School of Life Sciences
 

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Christopher Coleman

Assistant Professor of Infection Immunology, Faculty of Medicine & Health Sciences

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Research Summary

Studying the virus: host interactions of RNA viruses in vitro and in vivo, with specific focus on how viruses trigger and manipulate innate immune responses.

I am particularly interested in the highly pathogenic human coronaviruses, SARS-CoV-1, MERS-CoV and SARS-CoV-2. These viruses are important examples of emerging viruses that pose a significant risk to human health.

Recent Publications

Past Research

The overall theme of my career has been the study of virus: host interactions of important human pathogens. I have previously worked on:

  • Interactions between respiratory syncytial virus (RSV) and peripheral blood neutrophils
  • Dendritic cell mediated transmission of human immunodeficiency virus (HIV)-1 to T cells
  • HIV-1 restriction factors
  • Many aspects of highly pathogenic human coronavirus (CoV) biology, including: functions of viral proteins in blocking innate immune signaling, virus: cell interactions, development of a mouse model for MERS-CoV and testing drugs and vaccines in vitro and in vivo.

Future Research

I am interested in expanding my research to include other human and animal coronaviruses as well as other viruses in general. With an aim to discover common features that could be targeted by novel therapeutics for use against multiple viruses, in particular any future outbreak of a novel virus.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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