Christopher Coleman

Contact

• workRoom D82a
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158230105
• Christopher.Coleman@nottingham.ac.uk

Research Summary

Studying the virus: host interactions of RNA viruses in vitro and in vivo, with specific focus on how viruses trigger and manipulate innate immune responses.

I am particularly interested in the highly pathogenic human coronaviruses, SARS-CoV-1, MERS-CoV and SARS-CoV-2. These viruses are important examples of emerging viruses that pose a significant risk to human health.

Recent Publications

• KULCSAR KA, COLEMAN CM, BECK SE and FRIEMAN MB, 2019. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI insight. (In Press.)
• COLEMAN, CHRISTOPHER M., VENKATARAMAN, THIAGARAJAN, LIU, YE V., GLENN, GREGORY M., SMITH, GALE E., FLYER, DAVID C. and FRIEMAN, MATTHEW B., 2017. MERS-CoV spike nanoparticles protect mice from MERS-CoV infection VACCINE. 35(12), 1586-1589
• VENKATARAMAN, THIAGARAJAN, COLEMAN, CHRISTOPHER M. and FRIEMAN, MATTHEW B., 2017. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection JOURNAL OF VIROLOGY. 91(12),
• COLEMAN, CHRISTOPHER M., SISK, JEANNE M., HALASZ, GABOR, ZHONG, JIXIN, BECK, SARAH E., MATTHEWS, KRYSTAL L., VENKATARAMAN, THIAGARAJAN, RAJAGOPALAN, SANJAY, KYRATSOUS, CHRISTOS A. and FRIEMAN, MATTHEW B., 2017. CD8(+) T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome JOURNAL OF VIROLOGY. 91(1),

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Past Research

The overall theme of my career has been the study of virus: host interactions of important human pathogens. I have previously worked on:

• Interactions between respiratory syncytial virus (RSV) and peripheral blood neutrophils
• Dendritic cell mediated transmission of human immunodeficiency virus (HIV)-1 to T cells
• HIV-1 restriction factors
• Many aspects of highly pathogenic human coronavirus (CoV) biology, including: functions of viral proteins in blocking innate immune signaling, virus: cell interactions, development of a mouse model for MERS-CoV and testing drugs and vaccines in vitro and in vivo.

Future Research

I am interested in expanding my research to include other human and animal coronaviruses as well as other viruses in general. With an aim to discover common features that could be targeted by novel therapeutics for use against multiple viruses, in particular any future outbreak of a novel virus.

