University of London: BSc. & PhD 1989-1995
Wellcome Trust Research Career development Fellowship, University of Nottingham 2002-2006
University Lecturer/Assistant Professor, University of Nottingham 2006-present
CRISPR biology (prokaryotes)
I convene modules about molecular biology of DNA repair, CRISPR systems and RNA biology more generally.
Undergraduate projects join my group for funded summer vacation studentships and final year projects investigating the biology of CRISPR systems in bacteria, and mechanisms of DNA repair.
My group is currently (2022) funded by BBSRC responsive-mode project grants and by drug-discovery companies to investigate cancer biology and CRISPR.
Further information can be seen in Orcid; https://orcid.org/0000-0002-5656-7706
ROLLIE, CLARE, SCHNEIDER, STEFANIE, BRINKMANN, ANNA SOPHIE, BOLT, EDWARD L and WHITE, MALCOLM F, 2015. Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition. eLife. 4, CASS SD, HAAS KA, STOLL B, ALKHNBASHI O, SHARMA K, URLAUB H, BACKOFEN R, MARCHFELDER A and BOLT EL, 2015. The role of Cas8 in type I CRISPR interference BioScience Reports. 35(3), e00197
GONG B, SHIN M, SUN J, JUNG CH, BOLT EL, VAN DER OOST J and KIM JS, 2014. Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proc Natl Acad Sci U S A.
- BBSRC Pool of Experts, 2022-2025
- Scientific advisory board of Amphista Therapeutics, 2020-ongoing
- Consultant Scientist for Oxford Nanopore Technologies, 2010-2017
- Member of the Microbiology Society Impact and Influence Committee, 2019-ongoing
· Editorial board and associate editor for Portland Press, Royal Society and Frontiers Journals
· Guest editor, Genes (CRISPR) and Frontiers in Molecular Biosciences (Recombination-Repair)
· Grant application reviewer for BBSRC, MRC, Wellcome Trust, NSF (USA), ANR (France), DFF (Denmark) and ITC/ITSP (Hong Kong).
· PhD degree examiner, recently at Universities of Oxford (2021), St. Andrews (2021), Huddersfield (2020), and Sheffield (2019).
· Reviewer for, recently, Nature Communications, Nucleic Acids Research, ACS Synthetic Biology, Genes, Journal of Molecular Biology.