Gary Mirams

Contact

• workRoom B49 School of Mathematical Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 7486067
• Gary.Mirams@nottingham.ac.uk
• http://www.maths.nottingham.ac.uk/personal/pmzgm/

Research Summary

My research is in mathematical/computational biology. I work on modelling to address cardiac electrophysiology questions, particularly pharmaceutical drug safety (this involves mathematical modelling… read more

Recent Publications

• LEI, CHON LOK and MIRAMS, GARY R., 2021. Neural Network Differential Equations For Ion Channel Modelling FRONTIERS IN PHYSIOLOGY. 12,
• KEMP, JACOB M., WHITTAKER, DOMINIC G., VENKATESHAPPA, RAVICHANDRA, PANG, ZHAOKAI, JOHAL, RAJ, SERGEEV, VALENTINE, TIBBITS, GLEN F., MIRAMS, GARY R. and CLAYDON, THOMAS W., 2021. Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243 JOURNAL OF GENERAL PHYSIOLOGY. 153(10),
• CLERX, MICHAEL, MIRAMS, GARY R., ROGERS, ALBERT J., NARAYAN, SANJIV M. and GILES, WAYNE R., 2021. Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia FRONTIERS IN PHYSIOLOGY. 12,
• WHITTAKER, DOMINIC G., CAPEL, REBECCA A., HENDRIX, MAURICE, CHAN, XIN HUI S., HERRING, NEIL, WHITE, NICHOLAS J., MIRAMS, GARY R. and BURTON, REBECCA-ANN B., 2021. Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine ROYAL SOCIETY OPEN SCIENCE. 8(4),

• View all publications

Current Research

My research is in mathematical/computational biology. I work on modelling to address cardiac electrophysiology questions, particularly pharmaceutical drug safety (this involves mathematical modelling of ion channels, drug interactions with ion channels, cardiac action potential modelling, cardiac tissue modelling and arrhythmia mechanisms). On the mathematical side I am interested in statistical inference for mechanistic models, and in particular experimental design to help calibrate model parameters, select between alternative models, and assess model discrepancy. Please see my research homepage for more information.

• LEI, CHON LOK and MIRAMS, GARY R., 2021. Neural Network Differential Equations For Ion Channel Modelling FRONTIERS IN PHYSIOLOGY. 12,
• KEMP, JACOB M., WHITTAKER, DOMINIC G., VENKATESHAPPA, RAVICHANDRA, PANG, ZHAOKAI, JOHAL, RAJ, SERGEEV, VALENTINE, TIBBITS, GLEN F., MIRAMS, GARY R. and CLAYDON, THOMAS W., 2021. Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243 JOURNAL OF GENERAL PHYSIOLOGY. 153(10),
• CLERX, MICHAEL, MIRAMS, GARY R., ROGERS, ALBERT J., NARAYAN, SANJIV M. and GILES, WAYNE R., 2021. Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia FRONTIERS IN PHYSIOLOGY. 12,
• WHITTAKER, DOMINIC G., CAPEL, REBECCA A., HENDRIX, MAURICE, CHAN, XIN HUI S., HERRING, NEIL, WHITE, NICHOLAS J., MIRAMS, GARY R. and BURTON, REBECCA-ANN B., 2021. Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine ROYAL SOCIETY OPEN SCIENCE. 8(4),
• LEI, CHON LOK, FABBRI, ALAN, WHITTAKER, DOMINIC G, CLERX, MICHAEL, WINDLEY, MONIQUE J, HILL, ADAM P, MIRAMS, GARY R and DE BOER, TEUN P, 2020. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer. Wellcome open research. 5, 152
• CAMPORESI, MARIA, BARTOLUCCI, CHIARA, LEI, CHON LOK, MIRAMS, GARY R., DE BOER, TEUN P. and SEVERI, STEFANO, 2020. Development, Implementation and Testing of a Multicellular Dynamic Action Potential Clamp Simulator for Drug Cardiac Safety Assessment 2020 COMPUTING IN CARDIOLOGY.
