Understanding how best to measure treatment outcomes (benefits and harms of treatment) is one of our areas of interest
In vitiligo trials, “percentage re-pigmentation” is often used to assess the effectiveness of treatments, but this may not fully capture what is most important to patients, and it is often difficult to measure reliably.
Core Outcomes for Vitiligo
The Vitiligo Noticeability Scale (VNS) was developed as a way of assessing "cosmetic acceptability" of treatment response. It has been designed to be quick and simple to use in both clinical trials and in normal clinical practice.
"Compared to before treatment, how noticeable is the vitiligo now?
The VNS is free to use, but please let us know if you would like to use the scale.
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Further details are available of how the VNS was developed.
The VNS scale is being used as the primary outcome in the Home Interventions and Light Therapy for Vitiligo Trial.
Initial validation of the scale is promising and has demonstrated that scores on the VNS are more closely associated with overall 'treatment of success' than % re-pigmentation.Further details are available of how the VNS was validated.
Validation of the Vitiligo Noticeability Scale: a patient-reported outcome measure of vitiligo treatment success.Batchelor JM, Tan W, Tour S, Yong A, Montgomery AA, Thomas KS.Br J Dermatol. 2015 Sep 26.
Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus.Eleftheriadou V, Thomas K, et al.; Vitiligo Global Issues Consensus Group.Pigment Cell Melanoma Res. 2015 May;28(3):363-9.
Survey and online discussion groups to develop a patient-rated outcome measure on acceptability of treatment response in vitiligo.Tour SK, Thomas KS, Walker DM, Leighton P, Yong AS, Batchelor JM.BMC Dermatol. 2014 Jun 14;14:10.
Which outcomes should we measure in vitiligo? Results of a systematic review and a survey among patients and clinicians on outcomes in vitiligo trials.Eleftheriadou V, Thomas KS, Whitton ME, Batchelor JM, Ravenscroft JC.Br J Dermatol. 2012 Oct;167(4):804-14.
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