My research is focused upon characterising and understanding permeation mechanisms of active pharmaceutical, cosmetic and antibacterial compounds within complex tissues at the micron and nano scale. I have a particular interest and a number of projects on skin permeation. I lead a research team, comprised of postdoctoral associates and PhD students, who develop novel approaches for analysing both native tissue chemistry and the route and mechanisms of permeation of active compounds. An important goal of my research is to drive the development of more efficacious topically delivered compounds.
Much of my research is multidisciplinary and includes work in the area of Pharmacy, Materials Science, Chemistry and Engineering. Specific research project areas include skin analysis, microarray printing of biological tissue, pharmaceutical device characterisation, imaging mass spectrometry and the deconvolution of associated complex data-set using multivariate data analysis. I collaborate with a network of national and international academic and commercial partners, including The University of Leuven (Belgium), The University of Keele, The National Physical Laboratory, Walgreens Boots Alliance Inc. and LivingProof Inc. (USA). I have also performed numerous consultancy activities for a range of national and international commercial organisations over the last 10 years.
Current funding for my work includes a Knowledge Transfer Partnership (Innovate UK) with Walgreens Boots Alliance. I publish in a wide range of high quality journals and have given several invited academic research seminars and invited conference presentations, for example 'Challenges and Opportunities in Nanoparticle Analysis using ToF-SIMS' at The Institute of Physics (London) 2016.