Contact

• workSchool of Veterinary Medicine and Sciences, Academic Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• Nathan.Archer@nottingham.ac.uk

Biography

Dr Nathan Archer is examining post-transcriptional gene regulation by mRNA modifications.

Nathan completed his PhD "Internal and Cap-Adjacent Modifications of Messenger RNA in Eukaryotic Systems" in 2014. After postdoctoral research at the University of Warwick examining biological and technical sources of single cell genetic heterogeneity, he returned to the Univeristy of Nottingham as a Nottingham research fellow in 2018.

He recently completed his Nottingham Research Fellowship and was subsequently appointed as Assistant Professor in Epitranscriptomics. He has published key works in the RNA field, including characterising and correcting for sources of noise in gene expression data (Cell Systems. 2016, doi: 10.1016/j.cels.2016.10.012), and the characterisation of roles for epitranscriptomic marks in gene regulation (Nature. 2016, doi: 10.1038/nature20577; Nature Communications. 2022, doi: 10.1038/s41467-022-28753-3; Nature Communications. 2022, doi: 10.1038/s41467-022-28549-5).

Selected Publications

• HAUSSMANN IU, BODI Z, SANCHEZ-MORAN E, MONGAN NP, ARCHER N, FRAY RG and SOLLER M, 2016. m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature. 540(7632), 301-304
• ARCHER, NATHAN, WALSH, MARK D., SHAHREZAEI, VAHID and HEBENSTREIT, DANIEL, 2016. Modeling Enzyme Processivity Reveals that RNA-Seq Libraries Are Biased in Characteristic and Correctable Ways CELL SYSTEMS. 3(5), 467-+
• ARCHER, NATHAN, EGAN, SHARON A., COFFEY, TRACEY J., EMES, RICHARD D., ADDIS, M. FILIPPA, WARD, PHILIP N., BLANCHARD, ADAM M. and LEIGH, JAMES A., 2020. A Paradox in Bacterial Pathogenesis: Activation of the Local Macrophage Inflammasome Is Required for Virulence of Streptococcus uberis PATHOGENS. 9(12),
• MONGAN, NIGEL P, EMES, RICHARD D and ARCHER, NATHAN, 2019. Detection and analysis of RNA methylation. F1000Research. 8,

• View all publications

• ZHANG, MI, BODI, ZSUZSANNA, MACKINNON, KATARZYNA, ZHONG, SILIN, ARCHER, NATHAN, MONGAN, NIGEL P, SIMPSON, GORDON G and FRAY, RUPERT G, 2022. Two zinc finger proteins with functions in m⁶A writing interact with HAKAI. Nature communications. 13(1), 1127
• HAUSSMANN, IRMGARD U., WU, YANYING, NALLASIVAN, MOHANAKARTHIK P., ARCHER, NATHAN, BODI, ZSUZSANNA, HEBENSTREIT, DANIEL, WADDELL, SCOTT, FRAY, RUPERT and SOLLER, MATTHIAS, 2022. CMTr cap-adjacent 2 '-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses NATURE COMMUNICATIONS. 13(1),
• ARCHER, NATHAN, EGAN, SHARON A., COFFEY, TRACEY J., EMES, RICHARD D., ADDIS, M. FILIPPA, WARD, PHILIP N., BLANCHARD, ADAM M. and LEIGH, JAMES A., 2020. A Paradox in Bacterial Pathogenesis: Activation of the Local Macrophage Inflammasome Is Required for Virulence of Streptococcus uberis PATHOGENS. 9(12),
• MONGAN, NIGEL P, EMES, RICHARD D and ARCHER, NATHAN, 2019. Detection and analysis of RNA methylation. F1000Research. 8,
• HAUSSMANN IU, BODI Z, SANCHEZ-MORAN E, MONGAN NP, ARCHER N, FRAY RG and SOLLER M, 2016. m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature. 540(7632), 301-304
• ARCHER, NATHAN, WALSH, MARK D., SHAHREZAEI, VAHID and HEBENSTREIT, DANIEL, 2016. Modeling Enzyme Processivity Reveals that RNA-Seq Libraries Are Biased in Characteristic and Correctable Ways CELL SYSTEMS. 3(5), 467-+
• BODI, ZSUZSANNA, BOTTLEY, ANDREW, ARCHER, NATHAN, MAY, SEAN T and FRAY, RUPERT G, 2015. Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment. PloS one. 10(7), e0132090