Stroke
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Stroke Publications

 

2020

Bath, Philip M.; Heptinstall, Stan; Sprigg, Nikola; May, Jane; Dovlatova, Natalia; Richardson, Carla; Appleton, Jason P., Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel, BMJ Publishing Group, July 2020.

Godolphin, Peter J; Bath, Philip M; Algra, Ale; Berge, Eivind; Chalmers, John; Eliasziw, Misha; Hankey, Graeme J; Hosomi, Naohisa; Ranta, Annamarei; Weimar, Christian; Woodhouse, Lisa J; Montgomery, Alan A, Cost-benefit of outcome adjudication in nine randomised stroke trials, SAGE Publications, July 2020

Mchutchison, Caroline; Blair, Gordon W; Appleton, Jason P; Chappell, Francesca M; Doubal, Fergus; Bath, Philip M; Wardlaw, Joanna M, Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis, Stroke, American Heart Association, July 2020.

Bath, Philip M .; Montgomery, Alan A.; Woodhouse, Lisa J.; Scutt, Polly, Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine, BMJ Publishing Group, July 2020.

Evans, Scott R.; Knutsson, Mikael; Amarenco, Pierre; Albers, Gregory W.; Bath, Philip M.; Denison, Hans; Ladenvall, Per; Jonasson, Jenny; Easton, J. Donald; Minematsu, Kazuo; Molina, Carlos A.; Wang, Yongjun; Wong, K. S. Lawrence; Johnston, S. Claiborne, Methodologies for pragmatic and efficient assessment of benefits and harms: application to the SOCRATES trial, SAGE Publications, May 2020

Wardlaw, Joanna; Bath, Philip M.W.; Doubal, Fergus; Heye, Anna; Sprigg, Nikola; Woodhouse, Lisa J.; Blair, Gordon; Appleton, Jason; Cvoro, Vera; England, Timothy; Hassan, Ahamad; John Werring, David; Montgomery, Alan; The LACI-2 Trial Investigators, The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease, SAGE Publications, April 2020

McColl, Barry W; Allan, Stuart M; McFall, Aisling; Hietamies, Tuuli M; Bernard, Ashton; Aimable, Margaux; Bath, Philip M; Brezzo, Gaia; Carare, Roxana O; Carswell, Hilary V; Clarkson, Andrew N; Currie, Gillian; Farr, Tracy D; Fowler, Jill; Good, Mark; Hainsworth, Atticus H; Hall, Catherine; Horsburgh, Karen; Kalaria, Rajesh; Kehoe, Patrick; Lawrence, Catherine; Macleod, Malcolm; McNeilly, Alison; Miller, Alyson A; Miners, Scott; Mok, Vincent; O'Sullivan, Michael; Platt, Bettina; Sena, Emily S; Sharp, Matthew; Strangeward, Patrick; Szymkowiak, Stefan; Touyz, Rhian M; Trueman, Rebecca C; White, Claire; McCabe, Chris; Work, Lorraine M; Quinn, Terence J, UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings, SAGE Publications, March 2020

Godolphin, Peter J; Bath, Philip M; Partlett, Christopher; Berge, Eivind; Brown, Martin M; Eliasziw, Misha; Sandset, Per Morten; Serena, Joaquín; Montgomery, Alan A, Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification, SAGE Publications, February 2020.

Muir, Keith W; Bulters, Diederik; Willmot, Mark; Sprigg, Nikola; Dixit, Anand; Ward, Nick; Tyrrell, Pippa; Majid, Arshad; Dunn, Laurence; Bath, Philip M; Howell, Julian; Stroemer, Paul; Pollock, Kenneth; Sinden, John, Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2), BMJ Publishing Group, February 2020

Godolphin, Peter; Bath, Philip; Partlett, Christopher; Berge, Eivind; Brown, Martin; Eliasziw, Misha; Sandset, Per Morten; Serena, Joaquin; Montgomery, Alan, Outcome assessment by central adjudicators in randomised stroke trials: simulation of differential and non-differential misclassification, SAGE Publications, February 2020.

Wilson, Alastair; on behalf of the ESO Health Economics Working group; Cadilhac, Dominique A; Kim, Joosup; Berge, Eivind; Patel, Anita; Ali, Myzoon; Saver, Jeffrey; Christensen, Hanne; Cuche, Matthieu; Crews, Sean; Wu, Olivia; Provoyeur, Marine; McMeekin, Peter; Durand-Zaleski, Isabelle; Ford, Gary A; Muhlemann, Natalia; Bath, Philip M; Abdul-Rahim, Azmil H; Sunnerhagen, Katharina; Meretoja, Atte; Thijs, Vincent; Weimar, Christian; Massaro, Ayrton; Lees, Kennedy R; Ranta, Annemarei, Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group, SAGE Publications, January 2020.

Law, Zhe Kang; England, Timothy J; Mistri, Amit K.; Woodhouse, Lisa J.; Cala, Lesley; Dineen, Rob; Ozturk, Serefnur; Beridze, Maia; Collins, Ronan; Bath, Philip M.; Sprigg, Nikola; TICH-2 investigators,  Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid, SAGE Publications, January 2020.

 
2019

Wardlaw JM, Bath PMStroke research in 2018: extended time windows, refined benefit, and lifestyle prevention targets.Lancet Neurol. 2019 Jan;18(1):2-3. doi: 10.1016/S1474-4422(18)30457-5. No abstract available. PMID: 30563678

Appleton JP, Woodhouse LJ, Bereczki D, Berge E, Christensen HK, Collins R, Gommans J, Ntaios G, Ozturk S, Szatmari S, Wardlaw JM, Sprigg N, Rothwell PM, Bath PM; ENOS Investigators. Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke.Stroke. 2019 Feb;50(2):405-412. doi: 10.1161/STROKEAHA.118.023190.PMID:30626285

Godolphin PJ, Bath PM, Montgomery AA. Short email with attachment versus long email without attachment when contacting authors to request unpublished data for a systematic review: a nested randomised trial.BMJ Open. 2019 Jan 30;9(1):e025273. doi: 10.1136/bmjopen-2018-025273.PMID:30705243

Bath PM, Scutt P, Anderson CS, Ankolekar S, Appleton JP, Berge E, Cala L, Dixon M, England TJ, Godolphin PJ, Havard D, Haywood L, Hepburn T, Krishnan K, Mair G, Montgomery AA, Muir K, Phillips SJ, Pocock S, Potter J, Price CI, Randall M, Robinson TG, Roffe C, Rothwell PM, Sandset EC, Sanossian N, Saver JL, Shone A, Siriwardena AN, Wardlaw JM, Woodhouse LJ, Venables G, Sprigg N; for the RIGHT-2 Investigators. Pre-hospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trialLancet 2019; in press [Chief Investigator]

Bath PM, Lee HS, Everton LF. Swallowing Therapy for Dysphagia in Acute and Subacute Stroke. Stroke. 2019 Mar;50(3):e46-e47. doi: 10.1161/STROKEAHA.118.024299. No abstract available. PMID: 30776999

Wang Y, Johnston SC, Bath PM, Grotta JC, Pan Y, Amarenco P, Wang Y, Simon T, Kim JS, Jeng JS, Liu L, Lin Y, Wong KSL, Wang D, Li H. Acute dual antiplatelet therapy for minor ischaemic stroke or transient ischaemic attack. BMJ. 2019 Feb 28;364:l895. doi: 10.1136/bmj.l895. No abstract available. PMID: 30819687

Robinson TG, Bray BD, Paley L, Sprigg N, Wang X, Arima H, Bath PM, Broderick JP, Durham AC, Kim JS, Lavados PM, Lee TH, Martins S, Nguyen TH, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sharma VK, Wang J, Woodward M, Rudd AG, Chalmers J, S Anderson C; ENCHANTED Investigators and the SSNAP Collaboration. Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.Int J Stroke. 2019 Apr 8:1747493019841246. doi: 10.1177/1747493019841246. [Epub ahead of print] PMID: 30961463

Appleton JP, Woodhouse LJ, Belcher A, Bereczki D, Berge E, Caso V, Chang HM, Christensen HK, Collins R, Gommans J, Laska AC, Ntaios G, Ozturk S, Sare GM, Szatmari S, Wang Y, Wardlaw JM, Sprigg NBath PMIt is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis.Stroke Vasc Neurol. 2019 Mar 19;4(1):28-35. doi: 10.1136/svn-2019-000232. eCollection 2019 Mar. PMID: 31105976 [Chief Investigator]

Bath, P.M., Woodhouse, L.J., Krishnan, K., Appleton, J.P., Anderson, C.S., Berge, E., Cala, L., Dixon, M., England, T.J., Godolphin, P.J., Hepburn, T., Mair, G., Montgomery, A. A., Phillips, S.J., Potter, J., Price C.I., Randall, M., Robinson, T.G., Roffe, C., Rothwell, P.M., Sandset, E.C., Sanossian, N., Saver, J.L., Siriwardena, A.N., Venables, G., Wardlaw, J.M., Sprigg, N. Pre-hospital transdermal glyceryl trinitrate for ultra-acute intracerebral haemorrhage.  RIGHT-2, Open Access, 2019.

Salman, R., Dennis, M. S., Murray, G. D., Newby, D.E., Sandercock, P. A.G., Sprigg, N.,Stephen, J., Sudlow, C L.M., Wardlaw, J.M, Werring, D.J., White, P.M., Whiteley, W.N.  Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.  RESTART, Open Access, March 2019.

Sandset, E.C., Appleton, J.P., Berge, E., Christensen, H., Gommans, J., Krishnan, K., Ntaios, G., Phillips, S., Pocock, S., Sprigg, N.,Woodhouse, L.J., Bath, P.M.  Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial.  Journal of Hypertension 2019, 37:2104-2109

Appleton, J.P., Blair, G.W., Flaherty, K., Law, Z.K., May, J., Woodhouse, L.J., Doubal, F., Sprigg, N., Bath, P.M., Wardlaw, J.M.   Effects of isosorbide mononitrate and/or cilostazol on hematological markers, platelet function, and hemodynamics in patients with lacunar ischaemic stroke: Safety data from the Lacunar Intervention-1 (LACI-1) trial.  Frontiers in Neurology, Open Access, Volume 10, Article Number 723, July 2019.

Moullaali, T.J., Wang, X., Woodhouse, L.J., Law, Z.K., Delcourt, C., Sprigg, N., Krishnan, K., Robinson, T.G., Wardlaw, J.M., Al-Shahi Salman, R., Berge, E., Sandset, E.C., Anderson, C.S., Bath, P.M.  Lowering blood pressure after acute intracerebral haemorrhage: Protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC), BMJ Open, 9(7), art. No. 030121, p.1, 2019.

