Tracy D Farr

Contact

• workRoom E2g School of Life Sciences
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 0977
• T.Farr@nottingham.ac.uk

Research Summary

I am interested in the pathophysiology of cerebrovascular disease, in particular ischemic stroke and vascular dementia. I want to understanding how microstructural changes in the blood vessels and… read more

Selected Publications

• BOEHM-STURM P, FÜCHTEMEIER M, FODDIS M, MUELLER S, TRUEMAN RC, ZILLE M, RINNENTHAL JL, KYPRAIOS T, SHAW L, DIRNAGL U and FARR TD, 2017. Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke. 48(2), 468-475
• FÜCHTEMEIER M, BRINCKMANN MP, FODDIS M, KUNZ A, PO C, CURATO C, DIRNAGL U and FARR TD, 2015. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment Journal of cerebral blood flow and metabolism. 35(3), 476-484
• FARR TD, LAI CH, GRÜNSTEIN D, ORTS-GIL G, WANG CC, BOEHM-STURM P, SEEBERGER PH and HARMS C, 2014. Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters. 14(4), 2130-4
• LÓPEZ-GIL X, AMAT-ROLDAN I, TUDELA R, CASTAÑÉ A, PRATS-GALINO A, PLANAS AM, FARR TD and SORIA G, 2014. DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneously hypertensive rats undergoing executive function tests Frontiers in Aging Neuroscience. 6(167), 1-13

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Current Research

I am interested in the pathophysiology of cerebrovascular disease, in particular ischemic stroke and vascular dementia. I want to understanding how microstructural changes in the blood vessels and brain cause cognitive decline. I am interested in identifying neuroimaging biomarkers for cerebrovascular disease. Within this context, I use structural and functional neuroimaging techniques to identify pre-symptomatic changes in the diseased brain. I have an active interest in translation and testing various therapeutic strategies in an experimental setting.

