Leicester and Nottingham scientists discover new gene associated with debilitating lung disease

Lung ex
20 Oct 2017 20:30:00.000

PA 242/17

Health scientists at the University of Leicester and University of Nottingham have heralded the discovery of a gene associated with lung fibrosis as ‘a potential new avenue of treatment for further research into this terrible disease.’

The breakthrough is announced today in a paper published in The Lancet Respiratory Medicine.

Idiopathic Pulmonary Fibrosis (IPF) is a debilitating lung disease, affecting ~6,000 new people each year, where scarring (fibrosis) of the lungs makes it difficult to breathe.

Click here for full story

IPF, on average, results in death 3 years after diagnosis. There is no cure for IPF, and currently available drugs can only slow the disease down, and do not stop, or reverse, it. Furthermore, some patients may suffer unpleasant side-effects. A better understanding of the disease is needed to develop even more effective treatments.

Researchers Professor Louise Wain from the University of Leicester and Professor Gisli Jenkins from the University of Nottingham were lead authors of the study. They analysed the DNA from more than 2,700 people with IPF and 8,500 people without IPF from around the world and found that people with IPF are more likely to have changes in a gene called AKAP13.

New treatments urgently needed

The researchers were also able to show that these DNA changes affect how much AKAP13 protein is produced by the gene in the lungs. Researchers know from other studies, that AKAP13 is part of a biological pathway that promotes fibrosis (or scarring) and importantly that this biological pathway can be targeted with drugs. Taken together, the findings suggest targeting this pathway with drugs in people with IPF might lead to new treatments. To confirm this, the research team now need to undertake more detailed studies into the role of AKAP13 in people with IPF.

The work was led by researchers at Leicester and Nottingham and brought together collaborators from around the world to form the largest combined analysis of people with IPF undertaken to date.

Professor Wain, GSK/British Lung Foundation Chair in Respiratory Research at the University of Leicester, said: “We urgently need new ways to treat this terrible disease. Our findings highlight a potential new avenue for treatment and we now need more research to identify why this gene is important in IPF and how we can use that information to identify new therapies.”

Professor Gisli Jenkins, University of Nottingham, said: “What is really exciting about these studies is that this gene affects a pathway that can be targeted by drugs currently in development, opening the door to precision medicine in IPF.”

Ian Jarrold, Head of Research at the British Lung Foundation, said: “IPF is a condition with no known cause or cure and we urgently need to change this. Which is why funding for further research and campaigning for greater awareness is so crucial. This study is exciting and demonstrates that there is hope. We look forward to seeing how it develops.”

Steve Jones, Chair of Action for Pulmonary Fibrosis, said: “This is important research, which will give hope to the 33,000 people in the UK living with IPF and their families. We need more research like this into the genetic factors underlying the disease and possible treatments.” The research was funded by the UK Medical Research Council, NIHR and BLF (and other non-UK funders).

— Ends —

Our academics can now be interviewed for broadcast via our Media Hub, which offers a Globelynx fixed camera and ISDN line facilities at University Park campus. For further information please contact a member of the Communications team on +44 (0)115 951 5798, email mediahub@nottingham.ac.uk or see the Globelynx website for how to register for this service.

For up to the minute media alerts, follow us on Twitter

Notes to editors: 

The University of Nottingham is a research-intensive university with a proud heritage, consistently ranked among the world's top 100. Studying at the University of Nottingham is a life-changing experience and we pride ourselves on unlocking the potential of our 44,000 students - Nottingham was named University of the Year for Graduate Employment in the 2017 Times and Sunday Times Good University Guide, was awarded gold in the TEF 2017 and features in the top 20 of all three major UK rankings. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement. We are ranked eighth for research power in the UK according to REF 2014. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer and industry partner - locally and globally.

Impact: The Nottingham Campaign, its biggest-ever fundraising campaign, is delivering the University’s vision to change lives, tackle global issues and shape the future. More news…

 

Story credits

More information is available from Professor Gisli Jenkins in the School of Medicine, University of Nottingham on +44 (0)115 823 1711, gisli.jenkins@nottingham.ac.uk

Emma Thorne Emma Thorne - Media Relations Manager

Email: emma.thorne@nottingham.ac.uk Phone: +44 (0)115 951 5793 Location: University Park

Additional resources

No additional resources for this article

Media Relations - External Relations

The University of Nottingham
YANG Fujia Building
Jubilee Campus
Wollaton Road
Nottingham, NG8 1BB

telephone: +44 (0) 115 951 5798
email: pressoffice@nottingham.ac.uk