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Publications

2023

• Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS. bioRxiv.
• A potential alternative to fungicides using actives-free (meth) acrylate polymers for protection of wheat crops from fungal attachment and infection. Green Chemistry.
• Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS. Bio-protocol.
• Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases.
• Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. Applied Materials & Interfaces.
• Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip. Matter.
• Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF-SIMS and Self-Organizing maps. Advanced Materials Interfaces.
• Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation. Science Advances.
• Biomaterials discovery: experimental and computational approaches. Tissue Engineering.
• Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials. Biomacromolecules.

2022

• Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials.
• Feature importance in machine learning models: A fuzzy information fusion approach. Neurocomputing.
• Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials. Scientific Reports.
• Single-cell metabolic profiling of macrophages using 3D OrbiSIMS: Correlations with phenotype. Analytical Chemistry.
• A multifaceted ferrocene interlayer for highly stable and efficient lithium doped spiro‐OMeTAD‐based perovskite solar cells. Advanced Energy Materials.
• Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response. bioRxiv.
• Immune-instructive materials as new tools for immunotherapy. Current Opinion in Biotechnology.
• Elucidating the molecular landscape of the stratum corneum. Proceedings of the National Academy of Sciences.
• Molecular formula prediction for chemical filtering of 3D OrbiSIMS Datasets. Analytical Chemistry.

• A new particle mounting method for surface analysis. Surface Interface and Analysis.

• Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. Scientific Reports.

• Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti‐Fungal Surfaces. Global Challenges.

• Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. Biomaterials.

• Quantifiable correlation of ToF‐SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surface and Interface Analysis.

• Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation. bioRxiv.

• The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns. Small.

2021

• The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns Small 2021; 202105704

• Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices Biomaterials 2021;121350

• Inkjet 3D Printing of Polymers Resistant to Fungal Attachment Bio-protocol 2021; 9, 4016-e4016

• Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices  Advanced Science 2021; 2100249

• Preventing Biofilms on BACTIGON® Coated Camstent Urinary Catheters in Patients Undergoing Elective Colorectal Surgery: A Single Centre Pilot Study British Journal of Surgery 2021; znab134.015

• A New Particle Mounting Method for Surface Analysis Surface and Interface Analysis 2021; 7010

• Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) using Combined High-Throughput Methods ACS Applied Materials and Interfaces 2021; 202108662

• Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction Advanced Materials 2021; 202102084

• Droplet Microfluidic Optimisation Using Micropipette Characterisationof Bio-instructive Polymeric Surfactants Molecules 2021; 3302

• Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives Analytical Chemistry 2021; 5078

• High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology Chemical Reviews, 2021; 0752

• Fluorophore Selection & Incorporation Contribute to Permeation and Distribution Behaviours of Hyperbranched Polymers in Multi-Cellular Tumour Spheroids & Xenograft Tumour Models ACS Applied Bio Materials, 2021; 1616

• Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip Biomaterials, 2021; 120740

• Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion Advanced Healthcare Materials, 2021; 2001448

2020 

• Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling, Nature Communications, 2020; 11, 5832

• All surfaces are not equal in contact transmission of SARS-CoV-2 Matter, 2020; 3 (5) 1433-1441
  

• Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties Materials Today Bio, 2020; 100080

• Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) Biointerphases, 2020; 15, 061005

• Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering Biomaterials, 2020; 120450

• Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models Advance Healthcare Materials, 2020; 2000892

• Synthesis of Passerini‐3CR Polymers and Assembly into Cytocompatible Polymersomes Macromolecular Rapid Communications, 2020; 2000321

• Discovery of hemocompatible bacterial biofilm-resistant copolymers Biomaterials, 2020; 260: 120312

• A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials Frontiers in Microbiology, 2020; 11: 291

• Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants Advanced Functional Materials, 2020; 2001821

• Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme ACS Medicinal Chemistry Letters, 2020; 11 (5): 657–663

• Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration Science Advances, 2020; 6 (23): eaba6574

• Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide Biomaterials Science, 2020; 8 (5): 1329-1344

• Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation Advanced Science, 2020; 7 (11): 1903392

• Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo Matter, 2020; 2 (6): 1564-1581

• Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer Journal of Controlled Release, 2020; 323: 549-564

• Functionalized Block Co‐Polymer Pro‐Drug Nanoparticles with Anti‐Cancer Efficacy in 3D Spheroids and in an Orthotopic Triple Negative Breast Cancer Model Advanced Therapeutics, 2020; 2000103

• Polyphosphazenes for the delivery of biopharmaceuticals Journal of Applied Polymer Science, 2020; 137 (25): 48688

• Preparation of a User-Defined Peptide Gel for Controlled 3D Culture Models of Cancer and Disease JoVE, 2020

• Reduction-responsive polymers for drug delivery in cancer therapy-Is there anything new to discover? Nanomedicine and nanobiotechnology, 2020; 1678

• Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Frontiers in chemistry, 2020; 204

2019

• Remotely Controlled in Situ Growth of Silver Microwires Forming Bioelectronic Interfaces ACS Applied Materials and Interfaces, 2019; 11 (9): 8928–8936

• Role of self‐assembly conditions and amphiphilic balance on nanoparticle formation of PEG‐PDLLA copolymers in aqueous environments Journal of Polymer Science A Polymer Chemistry, 2019; 57 (17): 1801-1810

• Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function ACS Applied Materials and Interfaces, 2019; 11 (38): 34560–34574

• Validating a Predictive Structure–Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation Advanced Materials, 2019; 31 (49): 1903513

• Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior Advanced Functional Materials, 2019; 29 (38): 1902016

• Toward Interpretable Machine Learning Models for Materials Discovery Advanced Intelligent Systems, 2019; 1 (8): 1900045

• Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2019; 1860 (8): 628-639

• Biocompatible Unimolecular Micelles Obtained via the Passerini Reaction as Versatile Nanocarriers for Potential Medical Applications Biomacromolecules, 2019; 20 (1): 90–101

• Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles Biomaterials Science, 2019; 7 (9): 3832-3845

• Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo Biomaterials Science, 2019; 7 (10): 4099-4111

• A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers European Polymer Journal, 2019; 125: 109516

• Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments Journal of Materials Chemistry B, 2019; 7 (34): 5222-5229

• Synthesis of Methacrylate-Terminated Block Copolymers with Reduced Transesterification by Controlled Ring-Opening Polymerization Macromolecular Chemistry and Physics, 2019; 220 (2): 1800459

• Versatile, Highly Controlled Synthesis of Hybrid (Meth)acrylate–Polyester–Carbonates and their Exploitation in Tandem Post‐Polymerization–Functionalization Macromolecular Chemistry and Physics, 2019; 220 (21): 1900270

• Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro Matrix Biology, 2019; 85-86: 15-33

• Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators Reaction Chemistry and Engineering, 2019; 4: 1472-1476

2018

• Identification of Novel “Inks” for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery ACS Appl Mater Interfaces, 2018; 10(8):6841-6848

• Improved Extraction Repeatability and Spectral Reproducibility for Liquid Extraction Surface Analysis–Mass Spectrometry Using Superhydrophobic–Superhydrophilic Patterning Analytical Chemistry, 2018; 90 (10), 6001-6005

• Novel Combinations of Agents Targeting Translation That Synergistically Inhibit Fungal Pathogens Front Microbiol, 2018; 9, 1-15

• Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices ACS Appl. Mater. Interfaces, 2018; 10, 1, 139-149

• Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films RSC Adv, 2018; 8, 15352-15357

• A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo  Circulation Research,  2018;122:e5–e16

• Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN Nucleic Acids Research, 2018; 46 (13), 6823–684

• Synthetic Light‐Curable Polymeric Materials Provide a Supportive Niche for Dental Pulp Stem Cells Advanced Materials, 2018; 30 (4): 1704486

2017

• Water contact angle is not a good predictor of biological responses to materials Biointerphases. 2017;12(2): 02C201

• Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges Regenerative Medicine, 2017; 2 (23)

• Dually sensitive dextran-based micelles for methotrexate delivery RSC Advances, 2017; 7,14448-14460  

• Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels Advanced Healthcare Materials, 2017, 6(21)

• 3D printing of tablets using inkjet with UV photoinitiation International Journal of Pharmaceutics, 2017; 529(1–2), 523-530 

• Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum Front Microbiol. 2017 7;8:349

• Image based machine learning for identification of macrophage subsets Science Reports, 2017; 7:3521

• Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels Journal of Tissue Engineering and Regenerative Medicine, 2017; 12(2):330-340

• Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers Journal of Controlled Release: Official Journal of the Controlled Release Society, 2017; 247, 73-85

• High-throughput approaches for screening and analysis of cell behaviors Biomaterials, 2017; 153:85-101

• Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles Soft Matter, 2017,13, 7441-7452

• Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells Biomaterials Science, 2017, 5, 532-550

• A new photocrosslinkable polycaprolactone-based ink for three-dimensional inkjet printing Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2017: 105(6), 1645-1657 

• Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis American Journal of Respiratory Cell and Molecular Biology, 2017; 56(6), 772-783
  

• The Pseudomonas putida CsrA/RsmA homologues negatively affect c-di-GMP pools and biofilm formation through the GGDEF/EAL response regulator CfcR Environmental Microbiology, 2017; 19(9):3551-3566 

• Peptide Hydrogels—A Tissue Engineering Strategy for the Prevention of Oesophageal Strictures Advanced Functional Materials, 2017; 27 (38), 1702424 

• 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release Journal of Controlled Release, 2017; 261, 207-215

