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Cameron Alexander

Professor of Polymer Therapeutics, Faculty of Science

Personal Details
Research
Publications

Contact

workRoom B06 Boots Science Building
University Park
Nottingham
NG7 2RD
UK
work0115 8467678
fax0115 8466296
cameron.alexander@nottingham.ac.uk

Expertise Summary

Polymer synthesis, drug delivery, smart materials

Research Summary

Key research foci include smart materials (Adv. Mater.2015, Nature Mater 2014, Nanoscale 2014), drug and gene delivery (Mol. Ther 2015, PLosOne 2014, Small 2013, Mol. Pharmaceutics 2012), and… read more

Selected Publications

ALAZZO, ALI, AL-NATOUR, MOHAMMAD AHMAD, SPRIGGS, KEITH, STOLNIK, SNJEZANA, GHAEMMAGHAMI, AMIR, KIM, DONG-HYUN and ALEXANDER, CAMERON, 2019. Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling MOLECULAR OMICS. 15(1), 77-87
CONTE, CLAUDIA, MASTROTTO, FRANCESCA, TARESCO, VINCENZO, TCHORYK, ALEKSANDRA, QUAGLIA, FABIANA, STOLNIK, SNJEZANA and ALEXANDER, CAMERON, 2018. Enhanced uptake in 2D-and 3D-lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments JOURNAL OF CONTROLLED RELEASE. 277, 126-141
MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2014. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nature Materials. 13, 748-755
LUI LT, XUE X, SUI C, BROWN A, PRITCHARD DI, HALLIDAY N, WINZER K, HOWDLE SM, FERNANDEZ-TRILLO F, KRASNOGOR N and ALEXANDER C, 2013. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry. 5(12), 1058-65

View all publications

Current Research

Key research foci include smart materials (Adv. Mater.2015, Nature Mater 2014, Nanoscale 2014), drug and gene delivery (Mol. Ther 2015, PLosOne 2014, Small 2013, Mol. Pharmaceutics 2012), and synthetic biology (Artificial Life 2015, Nature Chem 2013, Angew Chem Int Ed. 2012 & 2011).

Current projects are investigating controlled release of therapeutics from synthetic-biopolymer complexes and conjugates, targeted degradable polymers for anti-microbial, drug, gene and cell therapies, and smart materials for protein and cell recognition. Collaborative projects span disciplines including synthetic chemistry, pharmaceutics, cell biology, regenerative medicine, microbial resistance and synthetic biology.

Measures of Esteem

Royal Society Wolfson Research Merit Award Holder, 2016-
EPSRC Impact Fellowship 2016-18
RSC/SCI Macro Group Medal and Lectureship 2014
EPSRC Leadership Fellowship - 2009-2014.
Chair of EPSRC Physical Sciences Strategic Advisory Team - 2016 -2019.
Academic Lead - EPSRC Impact Acceleration Account, Nottingham 2012-2015.
EPSRC Materials Science Strategy Review Panel 2012-2014.
Head of Division: Drug Delivery and Tissue Engineering, School of Pharmacy 2009-
Director - EPSRC/AstraZeneca/University of Nottingham Doctoral Training Centre 2006-
Member of Editorial Board, Journal of Materials Chemistry 2006-2013
Member of International Advisory Board, Biomaterials Science, 2012-
Steering Group Member for RSC Review of Chemical Biology, 2007.
EPSRC Peer Review College 2003--
Australian Research Council Peer Review College member 2014-
Teaching

Pharmaceutics lead for Cancers DMP module 2014 and contributor to drug delivery / pharmaceutics modules, Applied Biomolecular Technology MSc
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Past Research

Polymer synthesis, organic magnets, self-assembly of liquid crystalline polymers and molecular imprinting