• DAVIES, MARK R., MARTINEC, MICHAEL, WALLS, ROBERT, SCHWARZ, ROMAN, MIRAMS, GARY R., WANG, KEN, STEINER, GUIDO, SURINACH, ANDY, FLORES, CARLOS, LAVE, THIERRY, SINGER, THOMAS and POLONCHUK, LIUDMILA, 2020. Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk CELL REPORTS MEDICINE. 1(5),
• LEI, CHON LOK, CLERX, MICHAEL, WHITTAKER, DOMINIC G., GAVAGHAN, DAVID J., DE BOER, TEUN P. and MIRAMS, GARY R., 2020. Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
• MIRAMS, GARY R., NIEDERER, STEVEN A. and CLAYTON, RICHARD H., 2020. The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
• LEI, CHON LOK, GHOSH, SANMITRA, WHITTAKER, DOMINIC G., ABOELKASSEM, YASSER, BEATTIE, KYLIE A., CANTWELL, CHRIS D., DELHAAS, TAMMO, HOUSTON, CHARLES, NOVAES, GUSTAVO MONTES, PANFILOV, ALEXANDER V., PATHMANATHAN, PRAS, RIABIZ, MARINA, DOS SANTOS, RODRIGO WEBER, WALMSLEY, JOHN, WORDEN, KEITH, MIRAMS, GARY R. and WILKINSON, RICHARD D., 2020. Considering discrepancy when calibrating a mechanistic electrophysiology model PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
• RIDDER, BRADLEY J., LEISHMAN, DEREK J., BRIDGLAND-TAYLOR, MATTHEW, SAMIEEGOHAR, MOHAMMADREZA, HAN, XIAOMEI, WU, WENDY W., RANDOLPH, AARON, TRAN, PHU, SHENG, JIANSONG, DANKER, TIMM, LINDQVIST, ANDERS, KONRAD, DANIEL, HEBEISEN, SIMON, POLONCHUK, LIUDMILA, GISSINGER, EVGENIA, RENGANATHAN, MUTHUKRISHNAN, KOCI, BRYAN, WEI, HAIYANG, FAN, JINGSONG, LEVESQUE, PAUL, KWAGH, JAE, IMREDY, JOHN, ZHAI, JIN, ROGERS, MARC, HUMPHRIES, EDWARD, KIRBY, ROBERT, STOELZLE-FEIX, SONJA, BRINKWIRTH, NINA, ROTORDAM, MARIA GIUSTINA, BECKER, NADINE, FRIIS, SOREN, RAPEDIUS, MARKUS, GOETZE, TOM A., STRASSMAIER, TIM, OKEYO, GEORGE, KRAMER, JAMES, KURYSHEV, YURI, WU, CAIYUN, HIMMEL, HERBERT, MIRAMS, GARY R., STRAUSS, DAVID G., BARDENET, REMI and LI, ZHIHUA, 2020. A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm (vol 394C, 114961, 2020) TOXICOLOGY AND APPLIED PHARMACOLOGY. 395,
• LI, ZHIHUA, MIRAMS, GARY R., YOSHINAGA, TAKASHI, RIDDER, BRADLEY J., HAN, XIAOMEI, CHEN, JANELL E., STOCKBRIDGE, NORMAN L., WISIALOWSKI, TODD A., DAMIANO, BRUCE, SEVERI, STEFANO, MORISSETTE, PIERRE, KOWEY, PETER R., HOLBROOK, MARK, SMITH, GODFREY, RASMUSSON, RANDALL L., LIU, MICHAEL, SONG, ZHEN, QU, ZHILIN, LEISHMAN, DEREK J., STEIDL-NICHOLS, JILL, RODRIGUEZ, BLANCA, BUENO-OROVIO, ALFONSO, ZHOU, XIN, PASSINI, ELISA, EDWARDS, ANDREW G., MOROTTI, STEFANO, NI, HAIBO, GRANDI, ELEONORA, CLANCY, COLLEEN E., VANDENBERG, JAMIE, HILL, ADAM, NAKAMURA, MIKIKO, SINGER, THOMAS, POLONCHUK, LIUDMILA, GREITER-WILKE, ANDREA, WANG, KEN, NAVE, STEPHANE, FULLERTON, AARON, SOBIE, ERIC A., PACI, MICHELANGELO, TSHINANU, FLORA MUSUAMBA and STRAUSS, DAVID G., 2020. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy CLINICAL PHARMACOLOGY & THERAPEUTICS. 107(1), 102-111