Brainin, M., Feigin, V., Bath, P.M., Collantes, E., Martins, S., Pandian, J., Sacco, R., Teuschi, Y., Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization, International Journal of Stroke, V14(8), September 2019

 
2018

Aujla N, Vadhara K, Walker M, Sprigg N. Evaluating a stroke-specific version of the Illness Perception Questionnaire–Revised, using the Think-Aloud method. J of Health Psychology 2018 http://journals.sagepub.com/doi/full/10.1177/1359105318781942

Dziewas R, Stellato R, van der Tweel I, Walther E, Wermer C, Braun T, Citerio G, Jandl M, Friedrichs M, Nötzel K, Vosko M, Mistry S, Hamdy, S, McGowan S, Warnecke T, Zwittag P, Bath P. PHAryngeal electrical STimulation for early decannulation in TRACheotomised stroke patients with neurogenic dysphagia (PHAST-TRAC): a prospective randomised single-blinded trial. Lancet Neurol 2018

Ovesen C, Jakobsen JC, Gluud C, Steiner T, Law ZFlaherty K, Dineen RA, Bath PM, Sprigg N, Christensen H. Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial. BMC Res Notes 2018; 11;379 https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3481-8

Benfield JK, Everton LF, Bath PM, England TJ. Does therapy with biofeedback improve swallowing in adults with dysphagia? A systematic review and meta-analysis. Arch Phys Med Rehabil 2018

Bath PM, Appleton JP, Krishnan K, Sprigg N. Blood Pressure in Acute Stroke: To Treat or Not to Treat: That Is Still the Question. Stroke 2018; 11; 379 http://stroke.ahajournals.org/content/early/2018/06/11/STROKEAHA.118.021254.long

Ovesen C, Jakobsen JC, Gluud C, Steiner T, Law Z, Flaherty K, Dineen RA, Bath PM, Sprigg N, Christensen H. Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial. BMC Res Notes 2018 11 https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3481-8

Sprigg N, Flaherty K, Appleton JP, Salman RA, Bereczki D, Beridze M, Christensen H, Ciccone A, Collins R, Czlonkowska A, Dineen RA, Duley L, Egea-Guerrero JJ, England TJ, Krishnan K, Laska AC, Law ZK, Ozturk S, Pocock SJ, Roberts I, Robinson TG, Roffe C, Seiffge D, Scutt, P, Thanabalan J, Weeing D, Whynes D, Bath PM. Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet 2018; 391; 2107-2115 https://www.sciencedirect.com/science/article/pii/S014067361831033X?via%3Dihub

Reinink H, Jonge J, Bath P, van de Beek D, Berge E, Borregaard S, Ciccone A, Csiba L, Demotes J, Dippel D, Korv J, Kurkowska-Jastrzebska I, Lees K, Macleod M, Ntaios G, Randall G, Thomalla G, Bart van der Worp H. PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke: rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment. European Stroke J 2018 http://journals.sagepub.com/doi/abs/10.1177/2396987318772687

Scutt P, Appleton J, Dixon M, Woodhouse L, Sprigg N, Wardlaw J, Montgomery A, Pocock S, Bath P. Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’. European Stroke J 2018; 3; 193 http://journals.sagepub.com/doi/10.1177/2396987318756696

Sandset EC, Sanossian N, Woodhouse LJ, Anderson C, Berge E, Lees KR, Potter JF, Robinson TG, Sprigg N, Wardlaw JM, Bath PM; Blood pressure in Acute Stroke Collaboration Investigators. Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3. Int J Stroke 2018 http://journals.sagepub.com/doi/abs/10.1177/1747493018772733?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, et al. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clin Sci 2018; 132; 851-868

Minhas JS, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Donnan GA, Kim JS, Lavados PM, Lee TH, Martins SCO, Olavarría VV, Pandian JD, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Thang NH, Wang JG, Woodward M, Chalmers J, Anderson CS, et al. Lipid-Lowering Pretreatment and Outcome Following Intravenous Thrombolysis for Acute Ischaemic Stroke: A Post Hoc Analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study Trial. Cerebrovasc Diseases 2018; 45; 213-220

Al-Shahi Salman R, Law ZK, Bath PM, Steiner T, Sprigg N. Haemostatic therapies for acute spontaneous intracerebral haemorrhage. Cochrane Database Syst Rev 2018 http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD005951.pub4/abstract;jsessionid=ADEEF7D90FDCDD40456AEC393C2CF977.f03t01

Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, Drever J, Dinsmore L, Williams C, White PM, Whiteley WN, Sandercock PAG, Sudlow CLM, Newby DE, Sprigg N, Werring DJ; RESTART collaborators.. The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials 2018; 19; 162 https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2542-6

Bath PM, May J, Heptinstall S. Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders. Platelets 2018; 29; 425-430

Dineen RA, Pszczolkowski S, Flaherty K, Law ZK, Morgan PS, Roberts I, Werring DJ, Salman RA, England T, Bath PM, Sprigg N. Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial. BMJ Open 2018; 8 http://bmjopen.bmj.com/content/8/2/e019930.long

Hilkens NA, Algra A, Kappelle LJ, Bath PM, Csiba L, Rothwell PM, Greving JP; CAT Collaboration. Early time course of major bleeding on antiplatelet therapy after TIA or ischemic stroke. Neurology 2018; 90

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; et al. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet 2018; 391; 850-859 https://www.sciencedirect.com/science/article/pii/S0140673617328490?via%3Dihub

Krishnan K, Beishon L, Berge E, Christensen H, Dineen RA, Ozturk S, Sprigg N, Wardlaw JM, Bath PM; VISTA-ICH collaboration and ENOS Investigators. Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial. Int J Stroke 2018; 13; 362-373 http://journals.sagepub.com/doi/abs/10.1177/1747493017744463?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM. Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. Int J Stroke 2018; 13; 530-538 http://journals.sagepub.com/doi/abs/10.1177/1747493017731947?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Woodhouse LJ, Scutt P, Hamdy S, Smithard DG, Cohen DL, Roffe C, Bereczki D, Berge E, Bladin CF, Caso V, Christensen HK, Collins R, Czlonkowska A, de Silva A, Etribi A, Laska AC, Ntaios G, Ozturk S, Phillips SJ, Prasad K, Szatmari S, Sprigg N, Bath PM. Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial. Transl Stroke Res 2018; 9; 120-129 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849635/

 
2017

Ker K, Prieto-Merino D, Sprigg N, Mahmood A, Bath P, Kang Law Z, Flaherty K, Roberts I. The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis. Wellcome Open Res 2017; 2;120 https://wellcomeopenresearch.org/articles/2-120/v2

Flaherty K, Bath PM, Dineen R, Law Z, Scutt P, Pocock S, Sprigg N; TICH-2 investigators. Statistical analysis plan for the 'Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage' (TICH-2) trial. Trials 2017; 18; 607 https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2341-5

Winkel P, Bath PM, Gluud C, Lindschou J, van der Worp HB, Macleod MR, Szabo I, Durand-Zaleski I, Schwab S; EuroHYP-1 trial investigators. Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke. Trials 2017; 18; 573 https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2302-z

Wang X, Robinson TG, Lee TH, Li Q, Arima H, Bath PM, Billot L, Broderick J, Demchuk AM, Donnan G, Kim JS, Lavados P, Lindley RI, Martins SO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sharma VK, Thang NH, Wang JG, et al. Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke: Secondary Analysis of the ENCHANTED Randomized Clinical Trial. JAMA Neurol 2017; 74; 1328-1335 https://jamanetwork.com/journals/jamaneurology/fullarticle/2656324

Maddula M, Sprigg N, Bath PM, Munshi S. Cerebral misery perfusion due to carotid occlusive disease. Stroke Vasc Neurol 2017; 2; 88-93 http://svn.bmj.com/content/2/2/88

Armstrong S, Langlois A, Laparidou D, Dixon M, Appleton JP, Bath PM, Snooks H, Siriwardena AN. Assessment of consent models as an ethical consideration in the conduct of prehospital ambulance randomised controlled clinical trials: a systematic review. BMC Med Res Methodol 2017; 17; 142 https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-017-0423-4

Quinn TJ, Singh S, Lees KR, Bath PM, Myint PK; VISTA Collaborators. Validating and comparing stroke prognosis scales. Neurology 2017; 89; 997-1002 http://n.neurology.org/content/89/10/997.long

Hilkens NA, Algra A, Diener HC, Reitsma JB, Bath PM, Csiba L, Hacke W, Kappelle LJ, Koudstaal PJ, Leys D, Mas JL, Sacco RL, Amarenco P, Sissani L, Greving JP; Cerebrovascular Antiplatelet Trialists' Collaborative Group. Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S(2)TOP-BLEED. Neurology 2017; 89; 936-943 http://n.neurology.org/content/89/9/936.long

Drummond A, Hawkins L, Sprigg N, Ward NS, Mistri A, Tyrrell P, Mead GE, Worthington E, Lincoln NB. The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression. Clin Rehabil 2017;31; 1406-1415 http://journals.sagepub.com/doi/abs/10.1177/0269215517695857?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Hawkins L, Lincoln NB, Sprigg N, Ward NS, Mistri A, Tyrrell P, Worthington E, Drummond A. The Nottingham Fatigue After Stroke (NotFAST) study: results from follow-up six months after stroke. Top Stroke Rehabil 2017; 24; 592-596 https://www.tandfonline.com/doi/full/10.1080/10749357.2017.1368912

Appleton JP, Scutt P, Dixon M, Howard H, Haywood L, Havard D, Hepburn T, England T, Sprigg N, Woodhouse LJ, Wardlaw JM, Montgomery AA, Pocock S, Bath PM; RIGHT-2 Investigators. Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053). Int J Stroke 2017 http://journals.sagepub.com/doi/abs/10.1177/1747493017724627?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Learoyd AE, Woodhouse L, Shaw L, Sprigg N, Bereczki D, Berge E, Caso V, Christensen H, Collins R, Czlonkowska A, El Etribi A, Farr TD, Gommans J, Laska AC, Ntaios G, Ozturk S, Pocock SJ, Prasad K, Wardlaw JM, Fone KC, Bath PM, Trueman RC; et al. Infections Up to 76  Days After Stroke Increase Disability and Death. Transl Stroke Res 2017; 8; 541-548 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818141/

Cordonnier C, Sprigg N, Sandset EC, Pavlovic A, Sunnerhagen KS, Caso V, Christensen H; Women Initiative for Stroke in Europe (WISE) group. Stroke in women - from evidence to inequalities. Nat Rev Neurol 2017; 13; 521-532 https://www.nature.com/articles/nrneurol.2017.95

