I have been principal or co-investigator on successful project grants from UK research councils (MRC, BBSRC), the European Union (EUFP7), charities (Dunhill Medical Trust) and industrial (Ajinomoto, Abbott Nutrition, Fresenius-Kabi) sources to the tune of >£10 Million. I have published >120 peer-reviewed articles (H-index 50, i10 index 90, >10,000 citations - Google Scholar) and 6 invited book chapters and my work has placed me in the world's top 5% of cited authors for work in Biology & Biochemistry (source: Thomson Reuters). I have received prestigious early career awards (e.g. American Physiological Society World New investigator 2010) and am regularly invited to speak at both national (e.g. Physiological Society) and international (e.g. EB, ECSS, ASPEN, ICAAP, A/ESPEN) conferences. Our group collaborates nationally and internationally. Our labs presently hosts 3 technicians, ~15 PhD non-clinical and clinical MRes/PhD students & 3 Research Fellows. Our lab is housed at the Royal Derby hospital postgraduate entry medical school under the auspices of a UK Medical Research Council/Arthritis Research UK Centre of excellence for musculoskeletal ageing research, and NIHR Biomedical Research Centre (BRC) under a musculoskeletal theme.
I serve on a number of editorial boards.
Experimental Physiology - Associate Editor (http://physoc.onlinelibrary.wiley.com/hub/journal/10.1111/(ISSN)1469-445X/)
Applied Physiology, Nutrition & Metabolism - Associate Editor (http://www.nrcresearchpress.com/journal/apnm)
The American Journal of Physiology - Editor (http://ajpendo.physiology.org)
Clinical, Metabolic and Molecular Physiology
I teach on a variety of topics on both the Graduate Entry Medical Course and the BSc in Medical Physiology and Therapeutics.
Research synopsis: My past work has focused on the identification of central mechanisms regulating metabolism in human musculoskeletal tissues, and where appropriate, using more tractable in vitro… read more
Research synopsis: My past work has focused on the identification of central mechanisms regulating metabolism in human musculoskeletal tissues, and where appropriate, using more tractable in vitro cell or where appropriate, in vivo animal models. Combining molecular biology, stable isotope methodologies and detailed in vivo human physiology, I have been a key part of a team that has discovered a number of fundamental parameters that govern alterations in protein metabolism with age and disease. In particular, I have led the molecular analysis in the majority of my publications and over more recent years in becoming laboratory PI, been responsible for grant income, research direction and development of state-of-the-art physiological experiments. The current direction of my work involves the combining of detailed molecular physiology with the application of carbon/ deuterium stable isotope methodologies and more recently, the integration of OMIC (genomic/ metabolomic) techniques to discover predictors of, and the basis for, musculoskeletal decline in ageing and disease.