Future Research

Advanced Biomaterials

Nanomedicines

Responsive polymers

Anti-Microbial Resistance

Synthetic Biology

ALAZZO, ALI, AL-NATOUR, MOHAMMAD AHMAD, SPRIGGS, KEITH, STOLNIK, SNJEZANA, GHAEMMAGHAMI, AMIR, KIM, DONG-HYUN and ALEXANDER, CAMERON, 2019. Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling MOLECULAR OMICS. 15(1), 77-87
BRAIM, SHWANA, SPIEWAK, KLAUDYNA, BRINDELL, MALGORZATA, HEEG, DANIELA, ALEXANDER, CAMERON and MONAGHAN, TANYA, 2019. Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection JOURNAL OF PHARMACEUTICAL SCIENCES. 108(7), 2438-2446
FRANCINI, NORA, COCHRANE, DANIEL, ILLINGWORTH, SAM, PURDIE, LAURA, MANTOVANI, GIUSEPPE, FISHER, KERRY, SEYMOUR, LEONARD W., SPAIN, SEBASTIAN G. and ALEXANDER, CAMERON, 2019. Polyvalent Diazonium Polymers Provide Efficient Protection of Oncolytic Adenovirus Enadenotucirev from Neutralizing Antibodies while Maintaining Biological Activity In Vitro and In Vivo BIOCONJUGATE CHEMISTRY. 30(4), 1244-1257
SHERMAN, HARRY G., HICKS, JACQUELINE M., JAIN, AKHIL, TITMAN, JEREMY J., ALEXANDER, CAMERON, STOLNIK, SNOW and RAWSON, FRANKIE J., 2019. Mammalian-Cell-Driven Polymerisation of Pyrrole CHEMBIOCHEM. 20(8), 1008-1013
IRIA LOUZAO, BRITTA KOCH, VINCENZO TARESCO, LAURA RUIZ CANTU, DEREK J IRVINE, CLIVE J. ROBERTS, CHRISTOPHER J TUCK, CAMERON ALEXANDER, RICHARD J.M. HAGUE, RICKY D. WILDMAN and MORGAN R. ALEXANDER, 2018. Identification of Novel ‘Inks’ for 3D Printing Using High Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery ACS Appl. Mater. Interfaces.
SAYERS, EDWARD J., MAGNUSSON, JOHANNES P., MOODY, PAUL R., MASTROTTO, FRANCESCA, CONTE, CLAUDIA, BRAZZALE, CHIARA, BORRI, PAOLA, CALICET, PAOLO, WATSON, PETER, MANTOVANI, GIUSEPPE, AYLOTT, JONATHAN, SALMASO, STEFANO, JONES, ARWYN T. and ALEXANDER, CAMERON, 2018. Switching of Macromolecular Ligand Display by Thermoresponsive Polymers Mediates Endocytosis of Multiconjugate Nanoparticles BIOCONJUGATE CHEMISTRY. 29(4), 1030-1046
SOLIMAN, MAHMOUD E, ELMOWAFY, ENAS, CASETTARI, LUCA and ALEXANDER, CAMERON, 2018. Star-shaped poly(oligoethylene glycol) copolymer-based gels: Thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery. International journal of pharmaceutics. 543(1-2), 224-233
XUE, XUAN, THIAGARAJAN, LALITHA, DIXON, JAMES E., SAUNDERS, BRIAN R., SHAKESHEFF, KEVIN M. and ALEXANDER, CAMERON, 2018. Post-Modified Polypeptides with UCST-Type Behavior for Control of Cell Attachment in Physiological Conditions MATERIALS. 11(1),
SANNA, MONICA, SICILIA, GIOVANNA, ALAZZO, ALI, SINGH, NISHANT, MUSUMECI, FRANCESCA, SCHENONE, SILVIA, SPRIGGS, KEITH A., BURLEY, JONATHAN C., GARNETT, MARTIN C., TARESCO, VINCENZO and ALEXANDER, CAMERON, 2018. Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer-Drug Microarrays ACS MEDICINAL CHEMISTRY LETTERS. 9(3), 193-197
CONTE, CLAUDIA, MASTROTTO, FRANCESCA, TARESCO, VINCENZO, TCHORYK, ALEKSANDRA, QUAGLIA, FABIANA, STOLNIK, SNJEZANA and ALEXANDER, CAMERON, 2018. Enhanced uptake in 2D-and 3D-lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments JOURNAL OF CONTROLLED RELEASE. 277, 126-141
PURDIE, LAURA, ALEXANDER, CAMERON, SPAIN, SEBASTIAN G. and MAGNUSSON, JOHANNES P., 2018. Alkyl-Modified Oligonucleotides as Intercalating Vehicles for Doxorubicin Uptake via Albumin Binding MOLECULAR PHARMACEUTICS. 15(2), 437-446
ALAZZO A, LOVATO T, COLLINS HM, TARESCO V, STOLNIK S, SOLIMAN M, SPRIGGS K and ALEXANDER C, 2018. Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery Journal of Interdisciplinary Nanomedicine. (In Press.)
TURPIN, ELEANOR R., TARESCO, VINCENZO, AL-HACHAMI, WATHIQ A., BOOTH, JONATHAN, TREACHER, KEVIN, TOMASI, SIMONE, ALEXANDER, CAMERON, BURLEY, JONATHAN, LAUGHTON, CHARLES A. and GARNETT, MARTIN C., 2018. In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and chi FH MOLECULAR PHARMACEUTICS. 15(10), 4654-4667
LOVATO, TATIANA, TARESCO, VINCENZO, ALAZZO, ALI, SANSONE, CATERINA, STOLNIK, SNJEZANA, ALEXANDER, CAMERON and CONTE, CLAUDIA, 2018. Rapid formulation of redox-responsive oligo-aminoester polyplexes with siRNA via jet printing JOURNAL OF MATERIALS CHEMISTRY B. 6(41), 6550-6558
GULFAM M, MATINI T, MONTEIRO PF, RIVA R, COLLINS H, SPRIGGS K, HOWDLE SM, JÉRÔME C and ALEXANDER C, 2017. Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells. Biomaterials science.
MAKWANA H, MASTROTTO F, MAGNUSSON JP, SLEEP D, HAY J, NICHOLLS KJ, ALLEN S and ALEXANDER C, 2017. Engineered Polymer-Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems. Biomacromolecules. 18(5), 1532-1543
