Contact

• workRoom D04 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 84 68357
• jonathan.burley@nottingham.ac.uk

Biography

In 1998 I gained a MChem (First Class Honours) in Chemistry at New College, Oxford, and remained there to complete a DPhil in Inorganic Chemistry in 2001, under the supervision of Prof Peter Battle. I then spent two years working as a post-doc in the Materials Science Division at Argonne National Laboratory, Illinois, USA, in the laboratory of Dr John F Mitchell. I returned to the UK in 2003 to take up a Junior Research Fellowship at Jesus College, Cambridge, where I ran an independent research program in the Inorganic Chemistry sector. I moved to the Leicester School of Pharmacy at De Montfort University in 2006, as a lecturer in pharmaceutical technologies. In 2007 I was appointed to a lectureship in pharmaceutical nanotechnology here in the School of Pharmacy at Nottingham.

Research Summary

My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc.… read more

Recent Publications

• TRES, FRANCESCO, TREACHER, KEVIN, BOOTH, JONATHAN, HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2016. Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release MOLECULAR PHARMACEUTICS. 13(3), 1166-1175
• TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis POLYMER. 89, 41-49
• TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular pharmaceutics. 12(5), 1512-1522
• SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. 3D printing of tablets containing multiple drugs with defined release profiles International Journal of Pharmaceutics. 494(2), 643-650

• View all publications

Current Research

My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc. Phenomena of interest include crystallisation, polymorphism, hydration, dehydration, mapping of components in tablets and other drug delivery vehicles, formation of salts and co-crystals, etc.

A number of experimental techniques are employed, including Raman spectroscopy/microscopy, infra-red spectroscopy, X-ray diffraction (powder and single crystal), thermal methods etc. Experimental data are often complex (multi-variate) and are interpreted with appropriate statistical methods including Principal Component Analysis.

Current projects include investigations of:

• transitions from one solid form to another (polymorphism) on heating, important for formulating medicines
• rapid spatial mapping of tablets and complex drug delivery vehicles, for quality control of medicines and understanding controlled release
• new spectroscopic methods including Transmission Raman Spectroscopy, various new applications in pharmacy
• formation and stabilisation of amorphous materials, to produce new highly soluble medicines

Biography

• 2007-present Lecturer in Pharmaceutical Nanotechnology, University of Nottingham
• 2006-2007 Lecturer in Pharmaceutical Technology, De Montfort University, Leicester
• 2006-2003 Junior Research Fellow, Jesus College and Chemistry Department, University of Cambridge
• 2003-2001 Post-doctoral researcher, Materials Science Division, Argonne National Laboratory, USA
• 2001-1998 DPhil, Department of Chemistry, University of Oxford
• 1998-1994 MChem, University of Oxford

