Rates, Risks and Routes to Reduce Vascular Dementia (R4VaD)
Post stroke cognitive impairment (PSCI) is very common, however there is limited data to understand what the risk factors are. This study is looking at determining rates for PSCI and dementia for up to two years after stroke. Better understanding of the risk factors and profile would allow for better identification, management and treatment of vascular cognitive diseases.
Randomised controlled trial in which patients are randomised to either or any combination of Ceftriaxone*, Paracetamol, Metoclopramide or SOC.
*We are not running the ceftriaxone arm here at NUH.
Elderly patients are at the highest risk of complications after stroke such as, infections and fever. These drugs are known to be effective at preventing fever and infection. And metoclopramide is effective in managing dysphagia. This study is looking at whether these drugs can be effective at improving functional outcome at 90 days.
Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial 2
Wiki Journal Club
Tranexamic acid for hyperacute primary Intracerebral Haemorrhage (TICH-2)
Trial findings published in The Lancet
The EuroHyp-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit of therapeutic cooling in adult patients with acute ischaemic stroke.
Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke
Trial findings published in the HTA journal
A prospective, international, multicentre, randomised, parallel-group, blinded, controlled, collaborative, factorial trial to investigate the safety and efficacy of treatment with transdermal glyceryl trinitrate, a nitric oxide donor, and of stopping or continuing prior antihypertensive therapy, in patients with acute stroke (ISRCTN99414122)
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