Nigel Kendall

Contact

• workRoom B72 Veterinary Academic Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6447
• fax0115 951 6440
• nigel.kendall@nottingham.ac.uk

Expertise Summary

Expertise in trace element nutrition, especially of ruminants.

Particular interest in the copper, molybdenum, iron and sulphur complex interaction.

I have set up and run the NUVetNA laboratory within the Vet School which runs a trace element and metabolite analytical service for Veterinary Surgeons around the country.

Research Summary

I am currently actively researching across the two school themes of Population Health and Reproduction. I work with all aspects of nutrition and in reproduction, especially exploring the interactions… read more

Selected Publications

• GOULD L and KENDALL NR, 2011. Role Of The Rumen In Copper And Thiomolybdate Absorption. Nutrition Research Reviews. 24(2), 176-82
• KENDALL, N. R., MARSTERS, P., SCARAMUZZI, R. J. and CAMPBELL, B. K., 2003. Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media Reproduction. 125(5), 657-665
• KENDALL, N R, MARSTERS, P, GUO, L, SCARAMUZZI, R J and CAMPBELL, B K, 2006. Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro. Journal of Endocrinology. 189(3), 455-63
• TELFER, S B, KENDALL, N R, ILLINGWORTH, D V and MACKENZIE, A M, 2006. Caeruloplasmin: plasma copper ratios in cows. Veterinary Record. 159(18), 607-8

• View all publications

Current Research

I am currently actively researching across the two school themes of Population Health and Reproduction. I work with all aspects of nutrition and in reproduction, especially exploring the interactions between them.

I run the NUVetNA diagnostic laboratory service and research issues related to trace element status, and deficiency/toxicity diagnosis and the role of metabolites in fertility management.

My major area of expertise is in trace elements, with especial reference to the copper, molybdenum, sulphur and iron interactions which occur in ruminants, deer and camelids. As well as diagnosis and effects on fertility I am also interested in methods of supplementation and the investigation of the availability of different copper sources within the rumen in relation to the complex copper, sulphur molybdenum and iron interaction. I am currently moving into Horses and am looking at the selenium status of horses, mainly in relation to athletic performance.

Other current projects includes: the role of monosaccharides in ovarian function; effects of trace elements on many aspects of fertility - including thiomolybdate effects on ovarian and luteal function and a DVM student investigating the effect of Iodine status on dairy cow fertility; endocrine management of bovine infertility including specific research on ovarian cysts in cattle - including the role of energy status in cyst formation, and way to improve cyst diagnosis.

I also have an interest in experimental design and the application of statistics to experimental biological and medical data.

Past Research

In addition to the work still be carried out within the current research profile I have a varied research background.

I have worked on:

• the prevention of radiocaesium uptake into sheep
• the effects of conjugated linoleic acid on bovine fertility and endometrial prostaglandin production
• the effects of feeding lupins on the fertility of sheep
• the effect of BVD (bovine viral diarrhea) on fertility
• the effect of leptin on ovarian function
• the use of liquid potato waste a feedstuff for dairy cows
• the effect of zinc and selenium supplementation on ram semen quality
• the role of viagra in female ovarian function
• 3D ultrasound scanning in humans
• the role of progesterone supplementation in the maintenance of pregnancy in dairy cattle and much more besides...!

Future Research

I am interested in any research on trace elements in animals, not just ruminants. I am always looking to the use of diagnostic clinical chemistry, especially in relation to the assessment of nutritional status. I am increasingly involved in zoo animal nutrition and the management of feeding. Experimental design and statistical analysis are areas in which I enjoy working and am often open to collaboration.

