School of Life Sciences
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Andrew Bennett

Associate Professor of Molecular Biology/Biochemistry, Faculty of Medicine & Health Sciences

Contact

  • workRoom E131 The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30113
  • fax0115 82 30142

Biography

Dr Andy Bennett is a cell and molecular biologist by training. His research focuses on models of inflammation in disease states including neuro-inflammation and metabolic dysfunction/type II diabetes. Dr Bennett is the Director of the FRAME Alternatives Laboratory (https://frame.org.uk/our-work/the-frame-lab/ which uses human derived material to produce models of tissues and organs as translational tools for human disease research.

Research Summary

The FRAME Alternatives Laboratory uses human cells and tissues to produce models of organs such a liver, skin and skeletal muscle to model human disease states. We also use primary adult human… read more

Recent Publications

Current Research

The FRAME Alternatives Laboratory uses human cells and tissues to produce models of organs such a liver, skin and skeletal muscle to model human disease states. We also use primary adult human progenitor cells for the production of a renewable source of hepatocytes for disease and toxicological research

At the molecular level the work in our lab is focused on the role of nuclear receptors (LXR, PPAR and NR4A2 family) in neuroinflammation and metabolic dysfunction. Nuclear receptors in addition to their role as transcriptional activators, are able to suppress the expression of inflammatory genes and promote the resolution of inflammation. We are studying the role of nuclear receptors in activated immune cells such as microglia and kupffer cells and in metabolically active cells such as myotubes and hepatocytes. We are particularly interested in the role of post-translational modification - SUMOylation - in terms of modifying nuclear receptor activity.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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