• LIN, YU-PING, BAKOWSKI, DANIEL, MIRAMS, GARY R. and PAREKH, ANANT B., 2019. Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orail channel clusters NATURE COMMUNICATIONS. 10,
• BEENTJES, C. H. L., TAYLOR-KING, J. P., BAYANI, A., DAVIS, C. N., DUNSTER, J. L., JABBARI, S., MIRAMS, G. R., JENKINSON, C., KILBY, M. D., HEWISON, M. and TAMBLYN, J. A., 2019. Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 190, 152-160
• LI, ZHIHUA, MIRAMS, GARY R. and STRAUSS, DAVID G., 2019. Response to "CiPA's Complexity Bias" CLINICAL PHARMACOLOGY & THERAPEUTICS. 105(6), 1325-1325
• BOWLER, LOUISE A., GAVAGHAN, DAVID J., MIRAMS, GARY R. and WHITELEY, JONATHAN P., 2019. Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology BULLETIN OF MATHEMATICAL BIOLOGY. 81(1), 7-38
• LI, ZHIHUA, RIDDER, BRADLEY J., HAN, XIAOMEI, WU, WENDY W., SHENG, JIANSONG, TRAN, PHU N., WU, MIN, RANDOLPH, AARON, JOHNSTONE, ROSS H., MIRAMS, GARY R., KURYSHEV, YURI, KRAMER, JAMES, WU, CAIYUN, CRUMB, WILLIAM J., JR. and STRAUSS, DAVID G., 2019. Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative CLINICAL PHARMACOLOGY & THERAPEUTICS. 105(2), 466-475
• CLERX, MICHAEL, BEATTIE, KYLIE A., GAVAGHAN, DAVID J. and MIRAMS, GARY R., 2019. Four Ways to Fit an Ion Channel Model BIOPHYSICAL JOURNAL. 117(12), 2420-2437
• LEI, CHON LOK, CLERX, MICHAEL, BEATTIE, KYLIE A., MELGARI, DARIO, HANCOX, JULES C., GAVAGHAN, DAVID J., POLONCHUK, LIUDMILA, WANG, KEN and MIRAMS, GARY R., 2019. Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence BIOPHYSICAL JOURNAL. 117(12), 2455-2470
• LEI, CHON LOK, CLERX, MICHAEL, GAVAGHAN, DAVID J., POLONCHUK, LIUDMILA, MIRAMS, GARY R. and WANG, KEN, 2019. Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System BIOPHYSICAL JOURNAL. 117(12), 2438-2454
• SAMANTA, KRISHNA, MIRAMS, GARY R. and PAREKH, ANANT B., 2018. Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria NATURE COMMUNICATIONS. 9,
• BEATTIE, K, HILL, AP, CUI, Y, VANDENBERG, JI, GAVAGHAN, DJ, DE BOER, TP and MIRAMS, GR, 2018. Sinusoidal voltage protocols for rapid characterization of ion channel kinetics The Journal of Physiology. 596(10), 1813-1828
• DALY, AIDAN C, CLERX, MICHAEL, BEATTIE, KYLIE A, COOPER, JONATHAN, GAVAGHAN, DAVID J and MIRAMS, GARY R, 2018. Reproducible model development in the cardiac electrophysiology Web Lab. Progress in biophysics and molecular biology.
• LI, ZHIHUA, RIDDER, BRADLEY J, HAN, XIAOMEI, WU, WENDY W, SHENG, JIANSONG, TRAN, PHU N, WU, MIN, RANDOLPH, AARON, JOHNSTONE, ROSS H, MIRAMS, GARY R, KURYSHEV, YURI, KRAMER, JAMES, WU, CAIYUN, CRUMB, WILLIAM J JR and STRAUSS, DAVID G, 2018. Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative. Clinical pharmacology and therapeutics.
