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Stuart Astbury

Research Fellow, Faculty of Medicine & Health Sciences

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Biography

I am a postdoctoral researcher in the hepatology group in the Nottingham Digestive Diseases Centre. Currently I am part of an EU/IMI project aiming to understand the immune response during drug-induced liver injury (DILI) and develop new biomarkers to aid in its detection. I also provide bioinformatics methods support to researchers within the Nottingham Biomedical Research Centre, and am a deputy lead for postgraduate student training in the School of Medicine.

Other projects include:

  • Immune phenotyping in checkpoint and drug-induced liver injury using mass and flow cytometry
  • The microbiome in liver disease - 16S and metagenomic sequencing
  • Deep sequencing approaches for diagnosing pancreatic cysts
  • Serum and tissue markers of disease progression in both non-alcoholic and alcoholic liver disease
  • Circulating microRNAs and bacterial translocation in liver disease
  • Effects of genetic variation of hepatitis B virus on infection & diagnosis
  • Viral deep sequencing on Illumina and minION platforms
  • Using machine learning to automate the analysis of liver biopsies and aid diagnosis
  • Genome wide association studies and HLA imputation

A number of the above projects involve international collaboration, I have helped establish a molecular biology lab at the Population Health and Research Institute, Trivandrum, India as part of our NAFLD studies there, and have carried out HBV deep sequencing work at Hasanuddin University, South Sulawesi, Indonesia.

My PhD from the Division of Child Health, Obstetrics and Gynaecology at the University of Nottingham covered maternal gastrointestinal and liver adaptation to pregnancy, and the effect of maternal diet on this adaptation, as well as the effect of maternal diet on GI development in the offspring. I also spent 2 years as a Visiting Graduate Student in the Division of Human Nutrition at the University of Alberta, Canada studying the effect of high intakes of fructose during pregnancy.

I previously worked in the Molecular Gastroenterology group at the University of Sheffield, studying the role of fibre, butyrate and histone deacetylase inhibition in colorectal cancer progression.

Recent Publications

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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