GI and Liver Diseases Medical and Surgical Research

Welcome to the Autologous Stem Cell Transplantation for Crohn's Disease Trial (ASTIC)

ASTIC is a multicentre, prospective, randomised phase III study conducted by the European Crohn's and Colitis Organisation (ECCO), sponsored by the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation (EBMT). This study is funded by a grant from the Broad Medical Research Programme.

 ***This trial is now closed to recruitment. Initial analysis is due March 2013 .***


Chief Investigator:

Professor Chris Hawkey, Nottingham Digestive Diseases Centre; Email:

Study Administration Office:

ASTIC Study Administration Office
Nottingham Digestive Diseases Centre; Email: Tel: +44 (0) 115 8231079. Fax: +44 (0) 115 823 1409


See the Centres, members and sponsors page for a list of hospitals that are looking for patients to take part in the trial, and contact details of the people organising the study.

Patient Information - Frequently Asked Questions

Study Presentations 

Study ProtocolPDF format



Study Update


June 2012

Total number of patients transplanted is 38.

There are 4 patients left awaiting delayed transplants, the final of which is due Feb 2013

January 2012


Patient recruitment is halted. Initial analysis is due in a year.

A total of 45 patients have been randomised (of these 35 have been transplanted).

September 2011

A total of 39 patients have been randomised. Of these 27 patients have been transplanted.

July 2011 Nottingham consents their 13th patient

November 2010

27 patients randomised and a further 9 patients consented to the trial.

A total of 17 patients have been transplanted.

September 2010

Belgium joins the ASTIC Trial.

Leuven Hospital consents 2 patients.

20 July 2010

Edinburgh consents 4 patients in a day!

This brings the total number of patients for this site to 6.

April 2010 BARTS and the London consent their first patient.
January 2010 All approvals completed for Switzerland; the first patient enters the trial in Zurich.
July 2009

14 patients now consented into the trial, with 7 transplants complete.

Sites with patients in trial include:

  • UK(London, Oxford, Norfolk and Norwich)
  • France(Paris, Lille)
  • Spain(Barcelona)
  • Italy(Milan)
November 2008

Barcelona Storms Ahead - well done to Elena Ricart and her team.

5 patients registered and a further patient for discussion.

July 2008 The first transplants take place in Nottingham and Barcelona.
February 2008

Three sites now recruiting.

Nottingham, Oxford and Barcelona have completed trial registration.

July 2008 First patient recruited in Nottingham


Study presentations

Abstracts have been submitted to the following meetings:

  • 6th Congress of ECCO, February 23-26, 2011, Dublin
  • Digestive Diseases Week American Gastroenterology Association, Chicago, 30th May - 4th June 2009
  • British Society of Gastroentereology, Glasgow, 23rd-26th March 2009
  • ECCO IBD 4th Congress in Hamburg, 5-7th February 2009 

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Nottingham Digestive Diseases Centre

The University of Nottingham
E Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0) 115 82 31090