The National Centre for Macromolecular Hydrodynamics

Software 

All programs come complete with instructions manual   

Molecular Weight


SEDFIT-MSTAR  

MSTAR Graph

Released November 2013: a new adaptation of sedimentation equilibrium in the analytical ultracentrifuge providing a user-friendly method for the analysis of molecular weights of polymers. Based on the Creeth-Harding M* function and now implemented in the SEDFIT platform of P. Schuck.  

Download SEDFIT-MSTAR

Download the publication in Analyst

Download SEDFIT-MSTAR-PLUS

This is an associated ORIGIN based program where output from SEDFIT-MSTAR can be transferred into to give publication quality plots

Molecular Shape

 

ELLIPS

 ELLIPS Image

The General Ellipsoid

Representation of the overall shapes of proteins in solution as ellipsoids of revolution or general tri-axial ellipsoids*.  Deals with the problems of hydration and model non-uniqueness.

 

Windows XP version

Download ELLIPS * For non-regular shaped macro-molecules the bead modelling and flexible linear structure algorithms of the Physical Chemistry Group, Murcia are recommended.

 

Molecular Non-Ideality

COVOL image

COVOL

Prediction of the thermodynamic second virial coefficient from the size, shape and charge of a protein.

Based on Rallison-Harding theory for pairwise excluding volume interactions in dominant Brownian motion.

Download COVOL

 

 

 

    

National Centre for Macromolecular Hydrodynamics

School of Biosciences
The University of Nottingham
Sutton Bonington Campus
Loughborough, LE12 5RD

telephone: +44 (0)115 951 6148
fax: +44 (0)115 951 6142
email: Steve.Harding@nottingham.ac.uk