Synthesis of a Sonogel-Carbon Modified Sensor Electrode with Titanium Oxide (TiO2) to Detect Catecho
This experiment demonstrates cyclic voltammetry, surface modification, selectivity, and bioanalysis in assaying catechols in the presence of ascorbic acid. Pre- or post-lab questions are included, along with sample student data and instructor\'s notes.
Active Learning in Advanced Analytical Chemistry, a course for first year graduate students
The introductory lecture course for graduate-level analytical chemistry is commonly understood to require students to be broadly aware of analytical tools, current problems, and methods for linking problems and measurements. This article describes an active learning approach to this course, using review articles to focus discussion and reveal gaps in student knowledge. Students give most of the course\'s lectures, with grades based on lectures, exams, and a term paper.
Chromatography and Mass Spec Lectures
This site contains mass spectrometry and chromatography lecture notes for a graduate course. They are subdivided by topic (history, theory, etc.) and are easy to browse. They may be helpful to someone constructing their own course in chromatography and/or mass spectrometry. The notes are fairly complete. The historical sections may particularly save time in preparing courses. The notes also provide good information and a helpful outline to follow. The site also has some nice mass spectrometr
Animation of GC flame ionization detector
This site is one in a series of sites with very good animations related to separations. This animation deals specifically with flame ionization detection in GC. The animations are short (one to two minutes) and can easily be shown in class as part of a lecture. They are extremely helpful in illustrating key components and concepts of chromatographic systems. Users are encouraged to explore the site and the other brief animations as well. Separate links to other simulations by the same company (T
Chromatography Nomenclature and Definitions
This website gives the IUPAC approved definitions in the field of chromatography. It is critical for students to appreciate the importance of using standardized nomenclature and definitions.
Light sources - Technical Information
This is a commercial site with some detailed information included with product announcements. The discussion of light collection is an exceptional introduction to matching optical elements with maximum throughput. There are also illustrative spectra of typical sources and descriptions of laws of radiation and radiation units.
This commercial site is an extensive description of the fundamentals and applications of photomultipliers including their characteristics, structures, operating parameters, and applications areas. The contents are provided in 14 chapters covering 323 pages that include nearly everything that you ever wanted to know about photomultiplier tubes. Reading the text and accompanying illustrations with patience and care, you can become an expert on the subject. It will allow the practitioner to use th
Analytical Electrochemistry: Basic concepts
This module focuses on the basic concepts involved in dynamic electrochemistry when the net current is not zero - the combination of mass transfer and electrochemical reactions at the interface between solids and fluids. It is at an introductory level appropriate for undergraduates in their sophomore or junior years.
M.E. Muller Institute for Microscopy
This website is a nice primer for those who are interested in atomic-level surface imaging of biological samples with atomic force microscopy (AFM). The accompanying graphics are illustrative of what can be done and at what resolution. Note the material is a little dated (1996), but is still very useful. If one is interested in learning about biological imaging with other methods as well, it is recommended to open the home page site (http://www.mih.unibas.ch/Booklet/Booklet96/Intro/Intro.ht
Theme-Based Modular Approach for Delivering the Undergraduate Analytical Curriculum
This paper from the ABCs of Teaching Analytical Science in the journal Analytical and Bioanalytical Chemistry describes the modifications to the analytical curriculum at Butler University. The laboratory associated with the course in Quantitative Analysis was retooled to include a series of projects emphasizing report-writing, data reduction/analysis, method development, method comparison, and a guided-inquiry capstone project. The laboratory for Instrumental Analysis is a semester-long module
This article by Peter Griffiths, published in the ABCs of Teaching Analytical Science series of the journal Analytical and Bioanalytical Chemistry, will be of interest to faculty members teaching analytical or quantitative analysis courses to chemistry, biochemistry, pre-health or natural science majors. Drawing from a survey of colleges and universities in the western United States, Griffiths summarizes how the quantitative analysis course is currently being taught, highlighting difference
Atomic Spectroscopy in a Project-Based Lab
An article published in the \"ABCs of Teaching Analytical Science\" series of the journal Analytical and Bioanalytical Chemistry describes a project-based lab in which students investigate the distribution of Pb and As (from pesticides) in a contaminated apple orchard. Students have complete control of the lab, from designing a sampling strategy to using the primary literature to develop procedures for extracting the analytes and for their subsequent analysis by ICP-AES or ICP-MS.
Receptor Binding Assays
A tutorial on receptor binding assays used in bioanalysis. Both scintillation proximity assays and measurements based on fluorescence polarization are discussed. This page also features a good bibliography on related resources.
A learning module focused on principles and practice of NMR for quantitative analysis, an application less commonly associated with the technique than is structure determination. Links to simulation packages are included.
Atomic Force Microscopy
A video lecture on Atomic Force Microscopy (AFM) by Prof. Arvind Raman of Purdue University that discusses the historical development, instrumentation and operational principles of various AFM modes. The lecture is accompanied by power point slides with clear illustrative graphics. Basics are provided in the application examples with advantages and limitation discussed. Useful site to those interested in learning AFM.
Population Genetics and Statistics
This website is part of the President\'s DNA Initiative and is devoted to past and current methods of macromolecules such as DNA. This website introduces the student to the subject of population genetics and stresses factors that can alter allele frequencies in a population and calculations associated with the Hardy-Weinberg principle. The student will learn to use acceptable statistical approaches to evaluating DNA data and how DNA databases are constructed and applied. This site is designed as
Fundamentals of NMR
This e-text presents an introduction to the fundamentals of NMR covering magnetic resonance, pulsed NMR, relaxation, chemical shift, spin-spin coupling, the nuclear Overhauser effect and chemical exchange.
NMR of Paramagnetic Proteins
This site presents an overview of techniques used for structural elucidation of paramagnetic metalloproteins. The content is directed to the more advanced NMR user and would be suitable for an upper division or graduate level NMR class.
This article describes the use of fluorine (19F) NMR for the analysis and structure determination of biomaterials. Using a traditional text-with-figures format, the article gives an overview of the synthesis of 19F spin-labeled materials and detailed descriptions of 19F chemical shifts and relaxation phenomena as applied to both primary and tertiary structure determinations of biochemical interest.
A Pictorial Representation of Product Operator Formalism: Non-Classical Vector Diagrams for Multidim
This site presents a pictorial description of the product operator formalism using a non-classical vector approach. This approach allows for the representation of any arbitrary multidimensional or heteronuclear NMR experiment. A description of a complete set of 16 vector representations for weakly-coupled two-spin (I=1/2) systems is given followed by an extension of this set to three-spin systems. Finally the concepts of coherence transfer, multiple quantum spectroscopy and phase cycling are ill