• Polymers for binding of the gram-positive oral pathogen Streptococcus mutans PloS One, 12(7):e0180087

• Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems Biomacromolecules, 18(5), 1532-1543

• Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices ACS Applied Materials & Interfaces, 2017 ;10(1):139-149

• Bioprinting Using Mechanically Robust Core-Shell Cell-Laden Hydrogel Strands Macromolecular Bioscience, 2017; 17(6), 1-8 

• The 3D OrbiSIMS-label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power Nature Methods, 2017, 14, 1175–1183

• Versatile Routes to Functional RAFT Chain Transfer Agents through the Passerini Multicomponent Reaction ACS Macro Letters, 2017; 6 (7), pp 781–785

• Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures Biomed. Phys. Eng. Express, 2017; 3(1), 015002

• Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production Roy Soc Proc Biol Sci, 12;284(1852)

• Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation Acta Biomaterialia, 2017; 53, 389-398
  

• Image based Machine Learning for identification of macrophage subsets Scientific Reports, 2017; 20177(1), 3521

• A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies Biomedical Materials, 2017; 12(5): 055009

• The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs Scientific Reports, 2017; 7, 43337

• Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behavior Provides Insights beyond Predefined Polarization States ACS Biomaterials Science & Engineering, 2017; 3(6), 969-978

• 3D reactive inkjet printing of polydimethylsiloxane J. Mater. Chem. C, 2017,5, 9733-9743

• 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release Journal of Controlled Release  2017; 261, 207-215

• Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating Biointerphases, 2017; 23;12(2):02C412

• Small molecule absorption by PDMS in the context of drug response bioassays Biochemical and Biophysical Research Communications, 2017; 482(2): 323–328

• Particulate air pollution impacts directly on bacterial pathogen behaviour and infection Environ Microbiol, 2017; 19(10):3787-3788

• Strategies for inhibiting quorum sensing Emerging Topics in Life Sciences, 2017; 1 (1): 23-30

• Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment Journal of Materials Chemistry B, 2017; 5(25), 4926-4933

• 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus J Antimicrob Chemother. 2017 Mar 1;72(3):744-753

• Multi-branched benzylidene ketone based photoinitiators for multiphoton fabrication Additive Manufacturing 2017; 16, 206-212

2016

• A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow‐Bore Needles Stem Cells Transl. Med. 2016;5(3):366-78

• Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials Analytical Chemistry 2016; 88 (7) 3481-3487

• Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment Acta Biomaterialia 2016; Vol 34 84-92

• Combinatorial Biomolecular Nanopatterning for High‐Throughput Screening of Stem‐Cell Behavior Advanced Materials 2016; Vol 28 Issue 7 1472-1476

• 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling Biointerphases 2016; Vol 11 Issue 2 1-7

2015

• Scaling human pluripotent stem cell expansion and differentiation: are cell factories becoming a reality? Regenerative Medicine, 2015; 10 (8): 925-930

• Measuring Compositions in Organic Depth Profiling: Results from a VAMAS Interlaboratory Study Journal of Physical Chemistry B, 2015; 119 (33): 10784-10797

• Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation Advanced Materials, 2015; 27 (27): 4006-4012

• Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity Advanced Healthcare Materials, 2015; 4 (5): 295-701

• A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays Biomaterials, 2015; 61: 257-265

• 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling ACS Applied Materials and Interfaces, 2015; 7 (4): 2654-2659

2014

• Chapter 8 - Materiomics: A Toolkit for Developing New Biomaterials Tissue Engineering (Second Edition), 2014; 253-281

• High throughput screening for biomaterials discovery Journal of Controlled Release, 2014; 190 (28): 115-126

• Modelling and Prediction of Bacterial Attachment to Polymers Advanced Functional Materials, 2014; 24 (14): 2085-2093

• Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture Biomaterials Science, 2014;  2, (11): 1604-1611

• Materials for stem cell factories of the future Nature Materials 2014; 13 (6): 570-579

2013

• Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays Advanced Materials, 2013; 25 (18): 2542-2547

• Analysis and prediction of defects in UV photo-initiated polymer microarrays Journal of Materials Chemistry B, 2013; 1 (17) 1035-1043

• High throughput discovery of thermo‐responsive materials using water contact angle measurements and time‐of‐flight secondary ion mass spectrometry Surface and Interface Analysis, 2013; 45 (1): 181-184

2012

• Use of imaging multivariate analysis to improve biochemical and anatomical discrimination in desorption electrospray ionisation mass spectrometry imaging Analyst, 2012; 137 (17): 3946-3953

• Combinatorial discovery of polymers resistant to bacterial attachment Nature Biotechnology, 2012; 30 (9): 868-875

• Polymer Microarrays for High Throughput Discovery of Biomaterials JoVE, 2012; 59: e3636