Angus Brown

Contact

• workRoom E97 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30173
• fax0115 82 30142
• a.m.brown@nottingham.ac.uk
• http://www.nottingham.ac.uk/neuroscience/contact/a-z/brown_angus.phtml

Research Summary

Energy metabolism in the brain; role of non-glucose substrates, effects of glucose deprivation, role of glycogen.

Selected Publications

• BROWN, A.M., EVANS, R.D., BLACK, J. and RANSOM, B.R., 2012. Schwann cell glycogen selectively supports myelinated axon function Annals of Neurology. 72(3), 406-418
• EDGAR, J.M., MCLAUGHLIN, M., WERNER, H.B., MCCULLOCH, M.C., BARRIE, J.A., BROWN, A., FAICHNEY, A.B., SNAIDERO, N, NAVE, K.-A. and GRIFFITHS, I.R., 2009. Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1 Glia. 57(16), 1815-1824
• EDGAR, J.M., MCCULLOCH, M.C., MONTAGUE, P., BROWN, A.M., THILEMANN, S., PRATOLA, L., GRUENENFELDER, F.I., GRIFFITHS, I.R. and NAVE, K-A., 2010. Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease EMBO Molecular Medicine. 2(2), 42-50
• BROWN, A.M., SKAMARAUSKAS, J., LISTER, T., MADJD, A. and RAY, D.E., 2011. Differential susceptibility of astrocytic and neuronal function to 3-chloropropanediol in the rat inferior colliculus Journal of Neurochemistry. 116(6), 996-1004