• ASTON D, CAPEL RA, FORD KL, CHRISTIAN HC, MIRAMS GR, ROG-ZIELINSKA EA, KOHL P, GALIONE A, BURTON RA and TERRAR DA, 2017. High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart. Scientific reports. 7, 40620
• JOHNSTONE RH, BARDENET R, GAVAGHAN DJ and MIRAMS GR, 2017. Hierarchical Bayesian inference for ion channel screening dose-response data. Wellcome open research. 1, 6
• LIGNEAU, XAVIER, SHAH, RASHMI R., BERREBI-BERTRAND, ISABELLE, MIRAMS, GARY R., ROBERT, PHILIPPE, LANDAIS, LAURENT, MAISON-BLANCHE, PIERRE, FAIVRE, JEAN-FRANCOIS, LECOMTE, JEANNE-MARIE and SCHWARTZ, JEAN-CHARLES, 2017. Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies BRITISH JOURNAL OF PHARMACOLOGY. 174(23), 4449-4463
• LEI, CHON LOK, WANG, KEN, CLERX, MICHAEL, JOHNSTONE, ROSS H., HORTIGON-VINAGRE, MARIA P., ZAMORA, VICTOR, ALLAN, ANDREW, SMITH, GODFREY L., GAVAGHAN, DAVID J., MIRAMS, GARY R. and POLONCHUK, LIUDMILA, 2017. Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology FRONTIERS IN PHYSIOLOGY. 8,
• CHANG, KELLY C., DUTTA, SARA, MIRAMS, GARY R., BEATTIE, KYLIE A., SHENG, JIANSONG, TRAN, PHU N., WU, MIN, WU, WENDY W., COLATSKY, THOMAS, STRAUSS, DAVID G. and LI, ZHIHUA, 2017. Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment FRONTIERS IN PHYSIOLOGY. 8,
• MCMILLAN, BETH, GAVAGHAN, DAVID J. and MIRAMS, GARY R., 2017. Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator TOXICOLOGY RESEARCH. 6(6), 912-921
• HARTUNG, THOMAS, FITZGERALD, REX E., JENNINGS, PAUL, MIRAMS, GARY R., PEITSCH, MANUEL C., ROSTAMI-HODJEGAN, AMIN, SHAH, IMRAN, WILKS, MARTIN F. and STURLA, SHANA J., 2017. Systems Toxicology: Real World Applications and Opportunities CHEMICAL RESEARCH IN TOXICOLOGY. 30(4), 870-882
• MAHONEY VM, MEZZANO V, MIRAMS GR, MAASS K, LI Z, CERRONE M, VASQUEZ C, BAPAT A, DELMAR M and MORLEY GE, 2016. Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart. Scientific reports. 6, 26744
• AP HILL, MD PERRY, N ABI-GERGES, J-P COUDEREC, B FERMINI, JC HANCOX, BC KNOLLMANN, GR MIRAMS, J SKINNER, W ZAREBA and JI VANDENBERG, 2016. Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Grand Challenges for Cardiology in the 21(st) Century. The Journal of physiology. 594(23), 6893-6908
• GR MIRAMS, P PATHMANATHAN, RA GRAY, P CHALLENOR and RH CLAYTON, 2016. White paper: Uncertainty and variability in computational and mathematical models of cardiac physiology. The Journal of physiology. 594(23), 6833-6847
• DAVIES MR, WANG K, MIRAMS GR, CARUSO A, NOBLE D, WALZ A, LAVÉ T, SCHULER F, SINGER T and POLONCHUK L, 2016. Recent developments in using mechanistic cardiac modelling for drug safety evaluation. Drug discovery today. 21(6), 924-38
• COOPER J, SCHARM M and MIRAMS GR, 2016. The Cardiac Electrophysiology Web Lab. Biophysical journal. 110(2), 292-300
• JOHNSTONE RH, CHANG ET, BARDENET R, DE BOER TP, GAVAGHAN DJ, PATHMANATHAN P, CLAYTON RH and MIRAMS GR, 2016. Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models? Journal of Molecular and Cellular Cardiology. 96, 49-62
• KAR P, MIRAMS GR, CHRISTIAN HC and PAREKH AB, 2016. Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca(2+) Signals. Molecular cell. 64(4), 746-759
• SAMANTA K, KAR P, MIRAMS GR and PAREKH AB, 2015. Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression. Cell reports. 12(2), 203-16
• CAPEL RA, HERRING N, KALLA M, YAVARI A, MIRAMS GR, DOUGLAS G, BUB G, CHANNON K, PATERSON DJ, TERRAR DA and BURTON RA, 2015. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential. Heart rhythm : the official journal of the Heart Rhythm Society. 12(10), 2186-94
