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Paul Greenhaff

Professor of Muscle Metabolism, Faculty of Medicine & Health Sciences

Contact

  • workRoom D44 The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30133
  • fax0115 82 30103

Biography

Paul Greenhaff is Professor of Muscle Metabolism at the University of Nottingham. He heads the Metabolic and Molecular Physiology Research Group at Nottingham, is Deputy Director of the MRC/ARUK Centre for Musculoskeletal Ageing Research and is a member of the ARUK Centre for Sport, Exercise and Osteoarthritis. Paul is also a member of BBSRC Research Panel A, a member of the Editorial Boards of Acta Physiologica and the Scandinavian Journal of Medicine and Science in Sports. In 2001 he delivered the John French Lecture to the British Atherosclerosis Society and was awarded the Scientific Achievement Award by the Society for Guanidino Compounds in Biology and Medicine. In 2003 he was awarded a Medici Fellowship by the University of Nottingham. Paul has published >145 original full scientific papers, numerous review articles and book chapters and is an inventor on 3 patents filed by the University of Nottingham. His research interests focus on skeletal muscle mass regulation and muscle fuel metabolism in ageing, health, trauma and disease. He has received continuous research funding for more than 20 years from government (BBSRC, MRC), charity (ARUK, BHF, Dunhill Medical Trust, Wellcome Trust) and industry (AstraZeneca, GSK, Iovate, Merck, Novartis and Pfizer) sources.

Expertise Summary

Skeletal muscle mass regulation and muscle fuel metabolism.

Research Summary

Interests

Skeletal muscle metabolism, growth and atrophy in health and disease.

Skeletal muscle fatigue in health and disease.

Acute and chronic nutritional, physiological and pharmacological strategies to alter skeletal muscle metabolism and function.

Techniques

Determination of skeletal muscle function in vivo and ex vivo using a variety of approaches.

Biochemical characterisation of skeletal muscle intermediary metabolism (spectrophotometry, fluorimetry and luminesence).

mRNA and protein determination in anabolic and catabolic skeletal muscle (Taqman, Microarray, Western blotting).

Research Projects

Modulation of muscle protein synthesis by essential amino acids: exploring the"muscle-full" phenomenon in humans. 2011 - 2013, (with Dr P Atherton PI).

Reducing the burden of COPD by targeting skeletal muscle mass and function. Targets and endpoints for drug development. 2011 - 2014 MRC/ABPI Consortium in COPD.

META-PREDICT - Developing predictors of the health benefits of exercise for individuals. 2011-2015 European Union Seventh Framework Programme (Professor J Timmons PI).

Mechanism of eccentric training augmentation of muscle adaptation in humans and the potential negative impact of non-steroidal anti-inflammatory drugs. 2012 - 2014 BBSRC project grant (P Greenhaff PI).

Improving human skeletal muscle insulin sensitivity in healthy ageing. 2012 - 2014 Dunhill Medical Trust Project Grant (with Dr F Stephens PI).

MRC/ARUK Centre for Musculoskeletal Ageing Research. 2012 -2017 infrastructure award made to University of Birmingham/University of Nottingham to establish centre of excellent in musculoskeletal ageing research (PI Prof J Lord).

Feasibility and metabolic effects of carbohydrate loading in patients with fragility hip fracture - a randomized double blind pilot study. 2012 - 2014 National Institute of Academic Anaesthesia Project Grant (with Dr Iain Moppett PI).

Arthritis Research UK Centre for Sport and Exercise Injuries. 2013 - 2018 (PI Professor Mark Batt).

Local Academic Collaborators

  • Dr Phil Atherton
  • Dr Rudi Billeter-Clark
  • Dr. Tim Constantin-Teodosiu
  • Dr Sue Francis
  • Professor Penny Gowland
  • Dr Andy Murton
  • Professor Marco Narici
  • Dr Ken Smith
  • Dr Francis Stephens
  • Dr Nate Szewczyk

Local Clinical Collaborators

  • Professor Dileep Lobo (University of Nottingham)
  • Professor Ravi Mahajan (University of Nottingham)
  • Dr Iain Moppett (University of Nottingham)
  • Dr Mick Steiner (University of Leicester)

Selected Publications

Future Research

Regulation of skeletal muscle energy metabolism invivo and the significance that this has on muscle growth and function in the context of acute and chronic exercise intervention in health and disease utilising animal models and human volunteers.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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