ENGLAND RM, HARE JI, BARNES J, WILSON J, SMITH A, STRITTMATTER N, KEMMITT PD, WARING MJ, BARRY ST, ALEXANDER C and ASHFORD MB, 2017. Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of controlled release : official journal of the Controlled Release Society. 247, 73-85
B BLANCO-FERNANDEZ, A CONCHEIRO, H MAKWANA, F FERNANDEZ-TRILLO, C ALEXANDER and C ALVAREZ-LORENZO, 2017. Dually sensitive dextran-based micelles for methotrexate delivery RSC Advances. 7, 14448-14460
AMANDA K. PEARCE, ALESSANDRA TRAVANUT, BENOIT COUTURAUD, VINCENZO TARESCO, STEVEN M. HOWDLE, MORGAN R. ALEXANDER and CAMERON ALEXANDER, 2017. Versatile Routes to Functional RAFT Chain Transfer Agents through the Passerini Multicomponent Reaction ACS Macro Letters. 6, 781–785
MAGENNIS EP, FRANCINI N, MASTROTTO F, CATANIA R, REDHEAD M, FERNANDEZ-TRILLO F, BRADSHAW D, CHURCHLEY D, WINZER K, ALEXANDER C and MANTOVANI G, 2017. Polymers for binding of the gram-positive oral pathogen Streptococcus mutans. PloS one. 12(7), e0180087
BRAZZALE, C., MASTROTTO, F., MOODY, P., WATSON, P. D., BALASSO, A., MALFANTI, A., MANTOVANI, G., CALICETI, P., ALEXANDER, C., JONES, A. T. and SALMASO, S., 2017. Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells Nanoscale. 9, 11137-11147
XUE X, THIAGARAJAN L, BRAIM S, SAUNDERS BR, SHAKESHEFF KM and ALEXANDER C, 2017. Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment JOURNAL OF MATERIALS CHEMISTRY B. 5(25), 4926-4933
FORALOSSO R, MOIR L, MASTROTTO F, SASSO L, TCHORYK A, ABOUSELO A, GRABOWSKA AM, ASHFORD MB, AYLOTT J, GELLERT PR, SPAIN SG and ALEXANDER C, 2017. Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles Soft Matter. 13, 7441-7452
RUITER F, ALEXANDER C, ROSE FRAJ and SEGAL J, 2017. A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies J. Biomedical Materials. 12,
MAGENNIS, EUGENE P., FRANCINI, NORA, MASTROTTO, FRANCESCA, CATANIA, ROSA, REDHEAD, MARTIN, FERNANDEZ-TRILLO, FRANCISCO, BRADSHAW, DAVID, CHURCHLEY, DAVID, WINZER, KLAUS, ALEXANDER, CAMERON and MANTOVANI, GIUSEPPE, 2017. Polymers for binding of the gram-positive oral pathogen Streptococcus mutans PLOS ONE. 12(7),
SICILIA GIOVANNA, DAVIS ADRIENNE L, SPAIN SEBASTIAN G, MAGNUSSON JOHANNES P, BOASE NATHAN RB, THURECHT KRISTOFER J and ALEXANDER CAMERON, 2016. Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition Polymer Chemistry.
LUO T, MAGNUSSON J, PRÉAT V, FRÉDÉRICK R, ALEXANDER C, BOSQUILLON C and VANBEVER R, 2016. Synthesis and In Vitro Evaluation of Polyethylene Glycol-Paclitaxel Conjugates for Lung Cancer Therapy. Pharmaceutical research. 33(7), 1671-81
MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2016. Corrigendum: Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nature Materials. 15(2), 243
PURDIE L, ALEXANDER C, SPAIN SG and MAGNUSSON JP, 2016. Influence of Polymer Size on Uptake and Cytotoxicity of Doxorubicin-Loaded DNA-PEG Conjugates. Bioconjugate chemistry. 27(5), 1244-52
LOUZAO I., SUI C., WINZER K., FERNANDEZ-TRILLO F. and ALEXANDER C., 2015. Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers. European Journal of Pharmaceutics and Biopharmaceutics. 95, 47–62
ROSENGREN-HOLMBERG, J. P., ANDERSSON, J., SMITH, J. R., ALEXANDER, C., ALEXANDER, M. R., TOVAR, G., EKDAHL, K. N. and NICHOLLS, I. A., 2015. Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood Biomaterials Science. 3(8), 1208-1217
SAEED A, FRANCINI N, WHITE L, DIXON J, GOULD T, RASHIDI H, CHEIKH AL GHANAMI R, HRUSCHKA V, REDL H, SAUNDERS BR, ALEXANDER C and SHAKESHEFF KM, 2015. A Thermoresponsive and Magnetic Colloid for 3D Cell Expansion and Reconfiguration Advanced Materials. 27, 662-558
GRABOWSKA ANNA M, KIRCHEIS R, KUMARI R, CLARKE P, MCKENZIE A, HUGHES J, MAYNE C, DESAI A, SASSO L, WATSON S and ALEXANDER C, 2015. Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin–polyethyleneimine conjugates Biomaterials Science. Available online..
MALAKOOTI N, ALEXANDER C and ALVAREZ-LORENZO C, 2015. Imprinted Contact Lenses for Sustained Release of Polymyxin B and Related Antimicrobial Peptides Journal of Pharmaceutical Sciences. 104, 3386-3394
BRAIM SA, SHAKESHEFF KM and SAUNDERS BR, 2015. Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles Journal of Materials Chemistry B. 4, 962-972
MOODY, PAUL R., SAYERS, EDWARD J., MAGNUSSON, JOHANNES P., ALEXANDER, CAMERON, BORRI, PAOLA, WATSON, PETER and JONES, ARWYN T., 2015. Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes MOLECULAR THERAPY. 23(12), 1888-1898