• WILLIAMS G and MIRAMS GR, 2015. A web portal for in-silico action potential predictions. Journal of pharmacological and toxicological methods. 75, 10-6
• COOPER J, SPITERI RJ and MIRAMS GR, 2015. Cellular cardiac electrophysiology modeling with Chaste and CellML. Frontiers in physiology. 5, 511
• WANG K, LEE P, MIRAMS GR, SARATHCHANDRA P, BORG TK, GAVAGHAN DJ, KOHL P and BOLLENSDORFF C, 2015. Cardiac tissue slices: preparation, handling, and successful optical mapping. American journal of physiology. Heart and circulatory physiology. 308(9), H1112-25
• WALMSLEY J, MIRAMS GR, PITT-FRANCIS J, RODRIGUEZ B and BURRAGE K, 2014. Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue. Journal of theoretical biology. 365, 325-36
• MIRAMS GR, DAVIES MR, BROUGH SJ, BRIDGLAND-TAYLOR MH, CUI Y, GAVAGHAN DJ and ABI-GERGES N, 2014. Prediction of Thorough QT study results using action potential simulations based on ion channel screens. Journal of pharmacological and toxicological methods. 70(3), 246-54
• OSBORNE JM, BERNABEU MO, BRUNA M, CALDERHEAD B, COOPER J, DALCHAU N, DUNN SJ, FLETCHER AG, FREEMAN R, GROEN D, KNAPP B, MCINERNY GJ, MIRAMS GR, PITT-FRANCIS J, SENGUPTA B, WRIGHT DW, YATES CA, GAVAGHAN DJ, EMMOTT S and DEANE C, 2014. Ten simple rules for effective computational research. PLoS computational biology. 10(3), e1003506
• ELKINS RC, DAVIES MR, BROUGH SJ, GAVAGHAN DJ, CUI Y, ABI-GERGES N and MIRAMS GR, 2013. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment. Journal of pharmacological and toxicological methods. 68(1), 112-22
• BEATTIE KA, LUSCOMBE C, WILLIAMS G, MUNOZ-MURIEDAS J, GAVAGHAN DJ, CUI Y and MIRAMS GR, 2013. Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge. Journal of pharmacological and toxicological methods. 68(1), 88-96
• MIRAMS GR, ARTHURS CJ, BERNABEU MO, BORDAS R, COOPER J, CORRIAS A, DAVIT Y, DUNN SJ, FLETCHER AG, HARVEY DG, MARSH ME, OSBORNE JM, PATHMANATHAN P, PITT-FRANCIS J, SOUTHERN J, ZEMZEMI N and GAVAGHAN DJ, 2013. Chaste: an open source C++ library for computational physiology and biology. PLoS computational biology. 9(3), e1002970
• WALMSLEY J, RODRIGUEZ JF, MIRAMS GR, BURRAGE K, EFIMOV IR and RODRIGUEZ B, 2013. mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study. PloS one. 8(2), e56359
• BRIDGE, LJ, MIRAMS, GR, KIEFFER, ML, KING, JR and KEPINSKI, S, 2012. Distinguishing Possible Mechanisms For Auxin-Mediated Developmental Control In Arabidopsis: Models With Two Aux/Iaa And Arf Proteins, And Two Target Gene-Sets Mathematical Biosciences. 235(1), 32-44
• ZEMZEMI N, BERNABEU MO, SAIZ J, COOPER J, PATHMANATHAN P, MIRAMS GR, PITT-FRANCIS J and RODRIGUEZ B, 2012. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials. British journal of pharmacology. 168(3), 718-33
• MIRAMS GR, FLETCHER AG, MAINI PK and BYRNE HM, 2012. A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt. Journal of theoretical biology. 312, 143-56
• JONSSON MK, VOS MA, MIRAMS GR, DUKER G, SARTIPY P, DE BOER TP and VAN VEEN TA, 2012. Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. Journal of molecular and cellular cardiology. 52(5), 998-1008
• MIRAMS GR, DAVIES MR, CUI Y, KOHL P and NOBLE D, 2012. Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing. British journal of pharmacology. 167(5), 932-45
• MIRAMS GR and NOBLE D, 2012. Is it time for in silico simulation of drug cardiac side effects? Annals of the New York Academy of Sciences. 1245, 44-7
