Michael Jones

Contact

• workRoom B76 Veterinary Academic Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6435
• fax0115 951 6440
• michael.a.jones@nottingham.ac.uk

Biography

Michael Jones obtained a BSc (Hons) in Microbiology from the University of Sheffield. He carried out postgraduate research at the University of East Anglia obtaining an MSc (1991) and PhD (1994). He then spent three and a half years as a research fellow at the University of Aberdeen, Institute for Medical Sciences, studying stretch activated channels. He then moved to work at the Institute for Animal Health, Compton Laboratory in 1997 where he worked on host pathogen interactions during bacterial gastrointestinal disease in farm animals , vaccine development and host genetics. His research links molecular biology, bacterial physiology and host immune responses to infection.

In 2006 Dr Jones moved to help establish the School of Veterinary Medicine and Science where he was a foundation lecturer. Dr Jones planned, implemented and convenes the microbiology components of the BVM BVS and BVMedSci course. During this time he has obtained his PGCHE and an MA in higher education from the University of Nottingham and has carried on his research on intestinal pathogens and host interactions. He also convenes the principles of Veterinary Sciences module which combines a number of areas of teaching on pharmacology, pathology, immunology, microbiology and parasitology.

His current research is focused on two main zoonotic pathogens Campylobacter and Salmonella. In addition he has supported the development of undergraduate research projects and placements resulting in projects in the following areas. Understanding the micro-flora of zoological species, antibiotic Resistance and molecular detection cells models of infection.

Dr Jones acknowledges and would like to thanks the following for their support: DEFRA, BBSRC, FSA, EU, Novartis and Intervet in his research.

Expertise Summary

Dr Jones is responsible for overseeing the implementation of the Microbiology within the BVMS course. His work focuses on foodbourne bacterial pathogens in particular Campylobacter and Salmonella. He has worked in public health since 1994 and has been actively researching animal health since 1997. He studies both bacterial and host factors involved in carriage and disease in food producing animals.

Dr Jones is an experienced biological safety and school safety officer. He is also chair of the campus GMSC (Genetic modification scientific committee).

Teaching Summary

Dr Jones convenes the microbiology (hidden module) and principles of Veterinary Sciences module. He lectures in veterinary microbiology and molecular biology in years 1 - 4 of the BVMS course. The… read more

Research Summary

His current research is directed at understanding the host interactions of bacteria in intestinal disease and routes to control these infections. His research interests developed from the study of… read more

Selected Publications

• ROSHIER A.L., FOSTER N. and JONES M.A., 2011. Veterinary students' usage and perception of video teaching resources. BMC Medical Education. 10, 1
• CHAPPELL, L., KAISER, P., BARROW, P. A., JONES, M. A., JOHNSTON, C. and WIGLEY, P., 2008. The immunobiology of avian systemic salmonellosis. Veterinary Immunology and Immunopathology. [epub preprint],
• BUCKLEY, A.M., WANG, J., HUDSON, D.L., GRANT, A.J., JONES, M.A., MASKELL, D.J. and STEVENS, M.P., 2010. Evaluation of live-attenuated Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry. Vaccine. 1094-1105
• KAISER, P, HOWELL, J, FIFE, M, SADEYEN, J-R, SALMON, N, ROTHWELL, L, YOUNG, J, VAN DIEMEN, P, STEVENS, S, POH, T.-Y, JONES, M, BARROW, P, WIGLEY, P, HE, H, , SWAGGERTY, C and KOGUT, M, 2008. ntegrated Immunogenomics in the Chicken: Deciphering the Immune Response to Identify Disease Resistance Genes. In: PINARD, M.-H. (JOUY-EN-JOSAS), GAY, C. (BELTSVILLE), PASTORET, P.-P. (BRUSSELS), DODET, B. (LYON) and , eds., Developments in Biologicals 132. Karger, Basel. (In Press.)

• View all publications

Dr Jones convenes the microbiology (hidden module) and principles of Veterinary Sciences module. He lectures in veterinary microbiology and molecular biology in years 1 - 4 of the BVMS course. The course has an innovative integrated delivery and is based around body systems, so delivery of specific pathogens is related to both anatomy and physiology of specific body systems.

The principles of veterinary sciences module which bring together other integrated modules in the course of pharmacology, pathology, immunology microbiology and parasitology.

Current Research

His current research is directed at understanding the host interactions of bacteria in intestinal disease and routes to control these infections. His research interests developed from the study of bacterial physiology through to the molecular and immunological mechanisms involved in colonization and disease. The main focus of his work is on two genera, Campylobacter and Salmonella

These studies are researching the physiology of these bacteria during colonization of the intestinal tract and their interaction with the immune system in the intestine.