FARRUGIA M, MORGAN SP, ALEXANDER C and MATHER ML, 2014. Ultrasonic monitoring of drug loaded Pluronic F127 micellular hydrogel phase behaviour. Materials science & engineering. C, Materials for biological applications. 34, 280-6
ROLFE BE, BLAKEY I, SQUIRES O, PENG H, BOASE NRB, ALEXANDER C, PARSONS PG, BOYLE GM, WHITTAKER AK and THURECHT KJ, 2014. Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imaging in vivo. Journal of the American Chemical Society. 136(6), 2413-9
MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2014. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nature Materials. 13, 748-755
SICILIA, GIOVANNA, GRAINGER-BOULTBY, CHRISTINE, FRANCINI, NORA, MAGNUSSON, JOHANNES P., SAEED, ARAM O., FERNANDEZ-TRILLO, FRANCISCO, SPAIN, SEBASTIAN G. and ALEXANDER, CAMERON, 2014. Programmable polymer-DNA hydrogels with dual input and multiscale responses BIOMATERIALS SCIENCE. 2(2), 203-211
MATINI, TERESA, FRANCINI, NORA, BATTOCCHIO, ANNA, SPAIN, SEBASTIAN G., MANTOVANI, GIUSEPPE, VICENT, MARIA J., SANCHIS, JOAQUIN, GALLON, ELENA, MASTROTTO, FRANCESCA, SALMASO, STEFANO, CALICETI, PAOLO and ALEXANDER, CAMERON, 2014. Synthesis and characterization of variable conformation pH responsive block co-polymers for nucleic acid delivery and targeted cell. entry POLYMER CHEMISTRY. 5(5), 1626-1636
ALEXANDER C, 2014. Self-assembly of biopolymers - recent progress and future prospects. Faraday Discuss. 166, 449-452
MAGNUSSON, JOHANNES P., FERNANDEZ-TRILLO, FRANCISCO, SICILIA, GIOVANNA, SPAIN, SEBASTIAN G. and ALEXANDER, CAMERON, 2014. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition NANOSCALE. 6(4), 2368-2374
IVANOV DP, PARKER TL, WALKER DA, ALEXANDER C, ASHFORD MB, GELLERT PR and GARNETT MC, 2014. Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres. PloS one. 9(8), e103817
KHAN ADNAN R, MAGNUSSON JOHANNES PALL, WATSON SUE, GRABOWSKA ANNA M, WILKINSON ROBERT W, ALEXANDER CAMERON and PRITCHARD DAVID, 2014. Camptothecin prodrug block copolymer micelles with high drug loading and target specificity Polymer Chemistry. 5(18), 5320-5329
ABULATEEFEH, S.R., SPAIN, S.G., THURECHT, K.J., AYLOTT, J.W., CHAN, W.C., GARNETT, M.C. and ALEXANDER, C., 2013. Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line Biomaterials Science. 1(4), 434-442
SHAHIDAN NN, ALEXANDER C, SHAKESHEFF KM and SAUNDERS BR, 2013. Gelation of microsphere dispersions using a thermally-responsive graft polymer. Journal of colloid and interface science. 396, 187-96
FOWLER, R., VLLASALIU, D., TRILLO, F.F., GARNETT, M., ALEXANDER, C., HORSLEY, H., SMITH, B., WHITCOMBE, I., EATON, M. and STOLNIK, S., 2013. Nanoparticle transport in epithelial cells: pathway switching through bioconjugation Small. 9(19), 3282-3294
FOWLER R, VLLASALIU D, FALCONE FH, GARNETT M, SMITH B, HORSLEY H, ALEXANDER C and STOLNIK S, 2013. Uptake and transport of B12-conjugated nanoparticles in airway epithelium. Journal of controlled release : official journal of the Controlled Release Society. 172(1), 374-381
YAŞAYAN G, MAGNUSSON JP, SICILIA G, SPAIN SG, ALLEN S, DAVIES MC and ALEXANDER C, 2013. Multi-modal switching in responsive DNA block co-polymer conjugates. Physical chemistry chemical physics : PCCP. 15(38), 16263-74
GALLAS A, ALEXANDER C, DAVIES MC, PURI S and ALLEN S, 2013. Chemistry and formulations for siRNA therapeutics. Chemical Society reviews. 42(20), 7983-97
LUI, L.T., XUE, X., SUI, C., BROWN, A., PRITCHARD, D.I., HALLIDAY, N., WINZER, K., HOWDLE, S.M., FERNANDEZ-TRILLO, F., KRASNOGOR, N. and ALEXANDER, C., 2013. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes Nature Chemistry. n/a(n/a), n/a
VLLASALIU, DRITON, SHUBBER, SAIF, FOWLER, ROBYN, GARNETT, MARTIN, ALEXANDER, CAMERON and STOLNIK, SNOW, 2013. Epithelial toxicity of alkylglycoside surfactants JOURNAL OF PHARMACEUTICAL SCIENCES. 102(1), 114-125
MASTROTTO, FRANCESCA, SALMASO, STEFANO, ALEXANDER, CAMERON, MANTOVANI, GIUSEPPE and CALICETI, PAOLO, 2013. Novel pH-responsive nanovectors for controlled release of ionisable drugs JOURNAL OF MATERIALS CHEMISTRY B. 1(39), 5335-5346
SHAHIDAN NN, LIU R, THAIBOONROD S, ALEXANDER C, SHAKESHEFF KM and SAUNDERS BR, 2013. Hollow colloidosomes prepared using accelerated solvent evaporation. Langmuir : the ACS journal of surfaces and colloids. 29(45), 13676-85
LUI LT, XUE X, SUI C, BROWN A, PRITCHARD DI, HALLIDAY N, WINZER K, HOWDLE SM, FERNANDEZ-TRILLO F, KRASNOGOR N and ALEXANDER C, 2013. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry. 5(12), 1058-65
