Understanding the importance of stress responses in cancer adaptation

Regions of low oxygen (hypoxia) and acidosis are frequently found in solid tumours (in particular we work on breast, colon and brain tumours however other solid tumours are also relevant).

Clinically, hypoxia is associated with worse patient survival and resistance to chemotherapy and radiotherapy and acidosis increases tumour metastasis. An array of changes occur in response to hypoxia and acidosis leading to molecular adaptation through signalling, transcription, epigenetics and translation. Understanding these changes and the adaptations they enable will provide a better understanding of these therapy resistant microenvironments and therapeutic approaches to target these to improve patient survival. 

Available to Home/EU/International students.