Robinson TG, Wang X, Arima H, Bath PM, Billot L, Broderick JP, Demchuk AM, Donnan GA, Kim JS, Lavados PM, Lee TH, Lindley RI, Martins SCO, Olavarria VV, Pandian JD, Parsons MW, Pontes-Neto OM, Ricci S, Sato S, Sharma VK, Nguyen TH, Wang JG, et al. Low- Versus Standard-Dose Alteplase in Patients on Prior Antiplatelet Therapy: The ENCHANTED Trial (Enhanced Control of Hypertension and Thrombolysis Stroke Study). Stroke 2017; 48; 1877-1883 http://stroke.ahajournals.org/content/48/7/1877.long

Appleton JP, Scutt P, Sprigg N, Bath PM. Hypercholesterolaemia and vascular dementia. Clin Sci (Lond) 2017; 131; 1561-1578 http://www.clinsci.org/content/131/14/1561.long

Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, Heptinstall S, Investigators T. Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack. Stroke Res Treat 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463170/

Ban L, Sprigg N, Abdul Sultan A, Nelson-Piercy C, Bath PM, Ludvigsson JF, Stephansson O, Tata LJ. Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England. J Am Heart Assoc 2017; 6 http://jaha.ahajournals.org/content/6/4/e004601.long

Bath PM, Krishnan K, Appleton JP. Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. Cochrane Database Syst Rev 2017 http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD000398.pub2/abstract

Berge E, Al-Shahi Salman R, van der Worp HB, Stapf C, Sandercock P, Sprigg N, Macleod MR, Kelly PJ, Nederkoorn PJ, Ford GA; European Stroke Organisation Trials Network Committee. Increasing value and reducing waste in stroke research. Lancet Neurol 2017; 16; 399-408 https://www.sciencedirect.com/science/article/pii/S1474442217300789?via%3Dihub

Law ZK, Appleton JP, Bath PM, Sprigg N. Management of acute intracerebral haemorrhage an update. Clin Med (Lond) 2017; 17; 166-172

Mazlan-Kepli W, Macisaac RL, Walters M, Bath PMW, Dawson J; VISTA Collaborators. Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case-control study. Br J Clin Pharmacol 2017; 83; 2045-2055 https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.13290

England TJ, Hedstrom A, O'Sullivan S, Donnelly R, Barrett DA, Sarmad S, Sprigg N, Bath PM. RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke. Stroke 2017; 48; 1412-1415 http://stroke.ahajournals.org/content/48/5/1412.long

Woodhouse LJ, Manning L, Potter JF, Berge E, Sprigg N, Wardlaw J, Lees KR, Bath PM, Robinson TG; Blood Pressure in Acute Stroke Collaboration. Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute Stroke: An Individual Patient Data Meta-Analysis. Hypertension 2017; 69; 933-941 http://hyper.ahajournals.org/content/69/5/933.long

Hosseini AA, Simpson RJ, Altaf N, Bath PM, MacSweeney ST, Auer DP. Magnetic Resonance Imaging Plaque Hemorrhage for Risk Stratification in Carotid Artery Disease With Moderate Risk Under Current Medical Therapy. Stroke 2017; 48; 678-685 http://stroke.ahajournals.org/content/48/3/678.long

Patsko E, Godolphin PJ, Thomas KS, Hepburn T, Mitchell EJ, Craig FE, Bath PM, Montgomery AA. Investigating the effect of independent, blinded digital image assessment on the STOP GAP trial. Trials 2017; 18; 53 https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-1779-9

Bath PM, Scutt P, Blackburn DJ, Ankolekar S, Krishnan K, Ballard C, Burns A, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw JM, Ford GA; PODCAST Trial Investigators. Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial. PLoS One 2017; 12 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164608

Caso V, Falorni A, Bushnell CD, Acciarresi M, Remohí J, Sprigg N, Gerli S. Pregnancy, Hormonal Treatments for Infertility, Contraception, and Menopause in Women After Ischemic Stroke: A Consensus Document. Stroke 2017; 48; 501-506 http://stroke.ahajournals.org/content/48/2/501.long

Appleton JP, Sprigg N, Bath PM. Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke. CNS Drugs 2017; 31; 1-9 https://link.springer.com/article/10.1007%2Fs40263-016-0387-7

Bath PM, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Heptinstall S, James M, Krishnan K, Markus HS, Pocock S, Ranta A, Robinson TG, Flaherty K, Scutt P, Venables GS, Woodhouse LJ, Sprigg N. Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial. Int J Stroke 2017; 12;524-538 http://journals.sagepub.com/doi/abs/10.1177/1747493016677988?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Dziewas R, Mistry S, Hamdy S, Minnerup J, Van Der Tweel I, Schäbitz W, Bath PM; PHAST-TRAC Investigators. Design and implementation of Pharyngeal electrical Stimulation for early de-cannulation in TRACheotomized (PHAST-TRAC) stroke patients with neurogenic dysphagia: a prospective randomized single-blinded interventional study. Int J Stroke 2017; 12; 430-437 http://journals.sagepub.com/doi/abs/10.1177/1747493016676618?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Srivastava K, Bayraktutan U. Suppression of Protein Kinase C-α Ameliorates Hyperglycaemia-Evoked In Vitro Cerebral Barrier Dysfunction. Stroke Research & Therapy 2017;2;2

Loach B, Bayraktutan U. Therapeutic hypothermia protects in vitro brain barrier from ischaemic damage through attenuation of inflammatory cytokine release and apoptosis. Stroke Research & Therapy 2017; 2;4

Mathur M, Bayraktutan U. Therapeutic hypothermia protects in vitro brain barrier from ischaemic damage through attenuation of inflammatory cytokine release and apoptosis. Stroke Research & Therapy 2017; 2;4

Bayraktutan U. Endothelium, endothelial progenitor cells and stroke. Journal of Neurology and Clinical Neuroscience 2017; 1;21-22

 
2016

England TJ, Sprigg N, Alasheev AM, Belkin AA, Kumar A, Prasad K, Bath PM. Granulocyte-Colony Stimulating Factor (G-CSF) for stroke: an individual patient data meta-analysis. Sci Rep 2016; 6 https://www.nature.com/articles/srep36567

Sprigg N, O'Connor R, Woodhouse L, Krishnan K, England TJ, Connell LA, Walker MF, Bath PM. Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730). PLoS One 2016; 11 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161359

Kalladka D, Sinden J, Pollock K, Haig C, McLean J, Smith W, McConnachie A, Santosh C, Bath PM, Dunn L, Muir KW. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet 2016; 388; 787-96 https://www.sciencedirect.com/science/article/pii/S014067361630513X?via%3Dihub

Bath PM. William M. Feinberg Award for Excellence in Clinical Stroke: High Explosive Treatment for Ultra-Acute Stroke: Hype of Hope. Stroke 2016; 47; 2423-6 http://stroke.ahajournals.org/content/47/9/2423.long

Greenan C, Murphy L, Yu LM, Kehoe PG, Coulthard E, Bath P, Stewart R, Jones R, Corbett A, Thomas A, Connelly P, Arrojo F, Canning R, Wallach S, Henderson C, McGuinness B, O'Sullivan M, Holmes C, Knapp M, Ballard C, Passmore P; AFFECT Investigators. A randomised controlled trial of calcium channel blockade (CCB) with Amlodipine For the treatment oF subcortical ischaEmic vasCular demenTia (AFFECT): study protocol. Trials 2016; 17; 324 https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1449-3

Bath PM, Appleton JP, Sprigg N. The Insulin Resistance Intervention after Stroke trial: A perspective on future practice and research. Int J Stroke 2016; 11; 741-3 http://journals.sagepub.com/doi/abs/10.1177/1747493016660099?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Appleton JP, Sprigg N, Bath PM. Blood pressure management in acute stroke. Stroke Vasc Neurol 2016; 1; 72-82 https://svn.bmj.com/content/1/2/72

Jusufovic M, Sandset EC, Bath PM, Berge E; Scandinavian Candesartan Acute Stroke Trial (SCAST) Study Group. Early blood pressure lowering treatment in acute stroke. Ordinal analysis of vascular events in the Scandinavian Candesartan Acute Stroke Trial (SCAST). J Hypertens 2016; 34; 1594-8 https://insights.ovid.com/pubmed?pmid=27228435

Bath PM, Woodhouse L, Krishnan K, Anderson C, Berge E, Ford GA, Robinson TG, Saver JL, Sprigg N, Wardlaw JM, In Acute Stroke Collaboration Basc BP. Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials. Stroke Res Treat 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852111/

Bath PM, Scutt P, Love J, Clav P, Cohen D, Dziewas R, Iversen HK, Ledl C, Ragab S, Soda H, Warusevitane A, Woisard V, Hamdy S; Swallowing Treatment Using Pharyngeal Electrical Stimulation (STEPS) Trial Investigators. Pharyngeal Electrical Stimulation for Treatment of Dysphagia in Subacute Stroke: A Randomized Controlled Trial. Stroke 2016; 47; 1562-70 http://stroke.ahajournals.org/content/47/6/1562.long

Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarra VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, et al. Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. N Engl J Med 2016; 374; 2313-23 https://www.nejm.org/doi/10.1056/NEJMoa1515510?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov

Rakkar K, Bayraktutan U. Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis. Molecular Basis of Disease 2016; 1862; 56-71 https://www.sciencedirect.com/science/article/pii/S0925443915003166?via%3Dihub

Nunn A, Bath PM, Gray LJ. Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review. Stroke Res Treat 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818820/

Sprigg N, Robson K, Bath P, Dineen R, Roberts I, Robinson T, Roffe C, Werring D, Al-Shahi Salman R, Pocock S, Duley L, England T, Whynes D, Ciccone A, Laska AC, Christensen H, Ozturk S, Collins R, Bereczki D, Egea-Guerrero JJ, Law ZK, Czlonkowska A, et al. Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial. Int J Stroke 2016; 11; 683-94 http://journals.sagepub.com/doi/abs/10.1177/1747493016641960?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Scheitz JF, MacIsaac RL, Abdul-Rahim AH, Siegerink B, Bath PM, Endres M, Lees KR, Nolte CH; VISTA collaboration. Statins and risk of poststroke hemorrhagic complications. Neurology 2016; 86; 1590-6 http://n.neurology.org/content/86/17/1590.long

Cohen DL, Roffe C, Beavan J, Blackett B, Fairfield CA, Hamdy S, Havard D, McFarlane M, McLauglin C, Randall M, Robson K, Scutt P, Smith C, Smithard D, Sprigg N, Warusevitane A, Watkins C, Woodhouse L, Bath PM. Post-stroke dysphagia: A review and design considerations for future trials. Int J Stroke 2016; 11; 399-411 http://journals.sagepub.com/doi/abs/10.1177/1747493016639057?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Jusufovic M, Mishra NK, Lansberg MG, Bath PM, Berge E, Sandset EC. Blood Pressure Management in Acute Stroke. Curr Hypertens Rev 2016; 12; 121-6 http://www.eurekaselect.com/139958/article

