CARL W WHITE, SIMON PLATT, LAURA E KILPATRICK, NATASHA DALE, REKHATI S ABHAYAWARDANA, SEBASTIAN DEKKERS, NICHOLAS D KINDON, BARRIE KELLAM, MICHAEL J STOCKS, KEVIN D G PFLEGER and STEPHEN J HILL, 2024. CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans Science Signalling. 17, eabl3758 LYDIA OGRODZINSKI, SIMON PLATT, JOELLE GOULDING, CAMERON ALEXANDER, TRACY D FARR, JEANETTE WOOLARD, STEPHEN J HILL and LAURA E KILPATRICK, 2023. Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells iScience. 26, 107232 CHARLES S LAY, ALBERT ISIDRO-LLOBET, LAURA E KILPATRICK, PETER D CRAGGS and STEPHEN J HILL, 2023. Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes Nature Communications. 19, 2882 JAK GRIMES, ZSOMBOR KOSZEGI, YANN LANOISELEE, TAMARA MIJUS, SHANNON L O'BRIEN, TOMAZ M STEPNIEWSKI, BRIAN MEDEL-LACRUZ, MITHU BAIDYA, MARIA MAKAROVA, RAVI MISTRY, JOELLE GOULDING, JULIA DRUBE, CARSTEN HOFFMANN, DYLAN M OWEN, ARUN K SHUKLA, JANA SELENT, STEPHEN J HILL and DAVIDE CALEBIRO, 2023. Plasma membrane preassociation drives β-arrestin coupling to receptors and activation Cell. 186, 2238-2255e20 DEHAN COMEZ, JACQUELINE GLENN, STEPHANIE M ANBUHL, RAIMOND HEUKERS, MARTINE J SMIT, STEPHEN J HILL and LAURA E KILPATRICK, 2022. Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells Frontiers in Immunology. 13, 1006718 COOPER, SAMANTHA L., SOAVE, MARK, JOERG, MANUELA, SCAMMELLS, PETER J., WOOLARD, JEANETTE and HILL, STEPHEN J., 2019. Probe dependence of allosteric enhancers on the binding affinity of adenosine A(1)-receptor agonists at rat and human A(1)-receptors measured using NanoBRET BRITISH JOURNAL OF PHARMACOLOGY. 176(7), 864-878 ADLERE, I., SUN, S., ZARCA, A., ROUMEN, L., GOZELLE, M., VICIANO, C. PERPINA, CASPAR, B., ARIMONT, M., BEBELMAN, J. P., BRIDDON, S. J., HOFFMANN, C., HILL, S. J., SMIT, M. J., VISCHER, H. F., WIJTMANS, M., DE GRAAF, C., DE ESCH, I. J. P. and LEURS, R., 2019. Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 162, 631-649 BOUZO-LORENZO, MONICA, STODDART, LEIGH A., XIA, LIZI, IJZERMAN, ADRIAAN P., HEITMAN, LAURA H., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2019. A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A(3) receptor PURINERGIC SIGNALLING. 15(2), 139-153 BOSMA, REGGIE, STODDART, LEIGH A., GEORGI, VICTORIA, BOUZO-LORENZO, MONICA, BUSHBY, NICK, INKOOM, LORETTA, WARING, MICHAEL J., BRIDDON, STEPHEN J., VISCHER, HENRY F., SHEPPARD, ROBERT J., FERNANDEZ-MONTALVAN, AMAURY, HILL, STEPHEN J. and LEURS, ROB, 2019. Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor SCIENTIFIC REPORTS. 9, 7906 CLARK JC, KAVANAGH DM, WATSON S, PIKE JA, ANDREWS RK, GARDINER EE, POULTER NS, HILL SJ and WATSON SP, 2019. Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events. Thrombosis and haemostasis. 119(7), 1124-1137 SYKES, DAVID A., STODDART, LEIGH A., KILPATRICK, LAURA E. and HILL, STEPHEN J., 2019. Binding kinetics of ligands acting at GPCRs MOLECULAR AND CELLULAR ENDOCRINOLOGY. 