencing on Illumina and minION platforms
- Automated image analysis of liver biopsies to aid diagnosis
- The microbiome in NAFLD
- Immunophenotyping in drug-induced liver injury
A number of these projects involve international collaboration, I have helped establish a molecular biology lab at the Population Health and Research Institute, Trivandrum, India as part of our NAFLD studies there, and have carried out HBV deep sequencing work at Hasanuddin University, South Sulawesi, Indonesia.
My PhD from the Division of Child Health, Obstetrics and Gynaecology at the University of Nottingham covered maternal gastrointestinal and liver adaptation to pregnancy, and the effect of maternal diet on this adaptation, as well as the effect of maternal diet on GI development in the offspring. I also spent 2 years as a Visiting Graduate Student in the Division of Human Nutrition at the University of Alberta, Canada studying the effect of high intakes of fructose during pregnancy.
I previously worked in the Molecular Gastroenterology group at the University of Sheffield, studying the role of fibre, butyrate and histone deacetylase inhibition in colorectal cancer progression.
ASTBURY, STUART, ATALLAH, EDMOND, VIJAY, AMRITA, AITHAL, GURUPRASAD P, GROVE, JANE I and VALDES, ANA M, 2019. Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven nonalcoholic steatohepatitis. Gut microbes. 1-12 GROVE JI, THIAGARAJAN P, ASTBURY S, HARRIS R, DELAHOOKE T, GUHA IN and AITHAL GP, 2018. Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver.
ASTBURY, STUART, SONG, ALEIDA, ZHOU, MI, NIELSEN, BRENT, HOEDL, ABHA, WILLING, BENJAMIN P., SYMONDS, MICHAEL E. and BELL, RHONDA C., 2018. High Fructose Intake During Pregnancy in Rats Influences the Maternal Microbiome and Gut Development in the Offspring: Frontiers in Genetics Frontiers in Genetics. 9,