Krishnan K, Scutt P, Woodhouse L, Adami A, Becker JL, Cala LA, Casado AM, Chen C, Dineen RA, Gommans J, Koumellis P, Christensen H, Collins R, Czlonkowska A, Lees KR, Ntaios G, Ozturk S, Phillips SJ, Sprigg N, Szatmari S, Wardlaw JM, Bath PM; et al. Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial. J Stroke Cerebrovasc Dis 2016; 25; 1017-1026 https://www.sciencedirect.com/science/article/pii/S1052305716000239?via%3Dihub

Gibson CL, Bath PM. Feasibility of progesterone treatment for ischaemic stroke. J Cereb Blood Flow Metab 2016; 36; 487-91 http://journals.sagepub.com/doi/abs/10.1177/0271678X15616782?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Mathur M, Bayraktutan U. Therapeutic Hypothermia Protects In Vitro Brain Barrier from Ischaemic Damage: Roles of Oxidative Stress, Rho-Kinase and PKC-β. J Neurol and Experimental Neural Sci 2016; 114

Loach B, Bayraktutan U. Evaluation of Molecular Mechanisms Involved in Therapeutic Hypothermia- Mediated Neurovascular Protection. J Neurol and Experimental Neural Sci 2016; 115 https://www.gavinpublishers.com/articles/Review-article/Journal-of-Neurology-and-Experimental-Neural-Science-ISSN-2577-1442/evaluation-of-molecular-mechanisms-involved-in-therapeutic-hypothermia-mediated-neurovascular-protec

Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM. A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. J Cereb Blood Flow Metab 2016;36; 596-605 http://journals.sagepub.com/doi/abs/10.1177/0271678X15606714?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Krishnan K, Scutt P, Woodhouse L, Adami A, Becker JL, Berge E, Cala LA, Casado AM, Caso V, Chen C, Christensen H, Collins R, Czlonkowska A, Dineen RA, Gommans J, Koumellis P, Lees KR, Ntaios G, Ozturk S, Phillips SJ, Pocock SJ, de Silva A, Sprigg N, Szatmari S, Wardlaw J, Bath P. Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. Stroke 2016; 47; 44-52 http://stroke.ahajournals.org/content/47/1/44.long

Abdullah Z, Bayraktutan U. Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system. Biochim Biophys Acta 2016; 1862; 1354 https://www.sciencedirect.com/science/article/pii/S0925443916300710?via%3Dihub

Fletcher-Smith JC, Walker DM, Sprigg N, James M, Walker M, Allatt K, Mehta R, Pandyan AD. ESCAPS study protocol: a feasibility randomised controlled trial of 'Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm'. BMJ Open 2016; 6 https://bmjopen.bmj.com/content/6/1/e010079.long

 
2015

Scutt P, Lee HS, Hamdy S, Bath PM. Pharyngeal Electrical Stimulation for Treatment of Poststroke Dysphagia: Individual Patient Data Meta-Analysis of Randomised Controlled Trials. Stroke Res Treat 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672134/

Abdullah Z, Rakkar K, Bath P, Bayraktutan U. Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage. Molecular and Cellular Neuroscience 2015; 69; 65-79 https://www.sciencedirect.com/science/article/pii/S1044743115300282?via%3Dihub

Scutt P, Blackburn D, Krishnan K, Ballard C, Burns A, Ford GA, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw JM, Bath PM. Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST). Trials 2015; 15 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636808/

Woodhouse L, Scutt P, Krishnan K, Berge E, Gommans J, Ntaios G, Wardlaw J, Sprigg N, Bath PM; ENOS Investigators. Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial. Stroke 2015 46 3194 https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.009647?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus HS, Pocock S, Ranta A, Robinson T, Nikola N, Venables G, Bath P. Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). Int J Stroke 2015; 10; 1159 http://journals.sagepub.com/doi/abs/10.1111/ijs.12538?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Flint AC, Rao VA, Chan SL, Cullen SP, Faigeles BS, Smith WS, Bath PM, Wahlgren N, Ahmed N, Donnan GA, Johnston SC; SITS International and VISTA-plus investigators. Improved ischemic stroke outcome prediction using model estimation of outcome probability: the THRIVE-c calculation. Int J Stroke 2015; 10; 815 http://journals.sagepub.com/doi/abs/10.1111/ijs.12529?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Huang Y, Sharma VK, Robinson T, Lindley RI, Chen X, Kim JS, Lavados P, Olavarría V, Arima H, Fuentes S, Nguyen HT, Lee TH, Parsons MW, Levi C, Demchuk AM, Bath PM, Broderick JP, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Pandian J, Ricci S, Stapf C, Woodward M, Wang J, Chalmers J, Anderson CS; ENCHANTED investigators. Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment. Int J Stroke 2015; 10; 778 http://journals.sagepub.com/doi/abs/10.1111/ijs.12486?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Hornslien AG, Sandset EC, Igland J, Terént A, Boysen G, Bath PM, Murray GD, Berge E. Effects of candesartan in acute stroke on vascular events during long-term follow-up: results from the Scandinavian Candesartan Acute Stroke Trial (SCAST). Int J Stroke 2015; 10; 830 http://journals.sagepub.com/doi/abs/10.1111/ijs.12477?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Bath PM, Wardlaw JM. Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions. Int J Stroke 2015; 10; 469 http://journals.sagepub.com/doi/abs/10.1111/ijs.12466?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Sandset EC, Jusufovic M, Sandset PM, Bath PM, Berge E; SCAST Study Group. Effects of blood pressure-lowering treatment in different subtypes of acute ischemic stroke. Stroke 2015; 46; 877 https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.008512?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Bath PM, Robson K, Woodhouse LJ, Sprigg N, Dineen R, Pocock S; TARDIS Trialists. Statistical analysis plan for the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial. Int J Stroke 2015; 10; 449 http://journals.sagepub.com/doi/abs/10.1111/ijs.12445?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Berge E, Ford GA, Bath PM, Stapf C, van der Worp HB, Demotes J, Broderick J, Al-Shahi Salman R, Lees KR; ESO Trials Network Committee. Regulation and governance of multinational drug trials in stroke: barriers and possibilities. Int J Stroke 2015; 10; 425 http://journals.sagepub.com/doi/abs/10.1111/ijs.12427?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Krishnan K, Mukhtar SF, Lingard J, Houlton A, Walker E, Jones T, Sprigg N, Cala LA, Becker JL, Dineen RA, Koumellis P, Adami A, Casado AM, Bath PM, Wardlaw JM. Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial. J Neurol Neurosurg Psychiatry 2015; 86; 1258 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680163/

Jusufovic M, Sandset EC, Bath PM, Karlson BW, Berge E; Scandinavian Candesartan Acute Stroke Trial Study Group. Effects of blood pressure lowering in patients with acute ischemic stroke and carotid artery stenosis. Int J Stroke 2015; 10; 352 http://journals.sagepub.com/doi/abs/10.1111/ijs.12418?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

 
2014

Bath P, Robson K, Woodhouse L, Sprigg N, Dineen R, Pocock S, TARDIS Trialists. Relationship between poststroke cognition, baseline factors, and functional outcome: data from "efficacy of nitric oxide in stroke" trial. J Stroke Cerebrovasc Dis 2014; 23; 1821 https://www.sciencedirect.com/science/article/pii/S1052305714002080?via%3Dihub

Wong R, Gibson CL, Kendall DA, Bath PM. Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice. BMC Neurosci 2014; 15 https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-014-0131-5

Bath PM, Krishnan K. Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev 2014 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000039.pub3/full

Jusufovic M, Sandset EC, Bath PM, Berge E; Scandinavian Candesartan Acute Stroke Trial Study Group. Blood pressure-lowering treatment with candesartan in patients with acute hemorrhagic stroke. Stroke 2014; 45; 3440 https://www.ahajournals.org/doi/10.1161/STROKEAHA.114.006433?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Wong KS, Wang Y, Leng X, Mao C, Tang J, Bath PM, Markus HS, Gorelick PB, Liu L, Lin W, Wang Y. Response to letter regarding article, "early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis". Circulation 2014; 130 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.009357?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Bath PM, Brainin M, Brown C, Campbell B, Davis SM, Donnan GA, Ford GA, Hacke W, Iglesias C, Lees KR, Pugh SS, Saver JL, Schellinger PD, Truelsen T. Testing devices for the prevention and treatment of stroke and its complications. Int J Stroke 2014; 9; 683 http://journals.sagepub.com/doi/abs/10.1111/ijs.12302?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Flint AC, Gupta R, Smith WS, Kamel H, Faigeles BS, Cullen SP, Rao VA, Bath PM, Wahlgren N, Ahmed N, Donnan GA; SITS International and VISTA-plus investigators. The THRIVE score predicts symptomatic intracerebral hemorrhage after intravenous tPA administration in SITS-MOST. Int J Stroke 2014; 9; 705 http://journals.sagepub.com/doi/abs/10.1111/ijs.12335?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Van der Worp HB, Macleod MR, Bath PM, Demotes J, Durand-Zaleski I, Gebhardt B, Gluud C, Kollmar R, Krieger DW, Lees KR, Molina C, Montaner J, Roine RO, Petersson J, Staykov D, Szabo I, Wardlaw JM, Schwab S; EuroHYP-1 investigators. EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke. Int J Stroke 2014; 9; 642 http://journals.sagepub.com/doi/abs/10.1111/ijs.12294?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Ovbiagele B, Reeves MJ, Nasiri M, Johnston SC, Bath PM, Saposnik G; VISTA-Acute Collaboration Steering Committee. A simple risk index and thrombolytic treatment response in acute ischemic stroke. JAMA Neurol 2014; 71; 848 https://jamanetwork.com/journals/jamaneurology/fullarticle/1867707

Ankolekar S, Renton C, Sare G, Ellender S, Sprigg N, Wardlaw JM, Bath PM; ENOS Trial Investigators. Relationship between poststroke cognition, baseline factors, and functional outcome: data from "efficacy of nitric oxide in stroke" trial. J Stroke Cerebrovasc Dis 2014; 23; 1821 https://www.sciencedirect.com/science/article/pii/S1052305714002080?via%3Dihub

Abdullah Z, Bayraktutan U. NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time. Molecular and Cellular 2014; 61;72 https://www.sciencedirect.com/science/article/pii/S1044743114000633?via%3Dihub

Shao B, Bayraktutan U. Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase. Redox Biology 2014; 2; 694 https://www.sciencedirect.com/science/article/pii/S2213231714000706?via%3Dihub

