Dr. Iskandar Idris is a Professor of Diabetes and Metabolic Medicine at the University of Nottingham and Honorary Consultant Physician at the Derby Teaching Hospital. Originally a Nottingham University graduate he undertook his general medical training in Birmingham and completed his specialist training in 2004 within the Mid-Trent postgraduate deanery in Diabetes, Endocrinology and General Medicine. He was a lecturer at the Division of Vascular Medicine, University of Nottingham from 2000-2002, where he undertook a research on 'Experimental Pharmacology of Endothelial Permeability and Insulin Resistance' leading to a Doctor of Medicine degree.
Dr Idris is currently the Training Programme Director for Specialist Training in Diabetes and Endocrinology at the East Midlands postgraduate deanery and a lead physician within the East Midlands Bariatric & Metabolic Institute at the Derby Teaching Hospital. He is also a member of the Association of Physician Specialising in Obesity UK (APSO-UK). He has ongoing academic and research interests in the field of therapeutic and nutritional aspects of obesity, muscle metabolism and vascular complications of diabetes. Within the University of Nottingham, he is Principal Investigator within the MRC/ Arthritis Research UK Centre for Musculoskeletal Ageing Research and the Vascular Medicine Research group. He has published widely in the field of diabetes, obesity pharmacology and vascular complications. He also lectures widely (locally and nationally) in this clinical and research area.
Long standing interest and expertise in general aspects of diabetes, obesity and endocrinology; research interests in epidemiological, clinical and experimental studies relating to therapeutic,… read more
Experimental, basic science, clinical and epidemiological studies relating to aspects of insulin resistance, the metabolic syndrome and cardiovascular risks in patients with diabetes and obesity.… read more
IDRIS I, ZHANG R, MAMZA JB, FORD M, MORRIS T, BANERJEE A, KHUNTI K, TULIP J and GREENER M, 2021. Lower risk of hospitalisation for heart failure, kidney disease and death with sodium glucose co-transporter-2 compared to dipeptidyl peptidase-4 inhibitors in type 2 diabetes regardless of prior cardiovascular or kidney disease: a retrospective cohort study in UK primary care Diabetes Obesity and Metabolism. (In Press.)
ALKHARAIJI M, ANYANWAGU U and IDRIS I, 2021. The metabolic and liver-related outcomes of bariatric surgery in adult patients with insulin-treated type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) at high risk of liver fibrosis Surgery for Obesity and Related Disease. 17(4), 792-798
WEBB J, MOUNT J, VON ARX L, RACHMAN J, SPANOPOULOS D, WOOD R, TRITTON T, MASSEY O and IDRIS I, 2021. Cardiovascular risk profiles: A cross-sectional study evaluating the generalisability of the glucagon-like peptide-1 receptor agonist cardiovascular outcome trials REWIND, LEADER and SUSTAIN-6 to the real-world type 2 diabetes population in the UK Diabetes, Obesity and Metabolism.
Long standing interest and expertise in general aspects of diabetes, obesity and endocrinology; research interests in epidemiological, clinical and experimental studies relating to therapeutic, nutritional, surgical and biological aspects of diabetes, obesity, insulin resistance and vascular risks in patients with diabetes and obesity.
Teaching lead for Diabetes and Endocrinology CP1 and CP3 students at Derby TEaching Hospital.
Schoolof Medicine representative for the Inter Professional learning curriculum for the University of Nottingham.
Involved in Diabetes and Endocirnology curriculum and teaching for University of Nottingham undergraduates medical student
Experimental, basic science, clinical and epidemiological studies relating to aspects of insulin resistance, the metabolic syndrome and cardiovascular risks in patients with diabetes and obesity. Current research projects include;
i. Pharmaco-epidemiological research to investigate the role of insulin, bariatric surgery and DPP4 inhibitor on vascular and metabolic complications in patients with type 2 diabetes
ii. Effect of amino acid on GLP-1 production and its role in regulating muscle protein synthesis breakdown and microvascular blood flow in young and old persons (MRC musculoskeletal and ageing research)
iii. Molecular and microvascular mechanism of muscle atrophy in people without diabetes
iv. Effect of Very low calorie diet with or without exercise training on muscle metabolism, muscle volume and microvascular blood flow
v. Effect of pre-bariatric surgical diet on fatty liver disease - a randomised controlled study
vi. Effectiveness of Humalog mix 50 & Humalog U200 insulin in people with diabetes
Previous research involved experimental pharmacological studies on the cellular mechanisms of insulin resistance and diabetic microangiopathy particularly with regards to the role of PKC and the renin-angiotensin-system in mediating these processes. Clinical science research investigating the role of PKC-θ isoform in insulin resistance as well as examining the pharmacological regulation of insulin-stimulated glucose uptake in isolated cellular models of insulin action, e.g. L6 cells and 3T3-L1 adipocytes