• View all publications

• BROWN, ANGUS M., EVANS, RICHARD D., SMITH, PAUL A., RICH, LAURA R. and RANSOM, BRUCE R., 2019. Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification PHYSIOLOGICAL REPORTS. 7(5),
• BROWN, ANGUS M., 2019. The classics updated, or an act of electrophysiological sacrilege? JOURNAL OF PHYSIOLOGY-LONDON. 597(11), 2821-2825
• ANGUS M BROWN, 2018. Flowcharts to aid student comprehension of Nernst equation calculations Advances in Physiology Education. 42, 260-262
• RICH LR, 2018. Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve Journal of Physiology. 596.10, 1795-1812
• BARROS L F, BOLAÑOS J P, BONVENTO G, BOUZIER-SORE A-K, BROWN A M, HIRRLINGER J, KASPAROV S, KIRCHHOFF F, MURPHY A N, PELLERIN L and ROBINSON M B, 2018. Current technical approaches to brain energy metabolism Glia. 66, 1138-1159
• BARROS L F and BROWN A M, 2018. Glia in brain energy metabolism: A perspective Glia. 66, 1134-1137
• SAWYER JE, HENNEBRY JE, REVILL A and BROWN AM, 2017. The critical role of logarithmic transformation in Nernstian equilibrium potential calculations. Advances in physiology education. 41(2), 231-238
• CASES, M, LLOBET, A, TERNI, B, DE ARANDA, IG, BLANCH, M, REVILL, A, BROWN, A, BLASI, J, SOLSONA, C and SOLSONA, C, 2017. Acute Effect of Pore-Forming Clostridium perfringens Epsilon Toxin on Compound Action Potentials of Optic Nerve of Mouse eNeuro. 4(4)(e0051-17), 1-16
• BROWN, A, 2017. A Lifetime’s Adventure in Extracellular K+ Regulation: The Scottish Connection Neurochemical Research. 42(9), 2456–2467
• RICH L and BROWN AM, 2016. Glycogen: Multiple Roles in the CNS. The Neuroscientist. 23(4), 356-363
• ROCKLIFFE, A.M., EBLING, F.J.P. and BROWN, A.M., 2016. The role of nervous system glycogen during hypoglycemia Journal of Endocrine Disorders. 3(1), 1020
• BROWN AM and RANSOM BR, 2015. Astrocyte glycogen as an emergency fuel under conditions of glucose deprivation or intense neural activity. Metabolic brain disease. 30(1), 233-9
• FRYER KL and BROWN AM, 2015. Pluralistic roles for glycogen in the central and peripheral nervous systems. Metabolic brain disease. 30(1), 299-306
• SAWBRIDGE, JL, QURESHI, HK, BOYD, MJ and BROWN, AM, 2014. Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations Advances in Physiology Education. 38(3), 239-245
• CHAMBERS TW, DALY TP, HOCKLEY A and BROWN AM, 2014. Contribution of glycogen in supporting axon conduction in the peripheral and central nervous systems: the role of lactate. Frontiers in neuroscience. 8, 378
• BROWN AM and HAMANN M, 2014. Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in neuroanatomy. 8, 73
• YANG X, HAMNER MA, BROWN AM, EVANS RD, YE Z, CHEN S and RANSOM BR, 2014. Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. Annals of neurology. 75(4), 492-507
• LAMBERT R J W, MYTILINAIOS I, MAITLAND L & BROWN A M., 2012. Monte Carlo simulation of parameter confidence intervals for non-linear regression analysis of biological data using Microsoft Excel. Computers Methods and Programs in Biomedicine. 107, 155-163
• BROWN, A.M., EVANS, R.D., BLACK, J. and RANSOM, B.R., 2012. Schwann cell glycogen selectively supports myelinated axon function Annals of Neurology. 72(3), 406-418
• BROWN, A.M., SKAMARAUSKAS, J., LISTER, T., MADJD, A. and RAY, D.E., 2011. Differential susceptibility of astrocytic and neuronal function to 3-chloropropanediol in the rat inferior colliculus Journal of Neurochemistry. 116(6), 996-1004
• JONES, CA, BROWN, AM, AUER, DP and FONE, KCF, 2011. The mGLUR2/3 Agonist LY379268 Reverses Post-Weaning Social Isolation-Induced Recognition Memory Deficits In The Rat Psychopharmacology. 214(1), 269-283
• BROWN, AM, 2010. A Spreadsheet Template Compatible With Microsoft Excel And Iwork Numbers That Returns The Simultaneous Confidence Intervals For All Pairwise Differences Between Multiple Sample Means Computer Methods And Programs In Biomedicine. 98(1), 76-82
• EVANS, RD, WESTON, DA, MCLAUGHLIN, M and BROWN, AM, 2010. A Non-Linear Regression Analysis Method For Quantitative Resolution Of The Stimulus-Evoked Compound Action Potential From Rodent Optic Nerve Journal Of Neuroscience Methods. 188(1), 174-178
• EDGAR, J.M., MCCULLOCH, M.C., MONTAGUE, P., BROWN, A.M., THILEMANN, S., PRATOLA, L., GRUENENFELDER, F.I., GRIFFITHS, I.R. and NAVE, K-A., 2010. Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease EMBO Molecular Medicine. 2(2), 42-50
• JAMES, EL, PEACOCK, VAH, EBLING, FJP and BROWN, AM, 2010. Morphological And Electrophysiological Characterization Of The Adult Siberian Hamster Optic Nerve Anatomical Science International. 85(4), 214-223
• EDGAR, J.M., MCLAUGHLIN, M., WERNER, H.B., MCCULLOCH, M.C., BARRIE, J.A., BROWN, A., FAICHNEY, A.B., SNAIDERO, N, NAVE, K.-A. and GRIFFITHS, I.R., 2009. Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1 Glia. 57(16), 1815-1824
• WALLS, AB, SICKMANN, HM, BROWN, A, BOUMAN, SD, RANSOM, B, SCHOUSBOE, A and WAAGEPETERSEN, HS, 2008. Characterization Of 1,4-Dideoxy-1,4-Imino-D-Arabinitol (Dab) As An Inhibitor Of Brain Glycogen Shunt Activity Journal Of Neurochemistry. 105(4), 1462-1470
• BROWN, AM and RANSOM, BR, 2007. Astrocyte Glycogen And Brain Energy Metabolism Glia. 55(12), 1263-1271