MAGNUSSON JP, FERNÁNDEZ-TRILLO F, SICILIA G, SPAIN SG and ALEXANDER C, 2013. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition. Nanoscale. (In Press.)
SOLIMAN, M., NASANIT, R., ABULATEEFEH, S.R., ALLEN, S., DAVIES, M.C., BRIGGS, S.S., SEYMOUR, L.W., PREECE, J.A., GRABOWSKA, A.M., WATSON, S.A. and ALEXANDER, C., 2012. Multicomponent synthetic polymers with viral-mimetic chemistry for nucleic acid delivery Molecular Pharmaceutics. 9(1), 1-13
VLLASALIU, D., ALEXANDER, C., GARNETT, M., EATON, M. and STOLNIK, S., 2012. Fc-mediated transport of nanoparticles across airway epithelial cell layers Journal of Controlled Release. 158(3), 479–486
VLLASALIU D, SHUBBER S, GARNETT M, ALEXANDER C, EATON M and STOLNIK S, 2012. Evaluation Of Calcium Depletion As A Strategy For Enhancement Of Mucosal Absorption Of Macromolecules. Biochemical And Biophysical Research Communications. 418(1), 128-33
REDHEAD, M., MANTOVANI, G., NAWAZ, S., CARBONE, P., GORECKI, D.C., ALEXANDER, C. and BOSQUILLON, C., 2012. Relationship between the affinity of PEO-PPO-PEO block copolymers for biological membranes and their cellular effects Pharmaceutical Research. 29(7), 1908-1918
YASAYAN, GOKCEN, REDHEAD, MARTIN, MAGNUSSON, JOHANNES P., SPAIN, SEBASTIAN G., ALLEN, STEPHANIE, DAVIES, MARTYN, ALEXANDER, CAMERON and FERNANDEZ-TRILLO, FRANCISCO, 2012. Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol Polymer Chemistry. 3, 2596-2604
ALBUZAT T, KEIL M, ELLIS J, ALEXANDER C and WENZ G, 2012. Transfection of luciferase DNA into various cells by cationic cyclodextrin polyrotaxanes derived from ionene-11 Journal of Materials Chemistry. 22(17), 8558-8565
VLLASALIU D, SHUBBER S, FOWLER R, GARNETT M, ALEXANDER C and STOLNIK S, 2012. Epithelial toxicity of alkylglycoside surfactants. Journal of pharmaceutical sciences. (In Press.)
NAWAZ, S., REDHEAD, M., MANTOVANI, G., ALEXANDER, C., BOSQUILLON, C. and CARBONE, P., 2012. Interactions of PEO-PPO-PEO block copolymers with lipid membranes: a computational and experimental study linking membrane lysis with polymer structure Soft Matter. 8(25), 6744-6754
COOPER GJT, BOWMAN RW, MAGENNIS EP, FERNANDEZ-TRILLO F, ALEXANDER C, PADGETT MJ and CRONIN L, 2012. Directed assembly of inorganic polyoxometalate-based micrometer-scale tubular architectures by using optical control. Angewandte Chemie (International ed. in English). 51(51), 12754-8
SAEED, A.O., MAGNUSSON, J.P., MORADI, E., SOLIMAN, M., WANG, W., STOLNIK, S., THURECHT, K.J., HOWDLE, S.M. and ALEXANDER, C., 2011. Modular construction of multifunctional bioresponsive cell-targeted nanoparticles for gene delivery Bioconjugate Chemistry. 22(2), 156-168
XUE, X., PASPARAKIS, G., HALLIDAY, N., WINZER, K., HOWDLE, S.M., CRAMPHORN, C.J., CAMERON, N.R., GARDNER, P.M., DAVIS, B.G., FERNÁNDEZ-TRILLO, F. and ALEXANDER, C., 2011. Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference Angewandte Chemie International Edition. 50(42), 9852-9856
YASAYAN G., SAEED, A.O., FERNANDEZ-TRILLO, F., ALLEN, S., DAVIES, M.C., JANGHER, A., PAUL, A., THURECHT, K.J., KING, S.M., SCHWEINS, R., GRIFFITHS, P.C., MAGNUSSON, J.P. and ALEXANDER, C., 2011. Responsive hybrid block co-polymer conjugates of proteins-controlled architecture to modulate substrate specificity and solution behaviour Polymer Chemistry. 2(7), 1567-1578
IEONG, N.S., REDHEAD, M., BOSQUILLON, C., ALEXANDER, C., KELLAND, M. and O'REILLY, R.K., 2011. The missing lactam-thermoresponsive and biocompatible poly(N-vinylpiperidone) polymers by xanthate-mediated RAFT polymerization Macromolecules. 44(4), 886-893
SAMER R. ABULATEEFAH, SEBASTIAN G. SPAIN, JONATHAN W. AYLOTT, WENG CHAN, MARTIN C. GARNETT and CAMERON ALEXANDER, 2011. Thermoresponsive colloids in cancer therapy Macromolecular Bioscience.
DEY, S., KELLAM, B., ALEXANDER, M.R., ALEXANDER, C. and ROSE, F.R.A.J., 2011. Enzyme-passage free culture of mouse embryonic stem cells on thermo-responsive polymer surfaces Journal of Materials Chemistry. 21(19), 6883-6890
MASTROTTO, F., CALICETI, P., AMENDOLA, V., BERSANI, S., MAGNUSSON, J.P., MENEGHETTI, M., MANTOVANI, G., ALEXANDER, C. and SALMASO, S., 2011. Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting Chemical Communications. 47(35), 9846-9848
SHAHIDAN NN, LIU R, CELLESI F, ALEXANDER C, SHAKESHEFF KM and SAUNDERS BR, 2011. Thermally triggered assembly of cationic graft copolymers containing 2-(2-methoxyethoxy)ethyl methacrylate side chains. Langmuir : the ACS journal of surfaces and colloids. 27(22), 13868-78