Ankolekar S, Parry R, Sprigg N, Siriwardena AN, Bath PM. Views of paramedics on their role in an out-of-hospital ambulance-based trial in ultra-acute stroke: qualitative data from the Rapid Intervention With Glyceryl Trinitrate in Hypertensive Stroke Trial (RIGHT). Ann Emerg Med 2014; 64; 640 https://www.sciencedirect.com/science/article/pii/S0196064414002224?via%3Dihub

Estol CJ, Bath PM, Gorelick PB, Cotton D, Martin RH, Weber MA, Dahlof B; PRoFESS. Blood pressure measurement reliability among different racial-ethnic groups in a stroke prevention study. Blood Press Monit 2014; 19; 256 https://insights.ovid.com/pubmed?pmid=24736279

Sprigg N, Renton CJ, Dineen RA, Kwong Y, Bath PM. Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461). J Stroke Cerebrovasc Dis 2014; 23; 1312 https://www.sciencedirect.com/science/article/pii/S1052305713004734?via%3Dihub

Rakkar K, Srivastava K, Bayraktutan U. Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase. Eur J Neurosci 2014; 39; 2119 https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.12552

Estol CJ, Bath PM, Gorelick PB, Cotton D, Martin RH; PRoFESS Publications Committee and PRoFESS Investigators. Differences in ischemic and hemorrhagic recurrence rates among race-ethnic groups in the PRoFESS secondary stroke prevention trial. Int J Stroke 2014; 9 http://journals.sagepub.com/doi/abs/10.1111/ijs.12269?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Bath PM, Houlton A, Woodhouse L, Sprigg N, Wardlaw J, Pocock S; ENOS Trialists. Statistical analysis plan for the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial. Int J Stroke 2014; 9; 372 http://journals.sagepub.com/doi/abs/10.1111/ijs.12235?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Gibson CL, Srivastava K, Sprigg N, Bath PM, Bayraktutan U. Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. J Neurochem 2014; 129; 816 https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.12681

Toni D, Di Angelantonio E, Di Mascio MT, Vinisko R, Bath PM; PRoFESS Study Group. Types of stroke recurrence in patients with ischemic stroke: a substudy from the PRoFESS trial. Int J Stroke 2014; 9; 873 http://journals.sagepub.com/doi/abs/10.1111/ijs.12150?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Ali M, Bath PM, Lyden PD, Bernhardt J, Brady M; VISTA Collaboration. Representation of people with aphasia in randomized controlled trials of acute stroke interventions. Int J Stroke 2014; 9; 174 http://journals.sagepub.com/doi/abs/10.1111/ijs.12043?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

 
2013

Blackburn DJ, Krishnan K, Fox L, Ballard C, Burns A, Ford GA, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw J, Bath PM. Prevention of Decline in Cognition after Stroke Trial (PODCAST): a study protocol for a factorial randomised controlled trial of intensive versus guideline lowering of blood pressure and lipids. Trials 2013; 14

Ankolekar S, Renton C, Bereczki D, Sprigg N, Payne T, Gommans J, Berge E, Wardlaw J, Dennis MS, Bath PM; ENOS Trial Investigators. Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial. J Neurol Neurosurg Psychiatry 2013; 84; 342 https://jnnp.bmj.com/content/jnnp/84/3/342.full.pdf

De Silva DA, Omar E, Manzano JJ, Christensen S, Allen JC Jr, Bath PM, Chang HM, Wong MC, Chen CP. Comparison of small volume infarcts of lacunar and non-lacunar etiologies. Int J Stroke 2013; http://journals.sagepub.com/doi/pdf/10.1111/ijs.12120

Sprigg N, Selby J, Fox L, Berge E, Whynes D, Bath PM; Efficacy of Nitric Oxide in Stroke Investigators. Very low quality of life after acute stroke: data from the Efficacy of Nitric Oxide in Stroke trial. Stroke 2013; 44; 345 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.002201?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Wong R, Renton C, Gibson CL, Murphy SJ, Kendall DA, Bath PM; Progesterone Pre-Clinical Stroke Pooling Project Collaboration. Progesterone treatment for experimental stroke: an individual animal meta-analysis. J Cereb Blood Flow Metab 2013; 33; 1362 http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2013.120

Yong YP, Saunders J, Abisi S, Sprigg N, Varadhan K, MacSweeney S, Altaf N. Safety of carotid endarterectomy following thrombolysis for acute ischemic stroke. J Vasc Surg 2013; 58; 1671

Shao B, Bayraktutan U. Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C‐β. Diabetes, Obesity and Metabolism 2013; 15; 993

England TJ, Bath PM, Abaei M, Auer D, Jones DR. Hematopoietic stem cell (CD34+) uptake of superparamagnetic iron oxide is enhanced by but not dependent on a transfection agent. Cytotherapy 2013; 15; 384 https://ac.els-cdn.com/S1465324912000254/1-s2.0-S1465324912000254-main.pdf?_tid=ff434cca-d53d-47b8-89f0-5b4157a771fc&acdnat=1539078599_99e648c919fdc2ba822af93d2ff37039

Srivastava K, Shao B, Bayraktutan U. PKC-β Exacerbates in vitro Brain Barrier Damage in Hyperglycemic Settings via Regulation of RhoA/Rho-kinase/MLC2 Pathway. J Cereb Blood Flow Metabolism 2013; 33; 1928

Hisham NF, Bayraktutan U. Epidemiology, pathophysiology and treatment of hypertension in ischaemic stroke patients. J Stroke Cerebrovasc Dis 2013; 22

Wong KS, Wang Y, Leng X, Mao C, Tang J, Bath PM, Markus HS, Gorelick PB, Liu L, Lin W, Wang Y. Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation 2013; 128; 1656 https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.113.003187

Whiteley WN, Adams HP Jr, Bath PM, Berge E, Sandset PM, Dennis M, Murray GD, Wong KS, Sandercock PA. Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials. Lancet Neurol 2013; 12; 539 https://ac.els-cdn.com/S1474442213700796/1-s2.0-S1474442213700796-main.pdf?_tid=01f014e5-80a0-4648-ab39-417a244e4a76&acdnat=1539078796_c987988b104f3d70cdf7a29b0cd44a85

Ankolekar S, Renton C, Sprigg N, Bath PM. The cog-4 subset of the national institutes of health stroke scale as a measure of cognition: relationship with baseline factors and functional outcome after stroke using data from the virtual international stroke trials archive. Stroke Res Treat 2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622404/pdf/SRT2013-562506.pdf

Bath PM, Sprigg N, England T. Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke. Cochrane Database Syst Rev 2013 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005207.pub4/epdf/full

Ovbiagele B, Bath PM, Cotton D, Sha N, Diener HC; PRoFESS Investigators. Low glomerular filtration rate, recurrent stroke risk, and effect of renin-angiotensin system modulation. Stroke 2013; 44; 3223 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.002463?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Bath PM. Albumin for hyperacute stroke: another failed neuroprotectant. Lancet Neurol 2013; 12; 1036 https://ac.els-cdn.com/S1474442213702126/1-s2.0-S1474442213702126-main.pdf?_tid=5b043627-23d5-4d0d-aedc-570a44a56f44&acdnat=1539079180_66f25b77135f85773ed4c028decda72b

Saposnik G, Reeves MJ, Johnston SC, Bath PM, Ovbiagele B; VISTA Collaboration. Predicting clinical outcomes after thrombolysis using the iScore: results from the Virtual International Stroke Trials Archive. Stroke 2013; 44; 2755 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.001343?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Blackburn DJ, Krishnan K, Fox L, Ballard C, Burns A, Ford GA, Mant J, Passmore P, Pocock S, Reckless J, Sprigg N, Stewart R, Wardlaw J, Bath PM. Prevention of Decline in Cognition after Stroke Trial (PODCAST): a study protocol for a factorial randomised controlled trial of intensive versus guideline lowering of blood pressure and lipids. Trials 2013; 14 https://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-14-401

Flint AC, Faigeles BS, Cullen SP, Kamel H, Rao VA, Gupta R, Smith WS, Bath PM, Donnan GA; VISTA Collaboration. THRIVE score predicts ischemic stroke outcomes and thrombolytic hemorrhage risk in VISTA. Stroke 2013; 44; 3365 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.002794?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Whynes DK, Sprigg N, Selby J, Berge E, Bath PM; ENOS Investigators. Testing for differential item functioning within the EQ-5D. Med Decis Making 2013; 33; 252 http://journals.sagepub.com/doi/pdf/10.1177/0272989X12465016

Hornslien AG, Sandset EC, Bath PM, Wyller TB, Berge E; Scandinavian Candesartan Acute Stroke Trial Study Group. Effects of candesartan in acute stroke on cognitive function and quality of life: results from the Scandinavian Candesartan Acute Stroke Trial. Stroke 2013; 44; 2022 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.001022?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Weimar C, Cotton D, Sha N, Sacco RL, Bath PM, Weber R, Diener HC. Discontinuation of antiplatelet study medication and risk of recurrent stroke and cardiovascular events: results from the PRoFESS study. Cerebrovasc Dis 2013; 35; 538 https://www.karger.com/Article/Abstract/351144

Ankolekar S, Fuller M, Cross I, Renton C, Cox P, Sprigg N, Siriwardena AN, Bath PM. Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the rapid intervention with glyceryl trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824). Stroke 2013; 44; 3120 https://www.ahajournals.org/doi/abs/10.1161/STROKEAHA.113.001301?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

 
2012

Geeganage C, Beavan J, Ellender S, Bath PM. Interventions for dysphagia and nutritional support in acute and subacute stroke. Cochrane Database Syst Rev 2012

Bath PMW, Ankolekar S, England TJ, Sprigg N. Acute treatment and prevention of stroke. Clin Med 2012;12

Bohm M, Cotton D, Foster L, Custodis F, Laufs U, Sacco R, Bath PM, Yusuf S, Diener HC. Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke. Eur Heart J 2012; 33; 2804

Sprigg N, Gray LJ, Bath PM, Christensen H, De Deyn PP, Leys D, O’Neill D, Ringelstein EB, for the TAIST Investigators. Quality of Life after ischemic stroke varies in western countries: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). J Stroke Cerebrovasc Dis 2012; 21; 587

Ankolekar S, Rewell S, Howells DW, Bath PM. The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals. Int J Stroke 2012; 7 ;386

Sandset EC, Murray GD, Bath PM, Kjeldsen SE, Berge E;, Scandinavian Candesartan Acute Stroke Trial (SCAST) Study Group. Relation between change in blood pressure in acute stroke and risk of early adverse events and poor outcome. Stroke 2012; 43; 2108

Geeganage CM, Sprigg N, Bath MW, Bath PM. Balance of symptomatic pulmonary embolism and symptomatic intracerebral hemorrhage with low-dose anticoagulation in recent ischemic stroke: a systematic review and meta-analysis of randomized controlled trials. J Stroke Cerebrovasc Dis 2012