• HORSBURGH, K, WARDLAW, JM, VAN AGTMAEL, T, ALLAN, SM, ASHFORD, MLJ, BATH, PM, BROWN, R, BERWICK, J, ZAMEEL CADER, M, CARARE, RO, DAVIS, JB, DUNCOMBE, J, FARR, TD, FOWLER, JH, GOENSE, J, GRANATA, A, HALL, CN, HAINSWORTH, AH, HARVEY, A, HAWKES, CA, JOUTEL, A, KALARIA, RN, KEHOE, PG, LAWRENCE, CB, LOCKHART, A, LOVE, S, MACLEOD, MR, MACRAE, IM, MARKUS, HS, MCCABE, C, MCCOLL, BW, MEAKIN, PJ, MILLER, A, NEDERGAARD, M, O'SULLIVAN, M, QUINN, TJ, RAJANI, R, SAKSIDA, LM, SMITH, C, SMITH, KJ, TOUYZ, RM, TRUEMAN, RC, WANG, T, WILLIAMS, A, WILLIAMS, SCR and WORK, LM, 2018. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clin Sci. 132(8), 851-868
• AHMED J, DWYER DM, FARR TD, HARRISON DJ, DUNNETT SB and TRUEMAN RC, 2017. Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke. Journal of cerebral blood flow and metabolism. 37(3), 755-761
• DEMUTH HU, DIJKHUIZEN RM, FARR TD, GELDERBLOM M, HORSBURGH K, IADECOLA C, MCLEOD DD, MICHALSKI D, MURPHY TH, ORBE J, OTTE WM, PETZOLD GC, PLESNILA N, REISER G, REYMANN KG, RUEGER MA, SAUR D, SAVITZ SI, SCHILLING S, SPRATT NJ, TURNER RJ, VEMUGANTI R, VIVIEN D, YEPES M, ZILLE M, BOLTZE J and , 2017. Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative neurology and neuroscience. 35(1), 87-103
• BOEHM-STURM P, FÜCHTEMEIER M, FODDIS M, MUELLER S, TRUEMAN RC, ZILLE M, RINNENTHAL JL, KYPRAIOS T, SHAW L, DIRNAGL U and FARR TD, 2017. Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke. 48(2), 468-475
• DAM K, FÜCHTEMEIER M, FARR TD, BOEHM-STURM P, FODDIS M, DIRNAGL U, MALYSHEVA O, CAUDILL MA and JADAVJI NM, 2017. Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment. Behavioural brain research. 321, 201-208
• PERCIE DU SERT N, ALFIERI A, ALLAN SM, CARSWELL HV, DEUCHAR GA, FARR TD, FLECKNELL P, GALLAGHER L, GIBSON CL, HALEY MJ, MACLEOD MR, MCCOLL BW, MCCABE C, MORANCHO A, MOON LD, O'NEILL MJ, PÉREZ DE PUIG I, PLANAS A, RAGAN CI, ROSELL A, ROY LA, RYDER KO, SIMATS A, SENA ES, SUTHERLAND BA, TRICKLEBANK MD, TRUEMAN RC, WHITFIELD L, WONG R and MACRAE IM, 2017. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of cerebral blood flow and metabolism. 37(11), 3488-3517
• LEAROYD AE, WOODHOUSE L, SHAW L, SPRIGG N, BERECZKI D, BERGE E, CASO V, CHRISTENSEN H, COLLINS R, CZLONKOWSKA A, EL ETRIBI A, FARR TD, GOMMANS J, LASKA AC, NTAIOS G, OZTURK S, POCOCK SJ, PRASAD K, WARDLAW JM, FONE KC, BATH PM, TRUEMAN RC and , 2017. Infections Up to 76 Days After Stroke Increase Disability and Death. Translational stroke research. 8(6), 541-548
• KOCH S, MUELLER S, FODDIS M, BIENERT T, VON ELVERFELDT D, KNAB F, FARR TD, BERNARD R, DOPATKA M, REX A, DIRNAGL U, HARMS C and BOEHM-STURM P, 2017. Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. Journal of cerebral blood flow and metabolism. 271678X17726635
• ARIZA DE SCHELLENBERGER A, KRATZ H, FARR TD, LÖWA N, HAUPTMANN R, WAGNER S, TAUPITZ M, SCHNORR J and SCHELLENBERGER EA, 2016. Labeling of mesenchymal stem cells for MRI with single-cell sensitivity. International Journal of Nanomedicine. 11, 1517-35
• TRUEMAN RC, DIAZ C, FARR TD, HARRISON DJ, FULLER A, TOKARCZUK PF, STEWART A, STEWART A, STEWART A, PAISEY SJ and DUNNETT SB, 2016. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism. 37(4), 1349-1361
• DONATH, S, AN, J, LIN LIN LEE, S, GERTZ, K, DATWYLER, AL, HARMS, U, MUELLER, S, FARR, TD, FUECHTEMEIER, M, LAETTIG-TUENNEMANN, G, LIPS, J, FODDIS, M, MOSCH, L, BERNARD, R, GRITTNER, U, BALKAYA, M, KRONENBERG, G, DIRNAGL, U, ENDRES, M and HARMS, C, 2016. Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. The Journal of Neuroscience. 36(31), 8132-8148
• FÜCHTEMEIER M, BRINCKMANN MP, FODDIS M, KUNZ A, PO C, CURATO C, DIRNAGL U and FARR TD, 2015. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment Journal of cerebral blood flow and metabolism. 35(3), 476-484
• JADAVJI NM, FARR TD, LIPS J, KHALIL AA, BOEHM-STURM P, FODDIS M, HARMS C, FÜCHTEMEIER M and DIRNAGL U, 2015. Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research. 283, 215-26
• LÓPEZ-GIL X, AMAT-ROLDAN I, TUDELA R, CASTAÑÉ A, PRATS-GALINO A, PLANAS AM, FARR TD and SORIA G, 2014. DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneously hypertensive rats undergoing executive function tests Frontiers in Aging Neuroscience. 6(167), 1-13
