Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation res
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterized the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis.
A semaphorin code defines subpopulations of spinal motor neurons during mouse development.
In the spinal cord, motor neurons (MNs) with similar muscle targets and sensory inputs are grouped together into motor pools. To date, relatively little is known about the molecular mechanisms that control the establishment of pool-specific circuitry. Semaphorins, a large family of secreted and cell surface proteins, are important mediators of developmental processes such as axon guidance and cell migration. Here, we used mRNA in situ hybridization to study the expression patterns of semaphorins
Symptoms of Posttraumatic Stress Disorder in a New Orleans Workforce Following Hurricane Katrina
On August 29, 2005, Hurricane Katrina made landfall resulting in catastrophic damage and flooding to New Orleans, LA, and the Gulf Coast, which may have had significant mental health effects on the population. To determine rates and predictors of symptoms consistent with a diagnosis of posttraumatic stress disorder (PTSD) in New Orleans residents following Hurricane Katrina, we conducted a web-based survey 6 months after Hurricane Katrina made landfall. Participants included 1,542 employees from
Attitudes Toward HIV Protease Inhibitors and Medication Adherence in an Inner City HIV Population
The objective of this pilot study was to examine attitudes toward protease inhibitors (PIs) among HIV-infected individuals and to assess the relationship between PI attitudes and adherence to PIs. Respondents were recruited from four AIDS service organizations in New York City; the total sample consisted of 97 HIV-infected individuals who were taking a PI. The sample consisted largely of African Americans and Latinos from inner city areas, and most had a low level of education. Adherence was sub
GeoMaths MathHelp Material
This site provides students with mathematics self-study material which is embedded within the context of the geosciences. The material consists of many MathHelp "notebooks" covering specific mathematical topics related to a relevant geological context, such as plate velocity or cliff erosion. The notebooks contain explanations, illustrations, and examples. A mathematical glossary is also constantly available, providing a brief explanation of mathematical keywords and links to the relevant notebo
The Study of Metals and Alloys by X-ray Powder Diffraction Methods
The object of this lesson is to introduce research students with no previous experience to the basic ideas of the use of the powder method for the study of metals and alloys.
1850?: Joseph Slocum, Portrait
This image is a portrait of Joseph Slocum, father of Margaret Olivia Slocum Sage. He is wearing a dark suit with a brocade waistcoat, a white shirt, and a dark cravat. His left hand rests inside his jacket, and his right arm is held away from his body, perhaps resting on a shelf or table.,This portrait shows the Hon. Joseph Slocum, Olivia's father. His career included, in addition to the business ventures documented here, one term as New York State Representative for his district -- a bribe, it
Fort Raleigh National Historic Site Teacher's Page
Roanoke Revisited supplements concepts in core curricula courses and provides teachers and their students with appropriate information for the study of pre-colonial America. Although each classroom teacher is likely to find multiple uses for the materials, the suggested method for implementation is through the use of peer-counseling techniques and experiential activities.
Cabrillo National Monument: Cabrillo as Classroom
This site describes several classroom resources about the monument near San Diego, CA. Featured is the Cabrillo Tidepool Study, a 4-week on-line unit designed for students at the 5th grade level. It covers many life science topics including ecosystems, adaptation, life-cycle, food web, and conservation, and it integrates language arts and math activities.
Bridging the Watershed
Bridging the Watershed (BTW) is an outreach program of the Alice Ferguson Foundation, in partnership with the National Park Service and area schools, whose purpose is to provide personally meaningful, educational experiences that connect students to their place in the natural and cultural world. BTW offers 5 core modules, as well as a host of park-specific curriculum units, that offer classroom lessons to prepare students for their field studies, guidance for data analysis after a field study,
Boston's Arnold Arboretum: A Place for Study and Recreation
provides readings, maps, and lesson ideas about the first arboretum in the U.S., which opened to the public in the 1880s. This site, though focused on a place devoted to the study of trees, can help students learn how 19th-century urban conditions influenced the development of parks and how to research the history of parks in their own communities.
Environmental Catalyst Module
In the Environmental Catalysis Module, a joint project with the Institute for Environmental Catalysis at Northwestern University, students learn what a catalyst is and become aware of the use of catalysis to promote environmental protection. Besides introducing the concept of catalysis, the module also focuses other issues such as catalytic selectivity, specificity, poisoning, condition optimization, and waste minimization. The first activity of the module introduces the concept of catalysis in
The aim of this lesson is to help students identify their personal learning styles so they can study and learn more effectively. It is the ninth lesson in the study skills series and it introduces adult learners to the concept of learning styles. Students will have an opportunity to reflect on different ways of learning and to validate different abilities and capabilities, both their own and those of others. The lessons are designed as a package with key skills reinforced in each subsequent less
The aim of this lesson is to help students acquire skills that help them prepare for examinations in a focused and organized way. Students devise strategies for reviewing material and developing a revision timeline, and learn to identify the areas of study on which they should concentrate to prepare for tests. They review helpful tips and learn to use past examinations as a guide for future ones. It is the seventh lesson in the study skills series and is intended to support adult learners who ar
English Vocabulary Lessons-Food-What Do You Want to Eat?
This video is to help to improve English vocabulary and pronunciation. The focus of this video is on foods. A matching picture is shown (pizza, sandwich, salad, taco, cereal, etc.) as the commentator speaks the word. This is a good teaching resource for our ELL students, our youngest learners, and special education students (2:11).
The aim of this lesson is to enable students to take control of their learning in a positive way. It is the third lesson in the study skills series and is intended to support adult learners who are embarking on a course of study and need to acquire skills which will help them to be successful. The lessons are designed as a package with key skills reinforced in each subsequent lesson so that a study culture is developed over time. They can be delivered sequentially or used individually, as a whol
The Experience of MADD’s Protecting You/Protecting Me: Using Evaluation to Enhance Program Develop
Protecting You/Protecting Me (PY/PM) is a classroom-based alcohol-use prevention program developed by Mothers Against Drunk Driving (MADD) for students in grades 1–5. The goal of the intervention is to prevent injury and death of children and youth due to underage consumption of alcoholic beverages and vehicle crashes when riding with impaired drivers. Development of PY/PM began in the summer of 1998. In spring 2002, PY/PM was named a Model Program by the Substance Abuse and Mental Health Serv
Brother, Can You Spare a Dime: The Effects of the New Deal and the Great Depression
The New Deal programs and agencies, created under the leadership of Franklin Delano Roosevelt, had a powerful impact on the relationship of government to the people of the United States. Yet a study of New Deal programs often leaves the student with a disconnected list of 'alphabet soup' programs and no real grasp of the impact of the New Deal. This lesson takes a student through a process of examining primary sources, both photographs and life histories, to develop a sense of the profound impa
Drafting the Constitution
This lesson, a supplement to a study of the Constitutional Convention, focuses on The Committee of Detail's draft of the Constitution submitted on 6 August 1787. The delegates debated its contents for a month before referring the document to the Committee of Style. The Committee's report, presented to the Convention on 12 September, became the Constitution of the United States.
All about life
A primary curriculum based around life and environmental science draws on children's natural curiosity to teach reading, math, and more. For students to be successful in the science curriculum, they must study science through "hands-on" experiences. I use their past experiences as well as present experiences that I help to create to teach the curriculum. Many children today have never climbed a tree, walked in the woods, or waded in a stream, and I think that is sad. When they have the opportun