Contact

• workRoom A61 School of Veterinary Medicine and Science
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 82 30314
• ami.ketley@nottingham.ac.uk

Selected Publications

• KETLEY, AMI, WOJCIECHOWSKA, MARZENA, GHIDELLI-DISSE, SONJA, BAMBOROUGH, PAUL, GHOSH, TUSHAR K., MORATO, MARTA LOPEZ, SEDEHIZADEH, SAAM, MALIK, NAVEED ALTAF, TANG, ZHENZHI, POWALOWSKA, PAULINA, TANNER, MATTHEW, BILLETER-CLARK, RUDOLF, TRUEMAN, REBECCA C., GEISZLER, PHILIPPINE C., AGOSTINI, ALESSANDRA, OTHMAN, OTHMAN, BOSCHE, MARKUS, BANTSCHEFF, MARCUS, RUDIGER, MARTIN, MOSSAKOWSKA, DANUTA E., DREWRY, DAVID H., ZUERCHER, WILLIAM J., THORNTON, CHARLES A., DREWES, GERARD, UINGS, IAIN, HAYES, CHRISTOPHER J. and BROOK, J. DAVID, 2020. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model SCIENCE TRANSLATIONAL MEDICINE. 12(541),
• KETLEY A, CHEN CZ, LI X, ARYA S, ROBINSON TE, GRANADOS-RIVERON J, UDOSEN I, MORRIS GE, HOLT I, FURLING D, CHAOUCH S, HAWORTH B, SOUTHALL N, SHINN P, ZHENG W, AUSTIN CP, HAYES CJ and BROOK JD, 2014. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human molecular genetics. 23(6), 1551-62
• SIFRIM, ALEJANDRO, HITZ, MARC-PHILLIP, WILSDON, ANNA, BRECKPOT, JEROEN, AL TURKI, SAEED H., THIENPONT, BERNARD, MCRAE, JEREMY, FITZGERALD, TOMAS W., SINGH, TARJINDER, SWAMINATHAN, GANESH JAWAHAR, PRIGMORE, ELENA, RAJAN, DIANA, ABDUL-KHALIQ, HASHIM, BANKA, SIDDHARTH, BAUER, ULRIKE M. M., BENTHAM, JAMIE, BERGER, FELIX, BHATTACHARYA, SHOUMO, BU'LOCK, FRANCES, CANHAM, NATALIE, COLGIU, IRINA-GABRIELA, COSGROVE, CATHERINE, COX, HELEN, DAEHNERT, INGO, DALY, ALLAN, DANESH, JOHN, FRYER, ALAN, GEWILLIG, MARC, HOBSON, EMMA, HOFF, KIRSTIN, HOMFRAY, TESSA, KAHLERT, ANNE-KARIN, KETLEY, AMI, KRAMER, HANS-HEINER, LACHLAN, KATHERINE, LAMPE, ANNE KATRIN, LOUW, JACOBA J., MANICKARA, ASHOK KUMAR, MANASE, DORIN, MCCARTHY, KAREN P., METCALFE, KAY, MOORE, CARMEL, NEWBURY-ECOB, RUTH, OMER, SEHAM OSMAN, OUWEHAND, WILLEM H., PARK, SOO-MI, PARKER, MICHAEL J., PICKARDT, THOMAS, POLLARD, MARTIN O., ROBERT, LEEMA, ROBERTS, DAVID J., SAMBROOK, JENNIFER, SETCHFIELD, KERRY, STILLER, BRIGITTE, THORNBOROUGH, CHRIS, TOKA, OKAN, WATKINS, HUGH, WILLIAMS, DENISE, WRIGHT, MICHAEL, MITAL, SEEMA, DAUBENEY, PIERS E. F., KEAVNEY, BERNARD, GOODSHIP, JUDITH, ABU-SULAIMAN, RIYADH MANDI, KLAASSEN, SABINE, WRIGHT, CAROLINE F., FIRTH, HELEN V., BARRETT, JEFFREY C., DEVRIENDT, KOENRAAD, FITZPATRICK, DAVID R., BROOK, J. DAVID and HURLES, MATTHEW E., 2016. Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing NATURE GENETICS. 48(9), 1060-+
• KETLEY A, WARREN A, HOLMES E, GERING M, ABOOBAKER AA and BROOK JD, 2013. The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development. PloS one. 8(6), e65170

