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Joern Steinert

Assistant Professor in Neuroscience, Faculty of Medicine & Health Sciences

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Biography

Following my PhD in Vascular Biology at King's College London I took up postdoctoral positions in Tuebingen (2002) and Heidelberg (2004) to study physiological mechanisms of neurotransmission using mammalian and Drosophila model systems. In particular, when I started a Senior Investigator position at the MRC Toxicology Unit Leicester in 2006, I was focussing my research on the regulation of neuronal excitability under activity-dependent mechanisms involving nitric oxide signaling. In 2013 I took up a Program Leader position at the MRC Toxicology Unit to expand my research into areas of neurodegeneration using prion and Alzheimer's models.

Expertise Summary

During my research I predominantly applied neurophysiological methodologies to study neuronal and synaptic function as well as ion channel regulation. My main expertise lies in the electrophysiological assessment of neuronal function coupled with live imaging including measurements of intracellular calcium and nitric oxide.

I use mammalian model systems, brain slice preparation, and Drosophila models to address research questions.

Research Summary

I am interested in investigating pathways involved in regulating neuronal and synaptic function and more recently, I have developed projects expanding into studying aberrant neuronal signalling in… read more

Selected Publications

Current Research

I am interested in investigating pathways involved in regulating neuronal and synaptic function and more recently, I have developed projects expanding into studying aberrant neuronal signalling in neurodegeneration. I have investigated molecular mechanisms of neuronal dysfunction in mice developing neurodegeneration which display classical phenotypes of protein-misfolding neurological conditions such as occuring in Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease (prion-misfolding). In addition, I utilised advantages of the Drosophila model organism to study synaptic effects of protein misfolding and redox signalling, thus using complementary models to study neuronal function. In order to gain deeper insides into underlying and early-onset dysfunctional pathways in neurodegeneration, I assessed the metabolome in hippocampal and cortical tissue from prion-diseased mice. These data showed vast amounts of alterations in the neuronal metabolism, including glycolysis, arginine and prostaglandin pathways and oxidative stress signalling amongst many others. Importantly, dysfunction of these pathways has also been highlighted as predisposing and causal conditions during aging, thereby further facilitating and increasing the risk of developing neurodegenerative pathologies. Based on these data I developed new exciting projects related to neuroinflammation, redox and cellular stress signalling which includes oxidative and nitrergic stress.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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