Centre of Evidence Based Dermatology

Clothing for the relief of Eczema Symptoms (CLOTHES)


The CLOTHES Trial is a clinical trial involving 300 children with moderate or severe eczema. It has been designed to evaluate the role of specialist clothing in the management of eczema.

The study is being led by Professor Kim Thomas from the Centre of Evidence Based Dermatology at the University of Nottingham, and is being co-ordinated from the Nottingham Clinical Trials Unit.

Recruitment is taking place throughout England (currently Nottingham, London, Cambridge, Portsmouth and Isle of Wight).

If you think your child may be eligible to participate in this study or you would like more information, please contact the trial team on 0115 884 4938 or at clothes@nottingham.ac.uk




Key Facts

1. How many trial participants do you need?
We are looking for 300 children to take part.
2. Is my child eligible to take part?
Children will need to have quite bad eczema – that is eczema that requires treatment with corticosteroid creams and that causes quite a lot of bother for your child.

They will also need to be aged between 1 and 15 years old.
3. What treatments are you testing?
We are testing two types of underwear that are currently available on prescription for the management of eczema. These clothes are made of smooth fibres and have been designed to reduce rubbing on the skin.

All children involved in the study will also continue to use their usual eczema treatments.
4. How long will the study last for?
The study will last for three years from June 2013 to May 2016.

Each child will be enrolled in the study for eight months, during which time you will be asked to visit your local hospital four times. You will also be asked to fill in some questionnaires at home.

How to get involved


Media coverage

BBC radio interview with Amina Ahmed and Prof Kim Thomas - 15 January 2014 


Study to test 'silk'benefits for eczema patients - BBC news report January 2014

Is silk the right road for eczema treatment? - Press release January 2014

National Eczema Society Exchange Magazine article -November 2013

Award for the CLOTHES trial featured in the Times Higher Education - 18th July 2013

For researchers

  • Study Summary PDF format
  • Trial Protocol 
  • Trial Analysis Plan 
  • Study Summary Flowchart  


This is an independent trial that is being funded by the National Institute for Health Research Health Technology Appraisal programme. The views expressed on this website are those of the author(s) and not necessarily those of the NIHR.

Clothing to be used in the study has been kindly donated by the manufacturers. However, these companies have not been involved in the design or conduct of the study. 



Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR

telephone: +44 (0) 115 823 1048