School of Life Sciences
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Graham Sheridan

Assistant Professor in Neuroscience, Faculty of Medicine & Health Sciences

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Research Summary

An overarching goal of my research group is to understand how glial cells modify and promote neuronal plasticity in the brain. We study how astrocytes and microglia regulate homeostatic… read more

Selected Publications

Current Research

An overarching goal of my research group is to understand how glial cells modify and promote neuronal plasticity in the brain. We study how astrocytes and microglia regulate homeostatic neurotransmission and modulate synaptic plasticity and cognition.

We also investigate both biochemical signalling and mechanotransduction between myelin-forming oligodendrocytes and neurons. In particular, we are interested in how ageing and inflammation can disrupt the biochemistry and mechanobiology of glial cells and how reactive gliosis can impact neuronal plasticity and cognition.

Using interdisciplinary approaches from bioengineering and neurophysiology, we aim to identify novel drug targets for currently incurable conditions of the brain and spinal cord, such as Alzheimer's disease, multiple sclerosis and cancer-related cognitive impairment.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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