Mattéa Finelli

Contact

• workBiodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• Mattea.Finelli@nottingham.ac.uk
• https://mattea-finelli-lab.com

Biography

Education:

• DPhil in Physiology, Anatomy and Genetics - Neurosciences (University of Oxford, 2011)
• MRes in Biomedical Research (Imperial College, 2007)
• MSc in Bioengineering (SupAgro, 2007)

Research positions:

• Assistant Professor (University of Nottingham, 2023-present)
• Anne McLaren Fellow (University of Nottingham, 2020-2023)
• Honorary Research Fellow/Visiting Researcher (University of Oxford, 2018-2019)
• Postdoctoral Research Assistant (University of Oxford, 2013-2018)
• Postdoctoral Fellow (Mount Sinai School of Medicine, New York, 2011-2013)

Expertise Summary

The Finelli lab explores the multiple facets of the neurodegenerative process using a wide range of molecular and cellular approaches, as well as transcriptomics, metabolomics and proteomics. Their main research centers around the role of oxidative and nitrosative stresses and redox mechanisms in the pathophysiology of neurodegenerative conditions including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia.

Research Summary

Dr Mattéa Finelli established her group in January 2020 at the University of Nottingham Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms… read more

Recent Publications

• MONAGHAN TM, UGUN-KLUSEK A, FINELLI M, GURNANI P, CHAKRABARTI L, KAO D, ALEXANDER C and POLYTARCHOU C, 2023. Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut.
• CHISHOLM KI and FINELLI MJ, 2023. Enhancing research culture in academia: a spotlight on early career researchers BMC neuroscience.
• CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cellular and molecular life sciences. 78(7), 3503-3524
• FENEBERG E, GORDON D, THOMPSON AG, FINELLI MJ, DAFINCA R, CANDALIJA A, CHARLES PD, MÄGER I, WOOD MJ, FISCHER R, KESSLER BM, GRAY E, TURNER MR and TALBOT K, 2020. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress Neurobiology of disease.

• View all publications

Current Research

Dr Mattéa Finelli established her group in January 2020 at the University of Nottingham Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms underlying neurodegenerative disease and to develop and test new therapeutic strategies for these disorders.

In particular, the Finelli lab explores the proteins present in the human brain and how these proteins change in neurodegenerative diseases including Alzheimer's disease and motor neuron disease. They also develop new tools to promote the use of stem cell technology for improved disease modeling and drug testing.

The Finelli lab uses a combination of stem cell technology, gene editing, cell phenotyping, quantitative and redox proteomics, recombinant protein- and cell-based functional assays and in vitro drug screening.

More details can be found on the Finelli lab website.

Dr Mattéa Finelli is Deputy Director of the Centre for Dementia, and founder and Project Leader of the International Network of Neurodegenerative Disease Research (part of the Global Alliance of Medical Excellence Network) and of the International Dementia Network (part of Universitas 21).