Bath PM, Lees KR, Schellinger PD, Altman H, Bland M, Hogg C, Howard G, Saver JL; European Stroke Organisation Outcomes Working Group. Statistical analysis of the primary outcome in acute stroke trials. Stroke 2012; 43; 1171

Lees KR, Bath PM, Schellinger PD, Kerr DM, Fulton R, Hacke W, Matchar D, Sehra R, Toni D; European Stroke Organization Outcomes Working Group. Contemporary outcome measures in acute stroke research: choice of primary outcome measure. Stroke 2012; 43; 1163

Schellinger PD, Bath PM, Lees KR, Bornstein NM, Uriel E, Eisert W, Leys D; European Stroke Organisation Outcomes Working Group. Assessment of additional endpoints for trials in acute stroke – what, when, where, in who. Int J Stroke 2012; 7; 227

Myzoon A, Bath P, Brady M, Davis S, Diener HC, Donnan G, Fisher M, Hacke W, Hanley DF, Luby M, Tsivgoulis G, Wahlgren N, Warach S, Lees KR; VISTA Steering Committees. Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses. Int J Stroke 2012; 7; 133

Geeganage CM, Diener HC, Algra A, Chen C, Topol EJ, Dengler R, Markus HS, Bath MW, Bath PMW; Acute Antiplatelet Stroke Trialists Collaboration. Dual or mono antiplatelet therapy for patients with acute ischemic stroke or Transient Ischemic Attack: systematic

England TJ, Abaei M, Auer DP, Lowe J, Jones DR, Sare G, Walker M, Bath PM. Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the Stem cell Trial of recovery EnhanceMent after Stroke-2 randomized controlled trial. Stroke 2012; 43; 405

 
2011

Geeganage C, Tracy M, England T, Sare G, Moulin T, Woimant F, Christensen H, De Deyn PP, Leys D, O’Neill D, Ringelstein EB, Bath PM, for TAIST Investigators. Relationship between baseline blood pressure parameters (including mean pressure, pulse pressure and variability) and early outcome after stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke 2011; 42; 491

King A, Bath PM, Markus HS. Clopidogrel versus dipyridamole in addition to aspirin in reducing embolization detected with ambulatory transcranial Doppler: a randomized trial. Stroke 2011; 42; 650

Sandset EC, BathPM, BoysenG, JatuzisD, KõrvJ, LüdersS, MurrayGD, RichterPS, RoineRO, TeréntA, ThijsV, BergeE; SCAST Study Group. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo controlled, double-blind trial. Lancet 2011; 377; 741 

Murray GD, Sandset EC, Bath PMW, Berge E. Efficiency gains resulting from the ordinal analysis of a functional outcome scale: a case study of a major phase III stroke trial. Trials 2011; 12

Geeganage CM, Bath AJ, Bath PM. The effect of transdermal glyceryl trinitrate on 24 h ambulatory blood pressure in acute/subacute stroke. Int J Stroke 2011; 6; 290

Bath PMW. Clot-busting for stroke. Lancet 2011

Optimising the Analysis of Stroke Trials Collaboration with the writing committee, Bath P, Hogg C, Tracy M, Pocock S. Calculation of numbers-needed-to-treat in parallel group trials assessing ordinal outcomes: case examples from acute stroke and stroke prevention. Int J Stroke 2011; 6; 472

Bath PM, Ankolekar S. Lowering blood pressure in acute stroke: lessons learnt from the SCAST trial. Expert Rev Neurother 2011; 11; 1091

Ankolekar S, Bath P. Overview of recommended management of acute stroke. Prescriber 2011; 21

Ovbiagele B, Bath PM, Cotton D, Vinisko R, Diener HC. Obesity and recurrent vascular risk after a recent ischemic stroke. Stroke 2011; 42; 3397

Kerr DM, Fulton RL, Higgins P, Bath PM, Shuaib A, Lyden P, Lees KR; VISTA Collaborators. Response of blood pressure and blood glucose to treatment with recombinant plasminogen activator in acute ischaemic stroke: evidence from the Virtual International Stroke Trials Archive (VISTA). Stroke 2011; 43; 399

Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PRoFESS Investigators. Level of systolic blood pressure within the normal range and risk of recurrent stroke. JAMA 2011; 306; 2137

Srivastava K, Bath PM, Bayraktutan U. Current therapeutic strategies to mitigate the eNOS dysfunction in ischaemic stroke. Cell Mol Neurobiol 2011; 32; 319

 
2010

Whitehead P, Fellows K, Sprigg N, Drummond A. Research governance. There is nothing streamlined about the system. BMJ 2010; 341

Allen C, Srivastava K, Bayraktutan U. Small GTPase RhoA and its effector Rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction. Stroke 2010; 41; 2056

England TJ, Bath PM, Sare GM, Geeganage C, Moulin T, O’Neill D, Woimant F, Christensen H, De Deyn P, Leys D, Ringelstein EB; TAIST Investigators. Asymptomatic hemorrhagic transformation of infarction and its relationship with functional outcome and stroke subtype: assessment from the Tinzaparin in Acute Ischaemic Stroke Trial. Stroke 2010; 41; 2834

Muir AD, McKeown PP, Bayraktutan U. Role of Gender, Smoking Profile, Hypertension, and Diabetes on Saphenous Vein and Internal Mammary Artery Endothelial Relaxation in Patients with Coronary Artery Bypass Grafting. Oxidative Medicine and Cellular Longevity 2010; 3; 199

Natios G, Bath P, Michel P. Blood pressure treatment in acute ischemic stroke: a review of studies and recommendations. Curr Opin Neurol 2010; 23; 46

Ankolekar S, Geeganage C, Anderton P, Hogg C, Bath PM. Clinical trials for preventing post stroke cognitive impairment. J Neurol Sci 2010; 299; 168

Geeganage CM, Tracy M, Bath MW, Bath PM. Blood pressure reduction and cardiovascular prevention: meta-regression using ordered categorical (ordinal) event data. J Hypertens 2010; 28; 1995

Muir A., McKeown PP, Bayraktutan U. The Role of Oxidative Stress in Modulation of the Relaxant Responses of Saphenous Vein and Internal Mammary Artery. The Open Circulation and Vascular Journal 2010; 3; 59

Geeganage C, Wilcox R, Bath PMW. Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis. BMC Med 2010; 8; 36

Sena ES, van der Worp HB, Bath PMW, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biology 2010; 8

Bath PM, Cotton D, Martin RH, Palesch Y, Yusuf S, Sacco R, Diener HC, Estol C, Roberts R, PRoFESS Study Group. Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis. Stroke 2010; 41; 732

Bath PM, Anderton PR, Ankolekar S. Hemostasis and vascular dementia. Arterioscler Thromb Vasc Biol 2010; 30; 461

Gibson CL, Bath PMW, Murphy SP. G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene. JCBFM 2010; 30; 739

 
2009

Bath PM, Macleod MR, Green AR. Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. Int J Stroke 2009; 4; 471

Gray LJ, Ali M, Lyden PD, Bath PM, VISTA Collaboration. Interconversion of the National Institute of Health Stroke Scale and Scandinavian Stroke Scale in acute stroke. J Stroke Cerebrovasc Dis 2009; 18; 466

England TJ, Gibson CL, Bath PM. Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: A systematic review. Brain Res 2009; 62; 71

Bath PMW, England TJ. Thigh-length compression stockings and DVT after stroke. Lancet 2009; 373; 1923

Sprigg N, Bath PM. Speeding stroke recovery? A systematic review of amphetamine after stroke. J Neuro Sci 2009

Bath PM, Gray LJ, Bath AJ, Buchan A, Miyata T, Gren AR. Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 2009

Bath PM, Martin RH, Palesch Y, Cotton D, Yusuf S, Sacco R, Diener HC, Toni D, Estol C, Roberts R, PRoFESS Study Group. Effect of telmisartan on functional outcome, recurrence and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis. Stroke 2009; 40; 3541

Geeganage C, Bath PMW. Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression. Hypertension 2009; 54; 775

Bath PMW. Antiplatelet activity should be measured routinely: No. Stroke 2009; 40;  2273

England T, Martin P, Bath PM. Stem cells for enhancing recovery after stroke: a review. Int J Stroke 2009; 4; 101

Sare GM, Geeganage C, Bath PM. High blood pressure in acute ischaemic stroke--broadening therapeutic horizons. Cerebrovasc Dis 2009; 27 Suppl 1; 156

Sare GM, Ali M, Shuaib A, Bath PMW, and for the VISTA Collaboration. Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration. Stroke 2009; 40; 2098

Bath PM, Watson AR. Need for ethics approval and patient consent in clinical research. Stroke 2009; 40; 1555  

Bath PM, Gray LJ. Systematic reviews as a tool for planning and interpreting trials. Int J Stroke 2009; 4; 23

Geeganage CM, Bath PM. Interventions for deliberately altering blood pressure in acute stroke. Stroke 2009; 40

Optimising the Analysis of Stroke Trials (OAST) Collaboration, Gray LJ, Bath PM, Collier T. Should stroke trials adjust functional outcome for baseline prognostic factors? Stroke 2009; 40; 888

Sare GM, Gray LJ, Wardlaw J, Chen C, Bath PM; ENOS Trial Investigators. Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the ‘Efficacy of Nitric Oxide in Stroke’ trial. Blood Press Monit 2009; 14; 20

Sare GM, Bath PMW, Gray LJ, Moulin T, Woimant F, England T, Geeganage C, Christensen H,De Deyn PP, Leys D, O’Neill D, Ringelstein EB, for the TAIST Investigators. The relationship between baseline blood pressure and Computed Tomographic findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke 2009; 40; 41

Allen CL, Bayraktutan U. Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability. Diabetes, Obesity and Metabolism 2009; 11; 480

Sharif MA, Bayraktutan U, Arya N, O'Donnell ME, Badger SA, Young IS, Soong CV. Smoking impairs the endothelial function in human saphenous vein in an ex vivo model. Annals of Vascular Surgery 2009; 23; 116

Sharif MA, Bayraktutan U, Arya N, Badger SA, O’Donnell ME, Young IS, Soong CV. Effects of antioxidants on endothelial function in human saphenous vein in an ex vivo model. Angiology 2009; 60; 448

Ali M, Atula S, Bath PM, Grotta J, Hacke W, Lyden P, Marler JR, Sacco RL, Lees KR, for the VISTA investigators. Stroke outcome in clinical trial patients deriving from different countries. Stroke 2009; 40; 35

Allen CL, Bayraktutan U. Oxidative stress and its role in the pathogenesis of cerebrovascular disease International. Journal of Stroke 2009; 4; 461

