School of Life Sciences
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Paul Smith

Lecturer in Cell Signalling, Faculty of Medicine & Health Sciences

Contact

  • workRoom E153 The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30135
  • fax0115 82 30081

Expertise Summary

I am fascinated by the physiology and pharmacology of ion channels in white fat adipocytes. In particular I am interested in the connections between ion channel activity in the plasmamembrane and the mobilization of fat soluble compounds such as vitamins, pharmaceuticals and persistent organic pollutants (POPs) from their fat droplet.

Research summary

  • The electrophysiology of adipocytes and the role of ion channels in their function.
  • Regulation of the trafficking and expression of L-type Ca2+ channels in endocrine cells.
  • Mobilization of vitamin D, pharmaceuticals and POPs from white fat
  • Calcium homeostasis

Research Techniques/Expertise

  • Electrophysiology: sharp-electrode, patch-clamp
  • Ion channel physiology and pharmacology
  • Adipocyte physiology
  • Electrochemical measurement of secretion
  • Single-cell microfluorimetry
  • Measurement of oxidative respiration in single cells, suspensions and tissues:
  • Mathematical modelling and simulation (cell-signals, secretion, electrophysiology).

Teaching

B11NES Core Skills in Neuroscience

C12HSN Higher Skills in Neuroscience

Selected Publications

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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