School of Medicine
Medical tablets, capsules and caplets flying out of a bottle against a light blue background

People

Image of Tanya Monaghan

Tanya Monaghan

Clinical Associate Professor and Honorary Consultant in Gastroenterology, Faculty of Medicine & Health Sciences

Contact

Biography

PLEASE NOTE IF YOU ARE A PATIENT CONTACTING ME ABOUT CLINICAL MATTERS, I WILL NOT BE ABLE TO REPLY VIA THE ABOVE EMAIL DUE TO DATA PROTECTION LAW. PLEASE CONTACT MY NHS SECRETARY.

I was appointed as the first NIHR Academic Clinical Fellow in Gastroenterology in 2006. During my clinical training, I was subsequently awarded a three-year Wellcome Trust Clinical Training Fellowship in 2009 to study the host immune response to C. difficile toxins A and B, the principal virulence factors involved in disease pathogenesis, and was awarded my PhD in 2013. I then commenced an NIHR Academic Clinical Lectureship in Gastroenterology in the Nottingham Digestive Diseases Biomedical Research Unit. I was awarded an Academy of Medical Sciences Starter Grant for Clinical Lecturers to study novel antimicrobial treatments for C. difficile infection, utilising a human in vitro gut model of CDI developed by Professor Mark Wilcox, University of Leeds. In collaboration with the Immunology Department at UoN and with the help of a subsequent Hermes Fellowship, I have also adapted a protein microarray platform to investigate antigen-specific antibody responses in the circulation of patients with CDI. This assay is also being used a prediction tool and has recently moved into PCT.

I have established collaborations with Dr Nick Hannan, University of Nottingham and CHAIN Biotechnology to determine the utility of a human stem-cell derived intestinal organoid culture model in modelling Crohn's disease and studying C. difficile pathogenesis. We are exploring ways to use this model to develop and test new therapies for C. difficile infection and inflammatory bowel disease. I collaborate with Dr Nick Markham, Vanderbilt University and Dr Anna Seekatz of Clemson University, in studying C. difficile infection-associated epigenetic alterations using human minigut and murine models of infection. I work closely with Dr Benjamin Mullish, Imperial College London, Dr Dina Kao at the University of Alberta and Dr Christos Polytarchou at Nottingham Trent University to study molecular mechanisms of action of faecal microbiota transplantation therapy for C. difficile infection.

In 2017, I was awarded an Anne McLaren Fellowship to study Clostridium difficile infection in urbanised and tribal communities in Central India in collaboration with the Central India Institutes of Medical Sciences (CIIMS), Mahatma Gandhi Tribal Hospital, Melghat Tiger Reserve and the C. difficile Ribotyping Network, Leeds. Since commencing this project, we have expanded our research programme to also concentrate on more broadly studying the aetiology of infectious diarrhoea using multiplex PCR and anaerobic culture programmes. These studies have been funded by two University of Nottingham Research Priority Area grants. We have received GCRF funding to develop an Indo-UK interdisciplinary networking partnership for tackling infectious diarrhoea in Central India in collaboration with researchers in the School's of Geography, Health Sciences, Veterinary Medicine and Science in Nottingham, and externally with the London School of Hygiene and Tropical Medicine and multiple institutions in India including CIIMS, the Central Council of India Medicine, New Delhi, Government Medical College, Nagpur Veterinary College, National Environmental Engineering Research Institute, Nagpur, University of Hyderabad, Maharashtra Association of Anthropological Science, Pune and Kasturba Medical College and Hospital Manipal, Kamataka. As part of this collaborative network, we were recently awarded follow on GCRF funding to study the utility of wastewater-based epidemiology to predict disease outbreaks in Central India, including SARS-CoV-2.

On faecal metagenome studies, I collaborate with Dr Adam Blanchard, University of Nottingham, and Dr Stephen Stockdale, APC Microbiome Cork, as well as The Chinese University of Hong Kong (Siew Ng).

Allied to my research studies in India, I am working closely with Professor Weng Chan in the School of Pharmacy in Nottingham on a recently funded MRC DPFS grant to develop LY256, a novel and potent antibiotic for treating C. difficile infection. I also collaborate with Professor Cameron Alexander in the School of Pharmacy on the development of microRNA-based nanoscale delivery systems for the treatment of inflammatory bowel disease and C. difficile infection.

Expertise Summary

C. difficile infection - adaptive immune responses to C. difficile toxins A and B in varied patient groups (University of Nottingham)

  • Developmental ELISA and ELISPOT assays
  • Protein microarray assays
  • Antigen-specific flow cytometry
  • In vitro gut models of C. difficile infection

Novel anti-C. difficile antimicrobials (University of Nottingham)

  • LY256: a novel and potent antibiotic for treating C. difficile infection
  • MicroRNA-based nanoformulations for treating IBD and C. difficile infection

Mechanisms of action of faecal microbiota transplantation (University of Nottingham, Nottingham Trent University, Imperial College London, University of Alberta, University of British Columbia)

  • Specific focus on immunometabolic and epigenetic factors

Faecal metagenomics (University of Nottingham, Central India Institute of Medical Sciences, The Chinese University of Hong Kong, APC Microbiome)

  • Metagenomics reveals impact of geography, antibiotics and acute diarrhoeal disease on the gut microbiome of Central Indian populations
  • GAME-COSMIC Study
  • Deciphering gut microbiome-glycomic-immune system interactions in health and disease: a meta-omics study

Global Health Research

  • Tropical infectious diseases
  • Neglected pathogens
  • Wastewater-based epidemiology

Medical Education publishing:

  • Oxford Handbook of Clinical Examination and Practical Skills. Thomas J, Monaghan T. Pub: Oxford University Press, Oxford. June 2007.
  • 2 ed. published July 2014.
  • "Highly commended" at BMA Medical Book Awards 2015
  • Oxford Handbooks Clinical Tutor Study Cards: Medicine. Monaghan T, Thomas J. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Surgery. Monaghan T, Thomas J, Humes D. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Practical Procedures. Thomas J, Monaghan T, Thompson A. Pub: Oxford University Press, Oxford. September 2011.

Teaching Summary

Trust Lead for undergraduate teaching in Gastroenterology and Hepatology

Supervision of undergraduate BMedSci students and examiner for BMedSci dissertations

Supervision of 4 Ph.D. students and one international MSc student

Member of Global Engagement Committee for Faculty of Medicine and Health Sciences

Research Summary

Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes;… read more

Recent Publications

Current Research

Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Cambria","serif"; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-US; mso-fareast-language:EN-US;}

My current research interests are in understanding the pathophysiology of infection and inflammation of the gastrointestinal tract, specifically mechanisms of action of fecal microbiota transplantation (FMT) and the preclinical development of novel antimicrobials, refined microbiome-based therapeutics, and microRNA-based drugs for the treatment of gut dysbiosis-related disorders, including IBD and CDI.

I lead and co-ordinate multiomics-based studies with several UK-, Indian-, and North American labs and I am currently developing wastewater-based epidemiological approaches to better understand population health in the UK and India, where my team use a combination of genomic, metagenomic, metabolic and pharmacological readouts to track infectious diseases.

I also have a keen interest in medical education where I have a British Medical Association book award and I have co-authored 4 Oxford Handbook titles.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

Contacts: Please see our 'contact us' page for further details