School of Life Sciences
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Ed Bolt

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

University of London: BSc. & PhD 1989-1995

Wellcome Trust Research Career development Fellowship, University of Nottingham 2002-2006

University Lecturer/Assistant Professor, University of Nottingham 2006-present

Expertise Summary

Molecular biology of genome dynamics and maintenance;

CRISPR-Cas

Homologous Recombination

Antibiotic resistance mechanisms

Teaching Summary

I convene modules and provide lectures about molecular microbiology and biochemistry and convene a group research project for undergraduate students in which we manipulate bacterial genomes to… read more

Research Summary

We use genetic analysis and protein biochemistry to understand molecular biology of (a) CRISPR-cas immunity (b) Homologous recombination. Both require manipulation of nucleic acids by nuclease,… read more

Selected Publications

For most up-to-date information about my research please visit:

http://www.researchgate.net/profile/Edward_Bolt

I convene modules and provide lectures about molecular microbiology and biochemistry and convene a group research project for undergraduate students in which we manipulate bacterial genomes to analyze CRISPR-Cas and antibiotic resistance mechanisms.

Current Research

We use genetic analysis and protein biochemistry to understand molecular biology of (a) CRISPR-cas immunity (b) Homologous recombination. Both require manipulation of nucleic acids by nuclease, helicase and related enzymes (e.g. Cas1-Cas2, Cas3, RecG, HelQ) and recent research developments suggest that CRISPR-cas and DNA repair-recombination processes are functionally linked in bacteria and archaea. We are also interested in biochemistry of Hel308 and HelQ helicases.

For further details on research please see publications and http://www.researchgate.net/profile/Edward_Bolt

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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