Memberships of Committees & Professional Bodies

• Member, Royal Society of Chemistry

Teaching

• B31C07: Pharmaceutical Technology
• Laboratory studies in Pharmaceutics

• TRES, FRANCESCO, TREACHER, KEVIN, BOOTH, JONATHAN, HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2016. Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release MOLECULAR PHARMACEUTICS. 13(3), 1166-1175
• TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis POLYMER. 89, 41-49
• TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular pharmaceutics. 12(5), 1512-1522
• SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. 3D printing of tablets containing multiple drugs with defined release profiles International Journal of Pharmaceutics. 494(2), 643-650
• SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles Journal of Controlled Release. 217, 308-314
• MASON, LAURA MICHELLE, DOLORES CAMPINEZ, MARIA, PYGALL, SAMUEL R., BURLEY, JONATHAN C., GUPTA, PRANAV, STOREY, DAVID E., CARABALLO, ISIDORO and MELIA, COLIN D., 2015. The influence of polymer content on early gel-layer formation in HPMC matrices: The use of CLSM visualisation to identify the percolation threshold EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 94, 485-492
• BEECH, K. E., BIDDLECOMBE, J. G., VAN DER WALLE, C. F., STEVENS, L. A., RIGBY, S. P., BURLEY, J. C. and ALLEN, S., 2015. Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations: European Journal of Pharmaceutics and Biopharmaceutics European Journal of Pharmaceutics and Biopharmaceutics. 96, 247-254
• TRES, FRANCESCO, COOMBES, STEVEN R., PHILLIPS, ANDREW R., HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2015. Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR MOLECULES. 20(9), 16404-16418
• BEECH, KAREN E., BIDDLECOMBE, JAMES G., VAN DER WALLE, CHRISTOPHER F., STEVENS, LEE A., RIGBY, SEAN P., BURLEY, JONATHAN C. and ALLEN, STEPHANIE, 2015. Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 96, 247-254
• BUANZ, ASMA, PRIOR, TIMOTHY J., BURLEY, JONATHAN C., RAIMI-ABRAHAM, BAHIJJA TOLULOPE, TELFORD, RICHARD, HART, MICHAEL, SEATON, COLIN C., DAVIES, PHILIP J., SCOWEN, IAN J., GAISFORD, SIMON and WILLIAMS, GARETH R., 2015. Thermal Behavior of Benzoic Acid/lsonicotinamide Binary Cocrystals CRYSTAL GROWTH & DESIGN. 15(7), 3249-3256
• NANUBOLU, JAGADEESH BABU and BURLEY, JONATHAN C., 2015. In situ Raman mapping for identifying transient solid forms CRYSTENGCOMM. 17(28), 5280-5287
• SHABAN A. KHALED, JONATHAN C. BURLEY, MORGAN R. ALEXANDER and CLIVE J. ROBERTS, 2014. Desktop 3D printing of controlled release pharmaceutical bilayer tablets International Journal of Pharmaceutics. 461(1-2), 105–111
• JONATHAN C. BURLEY, ADEYINKA AINA, PAVEL MATOUSEK and CHRISTOPHER BRIGNELL, 2014. Quantification of pharmaceuticals via transmission Raman spectroscopy: data sub-selection Analyst. 139, 74-78
• MEGARRY, A. J., BOOTH, J. and BURLEY, J., 2014. Sucrose/Glucose Molecular Alloys by Cryomilling Journal of Pharmaceutical Sciences. (In Press.)
• TRES F, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2014. Real time Raman imaging to understand dissolution performance of amorphous solid dispersions. Journal of controlled release : official journal of the Controlled Release Society. 188, 53-60
• ALGAHTANI, MOHAMMED S., SCURR, DAVID J., HOOK, ANDREW L., ANDERSON, DANIEL G., LANGER, ROBERT S., BURLEY, JONATHAN C., ALEXANDER, MORGAN R. and DAVIES, MARTYN C., 2014. High throughput screening for biomaterials discovery JOURNAL OF CONTROLLED RELEASE. 190, 115-126
