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Kenton Arkill

Associate Professor in Endothelial and Vascular Imaging, Faculty of Medicine & Health Sciences

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Expertise Summary

Glycomicroscopy

Endothelial Glycocalyx and Vascular Permeability

Glomerular filtration

Transmission Electron Microscopy

General biological nanoscale techniques (inc. cryogenic/correlative and 3D techniques)

Glycosaminoglycans

Research Summary

My fundamental interest is in capillary ultrafiltration. This the the biophysical method by which molecules move between the blood and the the interstitium. The primary size (and charge) filter is… read more

Selected Publications

  • GAMEZ, MONICA, ELHEGNI, HESHAM E., FAWAZ, SARAH, HO, KWAN HO, CAMPBELL, NEILL W., COPLAND, DAVID A., ONIONS, KAREN L., BUTLER, MATTHEW J., WASSON, ELIZABETH J., CROMPTON, MICHAEL, RAMNATH, RAINA D., QIU, YAN, YAMAGUCHI, YU, ARKILL, KENTON P., BATES, DAVID O., TURNBULL, JEREMY E., ZUBKOVA, OLGA V., WELSH, GAVIN I., ATAN, DENIZE, SATCHELL, SIMON C. and FOSTER, REBECCA R., 2024. Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes: Cardiovascular Diabetology Cardiovascular Diabetology. 23(1), 50
  • BROWN,THOMAS J., RUTLAND,CATRIN S., CHOI,KATIE K., TSE,FENG, PEFFERS,MANDY J., MONGAN,NIGEL P., ARKILL,KENTON P., RITCHIE,ALISON, CLARKE,PHILIP A., RATAN,HARI, ALLEGRUCCI,CINZIA, GRABOWSKA,ANNA M. and JAMES,VICTORIA, 2024. Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles: Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology. 12,
  • POPE, IESTYN, TANNER, HUGH, MASIA, FRANCESCO, PAYNE, LUKAS, ARKILL, KENTON PAUL, MANTELL, JUDITH, LANGBEIN, WOLFGANG, BORRI, PAOLA and VERKADE, PAUL, 2023. Correlative light-electron microscopy using small gold nanoparticles as single probes: Light: Science & Applications Light: Science & Applications. 12(1), 80
  • DIGPAL, RONNEIL, ARKILL, KENTON P, DOHERTY, REGAN, YATES, JOSEPH, MILNE, LORNA K, BROOMES, NICOLE, KATSAMENIS, ORESTIS L, MACDONALD, JASON, DITCHFIELD, ADAM, NARATA, ANA PAULA, DAREKAR, ANGELA, CARARE, ROXANA O, FABIAN, MARK, GALEA, IAN and BUTLERS, DIEDERIK, 2024. A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging: International Journal of Molecular Sciences International Journal of Molecular Sciences. 25(5), 2700

Fellow of the Royal Microscopy Society

Member of the Institute of Physics

Member of the British Microcirculation Society (Committee 2015-2018)

Current Research

My fundamental interest is in capillary ultrafiltration. This the the biophysical method by which molecules move between the blood and the the interstitium. The primary size (and charge) filter is the endothelial glycocalyx, probably facilitated by the glycosaminoglycans. My research focuses on developing 3D correlative microscopy techniques in order to better describe this process and its components. I therefore contribute to research across these themes both together and independently. Some exciting ongoing work:

2024-2029 £4,448,789 BBSRC sLoLa Glycoweb BB/Y00311X/1

2024-2026 £169,488 Kidney Research UK ARP_001_20230830 Renal glycosaminoglycans in Alport Syndrome

2022-2025 £293,362 BHF PG/22/10913 SRPK1 as a potential therapeutic target in diabetic nephropathy

2024-2025 £49,565 Little Princess Trust Understanding how childhood cancers spread

Future Research

Funded PhD Studentships Available

Check out the BBSRC Doctoral Training program

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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