Allen CL, Bayraktutan U. Risk factors for ischaemic stroke. International journal of stroke 2009; 3; 105

Macleod MR, Fisher M, O’Collins V, Sena ES, Dirnagl U, Bath PMW, Buchan AM, van der Worp B, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke 2008; Epub 14 August. Reprinted in: Int J Stroke 2009;4:(1):3-5. Reprinted in: J Cereb Blood Flow Metab 2009; 29; 221

 
2008

Sprigg N, Gray LJ, England T, Willmot MR, Zhao L, Sare GM, Bath PM. A Randomised Controlled Trial of Triple Antiplatelet Therapy (Aspirin, Clopidogrel and Dipyridamole) in the Secondary Prevention of Stroke: Safety, Tolerability and Feasibility. PLoS ONE 2008; 3

Bath PMW, Geeganage C, Gray LJ, Collier T, Pocock S. Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials. Stroke 2008; 39; 2817

Sare G, Gray L, Bath PMW. Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta analysis. Eur Heart J 2008; 29; 2031

Halkes PHA, Gray LJ, Bath PM, Diener HC, Guiraud-Chaumeil B, Yatsu FM, Algra A. Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk. JNNP 2008; 79; 1218

Kobayashi A, Grabska K, Czlonkowska A, Gray L, Bath P. Efficacy of Nitric Oxide in Stroke – ENOS – a randomized trial – Characteristics of patients recruited in Poland. Neurol Neurochir Pol 2008; 42; 99

Sare GM, Gray LJ, Bath PMW. Effect of antihypertensive agents on cerebral blood flow and flow velocity in acute ischaemic stroke; systematic review of controlled studies. J Hypertens 2008; 26; 1058

König IR, Ziegler A, Bluhmki E, Hacke W, Bath PM, Sacco RL, Diener HC, Weimar C; on behalf of the Virtual International Stroke Trials Archive (VISTA) Investigators. Predicting long-term outcome after acute ischemic stroke. A simple index works in patients from controlled clinical trials. Stroke 2008

Allen CL, Bayraktutan U. Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. Journal of Molecular and Cellular Cardiology 2008; 45; 198

Demirci B, Mckeown PP, Bayraktutan U. The bimodal regulation of vascular function by superoxide anion: role of endothelium. BMB Reports 2008; 31; 223

Geeganage C, Sare G, Bath PMW. Pulse pressure as a predictor of stroke. Exp Rev Neurotherapeutics 2008; 8; 165

Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM, Macleod M, Dirnagl U. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 2008; 39; 929

Gibson CL, Gray LJ, Bath PMW, Murphy SP. Progesterone for the treatment of experimental brain injury: a systematic review. Brain 2008; 131; 318

 
2007

Gray LJ, Sprigg N, Bath PMW, Boysen G, De Deyn PP, Leys D, O’Neill D, Ringelstein EB, TAIST Investigators. Sex differences in quality of life in stroke survivors: data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST). Stroke 2007; 38; 2960

Bath PMW, Gray L. Should Data Monitoring Committees assess efficacy when considering safety in trials in acute stroke? Int J Clin Pract 2007; 61; 1749

Ali M, Bath PM, Curram J, Davis SM, Diener HC, Donnan GA, Fisher M, Gregson BA, Grotta J, Hacke W, Hennerici MG, Hommel M, Kaste M, Marler JR, Sacco RL, Teal P, Wahlgren NG, Warach S, Weir CJ, Lees KR. The Virtual International Stroke Trials Archive (VISTA). Stroke 2007; 38; 19

Sprigg N, Bath PMW. Colony stimulating factors (blood growth factors) are promising but unproven for treating stroke. Stroke 2007; 38; 19 

Bath P, Sprigg N. Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke. Cochrane Database Syst Rev 2007; 2; 18 

Sprigg N, Willmot MR, Gray LJ, Sunderland A, Pomeroy V, Walker M, Bath PM. Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomised controlled trial (ISRCTN 36285333). J Hum Hypertens 2007; 19 

Sare GM, Geeganage C, Bath PM. High blood pressure in acute stroke: to treat or not to treat? Int J Stroke 2007; 2; 172

Sharif MA, Bayraktutan U, Young IS, Soong CV. N-acetylcysteine does not improve the endothelial and smooth muscle in human saphenous vein. Vascular and Endovascular Surgery 2007; 41; 239

Sprigg N, Gray LJ, Bath PMW, Lindenstrøm E, Boysen G, De Deyn PP, Friis P, Leys D, Marttila R, Olsson J-E, O’Neill D, Ringelstein EB, van der Sande J-J, Turpie AGG, for the TAIST Investigators. Early recovery and functional outcome are related with causal stroke subtype: Data from the Tinzaparin in Acute Ischemic Stroke Trial. J Stroke Cerebrovasc Dis 2007; 16; 180

Optimising Analysis of Stroke Trials (OAST) Collaboration, Bath PM, Gray LJ, Collier T, Pocock S, Carpenter J. Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke 2007; 38; 1911

Sprigg N, Gray LJ, Bath PMW, Lindenstrom E, Boysen G, De Deyn PP, Friis P, Leys D, Marttila R, Olsson J-E, O’Neill D, Ringelstein B, van der Sande J-J, Turpie AGG, for the TAIST Investigators. Stroke severity, early recovery and outcome are each related with clinical classification of stroke: Data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST). J Neuro Sci 2007; 254; 54

Wardlaw JM, Bath P, Sandercock P, Perry D, Palmer J, Watson G, Lloyd S, Geddes J, Farrall A. The NeuroGrid stroke exemplar clinical trial protocol. Int J Stroke 2007; 2; 63

Bath PM. Is there a link between aspirin therapy and stroke severity? Nat Clin Pract Neurol 2007; 3; 12

 
2006

Mahadevan VS, Campbell M, McKeown, PP, Bayraktutan U. Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. Cardiovascular Research 2006; 72; 60

Gibson CL, Gray LJ, Murphy SP, Bath PM. Estrogens and experimental ischemic stroke: a systematic review. J Cereb Blood Flow Metab 2006; 26; 1103

Gray LJ, Sprigg N, Bath PM, Sørensen P, Lindenstrøm E, Boysen G, De Deyn PP, Friis P, Leys D, Marttila R, Olsson JE, O’Neill D, Ringelstein B, van der Sande JJ, Turpie AG. Significant variation in mortality and functional outcome after acute ischaemic stroke between western countries: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST). J Neurol Neurosurg Psychiatry. 2006; 77; 327

Zhao L, Gray L, Leonardi-Bee J, Weaver CS, Heptinstall S, Bath PM. Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke. Platelets 2006; 17; 100

HoranM, NewswayV, Yasmin, LewisMD, EasterTE, Rees DA, MahtoA, MillarDS, ProcterAM, ScanlonMF, WilkinsonIB, HallIP, WheatleyA, BlakeyJ, BathPM, CockcroftJR, KrawczakM, Cooper DN.Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke. Human Genetics 2006; 119; 527

Willmot M, Ghadami A, Whysall B, Clarke W, Wardlaw J, Bath PM. Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke. Hypertension 2006; 47; 1209

Sprigg N, Gray LJ, Bath PMW, Boysen G, De Deyn PP, Friis P, Leys D, Marttila R, Olsson J-E, O’Neill D, Ringelstein B, van der Sande J-J, Lindenstrøm E, for the TAIST Investigators. Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke: data from the TAIST trial. J Hypertension 2006; 24; 1413

Gray L, Sprigg N, Bath P. Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke. J Stroke Cerebrovasc Dis 2006; 15; 245

Sprigg N, Bath PMW, Zhao L, Willmot MR, Gray LJ, Walker MF, Dennis MS, Russell N. Granulocyte-colony stimulating factor mobilises bone marrow stem cells in patients with sub-acute ischaemic stroke: the ‘Stem cell Trial of recovery EnhanceMent after Stroke’ (STEMS) pilot randomised controlled trial (ISRCTN 16784092). Stroke 2006; 37; 2979

Martin PA, Coveney C, Kraft A, Brown N, Bath P. Commercial development of stem cell technology: lessons from the past, strategies for the future. Regen Med 2006; 1; 801

 
2005

Gibson CL, Jones NC, Prior MJ, Bath PM, Murphy SP. G-CSF suppresses edema formation and reduces interleukin-1beta expression after cerebral ischemia in mice. J Neuropathol Exp Neurol 2005; 64; 763

Willmot M, Gibson C, Gray L, Murphy S, Bath P. Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review. Free Radic Biol Med 2005; 39; 412

Bayraktutan U. Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox. Free Radical Biology and Medicine 2005; 39; 1342

Demirci B, McKeown PP, Bayraktutan U. Blockade of angiotensin II provides additional benefits in hypertension- and ageing-related cardiac and vascular dysfunctions beyond its blood pressure-lowering effects. Journal of Hypertension 2005; 23; 2219

Gibson CL, Constantin D, Prior MJ, Bath PM, Murphy SP. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 2005; 193; 522

Willmot M, Gray L, Gibson C, Murphy S, Bath PM. A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow. Nitric Oxide 2005; 12; 141

Bayraktutan U. Enhanced antioxidant capacity and decreased migratory response to ox-LDL render human internal mammary arteries immune to atherosclerosis. European Heart Journal 2005 26; 543

Bayraktutan U. Reactive oxygen species, nitric oxide and hypertensive endothelial dysfunction. Current Hypertension Reviews 2005; 1; 201

Gibson CL, Bath PM, Murphy SP. G-CSF reduces infarct volume and improves functional recovery after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 2005; 25; 431

Sprigg N, Gray LJ, Bath PMW, Boysen G, de Deyn PP, Leys D, Lindenstrøm E, O’Neill D, van der Sande J-J, on behalf of the TAIST Advisory Committee and TAIST Investigators. Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial. J Stroke Cerebrovasc Dis 2005; 14; 203

Zhao L, Fletcher S, Weaver C, Leonardi-Bee J, May J, Fox S, Willmot M, Heptinstall S, Bath P. Effects of aspirin, clopidogrel and dipyridamole administered singly and in combination on platelet and leucocyte function in normal volunteers and patients with prior ischaemic stroke. Thromb Haemost 2005; 93; 527

Leonardi-Bee J, Bath PMW, Acheson J, Bousser M-G, Davalos A, Diener H-C, Guiraud-Chaumeil B, Sivenius J, Yatsu F , Dewey ME, on behalf of the Dipyridamole in Stroke Collaboration (DISC). Dipyridamole for preventing recurrent ischemic stroke and other vascular events. A meta-analysis of individual patient data from randomized controlled trials. Stroke 2005; 36; 162

Bath PMW, Gray LJ. Hormone replacement therapy and subsequent stroke: a meta analysis. British Medical Journal 2005; 330; 342