• YAA ASANTEWAA, JONATHAN AYLOTT, JONATHAN C BURLEY, NASHIRU BILLA and CLIVE J ROBERTS, 2013. Correlating Physicochemical Properties of Boronic Acid-Chitosan Conjugates to Glucose Adsorption Sensitivity Pharmaceutics. 5, 69-80
• ALKHALIL, A, NANUBOLU, JB and BURLEY, JC, 2012. Analysis Of Phase Transitions In Molecular Solids: Quantitative Assessment Of Phonon-Mode Vs Intra-Molecular Spectral Data Rsc Advances. 2(1), 209-216
• BRADLEY JP, PICKARD CJ, BURLEY JC, MARTIN DR, HUGHES LP, COSGROVE SD and BROWN SP, 2012. Probing Intermolecular Hydrogen Bonding In Sibenadet Hydrochloride Polymorphs By High-Resolution (1) H Double-Quantum Solid-State Nmr Spectroscopy. Journal Of Pharmaceutical Sciences. 101(5), 1821-30
• BURLEY, J.C., ALKHALIL, A., BLOOMFIELD, M. and MATOUSEK, P., 2012. Transmission Raman spectroscopy for quality control in model cocrystal tablets Analyst. 137(13), 3052-3057
• GARETH R. WILLIAMS, JOHN CROWDER, JONATHAN C. BURLEY and ANDREW M. FOGG, 2012. The selective intercalation of organic carboxylates and sufonates into hydroxy double salts Journal of Material Chemistry. 22, 13600-13611
• NANUBOLU JB and BURLEY JC, 2012. Investigating the recrystallization behavior of amorphous paracetamol by variable temperature raman studies and surface raman mapping. Molecular pharmaceutics. 9(6), 1544-58
• MEGARRY, A J, BOOTH, J and BURLEY, J, 2011. Amorphous trehalose dihydrate by cryogenic milling. Carbohydrate research. 346(8), 1061-4
• BURLEY, J.C., O'HARE, D. and WILLIAMS, G.R., 2011. The application of statistical methodology to the analysis of time-resolved X-ray diffraction data Analytical Methods. 3(4), 814-821
• CHUAH LH, BILLA N, ROBERTS CJ, BURLEY JC and MANICKAM S, 2011. Curcumin-Containing Chitosan Nanoparticles As A Potential Mucoadhesive Delivery System To The Colon. Pharmaceutical Development And Technology. 1-9
• ALKHALIL, A, NANUBOLU, JB, ROBERTS, CJ, AYLOTT, JW and BURLEY, JC, 2011. Confocal Raman Microscope Mapping Of A Kofler Melt Crystal Growth & Design. 11(2), 422-430
• WEBBER, A.L., MASIERO, S., PIERACCINI, S., BURLEY, J.C., TATTON, A.S., IUGA, D., PHAM, T.N., SPADA, G.P. and BROWN, S.P., 2011. Identifying guanosine self assembly at natural isotopic abundance by high-resolution ¹H and ¹³C solid-state NMR spectroscopy Journal of the American Chemical Society. 133(49), 19777-19795
• BOUHROUM, ABDENNOUR, BURLEY, JONATHAN C, CHAMPNESS, NEIL R, TOON, RICHARD C, JINKS, PHILIP A, WILLIAMS, PHILIP M and ROBERTS, CLIVE J, 2010. An assessment of beclomethasone dipropionate clathrate formation in a model suspension metered dose inhaler. International Journal of Pharmaceutics. 391(1-2), 98-106
• AINA, A., HARGREAVES, M.D., MATOUSEK, P. and BURLEY, J.C., 2010. Transmission Raman spectroscopy as a tool for quantifying polymorphic content of pharmaceutical formulations Analyst. 135(9), 2328-2333
• AL-DULAIMI, S., AINA, A. and BURLEY, J., 2010. Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy CrystEngComm. 12(4), 1038-1040
• BURLEY, JONATHAN C, GILMOUR, RYAN, PRIOR, TIMOTHY J and DAY, GRAEME M, 2008. Structural diversity in imidazolidinone organocatalysts: a synchrotron and computational study. Acta crystallographica. Section C, Crystal structure communications. 64(Pt 1), o10-4