• JACKSON, R A, WILLS, J R, KENDALL, N R, GREEN, M J, MURRAY, R D and DOBSON, H, 2011. Energy metabolites in pre- and postpartum dairy cattle as predictors of reproductive disorders. The Veterinary record. 168(21), 562
• GOULD L and KENDALL NR, 2011. Role Of The Rumen In Copper And Thiomolybdate Absorption. Nutrition Research Reviews. 24(2), 176-82
• BLACK, DH and KENDALL, NR, 2010. The Attitudes And Approach To Trace Element Diagnosis And Treatment In The Uk Cattle Practice. 18, 67-72
• CAMPBELL, BK, KENDALL, NR, ONIONS, V and SCARAMUZZI, RJ, 2010. The Effect Of Systemic And Ovarian Infusion Of Glucose, Galactose And Fructose On Ovarian Function In Sheep Reproduction. 140(5), 721-732
• CAMPBELL, BK, ONIONS, V, KENDALL, NR, GUO, L and SCARAMUZZI, RJ, 2010. The Effect Of Monosaccharide Sugars And Pyruvate On The Differentiation And Metabolism Of Sheep Granulosa Cells In Vitro Reproduction. 140(4), 541-550
• KENDALL, NR, FLINT, APF and MANN, GE, 2009. Incidence And Treatment Of Inadequate Postovulatory Progesterone Concentrations In Repeat Breeder Cows Veterinary Journal. 181(2), 158-162
• CAMPBELL, BK, KENDALL, NR and BAIRD, DT, 2009. Effect Of Direct Ovarian Infusion Of Bone Morphogenetic Protein 6 (Bmp6) On Ovarian Function In Sheep Biology Of Reproduction. 81(5), 1016-1023
• JAYAPRAKASAN, K., HILWAH, N., KENDALL, N.R., HOPKISSON, J.F., CAMPBELL, B.K., JOHNSON, I.R. and RAINE-FENNING, N.J., 2007. Does 3D ultrasound offer any advantage in the pretreatment assessment of ovarian reserve and prediction of outcome after assisted reproduction treatment? Human Reproduction. 22(7), 1932-1941
• CAMPBELL, B K, KENDALL, N R and BAIRD, D T, 2007. The effect of the presence and pattern of luteinizing hormone stimulation on ovulatory follicle development in sheep. Biology of Reproduction. 76(4), 719-27
• JAYAPRAKASAN, K, HILWAH, N, KENDALL, NR, HOPKISSON, JF, CAMPBELL, BK, JOHNSON, IR and RAINE-FENNING, NJ, 2007. Does three-dimensional ultrasound offer any advantage in prediction of outcome after assisted reproduction treatment? In: 23rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology. I125-I126
• MANN, GE, LOCK, AL, BAUMAN, DE and KENDALL, NR, 2007. Reproductive function in dairy cows fed a lipid encapsulated conjugated linoleic acid supplement In: Joint Annual Meeting of the American-Dairy-Science-Association/Poultry-Science-Association-Asociacion-Mexicana-de-Produccion-Animal/American-Society-of-Animal-Science. 401-401
• SOMCHIT, A, CAMPBELL, BK, KHALID, M, KENDALL, NR and SCARAMUZZI, RJ, 2007. The Effect Of Short-Term Nutritional Supplementation Of Ewes With Lupin Grain (Lupinus Luteus), During The Luteal Phase Of The Estrous Cycle On The Number Of Ovarian Follicles And The Concentrations Of Hormones And Glucose In Plasma And Follicular Fluid Theriogenology. 68(7), 1037-1046
• CAMPBELL, BK, KENDALL, NR and BAIRD, DT, 2007. The Effect Of The Presence And Pattern Of Luteinizing Hormone Stimulation On Ovulatory Follicle Development In Sheep Biology Of Reproduction. 76(4), 719-727
• KENDALL, N R, MARSTERS, P, GUO, L, SCARAMUZZI, R J and CAMPBELL, B K, 2006. Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro. Journal of Endocrinology. 189(3), 455-63
• SCARAMUZZI, R.J, CAMPBELL, B.K, DOWNING, J.A, KENDALL, N.R, KHALID, M, MUNOZ-GUTIERREZ, M and SOMCHIT, A, 2006. A review of the effects of supplementary nutrition in the ewe on the concentrations of reproductive and metabolic hormones and the mechanisms that regulate folliculogenesis and ovulation rate. Reproduction, Nutrition, Development.. 46(4), 339-54
