Allergy and Infectious Diseases
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Nafal

Nafal Jamil Al-Barwary

Email:

paxnjalb@nottingham.ac.uk

Background

I studied Biomedical Science at the University of Karlstad in Sweden for one year. Afterwards, I completed an MSc in Immunoparasitology at the University of Mosul, Iraq. For this degree, I spent 3 years working on immunisation against the parasite Toxoplasma gondii. In my PhD project, I am working towards an IgE-based diagnosis of infection with the parasites Echinococcus and Schistosoma.

Research Project

Supervisors: Dr Franco H. Falcone (95%), Dr G. Sebastiaan Winkler (5%)

Despite major advances in the medical diagnosis of the vast majority of pathogenic organisms, there are still problems with immunodiagnosis of Echinococcus spp. and Schistosoma spp. infection, due to serological cross-reactivity with other species of cestodes and trematodes, respectively. Furthermore, there is a lack of serological techniques able to diagnose echinococcal infection in the initial stages of the disease.

This study focuses on developing a new method based on detection of parasite-specific IgE using reporter cell lines which can report IgE crosslinking with luciferase or fluorescent protein expression, and parasitic allergens produced using cell-free translation systems. 

Our hope is that such a technology will enable higher specificity and sensitivity for diagnosis of Echinococcus and Schistosoma infection, and ideally would have the ability to discriminate between alveolar and cystic echinococcosis.

 

 

 

 

Allergy and Infectious Diseases

The University of Nottingham
University Park
Nottingham, NG7 2RD


telephone:+44(0) 115 84 66073
email:franco.falcone@nottingham.ac.uk