• MONAGHAN TM, UGUN-KLUSEK A, FINELLI M, GURNANI P, CHAKRABARTI L, KAO D, ALEXANDER C and POLYTARCHOU C, 2023. Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut.
• CHISHOLM KI and FINELLI MJ, 2023. Enhancing research culture in academia: a spotlight on early career researchers BMC neuroscience.
• CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cellular and molecular life sciences. 78(7), 3503-3524
• FENEBERG E, GORDON D, THOMPSON AG, FINELLI MJ, DAFINCA R, CANDALIJA A, CHARLES PD, MÄGER I, WOOD MJ, FISCHER R, KESSLER BM, GRAY E, TURNER MR and TALBOT K, 2020. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress Neurobiology of disease.
• FINELLI MJ, 2020. Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions-Focus on S-Nitrosation Frontiers in aging neuroscience.
• FENEBERG E, CHARLES PD, FINELLI MJ, SCOTT C, KESSLER BM, FISCHER R, ANSORGE O, GRAY E, TALBOT K and TURNER MR, 2020. Detection and Quantification of Novel C-terminal TDP-43 Fragments in ALS-TDP Brain pathology.
• WILLIAMSON MG, FINELLI MJ, SLEIGH JN, REDDINGTON A, GORDON D, TALBOT K, DAVIES KE and OLIVER PL, 2019. Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo. Human molecular genetics. 28(21), 3584-3599
• SVISTUNOVA DM, SIMON JN, REMBEZA E, CRABTREE M, YUE WW, OLIVER PL and FINELLI MJ, 2018. Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum. Free radical biology & medicine. 130, 151-162
• FINELLI MJ, APRILE D, CASTROFLORIO E, JEANS A, MOSCHETTA M, CHESSUM L, DEGIACOMI MT, GRASEGGER J, LUPIEN-MEILLEUR A, BASSETT A, ROSSIGNOL E, CAMPEAU PM, BOWL MR, BENFENATI F, FASSIO A and OLIVER PL, 2018. The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons. Human molecular genetics. 28(4), 584-597
• FINELLI MJ, PARAMO T, PIRES E, RYAN BJ, WADE-MARTINS R, BIGGIN PC, MCCULLAGH J and OLIVER PL, 2018. Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Molecular neurobiology. 56(3), 1558-1577
• FINELLI MJ and OLIVER PL, 2017. TLDc proteins: new players in the oxidative stress response and neurological disease. Mammalian genome. 28(9-10), 395-406
• LOH YE, KOEMETER-COX A, FINELLI MJ, SHEN L, FRIEDEL RH and ZOU H, 2016. Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration. Epigenetics. 12(2), 77-92
• BALESTRINI S, MILH M, CASTIGLIONI C, LÜTHY K, FINELLI MJ, VERSTREKEN P, CARDON A, STRAŽIŠAR BG, HOLDER JL, LESCA G, MANCARDI MM, POULAT AL, REPETTO GM, BANKA S, BILO L, BIRKELAND LE, BOSCH F, BROCKMANN K, CROSS JH, DOUMMAR D, FÉLIX TM, GIULIANO F, HORI M, HÜNING I, KAYSERILI H, KINI U, LEES MM, MEENAKSHI G, MEWASINGH L, PAGNAMENTA AT, PELUSO S, MEY A, RICE GM, ROSENFELD JA, TAYLOR JC, TROESTER MM, STANLEY CM, VILLE D, WALKIEWICZ M, FALACE A, FASSIO A, LEMKE JR, BISKUP S, TARDIF J, AJEAWUNG NF, TOLUN A, CORBETT M, GECZ J, AFAWI Z, HOWELL KB, OLIVER KL, BERKOVIC SF, SCHEFFER IE, DE FALCO FA, OLIVER PL, STRIANO P, ZARA F, CAMPEAU PM and SISODIYA SM, 2016. TBC1D24 genotype-phenotype correlation: Epilepsies and other neurologic features. Neurology. 87(1), 77-85
• FINELLI MJ, SANCHEZ-PULIDO L, LIU KX, DAVIES KE and OLIVER PL, 2015. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. The Journal of biological chemistry. 291(6), 2751-63
• PARSONS MJ, BRANCACCIO M, SETHI S, MAYWOOD ES, SATIJA R, EDWARDS JK, JAGANNATH A, COUCH Y, FINELLI MJ, SMYLLIE NJ, ESAPA C, BUTLER R, BARNARD AR, CHESHAM JE, SAITO S, JOYNSON G, WELLS S, FOSTER RG, OLIVER PL, SIMON MM, MALLON AM, HASTINGS MH and NOLAN PM, 2015. The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell. 162(3), 607-21
• FINELLI MJ, LIU KX, WU Y, OLIVER PL and DAVIES KE, 2015. Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations. Human molecular genetics. 24(12), 3529-44
• LIU KX, EDWARDS B, LEE S, FINELLI MJ, DAVIES B, DAVIES KE and OLIVER PL, 2015. Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain. 138(Pt 5), 1167-81
• MOORE JM, OLIVER PL, FINELLI MJ, LEE S, LICKISS T, MOLNÁR Z and DAVIES KE, 2014. Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex. PloS one. 9(8), e105933
• FINELLI MJ, WONG JK and ZOU H, 2013. Epigenetic regulation of sensory axon regeneration after spinal cord injury. The Journal of neuroscience. 33(50), 19664-76
• FINELLI MJ, MURPHY KJ, CHEN L and ZOU H, 2013. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell reports. 3(5), 1592-606
• CARROLL B, MOHD-NAIM N, MAXIMIANO F, FRASA MA, MCCORMACK J, FINELLI M, THORESEN SB, PERDIOS L, DAIGAKU R, FRANCIS RE, FUTTER C, DIKIC I and BRAGA VM, 2013. The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Developmental cell. 25(1), 15-28
• OLIVER PL, FINELLI MJ, EDWARDS B, BITOUN E, BUTTS DL, BECKER EB, CHEESEMAN MT, DAVIES B and DAVIES KE, 2011. Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. PLoS genetics. 7(10), e1002338
• BITOUN E, FINELLI MJ, OLIVER PL, LEE S and DAVIES KE, 2009. AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development. The Journal of neuroscience. 29(49), 15366-74
• HALL SE, MAO A, NICOLAIDOU V, FINELLI M, WISE EL, NEDJAI B, KANJANAPANGKA J, HARIRCHIAN P, CHEN D, SELCHAU V, RIBEIRO S, SCHYLER S, PEASE JE, HORUK R and VAIDEHI N, 2009. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Molecular pharmacology. 75(6), 1325-36