ALEXANDER, C and O'REILLY, RK, 2011. Materials Chemistry In The Emerging Field Of Synthetic Biology
SOLIMAN, MAHMOUD, ALLEN, STEPHANIE, DAVIES, MARTYN C and ALEXANDER, CAMERON, 2010. Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics. Chemical Communications. 46(30), 5421-33
FRAYLICH, MICHAEL R, LIU, RUIXUE, RICHARDSON, STEPHEN M, BAIRD, PAULINE, HOYLAND, JUDITH, FREEMONT, ANTHONY J, ALEXANDER, CAMERON, SHAKESHEFF, KEVIN, CELLESI, FRANCESCO and SAUNDERS, BRIAN R, 2010. Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system. Journal of Colloid and Interface Science. 344(1), 61-9
SOLIMAN, M., NASANIT, R., ALLEN, S., DAVIES, M.C., BRIGGS, S.S., SEYMOUR, L.W., PREECE, J.A. and ALEXANDER, C., 2010. Interaction of reducible polypeptide gene delivery vectors with supported lipid bilayers: pore formation and structure–function relationships Soft Matter. 6(11), 2517-2524
ALEXANDER, C. and GILL, I., 2010. Responsive materials MRS BULLETIN- MATERIALS RESEARCH SOCIETY. VOL 35(NUMB 9), 659-664
NEWLAND, BEN, TAI, HONGYUN, ZHENG, YU, VELASCO, DIEGO, DI LUCA, ANDREA, HOWDLE, STEVEN M, ALEXANDER, CAMERON, WANG, WENXIN and PANDIT, ABHAY, 2010. A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP. Chemical Communications. 46(26), 4698-700
HEATH, F., SAEED, A., PENNADAM, S., THURECHT, K. and ALEXANDER, C., 2010. `Isothermal' phase transitions and supramolecular architecture changes in thermoresponsive polymers via acid-labile side-chains POLYMER CHEMISTRY. VOL 1(NUMBER 8), 1252-1262
THURECHT, K.J., BLAKEY, I., PENG, H., SQUIRES, O., HSU, S., ALEXANDER, C. and WHITTAKER, A.K., 2010. Functional hyperbranched polymers: toward targeted in vivo ¹⁹F magnetic resonance imaging using designed macromolecules Journal of the American Chemical Society. 132(15), 5336-5337
MAGNUSSON, JOHANNES PALL, BERSANI, SARA, SALMASO, STEFANO, ALEXANDER, CAMERON and CALICETI, PAOLO, 2010. In situ growth of side-chain PEG polymers from functionalized human growth hormone-a new technique for preparation of enhanced protein-polymer conjugates. Bioconjugate Chemistry. 21(4), 671-8
DONG, Y., GUNNING, P., CAO, H., MATHEW, A., NEWLAND, B., SAEED, A., MAGNUSSON, J., ALEXANDER, C., TAI, H. and PANDIT, A., 2010. Dual stimuli responsive PEG based hyperbranched polymers POLYMER CHEMISTRY. VOL 1(NUMBER 6), 827-830
SMALDON, J., ROMERO-CAMPERO, F.J., FERNÁNDEZ TRILLO, F., GHEORGHE, M., ALEXANDER, C. and KRASNOGOR, N., 2010. A computational study of liposome logic: towards cellular computing from the bottom up Systems and Synthetic Biology. 4(3), 157-179
WANG, W., LIANG, H., HAMILTON, L., FRAYLICH, M., SHAKESHEFF, K.M., SAUNDERS, B. and ALEXANDER, C., 2009. Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Systems prepared using a single-step process Advanced Materials. 21 (18), 1809-1813
SAEED, A.O., DEY, S., THURECHT, K.J., HOWDLE, S.M. and ALEXANDER, C., 2009. One pot controlled synthesis of biodegradable and biocompatible co-polymer micelles Journal of Materials Chemistry. 19, 4529-4535
SALMASO, S., CALICETI, P., AMENDOLA, V., MENEGHETTI, M., MAGNUSSON, J.P., PASPARAKIS, G. and ALEXANDER, C., 2009. Cell up-take control of gold nanoparticles functionalised with a thermoresponsive polymer Journal of Materials Chemistry. 19, 1608-1615
SMALDON, J., ALEXANDER, C., KRASNOGOR, N. and GHEORGHE, M., 2009. Liposome Logic: Artificial Life,Evolutionary Robotics, Adaptive Behaviour, Evolvable Hardware Track. GECCO (Proceedings of the 11th Genetic and Evolutionary Computation Conference. 2, 161-168
ROBINSON, I., ALEXANDER, C., TUNG, L.D., FERNIG, D.G. and THANH, N.T.K., 2009. Fabrication of water-soluble magnetic nanoparticles using thermo-responsive polymers Journal of Magnetism and Magnetic Materials. 321, 1421-1423
TAI, H., WANG, W., VERMONDEN, T., HEATH, F., ALEXANDER, C., HENNINK, W.E., SHAKESHEFF, K.M. and HOWDLE, S.M.., 2009. Thermoresponsive and Photocrosslinkable Hyperbranched Polymers from One-step ATRP Synthesis Biomacromolecules. 10, 822-828
PASPARAKIS, G, VAMVAKAKI, M, KRASNOGOR, N and ALEXANDER, C, 2009. Diol-Boronic Acid Complexes Integrated By Responsive Polymers-A Route To Chemical Sensing And Logic Operations Soft Matter. 5(20), 3839-3841
NASANIT, RUJIKAN, IQBAL, PARVEZ, SOLIMAN, MAHMOUD, SPENCER, NEIL, ALLEN, STEPHANIE, DAVIES, MARTYN C, BRIGGS, SIMON S, SEYMOUR, LEONARD W, PREECE, JON A and ALEXANDER, CAMERON, 2008. Combination dual responsive polypeptide vectors for enhanced gene delivery. Molecular BioSystems. 4(7), 741-5
