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Madeleine King

Senior Research Fellow, Faculty of Medicine & Health Sciences

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Biography

I graduated from the University of Bath in 2002 with a MSci in Pharmacology, which included an industrial placement in the Behavioural Neuroscience department of the Merck Sharp & Dohme Neuroscience Research Centre (2000-2001). I moved to Nottingham to complete a Roche-funded PhD on the role of 5-HT6 receptors in memory and attention, then enjoyed three years as a post-doctoral researcher on a multicentre EU FP6-funded project, developing novel models for glutamatergic CNS disorders using short hairpin RNA approaches. I was appointed to my current role as Senior Research Fellow in 2010 and lead an expanding team focused on improving understanding and treatment of common CNS disorders. I was named collaborator on an EU FP7-funded Marie Curie Initial Training Network, r'BIRTH - Brain Imaging Return to Health. I received the 2019 British Association for Psychopharmacology (BAP) Senior Award for Non-Clinical research, and recently joined BAP Council and the British Journal of Pharmacology Editorial Board.

Research Summary

My research uses neurodevelopmental models to investigate how adverse early-life events or drugs of abuse impact on brain neurochemistry and contribute to cognitive and social dysfunction. The group… read more

Selected Publications

Current Research

My research uses neurodevelopmental models to investigate how adverse early-life events or drugs of abuse impact on brain neurochemistry and contribute to cognitive and social dysfunction. The group has a track record of successful collaboration on EU and industry-funded projects, evaluating novel serotonergic, cholinergic, dopaminergic and glutamatergic treatments for disorders like schizophrenia, autism and depression.

We have expertise in:

- a broad range of behavioural techniques, using the latest software for computerised tracking, visual touchscreen tasks and recording of ultrasonic vocalisations (USVs)

- complimentary neurochemical approaches, from enzyme-based glutamate microsensors to microdialysis with HPLC-ED

- proteomic techniques, including protein microarray, western blotting and immunohistochemistry

- MRI and MRS

We welcome opportunities to establish new links with academic and industrial researchers.

Current group members are working on the following topics:

- Abigail Abrahams (BBSRC DTP PhD) - mechanisms underlying the prosocial effects of oxytocin

- Sara Wong (University of Nottingham Vice Chancellor's PhD Scholarship) - optimising nasal oxytocin delivery for potential treatment of neurodevelopmental disorders

- Chukwudi Okebaram (Tetfund Nigeria PhD) - role of BDNF and TrkB in schizophrenia

- Luke O'Hara (Faculty of Medicine and Health Sciences PhD Scholarship) - drug interactions and long term consequences of mephedrone, a novel psychoactive substance

- Lucy Adam (MRes student) - combined effect of mephedrone and caffeine on patterns of neuronal activation

Future Research

Interested in joining the group?

Interested in collaborating with me? I'd like to hear from you, please contact via email

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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