Centre of Evidence Based Dermatology
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Vitiligo Outcome Measures

Understanding how best to measure treatment outcomes (benefits and harms of treatment) is one of our areas of interest

In vitiligo trials, “percentage re-pigmentation” is often used to assess the effectiveness of treatments, but this may not fully capture what is most important to patients, and it is often difficult to measure reliably.

An international consensus study recommended that the following things should be measured in future vitiligo trials:

 

  •  Percentage re-pigmentation
  •  Cosmetic acceptability
  •  Cessation of spread
  •  Quality of life
  •  Maintenance of response
  •  Burden of treatment
  •  Harms
 

Vitiligo Noticeability Scale 

The Vitiligo Noticeability Scale (VNS) was developed as a way of assessing "cosmetic acceptability" of treatment response. It has been designed to be quick and simple to use in both clinical trials and in normal clinical practice.

Wording of the Vitiligo Noticeability Scale (VNS)

"Compared to before treatment, how noticeable is the vitiligo now?

  •  More noticeable (1)
  •  As noticeable (2)
  •  Slightly less noticeable (3)
  •  A lot less noticeable (4)
  • No longer noticeable (5)

The VNS is free to use, but please let us know if you would like to use the scale.

(©The University of Nottingham)

 

Further details are available of how the VNS was developed.

The VNS scale is being used as the primary outcome in the Home Interventions and Light Therapy for Vitiligo Trial.

How to interpret the VNS scale

  • VNS score of 1 or 2 = treatment not successful
  • VNS score of 3 = treatment partially successful
  • VNS score of 4 or 5 = treatment successful

 

Validation of the VNS scale

Initial validation of the scale is promising and has demonstrated that scores on the VNS are more closely associated with overall 'treatment of success' than % re-pigmentation.

Further details are available of how the VNS was validated.

Publications 

Validation of the Vitiligo Noticeability Scale: a patient-reported outcome measure of vitiligo treatment success.
Batchelor JM, Tan W, Tour S, Yong A, Montgomery AA, Thomas KS.
Br J Dermatol
. 2015 Sep 26.

Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus.
Eleftheriadou V, Thomas K, et al.; Vitiligo Global Issues Consensus Group.
Pigment Cell Melanoma Res. 2015 May;28(3):363-9.

Survey and online discussion groups to develop a patient-rated outcome measure on acceptability of treatment response in vitiligo.
Tour SK, Thomas KS, Walker DM, Leighton P, Yong AS, Batchelor JM.
BMC Dermatol. 2014 Jun 14;14:10.

Which outcomes should we measure in vitiligo? Results of a systematic review and a survey among patients and clinicians on outcomes in vitiligo trials.
Eleftheriadou V, Thomas KS, Whitton ME, Batchelor JM, Ravenscroft JC.
Br J Dermatol. 2012 Oct;167(4):804-14.

Other relevant links

 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR


telephone: +44 (0) 115 823 1048
email:cebd@nottingham.ac.uk