EmmerichJ, Le HeuzeyJY, BathPMW, ConnollySJ. Indication for antithrombotic therapy for atrial fibrillation: reconciling the guidelines with clinical practice. Eur Heart J Supp 2005; 7

Bath PMW, Zhao L, Heptinstall S. Current status of stroke prevention in patients with atrial fibrillation. Eur Heart J Supps 2005; 7

 
2004

Leys D, Kwiecinski H, Bogousslavsky J, Bath P, Brainin M, Diener H-C, Kaste M, Sivenius J, Hennerici MG, Hacke W, for the EUSI Executive Committee and the EUSI Writing Committee.  Cerebrovasc Dis 2004; 17; 15

Bath PMW. High blood pressure as risk factor and prognostic predictor in acute ischaemic stroke. When and how to treat it? Cerebrovasc Dis 2004; 17; 51

Sprigg N, Bath P. Pharmacological enhancement of recovery from stroke. Stroke Review 2004; 8;33

Willmot M, Leonardi-Bee J, Bath PM. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension 2004;43;  18

Bath P, Algert C, Chapman N, Neal B; for the PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke 2004; 35; 622

Weaver CS, Leonardi-Bee J, Bath FJ, Bath PM. Sample size calculations in acute stroke trials: a systematic review of their reporting, characteristics, and relationship with outcome. Stroke 2004; 35; 1216

Willmot M, Zhao L, Heptinstall S, Bath P. Triple antiplatelet therapy for secondary prevention of recurrent ischemic stroke. J Stroke Cerebrovasc Dis 2004; 13; 138

Walker MF, Leonardi-Bee J, Bath P, Langhorne P, Dewey M, Corr S, Drummond A, Gilbertson L, Gladman JRF, Jongbloed L, Logan P, Parker C. An individual patient data meta-analysis of randomised controlled trials of community occupational therapy for stroke patients. Stroke 2004; 35; 2226

 
2003

Rashid PA, Whitehurst A, Lawson N, Bath PMW. Plasma nitric oxide (nitrate/nitrite) levels in acute stroke and their relationship with severity and outcome. J Stroke Cerebrovasc Dis 2003; 12; 82

Elwood PC, Pickering J, Yarnell J, O’Brien JR, Shlomo YB, Bath P. Bleeding time, stroke and myocardial infarction: the Caerphilly prospective study. Platelets 2003; 14; 139

Rashid P, Weaver C, Leonard-Bee J, Bath F, Fletcher S, Bath P. The effects of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure, cerebral and cardiac haemodynamics, and plasma nitric oxide levels in acute stroke. J Stroke Cerebrovasc Dis 2003; 12; 143

Rashid P, Leonardi-Bee J, Bath PMW. Blood pressure reduction and the secondary prevention of stroke and other vascular events: a systematic review. Stroke 2003; 34; 2741

Haga KK, Gregory LJ, Hicks CA, Ward MA, Beech JS, Bath PM, Williams SC, O’Neill MJ. The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques. Brain Res 2003; 12; 42

Zhao L, Bath PMW, Fox S, May J, Judge H, Lösche W, Heptinstall S. The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions. Current Med Res Opinion 2003; 19; 1

Zhao L, Bath PMW, May J, LöscheW, HeptinstallS. P-selectin, tissue factor and CD40 ligand expression on platelet-leucocyte conjugates in the presence of a GPIIb/IIIa antagonist. Platelets 2003; 14; 473

Bath P. Management of blood pressure in acute stroke.  Ed: Bogousslavsky J. In: Acute Stroke treatment.  2nd Edition. London, 2003; 117

Bath P. Blood pressure lowering for secondary prevention of stroke: ACE inhibition is not the key. Stroke 2003; 34; 1334

Bath P, Chalmers J, Powers W, Beilin L, Davis S, Lenfant C, Mancia G, Neal B, Whitworth J, Zanchetti A; International Society of Hypertension Writing Group. International Society of Hypertension (ISH): statement on the management of blood pressure in acute stroke. J Hypertens 2003; 21; 665

Willmot MR, Bath PMW. The potential of nitric oxide therapeutics in stroke. Exp Opinion Investig Drugs 2003; 12; 455

Hacke W, Kaste M, Bogousslavsky J, Brainin M, Chamorro A, Lees K, Leys D, Kwiecinski H, Toni P, Langhorne P, Diener C, Hennerici M, Ferro J, Sivenius J, Gunnar N, Bath P, Olsen TS, Gugging M. European Union Stroke Initiative Executive Committee and the EUSI Writing Committee. Cerebrovasc Dis 2003; 16; 311

 
2002

Bath PMW. Future perspectives in stroke management. Br J Cardiol 2002; 9; 215

Bath PMW. Anticoagulants and antiplatelet agents in acute ischemic stroke. Lancet Neurology 2002; 1; 405

Bath P, Willmot M. Insights on managing blood pressure in acute stroke. Practical Neurology 2002

Scholz T, Zhao L, Temmler U, Bath P, Heptinstall S, Lösche W. The GPIIb/IIIa antagonist eptifibatide markedly potentiates platelet-leukocyte interaction and tissue factor expression following platelet activation in whole blood in vitro. Platelets 2002; 13; 401

van der Worp HB, Kappelle LJ, Algra A, Bar PR, Orgogozo JM, Ringelstein EB, Bath PM, van Gijn J. The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke. Neurology 2002; 58; 133

Smith NM, Pathansali R, Bath PMW. Altered megakaryocyte-platelet-haemostatic axis in patients with acute stroke. Platelets 2002; 13; 113

Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG, for the IST Collaborative Group. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 2002; 33; 1315

Sandercock P, Anderson C, Bath P, Bereczki D, Candelise L, Chen C, Fraser H, Haines S, Hankey G, Langhorne P, McInnes A, Robinson S, Thomas B. Cochrane Stroke Group. In: The Cochrane Library, Issue 3, 2002

Bath P, Leonardi-Bee J, Bath F. Low molecular weight heparin versus aspirin for acute ischemic stroke: a systematic review. J Stroke Cerebrovasc Dis 2002; 11; 55

Bath PM, Willmot M, Leonardi-Bee J, Bath FJ. Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute ischaemic stroke (Cochrane Review).  In: The Cochrane Library, 2002

 
2001

Bath PMW, Pathansali R, Iddenden R, Bath FJ. The effect of transdermal glyceryl trinitrate, a nitric oxide donor, on blood pressure and platelet function in acute stroke. Cerebrovasc Dis 2001; 11; 265

Harris ML, Polkey MI, Bath PMW, Moxham J. Quadriceps strength measurement in clinical practice: an investigation in acute stroke. Clin Rehab 2001; 15; 274

Bath PMW, Lindenstrom E, Boysen G, De Deyn P, Friis P, Leys D, Marttila R, Olsson J-E, O’Neill D, Ringelstein B, van der Sande J-J, Turpie AGG, for the TAIST Investigators. Tinzaparin in acute ischaemic stroke (TAIST): a randomised aspirin-controlled trial. Lancet 2001; 358; 702

Pathansali R, Smith NM, Bath PMW. Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study. Platelets 2001; 12; 144

Pathansali R. Smith N, Bath P. Altered megakaryocyte-platelet haemostatic axis in hypercholesterolaemia. Platelets 2001; 12; 292

Zhao L, Bath P, Heptinstall S. Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. Br J Pharmacol 2001; 134; 353

Cash D, Beech JS, Rayne RC, Bath PMW, Meldrum BS, Williams SCR. Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain. Brain Res 2001; 905; 91

Beech JS, Williams SCR, Campbell C, Meldrum B, Bath PMW, Parsons AA, et al. Further characterisation of a thromboembolic model of stroke in the rat? Brain Res 2001; 895; 18

Bath P, Rashid P. Acute ischaemic stroke: role of the GP. Trends Cardiol & Vasc Dis 2001; 3; 25

Rashid PA, Bath PMW. Review on immediate care and secondary prevention of stroke. Saudi J Disabil Rehabil 2001; 7; 110

 
2000

Bath PMW. Tissue plasminogen activator improved function at 6 and 12 months after ischemic stroke. Am Coll Phys J Club 2000; 132; 11

Rashid PA, Bath PMW. Blood pressure management immediately after acute stroke. Stroke Review 2000; 4; 1

Bath PMW, Lees KR. ABC of arterial and venous disease - Acute stroke. Br Med J 2000; 320; 920

Lees KR, Bath PMW, Naylor AR. ABC of arterial and venous disease - Secondary prevention of TIA and stroke. Br Med J 2000; 320; 991

Bath PM, Lees KR. Acute stroke. West J Med 2000; 173; 209

Lees KR, Bath PMW, Naylor AR. Secondary prevention of transient ischemic attack and stroke. West J Med 2000; 173; 254

Pearson BJ, Bath PMW, Spence JD. Hypertension in patients presenting with stroke. Current Hypertension Reports 2000; 2; 551

Bath PMW. Optimising homeostasis. Br Med Bull 2000; 56; 422

Bath PMW, Iddenden R, Bath FJ. Low molecular weight heparins and heparinoids in acute ischemic stroke: a systematic review. Stroke 2000; 31; 1770

Bath PMW, Blecic S, Bogousslavsky J, Boysen G, Davis S, Diez-Tejedor E, Ferro JM, Gommans J, Hacke W, Indredavik B, Norrving B, Orgogozo JM, Ringelstein EB, Sacchetti ML, Iddenden R, Bath FJ, Musch BC, Brosse DM, Naberhuis-Stehouwer SA. Tirilazad mesylate in acute ischaemic stroke. A systematic review. Stroke 2000; 32; 2257

Bath PMW. Acute treatment and coordinated care. Ed: Holland W. Stroke. The past, present, and future. 2000

Bath P. Blood pressure in acute stroke – a systematic review. Ed: Wahlgren NG. In: Update on stroke therapy. Karolinska Stroke Update, Stockholm 2000; 205

 
1999

Kaposzta Z, Young E, Bath PMW, Markus HS. Clinical application of asymptomatic embolic signal detection in acute stroke. A prospective study. Stroke 1999; 30; 1814

Bath PMW. Alteplase given within 6 hours of stroke did not improve clinical outcomes at 90 days. Am Coll Phys J Club 1999; 130; 34

Smith NM, Pathansali R, Bath PMW. Platelets and stroke. Vasc Med 1999; 4; 165

 
1998

Bath FJ, Owen VE, Bath PMW. Quality of full and final publications reporting acute stroke trials. A systematic review. Stroke 1998; 29; 2203

 

Stroke, Division of Clinical Neuroscience

The University of Nottingham
Clinical Sciences Building
Nottingham, NG5 1PB


telephone: +44 (0)115 823 1765
email:strokeadmin@nottingham.ac.uk