Campylobacter: The studies on Campylobacter include investigations into phase variation, the physiology and immunology of colonization of the chicken and the development of vaccines. This work is being carried out in collaboration with Departments of Food Sciences and Bimolecular sciences at the University of Nottingham, the University of Cambridge and the London School of Hygiene and Tropical Medicine.

Salmonella: The studies on Salmonella are investigating the molecular basis of host specificity and virulence of Salmonella serovars Gallinarum, Pullorum and Enteritidis. This work is in collaboration with Paul Barrow at the University of Nottingham, the Institute for Animal Health and the Sanger Institute.

The overall aim of the research program is to improve our understanding of the nature of gastric disease and identifying improved routes for control of important animal and zoonotic diseases.

Past Research

Previously Dr Jones worked as a research fellow in the University of Aberdeen where he worked on stretch activated channels and was part of the team which identified double membrane spanning MscL channel in E. coli.

Dr Jones then moved to the Institute for Animal Health to work on Type-III secretion systems in Salmonella.

He then established the IAH Campylobacter research group. This group was the first to identify defined lines of poultry resistant to Campylobacter colonisation, in vivo gene transcripts from bacteria in the GI tract and to show a proinflamatory avian immune responses to the commensal Campylobacter.

The work has been carried on to evaluate infection models for Campylobacter and to investigate the potential for vaccines against this important foodbourne pathogen.