FRAYLICH, M, WANG, W, SHAKESHEFF, K.M, ALEXANDER, C and SAUNDERS, B., 2008. Poly(d,l-lactide-co-glycolide) Dispersions Containing Pluronics: from Particle Preparation to Temperature-Triggered Aggregation. Langmuir. 24,, 7761-7768.
ALEXANDER, CAMERON, 2008. Convergence of synthetic and natural polymers: next generation nanomedicines? Nanomedicine (London, England). 3(6), 749-51
GRIFFITHS, PETER C, ALEXANDER, CAMERON, NILMINI, RENUKA, PENNADAM, SIVANAND S, KING, STEPHEN M and HEENAN, RICHARD K, 2008. Physicochemical characterization of thermoresponsive poly(N-isopropylacrylamide)-poly(ethylene imine) graft copolymers. Biomacromolecules. 9(4), 1170-8
JOHANNES PALL MAGNUSSON, ADNAN KHAN, GEORGE PASPARAKIS, ARAM OMER SAEED, WENXIN WANG, AND CAMERON ALEXANDER, 2008. Ion-sensitive ‘isothermal’ responsive polymers prepared in water Journal of the American Chemical Society. 130(33), 10852 - 10853
STOICA, FLORENTINA, ALEXANDER, CAMERON, TIRELLI, NICOLA, MILLER, ALINE F and SAIANI, ALBERTO, 2008. Selective synthesis of double temperature-sensitive polymer-peptide conjugates. Chemical Communications. 4433-5
ALEXANDER, CAMERON, 2008. Stimuli-responsive hydrogels: drugs take control. Nature Materials. 7(10), 767-8
PASPARAKIS, G. and ALEXANDER, C., 2008. Sweet talking double hydrophilic block copolymer vesicles Angewandte Chemie International Edition. 47(26), 4847-4850
FLORENTINA STOICA, CAMERON ALEXANDER, NICOLA TIRELLI, ALINE F. MILLER AND ALBERTO SAIANI, 2008. Selective synthesis of double temperature-sensitive polymer–peptide conjugates Chemical Communications. 4433 - 4435
WANG, WENXIN and ALEXANDER, CAMERON, 2008. Self-immolative polymers. Angewandte Chemie (International Edition in English). 47(41), 7804-6
PENNADAM, S.S., ELLIS, J.S., LAVIGNE, M.D., GORECKI, D.C., DAVIES, M.C. and ALEXANDER, C., 2007. Synthesis and characterization of variable-architecture thermosensitive polymers for complexation with DNA Langmuir. 23(1), 41-49
PASPARAKIS, G., COCKAYNE, A. and ALEXANDER, C., 2007. Control of bacterial aggregation by thermoresponsive glycopolymers Journal of the American Chemical Society. 129(36), 11014-11015
LAVIGNE, M.D., PENNADAM, S.S., ELLIS, J., YATES, L.L., ALEXANDER, C. and GÓRECKI, D.C., 2007. Enhanced gene expression through temperature profile-induced variations in molecular architecture of thermoresponsive polymer vectors Journal of Gene Medicine. 9(1), 44-54
HEATH, FELICITY, HARIA, PRINAL and ALEXANDER, CAMERON, 2007. Varying polymer architecture to deliver drugs. The AAPS journal. 9(2), E235-40
SALMASO, STEFANO, BERSANI, SARA, PENNADAM, SIVANAND S, ALEXANDER, CAMERON and CALICETI, PAOLO, 2007. Avidin bioconjugate with a thermoresponsive polymer for biological and pharmaceutical applications. International Journal of Pharmaceutics. 340(1-2), 20-8
ROBINSON, IAN, ALEXANDER, CAMERON, LU, LE T, TUNG, LE D, FERNIG, DAVID G and THANH, NGUYEN T K, 2007. One-step synthesis of monodisperse water-soluble 'dual-responsive' magnetic nanoparticles. Chemical Communications. 4602-4
STOICA, F., F. MILLER, A., ALEXANDER, C. and SAIANI, A., 2007. Thermo-Responsive PNIPAAm Copolymers with Hydrophobic Spacers MACROMOLECULAR SYMPOSIA. VOL 251, 33-40
PASPARAKIS, GEORGE and ALEXANDER, CAMERON, 2007. Synthetic polymers for capture and detection of microorganisms. Analyst. 132(11), 1075-82
CRONIN, L., KRASNOGOR, N., DAVIS, B.G., ALEXANDER, C., ROBERTSON, N., STEINKE, J.H.G., SCHROEDER, S.L.M., KHLOBYSTOV, A.N., COOPER, G., GARDNER, P.M., SEIPMANN, P., WHITAKER, B.J. and MARSH, D., 2006. The imitation game–a computational chemical approach to recognizing life. Nature Biotechnology. 24(10), 1203-1206
ALEXANDER,C., 2006. Temperature- and pH- responsive smart polymers for gene delivery Expert Opinion on Drug Delivery. 3(5), 573-581.
MOSS, GARY P, GULLICK, DARREN R, COX, PAUL A, ALEXANDER, CAMERON, INGRAM, MATTHEW J, SMART, JOHN D and PUGH, W JOHN, 2006. Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption. Journal of Pharmacy and Pharmacology. 58(2), 167-77
ALEXANDER, C., ANDERSSON, H. S., ANDERSSON, L. I., ANSELL, R. J., KIRSCH, N., NICHOLLS, I. A., OMAHONY, J. and WHITCOMBE, M. J., 2006. Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003 Journal of Molecular Recognition. VOL 19(NUMBER 2), 106-180
ALEXANDER,C.SHAKESHEFF,K.M., 2006. Polymers at the Biology/Materials Science Interface Advanced Materials. 18(24), 3321-3328
