I mainly teach on courses aimed at 3rd year biochemistry or biology students, with lectures on virology and/or immunology:
LIFE3124 (Year 3) Molecular Virology and Pathogenesis (Module Convenor)
LIFE3035 Pathogens (Year 3)
LIFE3090 Molecular Aspects of Diabetes and Obesity (Year 3)
I also teach some basic biochemistry to medical students as part of the MEDS1010 Medicine 1 (Year 1) module.
I supervise students on lab- or literature-based research projects at BSc, MSci or MSc levels.
I am personal tutor to small groups of students on the BSc/MSci Biochemistry, BSc Natural Sciences and MSc courses.
Studying the virus: host interactions of RNA viruses in vitro and in vivo, with specific focus on how viruses trigger and manipulate innate immune responses.
I am particularly interested in the highly pathogenic human coronaviruses, SARS-CoV-1, MERS-CoV and SARS-CoV-2. These viruses are important examples of emerging viruses that pose a significant risk to human health.
COLEMAN, CHRISTOPHER M., VENKATARAMAN, THIAGARAJAN, LIU, YE V., GLENN, GREGORY M., SMITH, GALE E., FLYER, DAVID C. and FRIEMAN, MATTHEW B., 2017. MERS-CoV spike nanoparticles protect mice from MERS-CoV infection VACCINE. 35(12), 1586-1589
COLEMAN, CHRISTOPHER M., SISK, JEANNE M., HALASZ, GABOR, ZHONG, JIXIN, BECK, SARAH E., MATTHEWS, KRYSTAL L., VENKATARAMAN, THIAGARAJAN, RAJAGOPALAN, SANJAY, KYRATSOUS, CHRISTOS A. and FRIEMAN, MATTHEW B., 2017. CD8(+) T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome JOURNAL OF VIROLOGY. 91(1),
The overall theme of my career has been the study of virus: host interactions of important human pathogens. I have previously worked on:
- Interactions between respiratory syncytial virus (RSV) and peripheral blood neutrophils
- Dendritic cell mediated transmission of human immunodeficiency virus (HIV)-1 to T cells
- HIV-1 restriction factors
- Many aspects of highly pathogenic human coronavirus (CoV) biology, including: functions of viral proteins in blocking innate immune signaling, virus: cell interactions, development of a mouse model for MERS-CoV and testing drugs and vaccines in vitro and in vivo.
I am interested in expanding my research to include other human and animal coronaviruses as well as other viruses in general. With an aim to discover common features that could be targeted by novel therapeutics for use against multiple viruses, in particular any future outbreak of a novel virus.