• LLINAS, A., BURLEY, J.C., PRIOR, T.J., GLEN, R.C. and GOODMAN, J.M., 2008. Concomitant Hydrate Polymorphism in the Precipitation of Sparfloxacin from Aqueous Solution Crystal Growth & Design. VOL 8(NUMB 1), 114-118
• FRISCIĆ, TOMISLAV, FÁBIÁN, LÁSZLÓ, BURLEY, JONATHAN C, REID, DAVID G, DUER, MELINDA J and JONES, WILLIAM, 2008. Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids? Chemical Communications. 1644-6
• LLINÀS, A., BOX, K.J., BURLEY, J.C., GLEN, R.C. and GOODMAN, J.M., 2007. A new method for the reproducible generation of polymorphs: two forms of sulindac with very different solubilities Journal of Applied Crystallography. 40(2), 379-381
• LLINÀS, A., BURLEY, J.C., BOX, K.J., GLEN, R.C. and GOODMAN, J.M., 2007. Diclofenac solubility: independent determination of the intrinsic solubility of three crystal forms Journal of Medicinal Chemistry. 50(5), 979-983
• BURLEY, J.C., MOTHERWELL, W.D.S., MAARANEN, J. and RINGWALD, M., 2007. Dichloro[(eta(5)-cyclopentadienyl)dimethyl(eta(5)-3-phenylindenyl)silane]hafnium(IV): a powder study Acta Crystallographica. Section E: Structure Reports Online. 63(1), M238-M240
• BURLEY, JONATHAN C, DUER, MELINDA J, STEIN, ROBIN S and VRCELJ, RANKO M, 2007. Enforcing Ostwald's rule of stages: isolation of paracetamol forms III and II. European Journal of Pharmaceutical Sciences. 31(5), 271-6
• FRIŠČIĆ, T., FÁBIÁN, L., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals Chemical Communications. 48, 5009-5011
• LLINAS, A., FABIAN, L., BURLEY, J.C., VAN DE STREEK, J. and GOODMAN, G.M., 2006. Amodiaquinium dichloride dihydrate from laboratory powder diffraction data Acta Crystallographica. Section E: Structure Reports Online. 62(9), O4196-O4199
• HAYNES, D.A., VAN DE STREEK, J., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Pamoic acid determined from powder diffraction data Acta Crystallographica. Section E: Structure Reports Online. 62(3), O1170-O1172
• BURLEY, JONATHAN C and PRIOR, TIMOTHY J, 2006. Insights into crystallization mechanism: a synchrotron study of polymorphism in a cobalt acetate cluster compound. Acta Crystallographica. Section C: Crystal Structure Communications. 62(Pt 2), m63-6
• DAY, G.M., VAN DE STREEK, J., BONNET, A., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Polymorphism of scyllo-inositol: Joining crystal structure prediction with experiment to elucidate the structures of two polymorphs Crystal Growth and Design. 6(10), 2301-2307
• BURLEY, J.C., VAN DE STREEK, J. and STEPHENS, P.W., 2006. Ampicillin trihydrate from synchrotron powder diffraction data Acta Crystallographica. Section E: Structure Reports Online. 62(2), O797-O799
• BURLEY, J.C., 2005. Structure and intermolecular interactions of glipizide from laboratory X-ray powder diffraction Acta Crystallographica. Section B: Structural Science. 61(6), 710-716
• BURLEY, J.C. and PRIOR, T.J., 2005. mu(2)-Aqua-bis(mu(2)-trifluoroaceto-k(2)O,O ')bis[bis-(pyridine-kN)(trifluoroacetato-kO) cobalt(II)] Acta Crystallographica. Section E: Structure Reports Online. 61(7), M1422-M1424
• ALVAREZ, CARMEN SORIA, BOSS, SALLY R, BURLEY, JONATHAN C, HUMPHRY, SIMON M, LAYFIELD, RICHARD A, KOWENICKI, RICHARD A, MCPARTLIN, MARY, RAWSON, JEREMY M, WHEATLEY, ANDREW E H, WOOD, PAUL T and WRIGHT, DO, 2004. Syntheses, structures and magnetic properties of Mn(II) dimers [CpMn(micro-X)]2(Cp = C5H5; X = RNH, R1R2N, C[triple bond]CR). Dalton transactions (Cambridge, England : 2003). 3481-7
• BURLEY, J.C., MITCHELL, J.F. and SHORT, S., 2004. Competing electronic ground states in La1-xCaxCoO3 Physical Review B: Condensed Matter. 69(5),