485, 9-19 KILPATRICK, LAURA E., ALCOBIA, DIANA C., WHITE, CARL W., PEACH, CHLOE J., GLENN, JACKIE R., ZIMMERMAN, KRIS, KONDRASHOV, ALEXANDER, PFLEGER, KEVIN D. G., OHANA, RACHEL FRIEDMAN, ROBERS, MATTHEW B., WOOD, KEITH, V, SLOAN, ERICA K., WOOLARD, JEANETTE and HILL, STEPHEN J., 2019. Complex Formation between VEGFR2 and the beta(2)-Adrenoceptor CELL CHEMICAL BIOLOGY. 26(6), 830-841 KHAN, ABDULLAH O., WHITE, CARL W., PIKE, JEREMY A., YULE, JACK, SLATER, ALEXANDRE, HILL, STEPHEN J., POULTER, NATALIE S., THOMAS, STEVEN G. and MORGAN, NEIL V., 2019. Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in SCIENTIFIC REPORTS. 9, 14219 BRIDDON, STEPHEN J., KILPATRICK, LAURA E. and HILL, STEPHEN J., 2018. Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age TRENDS IN PHARMACOLOGICAL SCIENCES. 39(2), 158-174 STODDART, LEIGH A., KILPATRICK, LAURA E. and HILL, STEPHEN J., 2018. NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs TRENDS IN PHARMACOLOGICAL SCIENCES. 39(2), 136-147 STODDART, LEIGH A., VERNALL, ANDREA J., BOUZO-LORENZO, MONICA, BOSMA, REGGIE, KOOISTRA, ALBERT J., DE GRAAF, CHRIS, VISCHER, HENRY F., LEURS, ROB, BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2018. Development of novel fluorescent histamine H-1-receptor antagonists to study ligand-binding kinetics in living cells SCIENTIFIC REPORTS. 8, 1572 SOAVE, MARK, CSEKE, GABRIELLA, HUTCHINGS, CATHERINE J., BROWN, ALASTAIR J. H., WOOLARD, JEANETTE and HILL, STEPHEN J., 2018. A monoclonal antibody raised against a thermo-stabilised beta(1)-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of beta(1)-adrenoceptors expressed in stable cell lines BIOCHEMICAL PHARMACOLOGY. 147, 38-54 CONROY, SEAN, KINDON, NICHOLAS D., GLENN, JACQUELINE, STODDART, LEIGH A., LEWIS, RICHARD JAMES, HILL, STEPHEN J., KELLAM, BARRIE and STOCKS, MICHAEL JOHN, 2018. Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y 2 Receptor Based on AR-C118925 Journal of Medicinal Chemistry. 61(7), 3089-3113 PEACH, CHLOE J., MIGNONE, VIVIANE W., ARRUDA, MARIA AUGUSTA, ALCOBIA, DIANA C., HILL, STEPHEN J., KILPATRICK, LAURA E. and WOOLARD, JEANETTE, 2018. Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 19(4), PEACH, CJ, KILPATRICK, LE, FRIEDMAN-OHANA, R, ZIMMERMAN, K, ROBERS, MB, WOOD, KV, WOOLARD, J and HILL, SJ, 2018. Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells Cell Chemical Biology. 25(10), 1208-1218. e5 GARCIA-ROSA S, TRIVELLA DB, MARQUES VD, SERAFIM RB, PEREIRA JG, LORENZI JC, MOLFETTA GA, CHRISTO PP, OLIVAL GS, MARCHITTO VB, BRUM DG, SABEDOT TS, NOUSHMEHR H, FARIAS AS, SANTOS LM, NOGUEIRA-MACHADO JA, SOUZA JE, ROMANO CM, CONDE RM, SANTOS AC, GUERREIRO CT, SCHREUDER WH, GLEBER-NETTO FO, AMORIM M, VALIERIS R, SILVA ITD, SILVA WA, NUNES DN, OLIVEIRA PS, VALENTE V, ARRUDA MA, HILL SJ, BARREIRA AA and DIAS-NETO E, 2018. A non-functional galanin receptor-2 in a multiple sclerosis patient. The pharmacogenomics journal. (In Press.)
