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Biography
After receiving a MSc in Bioengineering (SupAgro, 2007) and a MRes in Biomedical Research (Imperial College, 2007), Mattéa completed her DPhil in neurosciences at the University of Oxford (2010) in Prof Dame Kay Davies' group. She did her first postdoc at Mount Sinai School of Medicine, New York (2011-2013) in Dr Jenny Zou's laboratory where she investigated axonal regeneration after spinal cord injury. For her second postdoc (2013-2018) in Prof Peter Oliver's group at the University of Oxford, she studied a novel family of neuroprotective proteins implicated in the oxidative stress response. She then joined Prof Kevin Talbot's and Prof Martin Turner's groups (University of Oxford, 2018-2019) as a visiting researcher where she gained further expertise in stem cell technology and novel proteomic approaches.
Mattéa joined the University of Nottingham as an Anne McLaren Fellow in January 2020. She was promoted to an Assistant Professor position in January 2023.
Expertise Summary
Since her DPhil, Mattéa has been exploring the multiple facets of the neurodegenerative process and has acquired expertise in a wide range of molecular and cellular approaches, animal models, as well as in transcriptomics, metabolomics and proteomics. Her main research focus centers around the role of oxidative and nitrosative stresses and redox mechanisms in the pathophysiology of neurodegenerative conditions including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia.
Research Summary
Mattéa establised her research group in January 2020 in the University of Nottingham Biodiscovery Institute. Her group aims to advance our understanding of the molecular mechanisms underlying… read more
Recent Publications
CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cell Mol Life Sci.. 78(7), 3503-3524 EMILY FENEBERG, DAVID GORDON, ALEXANDER G THOMPSON, MATTÉA J FINELLI, RUXANDRA DAFINCA, ANA CANDALIJA, PHILIP D CHARLES, IMRE MÄGER, MATTHEW J WOOD, ROMAN FISCHER, BENEDIKT M KESSLER, ELIZABETH GRAY, MARTIN R TURNER and KEVIN TALBOT, 2020. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress Neurobiol Dis.. EMILY FENEBERG, PHILIP D CHARLES, MATTÉA J FINELLI, CONNOR SCOTT, BENEDIKT M KESSLER, ROMAN FISCHER, OLAF ANSORGE, ELIZABETH GRAY, KEVIN TALBOT and MARTIN R TURNER, 2020. Detection and Quantification of Novel C-terminal TDP-43 Fragments in ALS-TDP
Current Research
Mattéa establised her research group in January 2020 in the University of Nottingham Biodiscovery Institute. Her group aims to advance our understanding of the molecular mechanisms underlying neurodegenerative disease and to develop and test new therapeutic strategies for these disorders.
In particular, the Finelli lab explores which proteins are present in the human brain and how these proteins change in neurodegenerative diseases including Alzheimer's disease and motor neuron disease. They also develop new tools to promote the use of stem cell technology for improved disease modelling and drug testing.
Her group uses a combination of stem cell technology, gene editing, cell phenotyping, quantitative and redox proteomics, recombinant protein- and cell-based functional assays and in vitro drug screening.
More details can be found on the Finelli lab website.