• KULCSAR KA, COLEMAN CM, BECK SE and FRIEMAN MB, 2019. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI insight. (In Press.)
• COLEMAN, CHRISTOPHER M., VENKATARAMAN, THIAGARAJAN, LIU, YE V., GLENN, GREGORY M., SMITH, GALE E., FLYER, DAVID C. and FRIEMAN, MATTHEW B., 2017. MERS-CoV spike nanoparticles protect mice from MERS-CoV infection VACCINE. 35(12), 1586-1589
• VENKATARAMAN, THIAGARAJAN, COLEMAN, CHRISTOPHER M. and FRIEMAN, MATTHEW B., 2017. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection JOURNAL OF VIROLOGY. 91(12),
• COLEMAN, CHRISTOPHER M., SISK, JEANNE M., HALASZ, GABOR, ZHONG, JIXIN, BECK, SARAH E., MATTHEWS, KRYSTAL L., VENKATARAMAN, THIAGARAJAN, RAJAGOPALAN, SANJAY, KYRATSOUS, CHRISTOS A. and FRIEMAN, MATTHEW B., 2017. CD8(+) T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome JOURNAL OF VIROLOGY. 91(1),
• WIRBLICH, CHRISTOPH, COLEMAN, CHRISTOPHER M., KURUP, DRISHYA, ABRAHAM, TARA S., BERNBAUM, JOHN G., JAHRLING, PETER B., HENSLEY, LISA E., JOHNSON, REED F., FRIEMAN, MATTHEW B. and SCHNELL, MATTHIAS J., 2017. One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus JOURNAL OF VIROLOGY. 91(2),
• COLEMAN, CHRISTOPHER M., SISK, JEANNE M., MINGO, REBECCA M., NELSON, ELIZABETH A., WHITE, JUDITH M. and FRIEMAN, MATTHEW B., 2016. Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion JOURNAL OF VIROLOGY. 90(19), 8924-8933
• LUKE, THOMAS, WU, HUA, ZHAO, JINCUN, CHANNAPPANAVAR, RUDRAGOUDA, COLEMAN, CHRISTOPHER M., JIAO, JIN-AN, MATSUSHITA, HIROAKI, LIU, YE, POSTNIKOVA, ELENA N., ORK, BRITINI L., GLENN, GREGORY, FLYER, DAVID, DEFANG, GABRIEL, RAVIPRAKASH, KANAKATTE, KOCHEL, TADEUSZ, WANG, JONATHAN, NIE, WENSHENG, SMITH, GALE, HENSLEY, LISA E., OLINGER, GENE G., KUHN, JENS H., HOLBROOK, MICHAEL R., JOHNSON, REED F., PERLMAN, STANLEY, SULLIVAN, EDDIE and FRIEMAN, MATTHEW B., 2016. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo SCIENCE TRANSLATIONAL MEDICINE. 8(326),
• COLEMAN, CHRISTOPHER M and FRIEMAN, MATTHEW B, 2015. Growth and Quantification of MERS-CoV Infection. Current protocols in microbiology. 37, 15E.2.1-9
• PASCAL, KRISTEN E., COLEMAN, CHRISTOPHER M., MUJICA, ALEJANDRO O., KAMAT, VISHAL, BADITHE, ASHOK, FAIRHURST, JEANETTE, HUNT, CHARLEEN, STREIN, JOHN, BERREBI, ALEXANDER, SISK, JEANNE M., MATTHEWS, KRYSTAL L., BABB, ROBERT, CHEN, GANG, LAI, KA-MAN V., HUANG, TAMMY T., OLSON, WILLIAM, YANCOPOULOS, GEORGE D., STAHL, NEIL, FRIEMAN, MATTHEW B. and KYRATSOUS, CHRISTOS A., 2015. Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(28), 8738-8743
• TAYLOR, JUSTIN K., COLEMAN, CHRISTOPHER M., POSTEL, SANDRA, SISK, JEANNE M., BERNBAUM, JOHN G., VENKATARAMAN, THIAGARAJAN, SUNDBERG, ERIC J. and FRIEMAN, MATTHEW B., 2015. Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference JOURNAL OF VIROLOGY. 89(23), 11820-11833
• COLEMAN, CHRISTOPHER M. and FRIEMAN, MATTHEW B., 2014. Treating MERS-CoV during an outbreak LANCET INFECTIOUS DISEASES. 14(11), 1030-1031
• ADEDEJI, ADEYEMI O., SINGH, KAMALENDRA, KASSIM, ADEMOLA, COLEMAN, CHRISTOPHER M., ELLIOTT, RUTH, WEISS, SUSAN R., FRIEMAN, MATTHEW B. and SARAFIANOS, STEFAN G., 2014. Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 58(8), 4894-4898
• COLEMAN, CHRISTOPHER M., LIU, YE V., MU, HAIYAN, TAYLOR, JUSTIN K., MASSARE, MICHAEL, FLYER, DAVID C., GLENN, GREGORY M., SMITH, GALE E. and FRIEMAN, MATTHEW B., 2014. Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice VACCINE. 32(26), 3169-3174
• COLEMAN, CHRISTOPHER M. and FRIEMAN, MATTHEW B., 2014. Coronaviruses: Important Emerging Human Pathogens JOURNAL OF VIROLOGY. 88(10), 5209-5212
• MATTHEWS, KRYSTAL L., COLEMAN, CHRISTOPHER M., VAN DER MEER, YVONNE, SNIJDER, ERIC J. and FRIEMAN, MATTHEW B., 2014. The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling JOURNAL OF GENERAL VIROLOGY. 95, 874-882
• DYALL, JULIE, COLEMAN, CHRISTOPHER M., HART, BRIT J., VENKATARAMAN, THIAGARAJAN, HOLBROOK, MICHAEL R., KINDRACHUK, JASON, JOHNSON, REED F., OLINGER, GENE G., JR., JAHRLING, PETER B., LAIDLAW, MONIQUE, JOHANSEN, LISA M., LEAR-ROONEY, CALLI M., GLASS, PAMELA J., HENSLEY, LISA E. and FRIEMAN, MATTHEW B., 2014. Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 58(8), 4885-4893
• COLEMAN, CHRISTOPHER M. and FRIEMAN, MATTHEW B., 2013. Emergence of the Middle East Respiratory Syndrome Coronavirus PLOS PATHOGENS. 9(9),
• COLEMAN, CHRISTOPHER M., ST GELAIS, CORINE and WU, LI, 2013. Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells HIV INTERACTIONS WITH DENDRITIC CELLS: INFECTION AND IMMUNITY. 762, 109-130
• COLEMAN CM, MATTHEWS KL, GOICOCHEA L and FRIEMAN MB, 2013. Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus. The Journal of general virology. 95(Pt 2), 408-12
• ST GELAIS, CORINE, DE SILVA, SURESH, AMIE, SARAH M., COLEMAN, CHRISTOPHER M., HOY, HEATHER, HOLLENBAUGH, JOSEPH A., KIM, BAEK and WU, LI, 2012. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons RETROVIROLOGY. 9,
• ST GELAIS C, COLEMAN CM, WANG JH and WU L, 2012. HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation. PloS one. 7(3), e34521
• COLEMAN, CHRISTOPHER M, PLANT, KAREN, NEWTON, SUSAN, HOBSON, LYNSEY, WHYTE, MOIRA K B and EVERARD, MARK L, 2011. The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor. The open virology journal. 5, 114-23
• COLEMAN, CHRISTOPHER M., SPEARMAN, PAUL and WU, LI, 2011. Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef RETROVIROLOGY. 8,
• COLEMAN CM and WU L, 2009. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology. 6, 51
• EVERARD M, UGONNA K, COLEMAN C and PLANT K, 2009. Respiratory syncytial virus and persistent infection of dendritic cells. The Pediatric infectious disease journal. 28(5), 450; author reply 450-1