• BAYLISS CD, BIDMOS FA, ANJUM A, MANCHEV VT, RICHARDS RL, GROSSIER J, WOOLDRIDGE KG, KETLEY JM, BARROW PA, JONES MA and TRETYAKOV MV, 2012. Phase Variable Genes Of Campylobacter Jejuni Exhibit High Mutation Rates And Specific Mutational Patterns But Mutability Is Not The Major Determinant Of Population Structure During Host Colonization. Nucleic Acids Research. (In Press.)
• SETTA, A., BARROW, P., KAISER, P. and JONES, M., 2012. Immune dynamics following infection of avian macrophages and epithelial cells with typhoidal and non-typhoidal Salmonella enterica serovars; bacterial invasion and persistence, nitric oxide and oxygen production, differential host gene expression, NF-κB signalling and cell cytotoxicity Veterinary Immunology and Immunopathology. (In Press.)
• SETTA, A., BARROW, P.A., KAISER, P. and JONES, M. A., 2012. Early immune dynamics following infection with Salmonella enterica serovars Enteritidis, Infantis, Pullorum and Gallinarum; cytokine and chemokine gene expression profile and cellular changes of chicken caecal tonsils Comparative Immunology, Microbiology and Infectious Diseases. (In Press.)
• ROSHIER A.L., FOSTER N. and JONES M.A., 2011. Veterinary students' usage and perception of video teaching resources. BMC Medical Education. 10, 1
• DHAWI, A A, ELAZOMI, A, JONES, M A, LOVELL, M A, LI, H, EMES, R D and BARROW, P A, 2011. Adaptation to the chicken intestine in Salmonella Enteritidis PT4 studied by transcriptional analysis. Veterinary microbiology.
• HARVEY PC, WATSON M, HULME S, JONES MA, LOVELL M, BERCHIERI A, YOUNG J, BUMSTEAD N and BARROW P, 2011. Salmonella Enterica Serovar Typhimurium Colonizing The Lumen Of The Chicken Intestine Grows Slowly And Upregulates A Unique Set Of Virulence And Metabolism Genes. Infection And Immunity. 79(10), 4105-21
• CONLAN AJK, LINE JE, HIETT K, COWARD C, VAN DIEMEN PM, STEVENS MP, JONES MA, GOG JR and MASKELL DJ, 2011. Transmission And Dose-Response Experiments For Social Animals: A Reappraisal Of The Colonization Biology Of Campylobacter Jejuni In Chickens. Journal Of The Royal Society, Interface / The Royal Society. 8(65), 1720-35
• FIFE, MS, HOWELL, JS, SALMON, N, HOCKING, PM, VAN DIEMEN, PM, JONES, MA, STEVENS, MP and KAISER, P, 2011. Genome-Wide Snp Analysis Identifies Major Qtl For Salmonella Colonization In The Chicken Animal Genetics. 42(2), 134-140
• HITCHCOCK A, HALL S.J., MYERS J.D., MULHOLLAND F., JONES M.A. and KELLY D.J., 2010. Roles of the twin-arginine translocase and associated chaperones in the biogenesis of the electron transport chains of the human pathogen Campylobacter jejuni. Microbiology. 156, 2994-3010
• BUCKLEY, A.M., WANG, J., HUDSON, D.L., GRANT, A.J., JONES, M.A., MASKELL, D.J. and STEVENS, M.P., 2010. Evaluation of live-attenuated Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry. Vaccine. 1094-1105
• HOWARD, S.L., JAGANNATHAN, A., SOO, E.C., HUI, J.P., AUBRY, A.J., AHMED, I., KARLYSHEV, A., KELLY, J.F., JONES, M.A., STEVENS, M.P., LOGAN, S.M. and WREN, B.W., 2009. Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis, and colonization of chickens. Infection and Immunity. 77(6), 2544-2556
• THOMSON,, CLAYTON,, WINDHORST,, VERNIKOS,, DAVIDSON,, CHURCHER,, QUAIL,, STEVENS,, JONES,, WATSON,, BARRON,, LAYTON,, PICKARD,, KINGSLEY,, BIGNELL,, CLARK,, HARRIS,, ORMOND, and ABDELLA, 2008. Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways. Genome Research.
• COWARD, C., VAN DIEMEN, P.M., CONLAN, A.J.K., GOG, J.R., STEVENS, M.P., JONES, M.A. and MASKELL, D.J., 2008. Competing isogenic Campylobacter strains exhibit variable population structures in vivo. Applied and environmental microbiology. 74(12), 3857-67
• CHAPPELL, L., KAISER, P., BARROW, P. A., JONES, M. A., JOHNSTON, C. and WIGLEY, P., 2008. The immunobiology of avian systemic salmonellosis. Veterinary Immunology and Immunopathology. [epub preprint],
• KAISER, P, HOWELL, J, FIFE, M, SADEYEN, J-R, SALMON, N, ROTHWELL, L, YOUNG, J, VAN DIEMEN, P, STEVENS, S, POH, T.-Y, JONES, M, BARROW, P, WIGLEY, P, HE, H, , SWAGGERTY, C and KOGUT, M, 2008. ntegrated Immunogenomics in the Chicken: Deciphering the Immune Response to Identify Disease Resistance Genes. In: PINARD, M.-H. (JOUY-EN-JOSAS), GAY, C. (BELTSVILLE), PASTORET, P.-P. (BRUSSELS), DODET, B. (LYON) and , eds., Developments in Biologicals 132. Karger, Basel. (In Press.)
• ATACK, J.M., HARVEY, P., JONES, M.A. and KELLY, D.J., 2008. The Campylobacter jejuni thiol peroxidases Tpx and Bcp both contribute to aerotolerance and peroxide-mediated stress resistance but have distinct substrate specificities. Journal of bacteriology. 190(15), 5279-90
• SMITH, C., ABUOUN, A., CAWTHRAW, S., HUMPHREY, T., ROTHWELL, L., KAISER, P., BARROW, P. A. and JONES M. A., 2008. Campylobacter colonization of the chicken induces a proinflammatory response in mucosal tissues. FEMS Immunology and Medical Microbiology.
• ASHGAR S.S., OLDFIELD N.J., WOOLDRIDGE K.G., JONES M.A., IRVING G.J., TURNER D.P. and ALA'ALDEEN D.A., 2007. CapA, an autotransporter protein of <i>Campylobacter jejuni</i>, mediates association to human epithelial cells and colonization of the chicken gut. Journal of Bacteriology. 189(5), 1856-1865
