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Image of Alastair Campbell Ritchie

Alastair Campbell Ritchie

Assistant Professor, Faculty of Engineering

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Biography

Dr Alastair Campbell Ritchie is part of the Bioengineering Research Group.

Bioreactors for Tissue Engineering

I have developed a number of experimental bioreactors to test the response of mammalian cells to environmental factors, particularly to applied mechanical forces. These bioreactors incorporate high precision actuators to allow maximum control over the magnitude and frequency of stimulation.

These bioreactors have been used to demonstrate the effect of mechanical force on smooth muscle cells of oesophageal origin, as well as on epithelial cells from the oesophagus. My research has demonstrated the link between over-stimulation and a stress avoidance response, and the induction of differentiation in cells by mechanical stimulation.

Physiological and Biomechanical Modelling

I am also active in research into the effects of technique on athletic performance, particularly in the sport of rowing, and am active in a collaboration with the Republic of Singapore Air Force researching into the causes and prevention of G-induced loss of consciousness.

Expertise Summary

Bioreactors for Tissue Engineering

I have developed a number of experimental bioreactors to test the response of mammalian cells to environmental factors, particularly to applied mechanical forces. These bioreactors incorporate high precision actuators to allow maximum control over the magnitude and frequency of stimulation.

These bioreactors have been used to demonstrate the effect of mechanical force on smooth muscle cells of oesophageal origin, as well as on epithelial cells from the oesophagus. My research has demonstrated the link between over-stimulation and a stress avoidance response, and the induction of differentiation in cells by mechanical stimulation. The bioreactors developed can use tubular or flat sheet geometry, discussions are under way with the department of orthopaedic surgery to modify the design to allow compressive rather than tensile stimulation.

I have interests in the development of larger scale bioreactors for the production of sustainable energy and fuels for transportation.

Physiological and Biomechanical Modelling

I am also active in research into the effects of technique on athletic performance, particularly in the sport of rowing, and am active in a collaboration with the Republic of Singapore Air Force researching into the causes and prevention of G-induced loss of consciousness.

Service as a Technical Expert

I have served on the International Standards Organisation's Technical Committee on Implants for Surgery and on National Level Technical Committees in Singapore addressing international standardisation.

Teaching Summary

Biomaterials and biomaterial processing

Medical device regulation and standardisation

Research Summary

My current research focuses on the effect of mechanical environment on cells and cell-biomaterial constructs. We have recently developed a new bioreactor which is able to exert compressive… read more

Recent Publications

  • MARINESCU A., SHARPLES S., CAMPBELL RITCHIE A., SANCHEZ-LOPEZ T., MCDOWELL M. and MORVAN H., 2017. Physiological Parameter Response to Variations in Mental Workload. Human Factors: The Journal of Personalization Research. (In Press.)
  • YANG Y., CAMPBELL RITCHIE A. and EVERITT N., 2017. Comparison of glutaraldehyde and procyanidin cross-linked scaffolds for soft tissue engineering Materials Science and Engineering C. 80(1), 263-270
  • ENCERRADO FLORES A., SCOTCHFORD C. and CAMPBELL RITCHIE A., 2017. Fabrication of Pro-anthocyanidin Cross-Linked Chitosan-Gelatin Hydrogel Scaffolds for Tissue Engineering International Journal of Artificial Organs. 40(8), 421-422
  • WANG A., WILLIAMS R.L., JAMBU N., PAXTON J.Z., DAVIS E.T., SNOW M.A., CAMPBELL RITCHIE A., JOHANSSON C.B., DAVIS E.T., SAMMONS R.L. and GROVER L.M., 2016. Development of Tissue Engineered Ligaments with Titanium Spring Reinforcement RSC Advances: An international journal to further the chemical sciences. 2016:6, 98536-98544

Current Research

My current research focuses on the effect of mechanical environment on cells and cell-biomaterial constructs. We have recently developed a new bioreactor which is able to exert compressive stimulation on cells grown on softer substrates, in addition to existing research on bioreactors providing tensile and torsional stimulation.

In addition to the bioreactors themselves, we have also developed flexible substrates, allowing the effect of mechanical strain, and the response of cells to substrate flexibility/anisotropy to be studied.