• View all publications

• SEDEHIZADEH, SAAM, WOJCIECHOWSKA, MARZENA, KETLEY, AMI, BROOK, J. DAVID and MADDISON, PAUL, 2022. Splicing in two skeletal muscle transcripts correlates with clinical phenotype in myotonic dystrophy type 1 patients JOURNAL OF NEUROLOGY. 269(5), 2784-2787
• KETLEY, AMI, WOJCIECHOWSKA, MARZENA, GHIDELLI-DISSE, SONJA, BAMBOROUGH, PAUL, GHOSH, TUSHAR K., MORATO, MARTA LOPEZ, SEDEHIZADEH, SAAM, MALIK, NAVEED ALTAF, TANG, ZHENZHI, POWALOWSKA, PAULINA, TANNER, MATTHEW, BILLETER-CLARK, RUDOLF, TRUEMAN, REBECCA C., GEISZLER, PHILIPPINE C., AGOSTINI, ALESSANDRA, OTHMAN, OTHMAN, BOSCHE, MARKUS, BANTSCHEFF, MARCUS, RUDIGER, MARTIN, MOSSAKOWSKA, DANUTA E., DREWRY, DAVID H., ZUERCHER, WILLIAM J., THORNTON, CHARLES A., DREWES, GERARD, UINGS, IAIN, HAYES, CHRISTOPHER J. and BROOK, J. DAVID, 2020. CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model SCIENCE TRANSLATIONAL MEDICINE. 12(541),
• GHOSH, TUSHAR K., APARICIO-SANCHEZ, JOSE J., BUXTON, SARAH, KETLEY, AMI, MOHAMED, TASABEEH, RUTLAND, CATRIN S., LOUGHNA, SIOBHAN and BROOK, J. DAVID, 2018. Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 114, 185-198
• SIFRIM, ALEJANDRO, HITZ, MARC-PHILLIP, WILSDON, ANNA, BRECKPOT, JEROEN, AL TURKI, SAEED H., THIENPONT, BERNARD, MCRAE, JEREMY, FITZGERALD, TOMAS W., SINGH, TARJINDER, SWAMINATHAN, GANESH JAWAHAR, PRIGMORE, ELENA, RAJAN, DIANA, ABDUL-KHALIQ, HASHIM, BANKA, SIDDHARTH, BAUER, ULRIKE M. M., BENTHAM, JAMIE, BERGER, FELIX, BHATTACHARYA, SHOUMO, BU'LOCK, FRANCES, CANHAM, NATALIE, COLGIU, IRINA-GABRIELA, COSGROVE, CATHERINE, COX, HELEN, DAEHNERT, INGO, DALY, ALLAN, DANESH, JOHN, FRYER, ALAN, GEWILLIG, MARC, HOBSON, EMMA, HOFF, KIRSTIN, HOMFRAY, TESSA, KAHLERT, ANNE-KARIN, KETLEY, AMI, KRAMER, HANS-HEINER, LACHLAN, KATHERINE, LAMPE, ANNE KATRIN, LOUW, JACOBA J., MANICKARA, ASHOK KUMAR, MANASE, DORIN, MCCARTHY, KAREN P., METCALFE, KAY, MOORE, CARMEL, NEWBURY-ECOB, RUTH, OMER, SEHAM OSMAN, OUWEHAND, WILLEM H., PARK, SOO-MI, PARKER, MICHAEL J., PICKARDT, THOMAS, POLLARD, MARTIN O., ROBERT, LEEMA, ROBERTS, DAVID J., SAMBROOK, JENNIFER, SETCHFIELD, KERRY, STILLER, BRIGITTE, THORNBOROUGH, CHRIS, TOKA, OKAN, WATKINS, HUGH, WILLIAMS, DENISE, WRIGHT, MICHAEL, MITAL, SEEMA, DAUBENEY, PIERS E. F., KEAVNEY, BERNARD, GOODSHIP, JUDITH, ABU-SULAIMAN, RIYADH MANDI, KLAASSEN, SABINE, WRIGHT, CAROLINE F., FIRTH, HELEN V., BARRETT, JEFFREY C., DEVRIENDT, KOENRAAD, FITZPATRICK, DAVID R., BROOK, J. DAVID and HURLES, MATTHEW E., 2016. Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing NATURE GENETICS. 48(9), 1060-+
• KETLEY A, CHEN CZ, LI X, ARYA S, ROBINSON TE, GRANADOS-RIVERON J, UDOSEN I, MORRIS GE, HOLT I, FURLING D, CHAOUCH S, HAWORTH B, SOUTHALL N, SHINN P, ZHENG W, AUSTIN CP, HAYES CJ and BROOK JD, 2014. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human molecular genetics. 23(6), 1551-62
• KETLEY A, WARREN A, HOLMES E, GERING M, ABOOBAKER AA and BROOK JD, 2013. The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development. PloS one. 8(6), e65170
• GRANADOS-RIVERON JT, POPE M, BU'LOCK FA, THORNBOROUGH C, EASON J, SETCHFIELD K, KETLEY A, KIRK EP, FATKIN D, FENELEY MP, HARVEY RP and BROOK JD, 1. Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations. Congenital heart disease. 7(2), 151-9