I am a postdoctoral researcher currently working on a number of projects within the MRC funded Nottingham Molecular Pathology Node and the NIHR Nottingham Biomedical Research Centre. These projects focus on markers of non-alcoholic fatty liver disease progression (with Prof Guruprasad Aithal and Dr Jane Grove), and chronic hepatitis B infection (with Prof Will Irving and Dr Alexander Tarr).
My broader research interests are liver and GI inflammation, intestinal permeability, pregnancy and the GI tract, and interactions between diet, pregnancy and the microbiota.
Current projects include:
- Serum and tissue markers of disease progression in NAFLD and ALD
- Circulating microRNAs and bacterial translocation in liver disease
- Links between diet, genetics and NAFLD risk, particularly in South Asians
- Effects of genetic variation of hepatitis B virus on infection & diagnosis
- Hepatitis B virus sequencing approaches
- Automated analysis of liver biopsies to aid diagnosis
- The microbiome in NAFLD
A number of these projects involve international collaboration, I have helped establish a molecular biology lab at the Population Health and Research Institute, Trivandrum, India as part of our NAFLD studies there, and have carried out HBV sequencing work at Hasanuddin University, South Sulawesi, Indonesia.
My PhD from the Division of Child Health, Obstetrics and Gynaecology at the University of Nottingham covered maternal gastrointestinal and liver adaptation to pregnancy, and the effect of maternal diet on this adaptation, as well as the effect of maternal diet on GI development in the offspring. I also spent 2 years as a Visiting Graduate Student in the Division of Human Nutrition at the University of Alberta, Canada studying the effect of high intakes of fructose during pregnancy.
I previously worked in the Molecular Gastroenterology group at the University of Sheffield, studying the role of fibre, butyrate and histone deacetylase inhibition in colorectal cancer progression.
GROVE JI, THIAGARAJAN P, ASTBURY S, HARRIS R, DELAHOOKE T, GUHA IN and AITHAL GP, 2018. Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver.
ASTBURY, STUART, SONG, ALEIDA, ZHOU, MI, NIELSEN, BRENT, HOEDL, ABHA, WILLING, BENJAMIN P., SYMONDS, MICHAEL E. and BELL, RHONDA C., 2018. High Fructose Intake During Pregnancy in Rats Influences the Maternal Microbiome and Gut Development in the Offspring: Frontiers in Genetics Frontiers in Genetics. 9,
GROVE, J. I., THIAGARAJAN, P., ASTBURY, S., HARRIS, R., DELAHOOKE, T., CARD, T. R., GUHA, I. N. and AITHAL, G. P., 2017. Prevalence of combined PNPLA3 and GCKR variant genotype is increased in patients with risk factors for alcoholic or non-alcoholic liver disease who have clinically significant serum procollagen III levels Journal of Hepatology. 66(1), S587