• MEAKIN, PJ, FOWLER, MJ, RATHBONE, AJ, ALLEN, LM, RANSOM, BR, RAY, DE and BROWN, AM, 2007. Fructose Metabolism In The Adult Mouse Optic Nerve, A Central White Matter Tract Journal Of Cerebral Blood Flow And Metabolism. 27(1), 86-99
• ALLEN, L, ANDERSON, S, WENDER, R, MEAKIN, P, RANSOM, BR, RAY, DE and BROWN, AM, 2006. Fructose Supports Energy Metabolism Of Some, But Not All, Axons In Adult Mouse Optic Nerve Journal Of Neurophysiology. 95(3), 1917-1925
• BROWN, AM, 2006. A Non-Linear Regression Analysis Program For Describing Electrophysiological Data With Multiple Functions Using Microsoft Excel Computer Methods And Programs In Biomedicine. 82(1), 51-57
• BROWN, AM, SICKMANN, HM, FOSGERAU, K, LUND, TM, SHOUSBOE, A, WAAGEPETERSEN, HS and RANSOM, BR, 2005. Astrocyte Glycogen Metabolism Is Required For Neural Activity During Aglycemia Or Intense Stimulation In Mouse White Matter Journal of Neuroscience Research. 79, 74-80
• BROWN, AM, 2005. A New Software For Carrying Out One-Way Anova Post Hoc Tests Computer Methods And Programs In Biomedicine. 79(1), 89-95
• TEKKOK, SB, BROWN, AM, WESTENBROEK, R, PELLERIN, L and RANSOM, BR, 2005. Transfer Of Glycogen-Derived Lactate From Astrocytes To Axons Via Specific Monocarboxylate Transporters Supports Mouse Optic Nerve Activity Journal Of Neuroscience Research. 81(5), 644-652
• BROWN, A.M, 2004. Brain glycogen re-awakened. Journal of Neurochemistry. 89(3), 537-552
• BROWN, ANGUS M, BALTAN TEKKöK, SELVA and RANSOM, BRUCE R, 2004. Energy transfer from astrocytes to axons: the role of CNS glycogen. Neurochemistry International. 45(4), 529-36
• BYERS, MARGARET R, MAEDA, TAKEYASU, BROWN, ANGUS M and WESTENBROEK, RUTH E, 2004. GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP mice. Microscopy Research and Technique. 65(6), 295-307
• PRIOR, MJW, BROWN, AM, MAVROUDIS, G, LISTER, T and RAY, DE, 2004. Mri Characterisation Of A Novel Rat Model Of Focal Astrocyte Loss Magnetic Resonance Materials In Physics Biology And Medicine. 17(3-6), 125-132
• BROWN, A.M., TEKKÖK, S.B. and RANSOM, B.R, 2003. Glycogen regulation and functional role in mouse white matter. Journal of Physiology. 549(2), 501-512
• BROWN, A. M., 2003. A modeling study predicts the presence of voltage gated Ca2+ channels on myelinated central axons Computer Methods and Programs in Biomedicine. VOL 71(NUMBER 1), 25-31
• RANSOM, BRUCE R and BROWN, ANGUS M, 2003. Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back. Neuron. 40(1), 2-4
• TEKKOK, S. B., BROWN, A. M. and RANSOM, B. R., 2003. Axon Function Persists During Anoxia in Mammalian White Matter Journal of Cerebral Blood Flow and Metabolism. VOL 23(PART 11), 1340-1347
• MACVICAR, BRIAN A, FEIGHAN, DENISE, BROWN, ANGUS and RANSOM, BRUCE, 2002. Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytes. Glia. 37(2), 114-23
• BROWN, A M, TEKKöK, S B and RANSOM, B R, 2002. Hypoglycemia and white matter: pathophysiology of axon injury and role of glycogen. Diabetes Nutrition and Metabolism. 15(5), 290-3; discussion 293-4
• BROWN, A. M. and RANSOM, B. R., 2002. Neuroprotective Effects of Increased Extracellular Ca^2^+ During Aglycemia in White Matter Journal of Neurophysiology. VOL 88(PART 3), 1302-1307
• CHEN, CHUNLING, BHARUCHA, VANDANA, CHEN, YUAN, WESTENBROEK, RUTH E, BROWN, ANGUS, MALHOTRA, JYOTI DHAR, JONES, DOROTHY, AVERY, CHRISTY, GILLESPIE, PATRICK J, KAZEN-GILLESPIE, KRISTIN A, KAZARINOVA-NOYES, KATIE, SHRAGER, PETER, SAUNDERS, THOMAS L, MACDONALD, ROBERT L, RANSOM, BRUCE R, SCHEUER, TODD, CATTERALL, WILLIAM A and ISOM, LORI L, 2002. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proceedings of the National Academy of Sciences of the United States of America. 99(26), 17072-7
• BROWN, A.M., WENDER, R. and RANSOM, B.R, 2001. Ionic mechanisms of aglycemic axon injury in mammalian central white matter. Journal of Cerebral Blood Flow and Metabolism. 21(4), 385-395
• BROWN, A. M., 2001. A step-by-step guide to non-linear regression analysis of experimental data using a Microsoft Excel spreadsheet Computer Methods and Programs in Biomedicine. VOL 65(NUMBER 3), 191 - 200
• BROWN, A. M., WENDER, R. and RANSOM, B. R., 2001. Metabolic Substrates Other Than Glucose Support Axon Function in Central White Matter Journal of Neuroscience Research. VOL 66(NUMB 5), 839-843
• BROWN, A M, WESTENBROEK, R E, CATTERALL, W A and RANSOM, B R, 2001. Axonal L-type Ca2+ channels and anoxic injury in rat CNS white matter. Journal of Neurophysiology. 85(2), 900-11
• WENDER, R, BROWN, A M, FERN, R, SWANSON, R A, FARRELL, K and RANSOM, B R, 2000. Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter. Journal of Neuroscience. 20(18), 6804-10
• BROWN, A M, 2000. Simulation of axonal excitability using a Spreadsheet template created in Microsoft Excel. Computer Methods and Programs in Biomedicine. 63(1), 47-54
• BROWN, A M, 1999. A methodology for simulating biological systems using Microsoft Excel. Computer Methods and Programs in Biomedicine. 58(2), 181-90
• BROWN, A M, FERN, R, JARVINEN, J P, KAILA, K and RANSOM, B R, 1998. Changes in [Ca2+]0 during anoxia in CNS white matter. NeuroReport. 9(9), 1997-2000