DE LAS HERAS ALARCÓN, C., FARHAN, T., OSBORNE, V.L., HUCK, W.T.S. and ALEXANDER, C., 2005. Bioadhesion at micro-patterned stimuli-responsive polymer brushes Journal of Materials Chemistry. 15(21), 2089-2094
TWAITES, B.R., DE LAS HERAS ALARCÓN, C., LAVIGNE, M., SAULNIER, A., PENNADAM, S.S., CUNLIFFE, D., GÓRECKI, D.C. and ALEXANDER, C., 2005. Thermoresponsive polymers as gene delivery vectors: cell viability, DNA transport and transfection studies Journal of Controlled Release. 108(2-3), 472-483
CUNLIFFE, D., KIRBY, A. and ALEXANDER, C., 2005. Molecularly imprinted drug delivery systems Advanced Drug Delivery Reviews. VOL 57(NUMBER 12), 1836-1853
DE LAS HERAS ALARCON, C., PENNADAM, S. and ALEXANDER, C., 2005. Stimuli responsive polymers for biomedical applications Chemical Society Reviews. VOL 34(NUMB 3), 276-285
ALARCON, C. D., TWAITES, B., CUNLIFFE, D., SMITH, J. R. and ALEXANDER, C., 2005. Grafted thermo- and pH responsive co-polymers: Surface-properties and bacterial adsorption International Journal of Pharmaceutics. VOL 295(NUMBER 1-2), 77-91
TWAITES, B., DE LAS HERAS ALARCON, C. and ALEXANDER, C., 2005. Synthetic polymers as drugs and therapeutics Journal of Materials Chemistry. VOL 15(NUMB 4), 441-455
PENNADAM, S.S., LAVIGNE, M.D., DUTTA, C.F., FIRMAN, K., MERNAGH, D., GÓRECKI, D.C. and ALEXANDER, C., 2004. Control of a multisubunit DNA motor by a thermoresponsive polymer switch Journal of the American Chemical Society. 126(41), 13208-13209
TWAITES, B.R., DE LAS HERAS ALARCÓN, C., CUNLIFFE, D., LAVIGNE, M., PENNADAM, S., SMITH, J.R., GÓRECKI, D.C. and ALEXANDER, C., 2004. Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro Journal of Controlled Release. 97(3), 551-566
CUNLIFFE, D., PENNADAM, S. and ALEXANDER, C., 2004. Synthetic and biological polymers--merging the interface European Polymer Journal. VOL 40(NUMBER 1), 5-25
PENNADAM,, FIRMAN,, ALEXANDER, and GÃ³RECKI,, 2004. Protein-polymer nano-machines. Towards synthetic control of biological processes. Journal of Nanobiotechnology. 2(1), 8
KIRSCH, N., ALEXANDER, C., DAVIES, S. and WHITCOMBE, M. J., 2004. Sacrificial spacer and non-covalent routes toward the molecular imprinting of "poorly-functionalized" N-heterocycles Analytica Chimica Acta. VOL 504(NUMBER 1), 63-71
CUNLIFFE, D., DE LAS HERAS ALARCÓN, C., PETERS, V., SMITH, J.R. and ALEXANDER, C., 2003. Thermoresponsive surface-grafted poly(N-isopropylacrylamide) copolymers: effect of phase transitions on protein and bacterial attachment Langmuir. 19(7), 2888-2899
ALEXANDER, C., DAVIDSON, L. and HAYES, W., 2003. Imprinted polymers: artificial molecular recognition materials with applications in synthesis and catalysis Tetrahedron. VOL 59(NUMBER 12), 2025-2057
MARSH, L. H., ALEXANDER, C., COKE, M., DETTMAR, P. W., HAVLER, M., NEVELL, T. G., SMART, J. D., TIMMINS, B. and TSIBOUKLIS, J., 2003. Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion International Journal of Pharmaceutics. VOL 251(NUMBER 1-2), 155-163
JONES, D.M., SMITH, J.R., HUCK, W.T.S. and ALEXANDER, C., 2002. Variable adhesion of micropatterned thermoresponsive polymer brushes: AFM investigations of poly(N-isopropylacrylamide) brushes prepared by surface-initiated polymerizations Advanced Materials. 14(16), 1130-1134
MARSH, L.H., COKE, M., DETTMAR, P.W., EWEN, R.J., HAVLER, M., NEVELL, T.G., SMART, J.D.., SMITH, J.R., TIMMINS, B., TSIBOUKLIS, J. and ALEXANDER, C., 2002. Adsorbed poly(ethyleneoxide)–poly(propyleneoxide) copolymers on synthetic surfaces: spectroscopy and microscopy of polymer structures and effects on adhesion of skin-borne bacteria Journal of Biomedical Materials Research. 61(4), 641-652
D'SOUZA,S.M., ALEXANDER,C., CARR,S.W., WALLER,A.M., WHITCOMBE,M.J. and VULFSON,E.N., 1999. Directed nucleation of calcite at a crystal-imprinted polymer surface Nature. 398(6725), 312-316
ALEXANDER,C., SMITH,C.R., WHITCOMBE,M.J. and VULFSON,E.N, 1999. Imprinted polymers as protecting groups for regioselective modification of polyfunctional substrates Journal of the American Chemical Society. 121(28), 6640-6651.
PHAN, HIEN, MINUT, I, ROBERT, MCCRORIE, PHOEBE, VASEY, CATHERINE, LARDER, RYAN R., KRUMINS, EDUARDS, MARLOW, MARIA, RAHMAN, RUMAN, ALEXANDER, CAMERON, TARESCO, VINCENZO and PEARCE, AMANDA K., Role of self-assembly conditions and amphiphilic balance on nanoparticle formation of PEG-PDLLA copolymers in aqueous environments JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY.