Sian Bray

Contact

• workRoom B61 Life Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• Sian.Bray@nottingham.ac.uk

Biography

I am fascinated by evolution. My lab focusses on understanding genomic and proteomic adaptation to extreme environments. This work has recently branched out into computational methods development through a fruitful interdisciplinary collaboration (physics, mathematics and life sciences). I have a wide range of skills including 'dry-lab' bioinformatic and programming skills as well as 'wet-lab' biochemistry and structural biology skills. My teaching is focused on bioinformatic training for master's students - I am heavily involved in the design and delivery of Nottingham's new MSc course in Bioinformatics.

Recent Publications

• RAUCH, C., WATTIS, J., & BRAY, S.M., 2023. On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next? Organisms. Journal of Biological Sciences.
• BRAY, S.M., HAMALA, T, ZHOU, M., BUSOMS, S., FISCHER, S., DESJARDINS, S.D., MANDAKOVA, T., MOORE, C., MATHERS, T.C., COWAN, L., MONNAHAN, P., KOCH, J., WOLF E.M., LYSAK, M.A., KOLAR, F., HIGGINS, J.D., KOCH, M.A., YANT, L., 2023. Kinetochore and ionomic adaptation to whole genome duplication. bioRxiv.
• WATTIS, J.A.D., BRAY, S.M., KYRATZI, P., RAUCH, C., 2022. Analysis of phenotype-genotype associations using genomic informational field theory (GIFT). Journal of Theoretical Biology.
• RAUCH, C., KYRATZI, P., BLOTT, S., BRAY, S.M., WATTIS, J.A.D., 2022. GIFT: new method for the genetic analysis of small gene effects involving small sample sizes. Physical Biology.

• View all publications

• RAUCH, C., WATTIS, J., & BRAY, S.M., 2023. On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next? Organisms. Journal of Biological Sciences.
• BRAY, S.M., HAMALA, T, ZHOU, M., BUSOMS, S., FISCHER, S., DESJARDINS, S.D., MANDAKOVA, T., MOORE, C., MATHERS, T.C., COWAN, L., MONNAHAN, P., KOCH, J., WOLF E.M., LYSAK, M.A., KOLAR, F., HIGGINS, J.D., KOCH, M.A., YANT, L., 2023. Kinetochore and ionomic adaptation to whole genome duplication. bioRxiv.
• WATTIS, J.A.D., BRAY, S.M., KYRATZI, P., RAUCH, C., 2022. Analysis of phenotype-genotype associations using genomic informational field theory (GIFT). Journal of Theoretical Biology.
• RAUCH, C., KYRATZI, P., BLOTT, S., BRAY, S.M., WATTIS, J.A.D., 2022. GIFT: new method for the genetic analysis of small gene effects involving small sample sizes. Physical Biology.
• KONEČNÁ, V., BRAY, S.M., VLČEK, J., BOHUTÍNSKÁ, M., POŽÁROVÁ, D., CHOUDHURY, R.R., BOLLMANN-GIOLAI, A., FLIS, P., SALT, D.E., CHRISTIAN PARISOD, LEVI YANT, FILIP KOLÁŘ., 2021. Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles. Nature Communications.
• BOHUTÍNSKÁ, M., ALSTON, M., MONNAHAN, P., MANDÁKOVÁ, T., BRAY, S.M., PAAJANEN, P., KOLÁŘ, F., YANT, L., 2021. Novelty and convergence in adaptation to whole genome duplication. Molecular Biology and Evolution..
• ZABOLOTNAYA E, MELA I, WILLIAMSON MJ, BRAY SM, YAU SK, PAPATZIAMOU D, EDWARDSON JM, ROBINSON NP and HENDERSON RM, 2020. Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 117(26), 14936-14947
• RISA, GABRIEL TARRASON, HURTIG, FREDRIK, BRAY, SIAN, HARKER-KIRSCHNECK, HARKER-KIRSCHNECK, LENA, FAULL, PETER, DAVIS, COLIN, PAPATZIAMOU, DIMITRA, MUTAVCHIEV, DELYAN R., FAN, CATHERINE, MENEGUELLO, LETICIA, PULSCHEN, ANDRE ARASHIRO, DEY, GAUTAM, CULLEY, SIAN, KILKENNY, MAIRI, PELLEGRINI, LUCA, DE BRUIN, ROBERTUS A. M., HENRIQUES, RICARDO, SNIJDERS, AMBROSIUS P, SARIC, ANDJELA, LINDR AS, ANN-CHRISTIN, ROBINSON, NICK and BAUM, BUZZ, 2019. Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon bioRxiv.
• PREITE V., SAILER C., SYLLWASSCHY L., BRAY S.M., KRAEMER U., YANT L., 2019. Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils Philosophical Transactions of the Royal Society B.
• BADUEL, PIERRE, BRAY, SIAN, VALLEJO-MARIN, MARIO, KOLÁŘ, FILIP and YANT, LEVI, 2018. The “Polyploid Hop”: Shifting Challenges and Opportunities Over the Evolutionary Lifespan of Genome Duplications Frontiers in Ecology and Evolution. 6, 117
• BUSOMS, SILVIA, PAAJANEN, PIRITA, MARBURGER, SARAH, BRAY, SIAN, HUANG, XIN-YUAN, POSCHENRIEDER, CHARLOTTE, YANT, LEVI and SALT, DAVID E., 2018. Fluctuating selection on migrant adaptive sodium transporter alleles in coastal Arabidopsis thaliana Proceedings of the National Academy of Sciences. 115(52), E12443-E12452
• SCHMICKL, ROSWITHA, MARBURGER, SARAH, BRAY, SIAN and YANT, LEVI, 2017. Hybrids and horizontal transfer: introgression allows adaptive allele discovery JOURNAL OF EXPERIMENTAL BOTANY. 68(20), 5453-5470
• ANJUM RS, BRAY SM, BLACKWOOD JK, KILKENNY ML, COELHO MA, FOSTER BM, LI S, HOWARD JA, PELLEGRINI L, ALBERS SV, DEERY MJ and ROBINSON NP, 2015. Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius. Nature communications. 6, 8163
• RZECHORZEK NJ, BLACKWOOD JK, BRAY SM, MAMAN JD, PELLEGRINI L and ROBINSON NP, 2014. Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea. Nature communications. 5, 5506
• BLACKWOOD JK, RZECHORZEK NJ, BRAY SM, MAMAN JD, PELLEGRINI L and ROBINSON NP, 2013. End-resection at DNA double-strand breaks in the three domains of life. Biochemical Society transactions. 41(1), 314-20