Centre of Evidence Based Dermatology
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Rare Diseasesindex

 Research on other skin diseases    

This webpage features our research for other skin conditions including rare diseases

This page summarises research not otherwise described on our eczema, vitiligo, cellulitis and skin cancer pages. We are particularly interested in rare diseases. The evidence-base for such diseases is often poor as relatively few people are affected, making performing clinical trials difficult. However, we have found that by taking a broad collaborative approach, supported by the UK Dermatology Clinical Trials Network (UK DCTN), such difficulties can be overcome. 

Information for all of our other research projects is detailed in the table below.


Lichen Sclerosus Priority Setting Partnership (PSP)

Lichen sclerosus is a chronic, inflammatory skin condition that mainly affects genital skin.

The Lichen Sclerosus Priority Setting Partnership aims to identify and prioritise questions important to people who have, care for or treat the condition.


The BLISTER study

Bullous pemphigoid is a skin condition affecting mainly elderly people, which results in tense, itchy blisters and painful skin erosions that can affect the whole body.

The BLISTER study compared the safety and effectiveness of doxycycline with prednisolone for initial treatment of bullous pemphigoid.

BLISTER study logo

The hELP trial

Erosive lichen planus is a chronic, inflammatory, scarring skin condition that can effect the vulval area.

The hELP trial evaluated the effectiveness of four different tablet treatments (hydroxychloroquine, methotrexate, mycophenolate mofetil, prednisolone) for moderate-to-severe vulval erosive lichen planus.


HELP logo

The STOP GAP trial

Pyoderma gangrenosum is a rare skin condition, and thought to be a disorder of the immune system. It causes painful, rapidly spreading ulcers on the skin, and can take many months to heal.

The STOP GAP trial compared how effective oral prednisolone was compared to oral ciclosporin for the treatment of pyoderma gangrenosum.



All Projects

James Lind Alliance Lichen Sclerosus Priority Setting Partnership To identify and prioritise research questions that are important to people who have lichen sclerosus and those who treat them. BSSVD In progress.
The Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) study Examined whether doxycycline  would be a good alternative to prednisolone for treating bullous pemphigoid. NIHR HTA - 06/403/51 Published
A Randomised Controlled Trial of Systemic Therapy for Vulval Erosive Lichen Planus (hELP) trial A study that evaluated the effectiveness of tablet treatments for moderate or severe vulval erosive lichen planus. NIHR Doctoral Research Fellowship In write-up
Study of Treatments for Pyoderma Gangrenosum Patients (STOP GAP) trial  A study that compared the use of prednisolone and ciclosporin for the treatment of pyoderma gangrenosum. NIHR PGfAR RP-PG-0407-10177 Published
Real-life experience of managing vulval erosive lichen planus Case note review of normal practice for the treatment of erosive lichen planus of the vulva (ELPV) in ten UK hospitals.  Nottingham University Hospitals NHS Trust Published
Erosive Lichen Planus: Is systematic treatment better than topical alone? Developing and designing a pilot multi-centre randomised controlled trial. This package of research was developed over a 12 month period and it successfully achieved funding through the NIHR Doctoral Research Fellowship scheme. NIHR Research Flexibility and Sustainability Funding (FSF) Published,
paper 1, paper 2
Outcome measures for vulval skin disease - a systematic review of randomised controlled trials  Systematic review to identify outcome measures used in clinically based randomized controlled trials investigating therapeutic interventions in vulval disease. NIHR Doctoral Research Fellowship Published
Diagnostic Criteria for Erosive Lichen Planus effecting the Vulva: An international electronic-Delphi Consensus Exercise A three-stage electronic-Delphi exercise to reach consensus on clinicopathological diagnostic criteria for ELPV. Involved participation from 73 international expert clinicians from multiple disciplines. NIHR Doctoral Research Fellowship Published
Effective Verrucae Treatment (EVerT)  A trial compare the clinical effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts NIHR HTA 05/513/02 Published
Antimicrobial therapy in acne: a randomised controlled trial A trial to determine the relative efficacy and cost-effectiveness of five of the most commonly used antimicrobial preparations for treating mild to moderate facial acne in the community  NIHR HTA Published
Eye protection during dermatological surgery: prospective observational study A Prospective, observational study in a UK hospital skin surgery suite which assessed dermatological surgery procedures and operations. Nottingham University Hospitals NHS Trust Published 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR

telephone: +44 (0) 115 823 1048