WALKER AK, MARTELLI D, ZIEGLER AI, LAMBERT GW, PHILLIPS SE, HILL SJ, MCALLEN RM and SLOAN EK, 2018. Circulating epinephrine is not required for chronic stress to enhance metastasis. Psychoneuroendocrinology. 99, 191-195 BAKER JG, GARDINER SM, WOOLARD J, FROMONT C, JADHAV GP, MISTRY SN, THOMPSON KS, KELLAM B, HILL SJ and FISCHER PM, 2017. Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal. 31(7), 3150-3166 KILPATRICK, LE, FRIEDMAN-OHANA, R, ALCOBIA, DC, RICHING, K, PEACH, CJ, WHEAL, AJ, BRIDDON, SJ, ROBERS, MB, ZIMMERMAN, K, MACHLEIDT, T, WOOD, KV, WOOLARD, J and HILL, SJ, 2017. Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochemical Pharmacology. 136, 62-75 ARRUDA, MARIA AUGUSTA, STODDART, LEIGH A., GHERBI, KAROLINA, BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2017. A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A(3) Receptor in Living Cells FRONTIERS IN PHARMACOLOGY. 8, SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LO, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase delta (P13K delta) Inhibitors JOURNAL OF MEDICINAL CHEMISTRY. 60(4), 1534-1554 HOTHERSALL JD, GUO D, SARDA S, SHEPPARD RJ, CHEN H, KEUR W, WARING MJ, IJZERMAN AP, HILL SJ, DALE IL and RAWLINS PB, 2016. Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics. Molecular pharmacology. 91(1), 25-38 STODDART, LEIGH A., JOHNSTONE, ELIZABETH K. M., WHEAL, AMANDA J., GOULDING, JOELLE, ROBERS, MATTHEW B., MACHLEIDT, THOMAS, WOOD, KEITH V., HILL, STEPHEN J. and PFLEGER, KEVIN D. G., 2015. Application of BRET to monitor ligand binding to GPCRs NATURE METHODS. 12(7), 661-663 GHERBI, KAROLINA, MAY, LAUREN T., BAKER, JILLIAN G., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2015. Negative cooperativity across beta(1)-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 beta(1)-adrenoceptor binding conformation FASEB JOURNAL. 29(7), 2859-2871 STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77 STODDART, LEIGH A., KILPATRICK, LAURA E., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2015. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands NEUROPHARMACOLOGY. 98, 48-57 HOFFMANN, C., CASTRO, M., RINKEN, A., LEURS, R., HILL, S. J. and VISCHER, H. F., 2015. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It MOLECULAR PHARMACOLOGY. 88(3), 552-560 RANGANATHAN, ANIRUDH, STODDART, LEIGH A., HILL, STEPHEN J. and CARLSSON, JENS, 2015. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9578-9590 VAN UNEN, JAKOBUS, WOOLARD, JEANETTE, RINKEN, AGO, HOFFMANN, CARSTEN, HILL, STEPHEN J., GOEDHART, JOACHIM, BRUCHAS, MICHAEL R., BOUVIER, MICHEL and ADJOBO-HERMANS, MEREL J. W., 2015. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms MOLECULAR PHARMACOLOGY. 88(3), 589-595 HUTCHINGS, CATHERINE J., CSEKE, GABRIELLA, OSBORNE, GREG, WOOLARD, JEANETTE, ZHUKOV, ANDREI, KOGLIN, MARKUS, JAZAYERI, ALI, PANDYA-PATHAK, JAHNAVI, LANGMEAD, CHRISTOPHER J., HILL, STEPHEN J., WEIR, MALCOLM and MARSHALL, FIONA H., 2014. Monoclonal anti-beta(1)-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment MABS. 6(1), 246-261 VERNALL, ANDREA J., HILL, STEPHEN J. and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1073-1084 JAEGER WC, ARMSTRONG SP, HILL SJ and PFLEGER KDG, 2014. Biophysical Detection of Diversity and Bias in GPCR Function. Frontiers in endocrinology. 5, 26 CORRIDEN, ROSS, KILPATRICK, LAURA E., KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2014. Kinetic analysis of antagonist-occupied adenosine-A(3) receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism FASEB JOURNAL. 