Dr Wayne Grant Carter completed a BSc (Hons) degree in Biochemistry with Nutrition and then a PhD in Biochemistry at the University of Southampton. He subsequently undertook post-doctoral research posts at The Babraham Institute, Cambridge; Imperial College, London; University of California at Irvine, USA, and then at the University of Oxford. Additionally, Dr Carter has worked for a global reagent supplier, Sigma, a SME company, Mobious Genomics, and has been employed as a consultant for Syngenta. Dr Carter is currently an Associate Professor and Group Leader (Clinical Toxicology lab) within the School of Medicine, University of Nottingham. Dr Carter's research interests are varied and include detection and utilisation of novel biomarkers of toxicological exposure.
Understanding the molecular mechanisms that underpin disease provides the basis for targeted therapeutics. The research in my lab is concerned with understanding protein changes and modifications that can trigger pathology. In recent years we have focussed on hepato- and neuro-toxicological mechanisms. We employ cell and animal models and human postmortem tissue to understand pathological changes and utilize a broad range of biological and biochemical techniques to study disease. Current projects include the biological impact of environmental pesticides and heavy metals, liver and brain toxicity of alcohol, mechanisms that trigger protein aggregation in neurodegenerative diseases, and purification and assessment of the beneficial properties of phytochemicals.
BSc (Hons) Medical Physiology & Therapeutics, course code B121.
Year 1: A11 Body Structure & Function (teaching protein structure/function, cell cycle & genetics, & alimentary physiology).
Year 1: A11 Infection & Defense (teaching immunology).
Year 2: A12 Cancer Biology (teaching all elements of cancer cell biology, cellular signalling, genetics, radiotherapy, chemotherapy, etc).
Year 3: A13 Cellular Basis of Disease (teaching microbiological & neurodegenerative diseases & treatments).
Year 1: A11 Supply & Demand I (teaching nutrition & metabolism). A11 MVT Movement (teaching the motor system in health & disease).
Year 2: A12 Neuroscience (teaching neurodegeneration); A12 Pharmacology & Therapeutics (teaching drug use & toxicity); A12 Respiratory Disease (teaching lung cancer).
Year 3: A13 Final Year Research Project (Supervisor for lab-based research & systematic reviews & meta-analysis based research projects).
Bachelor of Medicine Bachelor of Surgery (BMBS), course codes A100 and A101:
Year 2: A12 Clinical Toxicology Studies (teaching clinical toxicology with case studies).
Year 1: A12 Structure, Function & Defense (teaching protein structure/function, bacteria & viral immunology); A12 Alimentary System (teaching liver structure, function, & pathology); A12 Respiratory Sciences (teaching respiratory inflammation, & oncogenesis).
Year 2: A12 Neuroscience (teaching neuroscience & neurodegeneration).
Year 1 & Year 2 problem based learning (PBL) facilitation.
Medicine 1: Basic Introduction to Toxicology
VIGNESWARA, V., CASS, S., WAYNE, D., BOLT, E.L., RAY, D.E. and CARTER, W.G., 2013. Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms PLoS ONE. 8(4), e61442 LEGGATE, M., CARTER, W.G., EVANS, M.J.C., VENNARD, R.A., SRIBALA-SUNDARAM, S. and NIMMO, M.A., 2012. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males Journal of Applied Physiology. 112(8), 1353-1360 TARHONI, M.H., VIGNESWARA, V., SMITH, M., ANDERSON, S., WIGMORE, P., LEES, J.E., RAY, D.E. and CARTER, W.G., 2011. Detection, quantification, and microlocalisation of targets of pesticides using microchannel plate autoradiographic imagers Molecules. 16(10), 8535-8551
CARTER, W.G., TARHONI, M.H. and RAY, D.E., 2010. Analytical approaches to investigate protein-pesticide adducts Journal of Chromatography B. 878(17-18), 1312-1319