Research and Innovation

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Kevin Hughes

Provide support to help secure translational healthcare funding for individual research projects from a range of funders including the Research Councils, NHS and medical charities and also to secure and manage institutional translational healthcare awards including the MRC Confidence in Concept (CiC) awards., Financial & Business Services



I received a degree in Biochemistry from the University of York followed by a PhD at the University of Nottingham where I studied under Prof. Yash Mahida investigating the role of intestinal myofibroblasts in inflammatory bowel disease. During this period, I also undertook work using murine models of parasite infection and inflammation.

I was subsequently employed as a postdoctoral research fellow at the University of Nottingham where I worked on intestinal stem cells in the murine gut using in vivo mouse models.

In 2011, I moved to a senior postdoctoral post in a joint appointment role between the University of East Anglia and the Institute for Food Research. Work was focussed primarily on the understanding of interactions between the gut epithelium and the intestinal microbiota.

In 2015, I joined Mars Petcare as a Research Manager in digestive health and as microbiome work-stream lead where my responsibilities included providing strategic direction, compiling and presenting business cases to senior management to secure internal funding, developing and maintaining collaborations with key external organisations, managing internal stakeholder interactions with varied business units and managing the delivery of the research through a team of researchers.

I finally returned to the University of Nottingham in June 2019 in my current role.

Expertise Summary

  • Gut epithelial / mucosal biology
  • Molecular biology
  • Microbiome
  • Project Management
  • Translational healthcare

Past Research

Slow Cycling Intestinal Stem Cell Responses to Trichinella Spiralis Infection

T. Javkar, K.R. Hughes, F. Sablitzky, J.M. Behnke, Y.R. Mahida

Parasitology International (2019) May 2:101923

Canine and Feline Microbiomes

C.V. Wallis, Z.V. Marshall-Jones, O. Deusch and K.R. Hughes

Understanding Host Microbe Interactions - An Omics Approach, Springer (2018), p.279-326

Characterisation of a Canine Epithelial Cell Line in Modelling the Intestinal Barrier

M. J. Farquhar, E. McCluskey, R.H. Staunton, K.R. Hughes, J.C. Coltherd

Alternatives to Laboratory Animal (2018) Jul; 46(3):115-132.

Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner

K.R. Hughes, L.C. Harnisch, C.Alcon-Giner, S.Mitra, C.J. Wright, J. Ketskemety, D. van Sinderen, A.J. Watson, L.J. Hall.

Open Biology (2017), Jan; 7(1)

Pilot Study to Assess Meal Progression Through the Gastrointestinal Tract of Habituated Dogs Determined by Fluoroscopic Imaging Without Sedation or Physical Restraint

D.J. Wrigglesworth, M.Q. Bailey, A. Colyer, K.R. Hughes.

Veterinary Radiology and Ultrasound (2016) Nov; 57(6):565-571

Toll-like Receptor Expression in Crypt Epithelial Cells, Putative Stem Cells and Intestinal Myofibroblasts Isolated from Controls and Patients with Inflammatory Bowel Disease

M Brown, K R Hughes, S Moossavi, A Robins, Y R Mahida.

Clinical and Experimental Immunology (2014), 178(1):28-39

A Mouse Model of Pathological Small Intestinal Epithelial Cell Apoptosis and Shedding Induced by Systemic Administration of Lipopolysaccharide

J.M. Williams, C.A. Duckworth, A.J.M. Watson, M.R. Frey, J.C. Miguel, M.D. Burkitt, R. Sutton, K.R. Hughes, L.J. Hall, J.H. Caamaño, B.J. Campbell, D.M. Pritchard

Disease models and mechanisms (2013), 6(6): 1388-1399

TNF-α-Induced Intestinal Epithelial Cell Shedding: Implications for Intestinal Barrier Function

A.J.M. Watson and K.R.Hughes

Annals of the New York Academy of Sciences (2012) 1258:1-8

Heterogeneity in Histone 2B-Green Fluorescent Protein-Retaining Putative Small Intestinal Stem Cells at Cell Position 4 and their Absence in the Colon

K.R. Hughes, R.M.C. Gandara, T. Javkar, F. Sablitzky, H. Hock, C.S. Potten, Y.R. Mahida

American Journal of Physiology (Gastrointestinal and liver physiology) (2012) 303(11):G1188-201

Primary Human Colonic Myofibroblasts are Resistant to Clostridium difficile Toxin-A Induced, but not Toxin-B Induced, Cell Death

N.Mullan, K.R.Hughes, Y.R.Mahida

Infection and Immunity (2011), 79(4): 1623-1630

Expression of Wnt Family of Genes in Primary Human Intestinal Myofibroblasts and Primary Human Intestinal Epithelial Cells

K.R. Hughes, F.S. Sablitzky and Y.R. Mahida

Inflammatory Bowel Diseases (2011), 17(1): 213-220

Effects of Trichinella Spiralis infection on intestinal pathology in mice lacking interleukin-4 (IL-4) or intestinal trefoil factor (ITF/TFF3)

M.S. Dehlawi, Y.R. Mahida, K. Hughes, D. Wakelin

Parasitology International (2006), 55(3): 207-11

Differential Expression of TGF-beta Isoforms by Normal and Inflammatory Bowel Disease Intestinal Myofibroblasts

B.C. McKaig, K. Hughes, P.J. Tighe, Y.R. Mahida

American Journal of Physiology; Cell Physiology (2002), 282(1):C172-82

Research and Innovation

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