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Centre of Evidence Based Dermatology
   
   

Clothing for the relief of Eczema Symptoms (CLOTHES)

Overview

The CLOTHES Trial is a clinical trial involving 300 children with moderate or severe eczema. It has been designed to evaluate the role of specialist clothing in the management of eczema.

The study is being led by Professor Kim Thomas from the Centre of Evidence Based Dermatology at the University of Nottingham, and is being co-ordinated from the Nottingham Clinical Trials Unit.

Recruitment is taking place throughout England (currently Nottingham, London, Cambridge, Portsmouth and Isle of Wight).

If you think your child may be eligible to participate in this study or you would like more information, please contact the trial team on 0115 884 4938 or at clothes@nottingham.ac.uk

CLOTHES trial

 

 

Key Facts

1. How many trial participants do you need?
We are looking for 300 children to take part.
 
2. Is my child eligible to take part?
Children will need to have quite bad eczema – that is eczema that requires treatment with corticosteroid creams and that causes quite a lot of bother for your child.

They will also need to be aged between 1 and 15 years old.
 
3. How long will the study last for?

 The study will last for three years from June 2013 to May 2016.

Each child will be enrolled in the study for eight months, during which time you will be asked to visit your local hospital four times. You will also be asked to fill in some questionnaires at home.
 
4. What treatments are you testing?

In recent years, silk clothing products have been developed for the management of eczema symptoms, but it has not yet been firmly established whether clothing provides measurable benefits for patients.

To decide whether silk clothing is a useful addition to the treatments currently available for children with eczema, we are testing two of the brands of silk clothing available on prescription for the management of eczema: DermaSilk® (Espère Healthcare Ltd) and DreamSkin® (DreamSkin Health Ltd).

All children involved in the study will also continue to use their usual eczema treatments.

 
5. Why are you only testing two brands of therapeutic silk garments?

The two brands of clothing used in the trial were chosen because the two brands of therapeutic silk clothing were the two available for prescription on the NHS at the time of trial set-up.

Since this time, the range of therapeutic silk-garments available to the consumer and on NHS prescription has grown (this now also includes Dermacea Ltd’s Skinnies™ Silk range).

At the present time, there is no accepted research to indicate that any silk garment products made for the management of eczema symptoms offer superior results over any others.

 
6. How is industry involved in this study?

The CLOTHES trial is an independent trial that has been funded through the National Institute for Health Research (NIHR) Health Technology Assessment Programme. The clothing being used in the trial has been donated by DreamSkin Health Ltd and Espère Healthcare Ltd, but these companies have had no involvement in the design, conduct or analysis of the trial results.

Whilst grateful to the companies for the donation of the garments, as independent researchers we maintain that impartiality is central to and necessary for the conduct of good medical research, and we do not endorse any of these garments over other similar products.

 

How to get involved

Updates

News

CLOTHES study reaches target recruitment for pilot phase -- 15 May 2014

Media coverage

BBC radio interview with Amina Ahmed and Prof Kim Thomas - 15 January 2014 

 

Study to test 'silk'benefits for eczema patients - BBC news report January 2014

Is silk the right road for eczema treatment? - Press release January 2014

National Eczema Society Exchange Magazine article -November 2013

Award for the CLOTHES trial featured in the Times Higher Education - 18th July 2013

For researchers

  • Study Summary PDF format
  • Trial Protocol 
  • Trial Analysis Plan 
  • Study Summary Flowchart  
 

Disclaimer

This is an independent trial that is being funded by the National Institute for Health Research Health Technology Appraisal programme. The views expressed on this website are those of the author(s) and not necessarily those of the NIHR.

Clothing to be used in the study has been kindly donated by the manufacturers. However, these companies have not been involved in the design or conduct of the study. 

This study has been developed with the help and support of the UK Dermatology Clinical Trials Network (UK DCTN). Based at the University of Nottingham, the UK DCTN is a collaborative group of over 700 dermatologists, nurses, primary care staff, health care researchers and patients/carers. The aim of the Network is simple -- to develop independent, high quality randomised controlled clinical trials of interventions for the treatment or prevention of skin disease. For further information please see the UK DCTN website.

 

 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR


telephone: +44 (0) 115 823 1048
email:cebd@nottingham.ac.uk