School of Chemistry

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Christopher Moody

Professor of Organic Chemistry (Emeritus),



Chris Moody is Sir Jesse Boot Professor of Chemistry and Head of Organic Chemistry at the University of Nottingham. He is a Mancunian and was educated at Manchester Grammar School and King's College, London, before carrying out his PhD research at the University of Liverpool under the supervision of Charles Rees investigating the synthesis and reactions of nitrogen-sulfur ylides. He spent a postdoctoral year at the ETH in Zürich working with Albert Eschenmoser on the stereochemistry of 1,4-elimination reactions before taking up a post in industry at Roche. In 1979 he was appointed to a lectureship at Imperial College, London, and was promoted to a readership in 1989. In 1990 moved to the chair of organic chemistry at Loughborough University, and in 1996 he was appointed Professor of Organic Chemistry at the University of Exeter. He moved to his current post in Nottingham in August 2005.

He has published over 390 papers and his work has been recognised with several awards including the RSC Hickinbottom Fellowship and Corday Morgan Medal (both in 1986), the Tilden Medal and Lectureship (2000-2001), the Adrien Albert Medal and Lectureship (2001), an EPSRC Senior Research Fellowship (2000-2005), the Royal Society of Chemistry Award for Synthetic Organic Chemistry (2006), the Pedler Lectureship (2008), the Novartis International Lectureship (2010-2011), and the Royal Society of Chemistry Charles Rees Award (2012).

Research Summary

Sustainable synthetic methodology

  • new methods in heterocyclic chemistry; new routes to indoles, pyridines, oxazoles, thiazoles etc.
  • dirhodium(II) catalysed N-H insertion reaction
  • precious metal free coupling reactions
  • solar photochemistry
  • catalytic oxidation methods in organic synthesis

Natural Product Synthesis

  • marine natural products
  • cyclic peptides
  • thiopeptide antibiotics
  • quinone ansamycin antibiotics

Molecular targeting of cancer, malaria and neurodegeneration

  • anticancer agents based on heterocyclic quinones
  • design of substrates and inhibitors of NADH quinone oxidoreductase (NQO1, NQO2)
  • role of other redox enzymes in disease, e.g. thioredoxin, indoleamine dioxygenase (IDO)
  • inhibitors of heat shock proteins.

Recent Publications

  • K. BOUZINAB, H. S. SUMMERS, M. F. G. STEVENS, C. J. MOODY, N. R. THOMAS, P. GERSHKOVICH, N. WESTON, M. B. ASHFORD, T. D. BRADSHAW and L. TURYANSKA, 2020. Delivery of temozolomide and N3-propargyl analog to brain tumors using an apoferritin nanocage: ACS Appl. Mater. Interfaces ACS Appl. Mater. Interfaces. 12, 12609-12617
  • H. S. SUMMERS, M. B. FOREITER, W. LEWIS, C. J. MOODY, T. D. BRADSHAW and M. F. G. STEVENS, 2020. Modulation of the acidity of the 8-carboxamide group in the temozolomide family of antitumour imidazo[5,1-d]-1,2,3,5-tetrazines: Arkivoc Arkivoc. 36-45
  • ROBINSON, H., OATLEY, S. A., ROWEDDER, J. E., SLADE, P., MACDONALD, S. J. F., ARGENT, S. P., HIRST, J. D., MCINALLY, T. and MOODY, C. J., 2020. Late-Stage Functionalization by Chan-Lam Amination: Rapid Access to Potent and Selective Integrin Inhibitors: Chemistry-a European Journal Chemistry-a European Journal. 26(34), 7678-7684
  • K. BOUZINAB, H. SUMMERS, J. ZHANG, M. F. G. STEVENS, C. J. MOODY, L. TURYANSKA, N. R. THOMAS, P. GERSHKOVICH, M. B. ASHFORD, E. VITTERSO, L. C. D. STORER, R. GRUNDY and T. D. BRADSHAW, 2019. In search of effective therapies to overcome resistance to temozolomide in brain tumours: Cancer Drug Resist. Cancer Drug Resist.. 2, 1018-1031

School of Chemistry

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