28(10), 4211-4222 CORRIDEN, R., SELF, T., AKONG-MOORE, K., NIZET, V., KELLAM, B., BRIDDON, S.J. and HILL, S.J., 2013. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes EMBO Reports. 14(8), 726-732 MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists Journal of Medicinal Chemistry. 56(10), 3852-3865 VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & biomolecular chemistry. 11(34), 5673-82 MISTRY, SHAILESH N., BAKER, JILLIAN G., FISCHER, PETER M., HILL, STEPHEN J., GARDINER, SHEILA M. and KELLAM, BARRIE, 2013. Synthesis and in Vitro and in Vivo Characterization of Highly beta(1)-Selective beta-Adrenoceptor Partial Agonists JOURNAL OF MEDICINAL CHEMISTRY. 56(10), 3852-3865 VERNALL, A.J., STODDART, L.A., BRIDDON, S.J., HILL, S.J. and KELLAM, B., 2012. Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-α]quinoxalin-1-one scaffold Journal of Medicinal Chemistry. 55(4), 1771-1782 AYLING, L.J., BRIDDON, S.J., HALLS, M.L., HAMMOND, G.R.V., VACA, L., PACHECO, J., HILL, S.J. and COOPER, D.M.F., 2012. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu Journal of Cell Science. 125(4), 869-886 STODDART, L.A., VERNALL, A.J., DENMAN, J.L., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2012. Fragment screening at adenosine-A3 receptors in living cells using a fluorescence-based binding assay Chemistry & Biology. 19(9), 1105-1115 BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2011. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods in Molecular Biology. 746, 211-36 BAKER, J.G., ADAMS, L.A., SALCHOW, K., MISTRY, S.N., MIDDLETON, R.J., HILL, S.J. and KELLAM, B., 2011. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors Journal of Medicinal Chemistry. 54(19), 6874-6887 MAY, L.T., BRIDGE, L.J., STODDART, L.A., BRIDDON, S.J. and HILL, S.J., 2011. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics FASEB Journal. 25(10), 3465-3476 BAKER JG, HILL SJ and SUMMERS RJ, 2011. Evolution Of Β-Blockers: From Anti-Anginal Drugs To Ligand-Directed Signalling. Trends In Pharmacological Sciences. 32(4), 227-34 BAKER, J.G., KEMP, P., MARCH, J., FRETWELL, L., HILL, S.J. and GARDINER, S.M., 2011. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses FASEB Journal. 25(12), 4486-4497 BAKER, JILLIAN G., ADAMS, LUKE A., SALCHOW, KAROLINA, MISTRY, SHAILESH N., MIDDLETON, RICHARD J., HILL, STEPHEN J. and KELLAM, BARRIE, 2011. Synthesis and Characterization of High-Affinity 4, 4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human beta-Adrenoceptors JOURNAL OF MEDICINAL CHEMISTRY. 54(19), 6874-6887 BAKER, JILLIAN G., KEMP, PHILIP, MARCH, JULIE, FRETWELL, LAURICE, HILL, STEPHEN J. and GARDINER, SHEILA M., 2011. Predicting in vivo cardiovascular properties of beta-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses FASEB JOURNAL. 25(12), 4486-4497 BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands British Journal of Pharmacology. 159(4), 772-786 WOODROFFE, P J, BRIDGE, L J, KING, J R, CHEN, C Y and HILL, S J, 2010. Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity. Journal of mathematical biology. 60(3), 313-46 ALCOCK, J., WARREN, A.Y., GOODSON, Y.J., HILL, S.J., KHAN, R.N. and LYMN, J.S., 2010. Inhibition of tissue transglutaminase 2 attenuates contractility of pregnant human myometrium Biology of Reproduction. 84(4), 646-653 BRIDGE, L J, KING, J R, HILL, S J and OWEN, M R, 2009. Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: Agonist-antagonist competition. Mathematical biosciences.
WILLIAMS, CHRISTINE and HILL, STEPHEN J, 2009. GPCR signaling: understanding the pathway to successful drug discovery. Methods in molecular biology (Clifton, N.J.). 552, 39-50 WOODROFFE, P J, BRIDGE, L J, KING, J R and HILL, S J, 2009. Modelling the activation of G-protein coupled receptors by a single drug. Mathematical biosciences. 219(1), 32-55 WOODROFFE, PJ, BRIDGE, LJ, KING, JR and HILL, SJ, 2009. Modelling The Activation Of G-Protein Coupled Receptors By A Single Drug Mathematical Biosciences. 219(1), 32-55 CORDEAUX, Y., BRIDDON, S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2008. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells FASEB Journal. 22(3), 850-860 CORDELL, REBECCA L, HILL, STEPHEN J, ORTORI, CATHARINE A and BARRETT, DAVID A, 2008. Quantitative profiling of nucleotides and related phosphate-containing metabolites in cultured mammalian cells by liquid chromatography tandem electrospray mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 871(1), 115-24 BAKER, J.G., PROUDMAN, R.G.W., HAWLEY, N.C., FISCHER, P.M. and HILL, S.J., 2008. Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human β1-adrenoceptor Molecular Pharmacology. 74(5), 1246-1260 MAY, LAUREN T and HILL, STEPHEN J, 2008. ERK phosphorylation: Spatial and temporal regulation by G protein-coupled receptors. International Journal of Biochemistry and Cell Biology. 40(10), 2013-7 BRIDDON, S.J., GANDÍA, J., AMARAL, O.B., FERRÉ, S., LLUÍS, C., FRANCO, R., HILL, S.J. and CIRUELA, F., 2008. Plasma membrane diffusion of g protein-coupled receptor oligomers Biochimica et Biophysica Acta: Molecular Cell Research. 1783(12), 2262-2268 MIDDLETON,R, BRIDDON,S.J., CORDEAUX,Y., YATES,A.S., DALE,C.L., GEORGE,M., BAKER,J.G., HILL,S.J. and KELLAM,B., 2007. New Fluorescent Adenosine A(1)-Receptor Agonists That Allow Quantification of Ligand-Receptor Interactions in Microdomains of Single Living Cells. Journal of Medicinal Chemistry. 50(4), 782-793 ANDERSON, D., SELF, T., MELLOR, I.R., GOH, G., HILL, S.J. and DENNING, C., 2007. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Molecular Therapy. 15(11), 2027-2036 HILL, S.J., 2006. G-protein-coupled receptors: past, present and future British Journal of Pharmacology. 147(Supplement 1), S27-37 LIU, B., HILL, S.J. and KHAN, R.N., 2005. Oxytocin inhibits T-type calcium current of human decidual stromal cells. Journal of Clinical Endocrinology & Metabolism. 90(7), 4191-4197 SELF, T.J., OAKLEY, S.M. and HILL, S.J., 2005. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells British Journal of Pharmacology. 146(4), 612-24 BRIDDON, S.J., MIDDLETON, R.J., CORDEAUX, Y., FLAVIN, F.M., WEINSTEIN, J.A., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells Proceedings of the National Academy of Sciences of the United States of America. 101(13), 4673-4678 BRIDDON, S.J., MIDDLETON, R.J., YATES, A.S., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level Faraday Discussions. 126, 197-207 LIU, B., ARULKUMARAN, S., HILL, S.J. and KHAN, R.N., 2003. Comparison of potassium currents in human decidua before and after the onset of labor Biology of Reproduction. 68(6), 2281-2288 HILL, S.J. and BAKER, J.G., 2003. The ups and downs of Gs- to Gi-protein switching British Journal of Pharmacology. 138(7), 1188-1190 HILL, K.J., WEBBER, A.C. and HILL, S.J., 2003. A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus British Journal of Pharmacology. 139(4), 721-32 CHEN, C.Y., CORDEAUX, Y., HILL, S.J. and KING, J.R., 2003. Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy Bulletin of Mathematical Biology. 65(5), 933-58 BAKER, J.G, HALL, I.P and HILL, S.J., 2002. Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor British Journal of Pharmacology. 137(3), 400-8 CORDEAUX, Y. and HILL, S.J., 2002. Mechanisms of cross-talk between G-protein-coupled receptors Neuro-Signals. 11(1), 45-57
