Assistant Professor of Cell Biology, Faculty of Medicine & Health Sciences
2002: PhD in Developmental Neurobiology, King's College, London. 2003: awarded an EMBO long-term fellowship to work at the IMP in Vienna. 2004: post-doctoral fellow at the MRC Laboratory of Molecular Cell Biology, UCL.
Marios joined the University of Nottingham in 2011 as a Assistant Professor of Cell Biology. He was awarded a prestigious Cancer Research UK Career Establishment Award in 2011.
Dr Marios Georgiou is Assistant Professor of Cell Biology at the School of Life Sciences, University of Nottingham.
Dr Georgiou is a Cancer Research UK Career Establishment Award Fellow.
Dr Georgiou is a member of Cancer Research Nottingham.
Dr Georgiou is module convenor for the following module:
LIFE4114 Biochemistry of Cancer
And contributes to the following modules:
LIFE3039 Molecular Diagnostics and Therapeutics (Gene Therapy)
LIFE2063 Genotype to Phenotype and Back Again
LIFE2074 Signalling and Metabolic Regulation
During animal development, individual cells change their shape in response to an unfolding morphogenetic program. This process culminates in the generation of hundreds of terminally differentiated… read more
BRENDA CANALES COUTIÑO, EMMA SZAMEK, ZSUZSA MARKUS and MARIOS GEORGIOU, 2021. Generation and live imaging of tumors with specific genotypes in the living fly pupa STAR Protocols. 2(3), 100672 COUTINO, BRENDA CANALES, CORNHILL, ZOE E., COUTO, AFRICA, MACK, NATALIE A., RUSU, ALEXANDRA D., NAGARAJAN, USHA, FAN, YUEN NGAN, HADJICHARALAMBOUS, MARINA R., URIBE, MARCOS CASTELLANOS, BURROWS, AMY, LOURDUSAMY, ANBARASU, RAHMAN, RUMAN, MAY, SEAN T. and GEORGIOU, MARIOS, 2020. A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion ISCIENCE. 23(6), RUSU, ALEXANDRA D. and GEORGIOU, MARIOS, 2020. The multifarious regulation of the apical junctional complex OPEN BIOLOGY. 10(2),
COUTO A, MACK NA, FAVIA L and GEORGIOU M, 2017. An apicobasal gradient of Rac activity determines protrusion form and position. Nature communications. 8, 15385
Applications are invited from exceptional graduates and post-doctoral researchers with an interest in cell morphogenesis and cancer biology. Additionally, we also have an interest in the study of a wide range of human diseases, including COPD, asthma, Alzheimer's Disease, and motor neurone disease. Our study of cell and tissue morphology is relevant to an array of human diseases.
Candidates interested in joining our lab to work in these research areas can contact Dr Georgiou by sending an e-mail to email@example.com
BBSRC DTP PhD PROJECTS AVAILABLE
We regularly offer exciting PhD opportunities as part of the BBSRC Doctoral Training Programme (DTP).
For more on the scheme see: https://www.nottingham.ac.uk/bbdtp/
The BBSRC DTP provides FOUR years funding as well as a tailored training programme for each student.
Additionally, in the third year of your PhD you will be able to undertake a 3-month Professional Internship or 'PIP'. This internship is not directly related to the PhD project, but is designed to offer you experience in one of a number of career sectors, including: teaching, policy-making, media, industry etc.
Other positions are also available to self-funded applicants.
Please be aware that applications for PhD or post-doc funding should be made at least 9 months before desired starting date.
Funding for PhDs:
There are a number of international studentships available to international applicants, see: http://www.nottingham.ac.uk/InternationalOffice/prospective-students/scholarships/index.aspx
Funding for Post-docs:
Wellcome Trust: https://wellcome.org/grant-funding/schemes/early-career-awards
EMBO fellowships: http://www.embo.org/funding-awards/fellowships
EU fellowships: http://ec.europa.eu/research/mariecurieactions/about-msca/actions/if/index_en.htm
Human Frontier Science Program fellowships: http://www.hfsp.org/funding/postdoctoral-fellowships
Royal Society Dorothy Hodgkin Fellowship: https://royalsociety.org/grants-schemes-awards/grants/dorothy-hodgkin-fellowship/
MRC Career Development Award: https://www.ukri.org/opportunity/mrc-career-development-award/
BBSRC Discovery Fellowship: https://www.ukri.org/opportunity/discovery-fellowship-2021/
Royal Society University Research Fellowship: http://royalsociety.org/grants/schemes/university-research/
CRUK Career Development Fellowship: http://www.cancerresearchuk.org/science/funding/find-grant/all-funding-schemes/career-development-fellowship/
During animal development, individual cells change their shape in response to an unfolding morphogenetic program. This process culminates in the generation of hundreds of terminally differentiated cell types with distinct forms and functions. The developmental mechanisms behind the generation of these distinct morphologies are still largely unknown. My interest lies in studying the process of cell morphogenesis to give insights into cell function, tissue homeostasis and disease.
The lab uses the fruit fly Drosophila melanogaster as a model organism. With Drosophila it is possible to use sophisticated genetic techniques to label and manipulate individual cells within a living tissue. Combined with state-of-the-art cell biology it is possible to image, in real time, in a living organism, cell morphology and behaviour in high resolution. Our research ambitions are to identify the fundamental cell biological processes that orchestrate cell and tissue morphogenesis, both during normal development, and under conditions that mimic those of human disease, primarily focusing on cancer biology, but also collaborating with other groups whose interest lies in the study of other human diseases where normal cell or tissue morphology is compromised (including COPD, asthma, Alzheimer's Disease, and motor neurone disease).