• TELFER, S B, KENDALL, N R, ILLINGWORTH, D V and MACKENZIE, A M, 2006. Caeruloplasmin: plasma copper ratios in cows. Veterinary Record. 159(18), 607-8
• MUNOZ-GUTIERREZ, M, FINDLAY, P A, ADAM, C L, WAX, G, CAMPBELL, B K, KENDALL, N R, KHALID, M, FORSBERG, M and SCARAMUZZI, R J, 2005. The ovarian expression of mRNAs for aromatase, IGF-I receptor, IGF-binding protein-2, -4 and -5, leptin and leptin receptor in cycling ewes after three days of leptin infusion. Reproduction. 130(6), 869-81
• KENDALL, N.R., GUTIERREZ, C.G., SCARAMUZZI, R.J., BAIRD, D.T., WEBB, R. and CAMPBELL, B.K., 2004. Direct <i>in vivo</i> effects of leptin on ovarian steroidogenesis in sheep. Reproduction. 128(6), 757-765
• RAINE-FENNING, N.J., CAMPBELL, B.K., KENDALL, N.R., CLEWES, J.S. and JOHNSON, I.R., 2004. Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography Human Reproduction. 19(2), 330-338
• RAINE-FENNING, N.J., CAMPBELL, B.K., KENDALL, N.R., CLEWES, J.S. and JOHNSON, I.R., 2004. Endometrial and sub-endometrial perfusion are impaired in women with unexplained subfertility Human Reproduction. 19(11), 2605-2614
• RAINE-FENNING, N.J., CAMPBELL, B.K., CLEWES, J.S., KENDALL, N.R. and JOHNSON, I.R., 2004. The interobserver reliability of three-dimensional power Doppler data acquisition within the female pelvis Ultrasound in Obstetrics & Gynecology. 23(5), 501-508
• RAINE-FENNING, N.J., CAMPBELL, B.K., CLEWES, J.S., KENDALL, N. and JOHNSON, I.R, 2004. Defining endometrial growth during the normal menstrual cycle with three-dimensional ultrasound BJOG. 111(9), 944-949
• MARSTERS, P, KENDALL, N.R and CAMPBELL, B.K, 2003. Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture. Molecular and Cellular Endocrinology. 203(1-2), 117-27
• KENDALL, N. R., MARSTERS, P., SCARAMUZZI, R. J. and CAMPBELL, B. K., 2003. Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulosa cells cultured in serum-free media Reproduction. 125(5), 657-665
• RAINE-FENNING, N.J., CLEWES, J., KENDALL, N.R., BUNKHEILA, A., CAMPBELL, B.K. and JOHNSON, I.R., 2003. The interobserver reliability and validity of volume calculation from three-dimensional ultrasound datasets in the in vitro setting Ultrasound in Obstetrics and Gynecology. 21(3), 283-291
• RAINE-FENNING, N. J., CAMPBELL, B. K., CLEWES, J. S., KENDALL, N. R. and JOHNSON, I. R., 2003. The reliability of virtual organ computer-aided analysis (VOCAL) for the semiquantification of ovarian, endometrial and subendometrial perfusion Ultrasound in Obstetrics & Gynecology. 22(6), 633-639
• CAMPBELL, B.K., SOUZA, C., GONG, J., WEBB, R., KENDALL, N., MARSTERS, P., ROBINSON, G., MITCHELL, A., TELFER, E.E. and BAIRD, D.T., 2003. Review: Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans. Reproduction. Supplement. 61, 429-443
• KENDALL, N. R., MCMULLEN, S., GREEN, A. and RODWAY, R. G., 2000. The effect of a zinc, cobalt and selenium soluble glass bolus on trace element status and semen quality of ram lambs Animal Reproduction Science. VOL 62(NUMBER 4), 277-283
• KENDALL, N R and TELFER, S B, 2000. Induction of zinc deficiency in sheep and its correction with a soluble glass bolus containing zinc. Veterinary Record. 146(22), 634-7
• SHEIKHA, HM and KENDALL, NR, 1900. Linking Theory To Practice In An Undergraduate Veterinary Curriculum: Students' Perspectives Journal Of Veterinary Medical Education. 36(3), 291-296