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Microscopic worms could hold the key to living life on Mars

   
   
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30 Nov 2011 00:01:00.000

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The astrophysicist Stephen Hawking believes that if humanity is to survive we will have to up sticks and colonise space. But is the human body up to the challenge?

Scientists at The University of Nottingham believe that Caenorhabditis elegans (C. elegans), a microscopic worm which is biologically very similar to the human being, could help us understand how humans might cope with long-duration space exploration.

 

Their research, published on Wednesday November 30 2011 in Interface, a journal of The Royal Society, has shown that in space the C. elegans develops from egg to adulthood and produces progeny just as it does on earth. This makes it an ideal and cost-effective experimental system to investigate the effects of long duration and distance space exploration.

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In December 2006 a team of scientists led by Dr Nathaniel Szewczyk from the Division of Clinical Physiology in the School of Graduate Entry Medicine blasted 4,000 C. elegans into space onboard the Space Shuttle Discovery. The researchers were able to successfully monitor the effect of low Earth orbit (LEO) on 12 generations of C. elegans during the first three months of their six month voyage onboard the International Space Station. These are the first observations of C. elegans behaviour in LEO.

Dr Szewczyk said: “A fair number of scientists agree that we could colonise other planets. While this sounds like science fiction it is a fact that if mankind wants to avoid the natural order of extinction then we need to find ways to live on other planets. Thankfully most of the world’s space agencies are committed to this common goal.

“While it may seem surprising, many of the biological changes that happen during spaceflight affect astronauts and worms and in the same way. We have been able to show that worms can grow and reproduce in space for long enough to reach another planet and that we can remotely monitor their health. As a result C. elegans is a cost effective option for discovering and studying the biological effects of deep space missions. Ultimately, we are now in a position to be able to remotely grow and study an animal on another planet.”

Many experts believe the ultimate survival of humanity is dependent upon colonisation of other planetary bodies. But we face key challenges associated with long term space exploration. Radiation exposure and musculoskeletal deterioration are thought to be two of the key obstacles to successful habitation beyond LEO.

The C. elegans has been used on Earth to help us understand human biology — now it could help us investigate living on Mars.

C. elegans was the first multi-cellular organism to have its genetic structure completely mapped and many of its 20,000 genes perform the same functions as those in humans. Two thousand of these genes have a role in promoting muscle function and 50 to 60 per cent of these have very obvious human counterparts.

Dr Szewczyk is no stranger to space flight — this was his third space-worm mission. Dr Szewczyk and his team at Nottingham collaborated with experts at the University of Pittsburgh, the University of Colorado and the Simon Fraser University in Canada, to develop a compact automated C. elegans culturing system which can be monitored remotely to observe the effect of environmental toxins and in-flight radiation.

Dr Szewczyk said: “Worms allow us to detect changes in growth, development, reproduction and behaviour in response to environmental conditions such as toxins or in response to deep space missions. Given the high failure rate of Mars missions use of worms allows us to safely and relatively cheaply test spacecraft systems prior to manned missions.”

The 2006 space mission, which led to this latest research, was followed up with a fourth mission in November 2009. Some of the results of the 2009 mission were published earlier this year in the journal PLoS ONE: http://tiny.cc/plosonespacemission

Together these two missions have established that the team are not only in a position to send worms to other planets but also to experiment on them on the way there and/or once there. More results, including a mechanism by which muscles can repair themselves are due to be published shortly.

The origins of Dr Szewczyk’s worms can be traced back to a rubbish dump in Bristol.  C. elegans often feed on bacteria that develop on decaying vegetable matter.

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Notes to editors:  The University of Nottingham, described by The Sunday Times University Guide 2011 as ‘the embodiment of the modern international university’, has award-winning campuses in the United Kingdom, China and Malaysia. It is ranked in the UK's Top 10 and the World's Top 75 universities by the Shanghai Jiao Tong (SJTU) and the QS World University Rankings. It was named ‘Europe’s greenest university’ in the UI GreenMetric World University Ranking, a league table of the world’s most environmentally-friendly higher education institutions, which ranked Nottingham second in the world overall.

The University is committed to providing a truly international education for its 40,000 students, producing world-leading research and benefiting the communities around its campuses in the UK and Asia. Impact: The Nottingham Campaign, its biggest ever fund-raising campaign, will deliver the University’s vision to change lives, tackle global issues and shape the future. For more details, visit: http://www.nottingham.ac.uk/impactcampaign.

More than 90 per cent of research at The University of Nottingham is of international quality, according to the most recent Research Assessment Exercise, with almost 60 per cent of all research defined as ‘world-leading’ or ‘internationally excellent’. Research Fortnight analysis of RAE 2008 ranked the University 7th in the UK by research power. The University’s vision is to be recognised around the world for its signature contributions, especially in global food security, energy & sustainability, and health.

More news from the University at:

www.nottingham.ac.uk/news

Story credits

More information is available from Dr Nathaniel Szewczyk, on +44 (0)1332 724 615 or nathaniel.szewczyk@nottingham.ac.uk
Lindsay Brooke

Lindsay Brooke - Media Relations Manager

Email: lindsay.brooke@nottingham.ac.uk Phone: +44 (0)115 951 5751 Location: University Park

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