• JONES, M.A., HULME, S.D., BARROW, P.A, and WIGLEY, P., 2007. The Salmonella pathogenicity island 1 and Salmonella pathogenicity island 2 type III secretion systems play a major role in pathogenesis of systemic disease and gastrointestinal tract colonization of Salmonella enterica serovar Typhimurium in the chicken. Avian Pathology. 36(3), 199-203
• PITTMAN, M.S., ELVERS, K. T., LEE, L., JONES, M. A., POOLE, R. K., PARK, S. F. and KELLY, D. J., 2007. Growth of Campylobacter jejuni on nitrate and nitrite: electron transport to NapA and NrfA via NrfH and distinct roles for NrfA and the globin Cgb in protection against nitrosative stress. Molecular Microbiology. 63(2), 575-590
• SMITH, C.K., KAISER, P., ROTHWELL, L., HUMPHREY, T., BARROW, P.A. and JONES, M.A., 2005. <i>Campylobacter jejuni</i>-induced cytokine responses in avian cells Infection and Immunity. 73(4), 2094-2100
• WOODALL, C.A., JONES, M.A., BARROW, P.A., HINDS, J., MARSDEN, G.L., KELLY, D.J., DORRELL, N., WREN, B.W. and MASKELL, D.J., 2005. <i>Campylobacter jejuni</i> gene expression in the chick cecum: evidence for adaptation to a low-oxygen environment Infection and Immunity. 73(8), 5278-5285
• BOYD, Y., HERBERT, E.G., MARSTON, K.L., JONES, M.A. and BARROW, P.A., 2005. Host genes affect intestinal colonisation of newly hatched chickens by <i>Campylobacter jejuni</i> Immunogenetics. VOL 57(NUMBER 3-4), 248-253
• GRANT, A. J., COWARD, C., JONES, M. A., WOODALL, C. A., BARROW, P. A. and MASKELL, D. J., 2005. Signature-Tagged Transposon Mutagenesis Studies Demonstrate the Dynamic Nature of Cecal Colonization of 2-Week-Old Chickens by Campylobacter jejuni Applied and Environmental Microbiology. VOL 71(NUMB 12), 8031-8041
• JONES, M.A., MARSTON, K.L., WOODALL, C.A., MASKELL, D.J., LINTON, D., KARLYSHEV, A.V., DORRELL, N., WREN, B.W. and BARROW, P.A., 2004. Adaption of Campylobacter Jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract. Infection and Immunity. 72(7), 3769-76
• VELAYUDHAN, J., JONES, M. A., BARROW, P. A. and KELLY, D. J., 2004. L-Serine Catabolism via an Oxygen-Labile L-Serine Dehydratase Is Essential for Colonization of the Avian Gut by Campylobacter jejuni Infection and Immunity. VOL 72(PART 1), 260-268
• TURNER, A.K., BARBER,L. Z., WIGLEY,P., MUHAMMAD, S., JONES, M.A., LOVELL, M.A., HULME, S. and BARROW, P.A., 2003. Contribution of proton-translocating proteins to the virulence of <i>Salmonella enterica</i> serovars Typhimurium, Gallinarum, and Dublin in chickens and mice Infection and Immunity. 71(6), 3392-3401
• JONES, M.A., TÖTEMEYER, S., MASKELL, D.J., BRYANT, C.E. and BARROW, P.A., 2003. Induction of proinflammatory responses in the human monocytic cell line THP-1 by<i> Campylobacter jejuni</i> Infection and Immunity. 71(5), 2626-2633
• BARROW, P.A., ADAMS, P., MIDDLETON, A., LOVELL, M.A., MARSTON, K., BUMSTEAD, M. and JONES, M.A., 2003. Salmonella in the chicken intestine behave differently to those grown in vitro and show stationary-phase characteristics. In: The Society for General Microbiology Ordinary Meeting.
• WIGLEY, P., JONES, M. A. and BARROW, P. A., 2002. Salmonella enterica serovar Pullorum requires the Salmonella pathogenicity island 2 type III secretion system for virulence and carriage in the chicken Avian Pathology. VOL 31(PART 5), 501-506
• JONES, M.A., FOSTER, N., PAGE, K., HULME, S.D. and BARROW, P.A., 2002. Salmonella enterica serovar Typhimurium F98 modulation of NO production is not host cell dependent and is inv/spa dependent. In: The International Symposium on Salmonella and Salmonellosis.. 203-204
• JONES, M.A., WIGLEY, P., PAGE, K.L., HULME, S.D. and BARROW, P.A., 2002. The role of Type-III secretion in the virulence of Salmonella enterica serovar Gallinarum and Salmonella enterica serovar Pullorum. In: International Symposium on Salmonella and Salmonellosis. 145-149
• HARVEY, P., MUHAMMAD, S., JONES, M. and BARROW, P.A., 2002. Microarray analysis of Salmonella gene expression: identification of genes with a role in growth suppression in stationary phase. In: The international Symposium on Salmonella and Salmonellosis.. 217-218
• MUHAMMAD, S., JONES, M.A. and BARROW, P.A., 2002. Bacterial energetics in rpoS expression and stability in stationary-phase growth of Salmonella Typhimurium. In: International Symposium on Salmonella and Salmonellosis.. 219-220
• MCLAGGAN, D., JONES, M. A., GOUESBET, G., LEVINA, N., LINDEY, S., EPSTEIN, W. and BOOTH, I. R., 2002. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli Molecular Microbiology. VOL 43(PART 2), 521-536
• JONES, M. A., WIGLEY, P., PAGE, K. L., HULME, S. D. and BARROW, P. A., 2001. Salmonella enterica Serovar Gallinarum Requires the Salmonella Pathogenicity Island 2 Type III Secretion System but Not the Salmonella Pathogenicity Island 1 Type III Secretion System for Virulence in Chickens Infection and Immunity. VOL 69(PART 9), 5471-5476
• HOSIE, A. H. F., ALLAWAY, D., JONES, M. A., WALSHAW, D. L., JOHNSTON, A. W. B. and POOLE, P. S., 2001. Solute-binding protein-dependent ABC transporters are responsible for solute efflux in addition to solute uptake Molecular Microbiology. VOL 40(PART 6), 1449-1460