• QUINN TA, GRANITE S, ALLESSIE MA, ANTZELEVITCH C, BOLLENSDORFF C, BUB G, BURTON RA, CERBAI E, CHEN PS, DELMAR M, DIFRANCESCO D, EARM YE, EFIMOV IR, EGGER M, ENTCHEVA E, FINK M, FISCHMEISTER R, FRANZ MR, GARNY A, GILES WR, HANNES T, HARDING SE, HUNTER PJ, IRIBE G, JALIFE J, JOHNSON CR, KASS RS, KODAMA I, KOREN G, LORD P, MARKHASIN VS, MATSUOKA S, MCCULLOCH AD, MIRAMS GR, MORLEY GE, NATTEL S, NOBLE D, OLESEN SP, PANFILOV AV, TRAYANOVA NA, RAVENS U, RICHARD S, ROSENBAUM DS, RUDY Y, SACHS F, SACHSE FB, SAINT DA, SCHOTTEN U, SOLOVYOVA O, TAGGART P, TUNG L, VARRÓ A, VOLDERS PG, WANG K, WEISS JN, WETTWER E, WHITE E, WILDERS R, WINSLOW RL and KOHL P, 2011. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Progress in biophysics and molecular biology. 107(1), 4-10
• BRIDGE LJ, MIRAMS GR, KIEFFER ML, KING JR and KEPINSKI S, 2011. Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: models with two Aux/IAA and ARF proteins, and two target gene-sets. Mathematical biosciences. 235(1), 32-44
• COOPER J, MIRAMS GR and NIEDERER SA, 2011. High-throughput functional curation of cellular electrophysiology models. Progress in biophysics and molecular biology. 107(1), 11-20
• FLETCHER K, SHAH RR, THOMAS A, TOBIN F, RODRIGUEZ B, MIRAMS GR, SAIZ J and NOBLE D, 2011. Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs. Drug safety. 34(5), 439-43
• MIRAMS GR, CUI Y, SHER A, FINK M, COOPER J, HEATH BM, MCMAHON NC, GAVAGHAN DJ and NOBLE D, 2011. Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research. 91(1), 53-61
• MIRAMS, G.R and BYRNE, H.M. AND KING, J.R., 2010. A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway. J. Math. Biol.. 60, 131-160
• OSBORNE, J.M., WALTER, A., KERSHAW, S., MIRAMS, G.R., FLETCHER, A.G., PATHMANATHAN, P., GAVAGHAN, D., JENSEN, O.E., MAINI, P.K. and BYRNE, H.M., 2010. A hybrid approach to multiscale modelling of cancer Philosophical Transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences. 368, 5013-5028
• WALMSLEY J, MIRAMS G, BAHOSHY M, BOLLENSDORFF C, RODRIGUEZ B and BURRAGE K, 2010. Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2010, 1457-60
• MURRAY PJ, KANG JW, MIRAMS GR, SHIN SY, BYRNE HM, MAINI PK and CHO KH, 2010. Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts. Biophysical journal. 99(3), 716-25
• OSBORNE JM, WALTER A, KERSHAW SK, MIRAMS GR, FLETCHER AG, PATHMANATHAN P, GAVAGHAN D, JENSEN OE, MAINI PK and BYRNE HM, 2010. A hybrid approach to multi-scale modelling of cancer. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. 368(1930), 5013-28
• VAN LEEUWEN, I.M.M, MIRAMS, G.R, WALTER, A, FLETCHER, A, MURRAY, P, OSBORNE, J, COOPER, J, PITT-FRANCIS, J, MOMTAHAN, L, PATHMANATHAN, P, WHITELEY, J.P, JENSEN, O.E, EASTBURN, S.J and VARMA,, 2009. An integrative computational model for intestinal tissue renewal Cell Proliferation. 42, 617-636
• VAN LEEUWEN IM, MIRAMS GR, WALTER A, FLETCHER A, MURRAY P, OSBORNE J, VARMA S, YOUNG SJ, COOPER J, DOYLE B, PITT-FRANCIS J, MOMTAHAN L, PATHMANATHAN P, WHITELEY JP, CHAPMAN SJ, GAVAGHAN DJ, JENSEN OE, KING JR, MAINI PK, WATERS SL and BYRNE HM, 2009. An integrative computational model for intestinal tissue renewal. Cell proliferation. 42(5), 617-36
• PATHMANATHAN P, COOPER J, FLETCHER A, MIRAMS G, MURRAY P, OSBORNE J, PITT-FRANCIS J, WALTER A and CHAPMAN SJ, 2009. A computational study of discrete mechanical tissue models. Physical biology. 6(3), 036001