Stephen Gray

Contact

• workRoom D117
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158 230110
• Stephen.Gray@nottingham.ac.uk
• http://www.genomedynamics.co.uk

Biography

2005 - 2008: B.Sc. (Hons) Biology - University of Sussex

2011: Associate of the Higher Education Academy

2008 - 2012: Ph.D. Biochemistry - in the lab of Prof. Matt Neale, Genome Damage and Stability Centre, University of Sussex. Thesis Title: Investigating the Molecular Mechanisms of Meiotic Recombination

2012 - 2013: MRC Centenary Award Postdoctoral Fellow - in the lab of Prof. Eva Hoffmann, - Genome Damage and Stability Centre, University of Sussex

2012 - 2013: PGCHe in Learning and Teaching - University of Sussex

2013: Fellow of the Higher Education Academy

2013 - 2014: Postdoctoral Research Fellow - in the lab of Prof. Matt Neale, - Genome Damage and Stability Centre, University of Sussex

2014 - 2019: Postdoctoral Associate and Research Associate - in the lab of Prof. Paula Cohen, Department of Biomedical Sciences and Center for Reproductive Genomics, Cornell University

2019 - Present: Assistant Professor of Genome Dynamics - Division of Infections, Immunity and Microbes, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham

Recent Publications

• SHANZHI WANG, KYERYOUNG LEE, STEPHEN GRAY, YONGWEI ZHANG, CATHERINE TANG, RIKKE B. MORRISH, ELENA TOSTI, JOHANNA VAN OERS, MOHAMMAD RUHUL AMIN, PAULA E. COHEN, THOMAS MACCARTHY, SERGIO ROA, MATTHEW D. SCHARFF, WINFRIED EDELMANN and RICHARD CHAHWAN, 2022. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice Nucleic Acids Research.
• GRAY S, SANTIAGO ER, CHAPPIE JS and COHEN PE, 2020. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Cell reports. 32(1), 107858
• TOLEDO M, SUN X, BRIEÑO-ENRÍQUEZ MA, RAGHAVAN V, GRAY S, PEA J, MILANO CR, VENKATESH A, PATEL L, BORST PL, ALANI E and COHEN PE, 2019. A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I. PLoS genetics. 15(6), e1008177
• GRAY, S. and COHEN, P. E., 2016. Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation: Annu Rev Genet Annu Rev Genet. 50, 175-210

• View all publications

• SHANZHI WANG, KYERYOUNG LEE, STEPHEN GRAY, YONGWEI ZHANG, CATHERINE TANG, RIKKE B. MORRISH, ELENA TOSTI, JOHANNA VAN OERS, MOHAMMAD RUHUL AMIN, PAULA E. COHEN, THOMAS MACCARTHY, SERGIO ROA, MATTHEW D. SCHARFF, WINFRIED EDELMANN and RICHARD CHAHWAN, 2022. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice Nucleic Acids Research.
• GRAY S, SANTIAGO ER, CHAPPIE JS and COHEN PE, 2020. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Cell reports. 32(1), 107858
• TOLEDO M, SUN X, BRIEÑO-ENRÍQUEZ MA, RAGHAVAN V, GRAY S, PEA J, MILANO CR, VENKATESH A, PATEL L, BORST PL, ALANI E and COHEN PE, 2019. A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I. PLoS genetics. 15(6), e1008177
• GRAY, S. and COHEN, P. E., 2016. Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation: Annu Rev Genet Annu Rev Genet. 50, 175-210
• BRIENO-ENRIQUEZ, M. A., MOAK, S. L., TOLEDO, M., FILTER, J. J., GRAY, S., BARBERO, J. L., COHEN, P. E. and HOLLOWAY, J. K., 2016. Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1gamma-WAPL Axis in the Mouse: Cell Rep Cell Rep. 17(4), 977-986
• GARCIA, V., GRAY, S., ALLISON, R. M., COOPER, T. J. and NEALE, M. J., 2015. Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation: Nature Nature. 520(7545), 114-8
• COPSEY, A., TANG, S., JORDAN, P. W., BLITZBLAU, H. G., NEWCOMBE, S., CHAN, A. C., NEWNHAM, L., LI, Z., GRAY, S., HERBERT, A. D., ARUMUGAM, P., HOCHWAGEN, A., HUNTER, N. and HOFFMANN, E., 2013. Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions: PLoS Genet PLoS Genet. 9(12), e1004071
• GRAY, S., ALLISON, R. M., GARCIA, V., GOLDMAN, A. S. and NEALE, M. J., 2013. Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR): Open Biol Open Biol. 3(7), 130019
• GARCIA, V., PHELPS, S. E., GRAY, S. and NEALE, M. J., 2011. Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1: Nature Nature. 479(7372), 241-4