• VANDEPUTTE C, REUMERS V, AELVOET SA, THIRY I, DE SWAEF S, VAN DEN HAUTE C, PASCUAL-BRAZO J, FARR TD, VANDE VELDE G, HOEHN M, HIMMELREICH U, VAN LAERE K, DEBYSER Z, GIJSBERS R and BAEKELANDT V, 2014. Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of disease. 69, 144-55
• FARR TD, LAI CH, GRÜNSTEIN D, ORTS-GIL G, WANG CC, BOEHM-STURM P, SEEBERGER PH and HARMS C, 2014. Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters. 14(4), 2130-4
• HARMS C, DATWYLER AL, WIEKHORST F, TRAHMS L, LINDQUIST R, SCHELLENBERGER E, MUELLER S, SCHÜTZ G, ROOHI F, IDE A, FÜCHTEMEIER M, GERTZ K, KRONENBERG G, HARMS U, ENDRES M, DIRNAGL U and FARR TD, 2013. Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke Journal of cerebral blood flow and metabolism. 33(5), E1-E9
• BOEHM-STURM P, FARR TD, ADAMCZAK JA, JIKELI J, MENGLER L, WIEDERMANN D, KALLUR T, KISELEV V and HOEHN M, 2013. Vascular changes after stroke in the rat: a longitudinal study using optimized magnetic resonance imaging Contrast Media and Molecular Imaging. 8(5), 383-392
• ZILLE M, FARR TD, PRZESDZING I, MÜLLER J, SOMMER C, DIRNAGL U and WUNDER A, 2012. Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives Journal of cerebral blood flow and metabolism. 32(2), 213-31
• TRUEMAN RC, HARRISON DJ, DWYER DM, DUNNETT SB, HOEHN M and FARR TD, 2011. A critical re-examination of the intraluminal filament MCAO model: impact of external carotid artery transection Translational Stroke Research. 2(4), 651-61
• PATKAR S, FARR TD, COOPER E, DOWELL FJ and CARSWELL HV, 2011. Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain. European Journal of Neuroscience. 34(3), 382-93
• BAHMANI P, SCHELLENBERGER E, KLOHS J, STEINBRINK J, CORDELL R, ZILLE M, MULLER J, HARHAUSEN D, HOFSTRA L, REUTELINGSPERGER C, FARR TD, DIRNAGL U and WUNDER A, 2011. Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining Journal of cerebral blood flow and metabolism. 31(5), 1311-20
• FARR TD, SEEHAFER JU, NELLES M and HOEHN M, 2011. Challenges towards MR-imaging of the peripheral inflammatory response in the subacute and chronic stages of transient focal ischemia NMR in Biomedicine. 24(1), 35- 45
• FARR TD and TRUEMAN RC, 2011. Chapter 6. Functional assessment of subcortical ischemia.. In: Animal models of movement disorders. 2. Springer/Humana Publishing. 91-114
• KALLUR T, FARR TD, BÖHM-STURM P, KOKAIA Z and HOEHN M, 2011. Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain European Journal of Neuroscience. 34(3), 382-393
• FARR TD and WEGENER S, 2010. The use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence Journal of cerebral blood flow and metabolism. 30(4), 703-717
• SEEHAFER JU, KALTHOFF D, FARR TD, WIEDERMANN D and HOEHN M, 2010. No increase of the blood oxygenation level-dependent functional magnetic resonance imaging signal with higher field strength: implications for brain activation studies Journal of Neuroscience. 30(15), 704-712
• ADAMCZAK JM, FARR TD, SEEHAFER JU, KALTHOFF D and HOEHN M, 2010. High field BOLD response to forepaw stimulation in the mouse Neuroimage. 51(2), 704-712
• CARSWELL HVO, MACRAE IM and FARR TD, 2009. Complexities of oestrogen in stroke Clinical Science. 118(6), 375-389
• FARR TD, CARSWELL HV, MCCANN DJ, SATO M, BRYANT HU, DODGE JA and MACRAE IM, 2008. The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia Journal of Neuroendocrinology. 20(3), 366-374
• FARR TD, CARSWELL HV, GSELL W and MACRAE IM, 2007. Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Research. 1185, 275-282
• HOEHN M, WIEDERMANN D, JUSTICIA C, RAMOS-CABRER P, KRUTTWIG K, FARR T and HIMMELREICH U, 2007. Cell tracking using magnetic resonance imaging Journal of Physiology. 584((pT 1)), 25-30
• FARR TD, CARSWELL HV, GALLAGHER L, CONDON B, FAGAN AJ, MULLIN J and MACRAE IM, 2006. 17beta-Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function Neurobiology of Disease. 23(3), 552-562
• FARR TD, LIU L, COLWELL K, WHISHAW IQ and METZ GA, 2006. Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models Journal of Neuroscience Methods. 153(1), 104-113
• FARR TD and WHISHAW IQ, 2002. Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke Stroke. 33(7), 1869-1875
• METZ GA, FARR T, BALLERMANN M and WHISHAW IQ, Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine depleted (hemi-Parkinson analogue) rats European Journal of Neuroscience. 14(1), 27-37