BURTON, C.L., CHHABRA, S.R., SWIFT, S., BALDWIN, T.J., WITHERS, H., HILL, S.J. and WILLIAMS, P., 2002. The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system Infection and Immunity. 70(11), 5913-5923 MEGSON, A.C., WALKER, E.M. and HILL, S.J., 2001. Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus Molecular Pharmacology. 59(5), 1012-1021
HILL, S J, BAKER, J G and REES, S, 2001. Reporter-gene systems for the study of G-protein-coupled receptors. Current Opinion in Pharmacology. 1(5), 526-32 MIDDLETON, A., NURY, D., WILLINGTON, S. J., LATIF, L., HILL, S. J. and MIDDLETON, B., 2001. Modulation by cellular cholesterol of gene transcription via the cyclic AMP response element Biochemical Pharmacology. VOL 62(NUMBER 2), 171-181 CORDEAUX, Y, BRIDDON, S J, MEGSON, A E, MCDONNELL, J, DICKENSON, J M and HILL, S J, 2000. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Molecular Pharmacology. 58(5), 1075-84
MCDONNELL, J, LATIF, M L, REES, E S, BEVAN, N J and HILL, S J, 1998. Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor. British Journal of Pharmacology. 125(4), 717-26 HILL, S J, GANELLIN, C R, TIMMERMAN, H, SCHWARTZ, J C, SHANKLEY, N P, YOUNG, J M, SCHUNACK, W, LEVI, R and HAAS, H L, 1997. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacological Reviews. 49(3), 253-78
SELBIE, L A, KING, N V, DICKENSON, J M and HILL, S J, 1997. Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors. Biochemical Journal. 328 ( Pt 1), 153-8
MARSH, K A, HARRISSS, D R and HILL, S J, 1996. Desensitization of muscarinic receptor-coupled inositol phospholipid hydrolysis in human detrusor cultured smooth cells. The Journal of urology. 155(4), 1439-43
MCCREA, K E and HILL, S J, 1996. Comparison of duration of agonist action at beta 1- and beta 2- adrenoceptors in C6 glioma cells: evidence that the long duration of action of salmeterol is specific to the beta 2-adrenoceptor. Molecular Pharmacology. 49(5), 927-37
HAYNES, J M and HILL, S J, 1996. Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig. British Journal of Pharmacology. 119(6), 1203-10
IREDALE, P A, ALEXANDER, S P and HILL, S J, 1994. Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. British Journal of Pharmacology. 111(4), 1252-6
ALEXANDER, S P, CURTIS, A R, KENDALL, D A and HILL, S J, 1994. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex. British Journal of Pharmacology. 113(4), 1501-7
ALEXANDER, S P, LOSINSKI, A, KENDALL, D A and HILL, S J, 1994. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta. British Journal of Pharmacology. 111(1), 185-90
DICKENSON, J M and HILL, S J, 1994. Characteristics of [3H]mepyramine binding in DDT1MF-2 cells: evidence for high affinity binding to a functional histamine H1 receptor. European Journal of Pharmacology. 268(2), 257-62
MCCREATH, G, HALL, I P and HILL, S J, 1994. Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells. British Journal of Pharmacology. 113(3), 823-30
DICKENSON, J M and HILL, S J, 1994. Interactions between adenosine A1- and histamine H1-receptors. The International journal of biochemistry. 26(8), 959-69 MARSH, K A and HILL, S J, 1994. Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. British Journal of Pharmacology. 112(3), 934-8
PEAKMAN, M C and HILL, S J, 1994. Endogenous expression of histamine H1 receptors functionally coupled to phosphoinositide hydrolysis in C6 glioma cells: regulation by cyclic AMP. British Journal of Pharmacology. 113(4), 1554-60
PEAKMAN, M C and HILL, S J, 1994. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. British Journal of Pharmacology. 111(1), 191-8
DICKENSON, J M, BULMER, S, WHITTAKER, A, SALWEY, M, HAWLEY, J and HILL, S J, 1994. Bradykinin B2- and 5-hydroxytryptamine (5-HT2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. Biochemical Pharmacology. 47(6), 947-52 VERNALL, ANDREA J., STODDART, LEIGH A., BRIDDON, STEPHEN J., HILL, STEPHEN J. and KELLAM, BARRIE, Highly Potent and Selective Fluorescent Antagonists of the Human Adenosine A(3) Receptor Based on the 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Scaffold JOURNAL OF MEDICINAL CHEMISTRY. 55(4), 1771-1782