Bio-Instructive Materials Institute
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Selected Publications

Delivery-strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications

Delivery strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications.

Alvarez MM, Liu JC, Trujillo-de Santiago G, Cha BH, Vishwakarma A, Ghaemmaghami AM, Khademhosseini A. J Controlled Release. 2016 Oct 28;240:349-363. doi: 10.1016/ j.jconrel.2016.01.026.

 

The impact of surface chemistry modification on macrophage polarization

Rostam HM, Singh S, Salazar F, Magennis P, Hook A, Singh T, Vrana NE, Alexander MR, Ghaemmaghami AM. Immunobiology. 2016 Nov;221(11):1237-46. doi: 10.1016/j.imbio.2016.06.010. 

 

Phagocytic activity of monocytes cultured on O2-PS40 and PS surfaces for 6 days. On Day 6 of culture, monocyte-derived macrophages on (A) O2-PS40 and (B) PS were treated with Alexa Fluor 488-labelled zymosan particles for 30 min at 37 ◦C, 5% CO2. Data shown are representative of 3 independent experiments. 

 

Phagocytic activity of monocytes cultured on O2-PS40 and PS surfaces for 6 days. On Day 6 of culture, monocyte-derived macrophages on (A) O2-PS40 and (B) PS were treated with Alexa Fluor 488-labelled zymosan particles for 30 min at 37 ◦C, 5% CO2. Data shown are representative of 3 independent experiments.

 

 

 

 

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings.

Knopf-Marques H, Singh S, Htwe SS, Wolfova L, Buffa R, Bacharouche J, Francius G, Voegel JC, Schaaf P, Ghaemmaghami AM, Vrana NE, Lavalle P. Biomacromolecules. 2016 Jun 13;17(6):2189-98. doi: 10.1021/ acs.biomac.6b00429.

 

 

Monocytes split into macrophages M I (implant surface) and M II (PLL/HA-ald)

 

 

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.

Vishwakarma A, Bhise NS, Evangelista MB, Rouwkema J, Dokmeci MR, Ghaemmaghami AM, Vrana NE, Khademhosseini A. Trends Biotechnol. 2016 Jun;34(6):470-82. doi: 10.1016/j.tibtech.2016.03.009. 

 

Biomaterial Implantation - Immediate innate immune respinse 0-4 hrs, Induced innate immune response (4h to 4 days), adaptive immune response (4 days until resolution or healing)

 

 

 

Impact of surface chemistry and topography on the function of antigen presenting cells.

Rostam HM, Singh S, Vrana NE, Alexander MR, Ghaemmaghami AM. Biomaterials Sci. 2015 Mar;3(3):424-41. doi: 10.1039/c4bm00375f.

Different types of proteins adhere to biomaterials; β2 integrin from cells can mediate cell adherence at the biomaterial surface. IL-4 and IL-13 from mast cell and TH2 cell stimulate macrophage aggregation and FBGC formation, which secrete primary mediators for immune cells and fibroblasts, causing fibrogenesis and encapsulation of the implanted biomaterial.

Different types of proteins adhere to biomaterials; β2 integrin from cells can mediate cell adherence at the biomaterial surface.
 

Rostam HM, Singh S, Vrana NE, Alexander MR, and Ghaemmaghami AM Impact of surface chemistry and topography on the function of antigen presenting cells. Biomaterials Science 3, 424-441 (2015).

Passarelli MK, Newman CF, Marshall PS, West A, Gilmore IS, Bunch J, Alexander MR, and Dollery CT Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging. Analytical Chemistry 87, 6696-6702 (2015).

Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, and Hook AL Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Advanced Healthcare Materials 4, 695-701 (2015).

Hook AL, Chang C, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P & Alexander MR Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials 2013, 25, 2542-2547.

Hook AC C-Y, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine D, Langer R, Anderson D, Williams P, Davies M & Alexander M Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology 2012, 30(9), 868 - 875.

Bio-Instructive Materials Institute

The University of Nottingham
University Park
Nottingham, NG7 2RD


telephone: +44 (0) 115 846 6246
email: Elizabet.Hudson@nottingham.ac.uk