Cell morphogenesis: Using this in vivo system we can study diverse cell types and cell shapes, from simple columnar epithelial cells to the neurones of the central nervous system, which possess morphologies of astounding complexity. We aim to identify the genes involved in generating this vast array of distinct morphologies.
Cancer biology: Additionally, by focusing on epithelial sheets of cells, we can identify the fundamental cell biological processes that orchestrate cell and tissue morphogenesis during normal development and under conditions that mimic those of tumour development. With funding from Cancer Research UK, undertook a large-scale screen for conserved modulators of tumour behaviour, allowing the identification of numerous tumour and invasion suppressors. This screen is now completed and published in full (Canales Coutiño et al., iScience, 2020).
To increase the accessibility of the results from our genetic screen, we also developed an open access, searchable online resource (see: https://flycancerscreen.nottingham.ac.uk/). This resource makes our database, as well as all high-resolution images, available to the scientific community in an online, user-friendly, custom made website.
Research at the lab therefore lies at an interface between cell, developmental and cancer biology, with recent papers addressing a number of fundamental processes such as the regulation of the actin cytoskeleton, cell polarity, cell morphology, cell adhesion, endocytosis, trafficking, tissue architecture and cell signalling.
Key areas of research interest:
Cell and tissue morphology
The use of the fruit fly to model human disease
URAS, GIUSEPPE, MANCA, ALESSIA, ZHANG, PENGFEI, MARKUS, ZSUZSA, MACK, NATALIE, ALLEN, STEPHANIE, BO, MARCO, XU, SHENGTAO, XU, JINYI, GEORGIOU, MARIOS and ZHU, ZHEYING, 2021. In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer's Disease. Frontiers in neuroscience. 15, 691222 BRENDA CANALES COUTIÑO, EMMA SZAMEK, ZSUZSA MARKUS and MARIOS GEORGIOU, 2021. Generation and live imaging of tumors with specific genotypes in the living fly pupa STAR Protocols. 2(3), 100672
RUSU, ALEXANDRA D, CORNHILL, ZOE E, COUTINO, BRENDA CANALES, URIBE, MARCOS CASTELLANOS, LOURDUSAMY, ANBARASU, MARKUS, ZSUZSA, MAY, SEAN T, RAHMAN, RUMAN and GEORGIOU, MARIOS, 2021. CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. Open biology. 11(9), 210077
RUSU, ALEXANDRA D. and GEORGIOU, MARIOS, 2020. The multifarious regulation of the apical junctional complex OPEN BIOLOGY. 10(2), COUTINO, BRENDA CANALES, CORNHILL, ZOE E., COUTO, AFRICA, MACK, NATALIE A., RUSU, ALEXANDRA D., NAGARAJAN, USHA, FAN, YUEN NGAN, HADJICHARALAMBOUS, MARINA R., URIBE, MARCOS CASTELLANOS, BURROWS, AMY, LOURDUSAMY, ANBARASU, RAHMAN, RUMAN, MAY, SEAN T. and GEORGIOU, MARIOS, 2020. A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion ISCIENCE. 23(6), COUTO A, MACK NA, FAVIA L and GEORGIOU M, 2017. An apicobasal gradient of Rac activity determines protrusion form and position. Nature communications. 8, 15385 PAKKIRISWAMI, SHANMUGASUNDARAM, COUTO, AFRICA, NAGARAJAN, USHA and GEORGIOU, MARIOS, 2016. Glycosylated Notch and Cancer Frontiers in Oncology. 6, LO, PRISCILLA, HAWROT, HANNAH and GEORGIOU, MARIOS, 2012. Apicobasal polarity and its role in cancer progression Biomolecular Concepts. 3(6), 505–521 KING, J.S., VELTMAN, D.M., GEORGIOU, M., BAUM, B. and INSALL, R.H., 2010. SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis Journal of Cell Science. 123(13), 2246-2255 COHEN, M., GEORGIOU, M., STEVENSON, N.L., MIODOWNIK, M. and BAUM, B., 2010. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition Developmental Cell. 19(1), 78-89 GEORGIOU, M., MARINARI, E., BURDEN, J. and BAUM, B., 2008. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability Current Biology. 18(21), 1631-1638 TEAR, GUY and GEORGIOU, MARIOS., 2003. Axon guidance at the midline. Encyclopaedia of Life Sciences.
GEORGIOU, MA and TEAR, G, 2000. An investigation into commissureless function. In: EUROPEAN JOURNAL OF NEUROSCIENCE 12. 339-339
BALAS, D, GONZALEZ, I, GEORGIOU, M, ALCAIDE, F, LINARES, J and DE LA CAMPA, AG, 1999. Fluoroquinolone resistance mutations in the DNA topoisomerase II genes of viridans group streptococci clinical isolates. In: DRUGS 58. 125-127
GONZÁLEZ, I, GEORGIOU, M, ALCAIDE, F, BALAS, D, LIÑARES, J and DE LA CAMPA, A G, 1998. Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci. Antimicrobial agents and chemotherapy. 42(11), 2792-8
CAMPOS, J, ROMAN, F, GEORGIOU, M, GARCIA, C, GOMEZLUS, R, CANTON, R, ESCOBAR, H and BAQUERO, F, 1996. Long-Term Persistence Of Ciprofloxacin-Resistant Haemophilus Influenzae In Patients With Cystic Fibrosis Journal Of Infectious Diseases. 174(6), 1345-1347
GEORGIOU, M, MUNOZ, R, ROMAN, F, CANTON, R, GOMEZLUS, R, CAMPOS, J and DELACAMPA, AG, 1996. Ciprofloxacin-Resistant Haemophilus Influenzae Strains Possess Mutations In Analogous Positions Of Gyra And Parc Antimicrobial Agents And Chemotherapy. 40(7), 1741-1744