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Clinical Stroke Trials or Other Studies

Current Clinical Trials and Studies
  DescriptionFunder Date
DASH Desmopressin for treatment of patients taking Antiplatelet agents with Stroke due to Haemorrhage NIHR 2018 - 2020
LACI-2 LACunar Intervention (LACI-2) Trial-2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease. British Heart Foundation 2018 - 2020
R4VAD Rates, Risks and Routes to Reduce Vascular Dementia (R4VaD) The Alzheimer’s Society, British Heart Foundation, Dementias Platform UK & The Stroke Association 2017 - 2022
EuroHyp-1 The EuroHyp-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit of therapeutic cooling in adult patients with acute ischaemic stroke. European Commission 2013 - 2018
BASC BASC (Blood Pressure in Acute Stroke Collaboration) is an international collaborative project with the aim of producing a set of systematic reviews relating to the best management of blood pressure (including hypertension and hypotension) in patients with acute stroke. UK NHS Executive South Thames & UK NHS Executive Trent 1996 -


Previous Clinical Stroke Trials and Studies
   Description Funder Date

Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial 2

Wiki Journal Club

British Heart Foundation 2015 - 2018

Tranexamic acid for hyperacute primary Intracerebral Haemorrhage (TICH-2)

Trial findings published in The Lancet

NIHR HTA 2013 - 2017
LACI-1 Lacunar Intervention Trial 1 (LACI-1) University of Edinburgh 2016 - 2017
STEMS-3 Stem Cell Trial of recovery EnhanceMent after Stroke 3 (STEMS-3) Research for Patient Benefits, NIHR 2011 - 2013
PODCAST Prevention Of Decline in Cognition After Stroke Trial (PODCAST): a factorial randomised controlled trial of blood pressure and lipid lowering The Stroke Association & The Alzheimer's Society 2010 - 2014

Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke

Trial findings published in The Lancet

Trial findings published in the HTA journal

Wiki Journal Club

British Heart Foundation 2009 - 2017
TICH A randomised controlled trial of tranexamic acid in Intracerebral Haemorrhage (TICH) University of Nottingham 2010 - 2013
RIGHT Rapid Intervention with GTN in Hypertensive stroke Trial (RIGHT) Nottingham University Hospitals Charity 2010 - 2012
STEMS-2 Stem cell Trial of recovery EnhanceMent after Stroke 2(STEMS 2) pilot randomised controlled trial Medical Research Council 2006 - 2008
STEMS A randomised placebo-controlled pilot trial of granulocyte-colony stimulating factor in mobilising bone marrow stem cells in sub-acute stroke: the ‘Stem cell Trial of recovery EnhanceMent after Stroke’ (STEMS) pilot study The Stroke Association 2003 - 2005

A prospective, international, multicentre, randomised, parallel-group, blinded, controlled, collaborative, factorial trial to investigate the safety and efficacy of treatment with transdermal glyceryl trinitrate, a nitric oxide donor, and of stopping or continuing prior antihypertensive therapy, in patients with acute stroke (ISRCTN99414122)

Trial findings published in The Lancet

Medical Research Council 2001 - 2013


Stroke, Division of Clinical Neuroscience

The University of Nottingham
Clinical Sciences Building
Nottingham, NG5 1PB

telephone: +44 (0)115 823 1765