Future Research

A major hurdle to adoption of tissue engineered technologies is the cost of specialist biomaterials, growth factors, and cell expansion from biopsies. My current research aims to develop new biodegradable materials which can be produced repeatably with a sustainable regulatory route to market.

  • MARINESCU A., SHARPLES S., CAMPBELL RITCHIE A., SANCHEZ-LOPEZ T., MCDOWELL M. and MORVAN H., 2017. Physiological Parameter Response to Variations in Mental Workload. Human Factors: The Journal of Personalization Research. (In Press.)
  • YANG Y., CAMPBELL RITCHIE A. and EVERITT N., 2017. Comparison of glutaraldehyde and procyanidin cross-linked scaffolds for soft tissue engineering Materials Science and Engineering C. 80(1), 263-270
  • ENCERRADO FLORES A., SCOTCHFORD C. and CAMPBELL RITCHIE A., 2017. Fabrication of Pro-anthocyanidin Cross-Linked Chitosan-Gelatin Hydrogel Scaffolds for Tissue Engineering International Journal of Artificial Organs. 40(8), 421-422
  • WANG A., WILLIAMS R.L., JAMBU N., PAXTON J.Z., DAVIS E.T., SNOW M.A., CAMPBELL RITCHIE A., JOHANSSON C.B., DAVIS E.T., SAMMONS R.L. and GROVER L.M., 2016. Development of Tissue Engineered Ligaments with Titanium Spring Reinforcement RSC Advances: An international journal to further the chemical sciences. 2016:6, 98536-98544
  • CAMPBELL RITCHIE A., JAMBU N., PAXTON J., WANG A. and GROVER L., 2015. Development of HYbrid Bio-Artificial Anterior Cruciate Ligament International Journal of Artificial Organs. 38(7), 364
  • MOLES M.D., SCOTCHFORD C.A. and CAMPBELL RITCHIE A., 2014. Development of an elastic cell culture substrate for a novel uniaxial tensile strain bioreactor Journal of Biomedical Materials Research - Part A. 102(7), 2356-2364
  • CAMPBELL RITCHIE A, MOLES MD, SOTTILE V, SCOTCHFORD CA, 2014. Dynamic culture of mesenchymal stem cells and effect of mechanical environment on proliferation and differentiation International Journal of Artificial Organs.
  • RITCHIE, A.C. and DOMINY, J., 2013. Rowing Equipment. In: FUSS, F.K., SUBIC, A., STRANGWOOD, M. and MEHTA, R., eds., Routledge handbook of sports technology and engineering Routledge. (In Press.)
  • RATNER BD, HOFFMAN AS, SCHOEN FJ, LEMONS JE, 2013. In: Extracorporeal Artificial Organs - Biomaterials Science - An introduction to Materials in Medicine 3rd Edition
  • RITCHIE AC, MOLES MD, SCOTCHFORD CA, SOTTILE V, 2013. Mesenchymal Stem Cell Culture on Substrates with Biomimetic Flexibility International Journal of Artificial Organs.
  • RITCHIE, A.C., 2012. Extracorporeal artificial organs. In: RATNER, B.D., HOFFMAN, A.S., SCHOEN, F.J. and LEMONS, J.E., eds., Biomaterials science: an introduction to materials in medicine Elsevier Academic Press. 827-841
  • RITCHIE, A.C., MOLES, M.D., POUGET, J.A., KINNELL, P.K. and SCOTCHFORD, C.A., 2011. Effect of compressive plane strain on osteoblast-like cells in vitro International Journal of Artificial Organs. 34(8), 690
  • CAMPBELL RITCHIE, A. and SELAMAT, M.F.B., 2010. Comparison of blade designs in paddle sports Sports Technology. 3(2), 141-149
  • RITCHIE, A.C., WIJAYA, S., ONG, W.F., ZHONG, S.P. and CHIAN, K.S., 2009. Dependence of alignment direction on magnitude of strain in esophageal smooth muscle cells Biotechnology and Bioengineering. 102(6), 1703-1711

Department of Mechanical, Manufacturing and Materials Engineering

The University of Nottingham
University Park
Nottingham, NG7 2RD


telephone: +44 (0) 115 95 14081