• BATTLE, P.D., BURLEY, J.C., GALLON, D.J., GREY, C.P. and SLOAN, J., 2004. Magnetism and structural chemistry of the n=2 Ruddlesden-Popper phase La3LiMnO7 Journal of Solid State Chemistry. 177(1), 119-125
• BURLEY, J.C., BATTLE, P.D., JORDAN, N.A., SLOAN, J. and WEILL, F., 2003. Synthesis and structural characterization of BA14Pd3Ir8O33 Journal of Solid State Chemistry. 174(1), 96-103
• ALEXANDER, A., BATTLE, P.D., BURLEY, J.C., GALLON, D.J. and GREY, C.P., 2003. Structural and magnetic properties of Li3RuO4 Journal of Materials Chemistry. 13(10), 2612-2616
• SCHMIDT, H., GRAY, K. E., HINKS, D. G., ZASADZINSKI, J. F., AVDEEV, M., JORGENSEN, J. D. and BURLEY, J. C., 2003. Retention of two-band superconductivity in highly carbon-doped MgB~2 (4 pages) PHYSICAL REVIEW -SERIES B-. VOL 68(PART 6), 060508(R)
• BURLEY, J.C., MITCHELL, J.F., SHORT, S., MILLER D. and TANG, Y., 2003. Structural and magnetic chemistry of NdBaCo2O5+delta Journal of Solid State Chemistry. 170(2), 339-350
• JORGENSEN, J. D., AVDEEV, M., HINKS, D. G., BURLEY, J. C. and SHORT, S., 2003. Crystal structure of the sodium cobaltate deuterate superconductor Na~xCoO~2.4xD~2O (x⅓) (10 pages) PHYSICAL REVIEW -SERIES B-. VOL 68(PART 21), 214517
• MITCHELL, J. F., BURLEY, J. and SHORT, S., 2003. Crystal and magnetic structure of NdBaCo~2O~5~+~d~e~l~t~a: Spin states in a perovskite-derived, mixed-valent cobaltite JOURNAL OF APPLIED PHYSICS. VOL 93(PART 10), 7364-7366
• GALLON, D. J., BATTLE, P. D., BLUNDELL, S. J., BURLEY, J. C., COLDEA, A. I., CUSSEN, E. J., ROSSEINSKY, M. J. and STEER, C., 2002. Synthesis and Characterization of Ru-Doped n = 1 and n = 2 Ruddlesden-Popper Manganates Chemistry of Materials. VOL 14(PART 9), 3976-3983
• BURLEY, J. C., BATTLE, P. D., GALLON, D. J., SLOAN, J., GREY, C. P. and ROSSEINSKY, M. J., 2002. Magnetism and Structural Chemistry of the n = 1 Ruddlesden-Popper Phases La~4LiMnO~8 and La~3SrLiMnO~8 JOURNAL- AMERICAN CHEMICAL SOCIETY. VOL 124(PART 4), 620-628
• BURLEY, J. C., BATTLE, P. D., GASKELL, P. J. and ROSSEINSKY, M. J., 2002. Structural and Magnetic Chemistry of La~2Sr~2BMnO~8 (B = Mg, Zn) JOURNAL OF SOLID STATE CHEMISTRY. VOL 168(PART 1), 202-207
• CUSSEN, E. J., ROSSEINSKY, M. J., BATTLE, P. D., BURLEY, J. C., SPRING, L. E., VENTE, J. F., BLUNDELL, S. J., COLDEA, A. I. and SINGLETON, J., 2001. Control of Magnetic Ordering by Jahn-Teller Distortions in Nd~2GaMnO~6 and La~2GaMnO~6 Journal of the American Chemical Society. VOL 123(PART 6), 1111-1122
• BATTLE, P. D., BURLEY, J. C., CUSSEN, E. J., HARDY, G. C., HAYWARD, M. A., NOAILLES, L. D. and ROSSEINSKY, M. J., 1999. Strong ferromagnetic coupling in the K~2NiF~4-structured oxide La~0~.~8Sr~1~.~2Mn~0~.~6Rh~0~.~4O~4 Chemical Communications. NUMBER 19, 1977-1978
• BATTLE, P. D., BURLEY, J. C., CUSSEN, E. J., DARRIET, J. and WEILL, F., 1999. Incommensurate phases in the Ba-Mn-Pd-O system Journal of Materials Chemistry. VOL 9(NUMBER 2), 479-484
• BATTLE, P.D., BLAKE, G.R., BURLEY, J.C., CUSSEN, E.J., SLOAN, J., VENTE, J.F., DARRIET, J. and WEILL, F., 1998. Commensurate and incommensurate oxide structures related to 2H perovskite In: Materials Research Symposium Proceedings. 45-51
• WU J., LYNN J.W., GLINKA C.J., BURLEY J.C., ZHENG H., MITCHELL J.F. and LEIGHTON C., Intergranular Giant Magnetoresistance in a Spontaneously Phase Separated Perovskite Oxide Physical Review Letters. 94, 037201