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Physiological process of sepsis

The stages of the physiological process of sepsis are outlined below:

  1. Infection occurs - infectious cell releases toxins/mediators
  2. White cell responds (monocyte)
  3. Reaction initiates cytokines, tumour necrosis factor and interleukins
  4. More mediators released by TNF and interleukins which affect the endothelial lining - increasing capillary permeability
  5. Tissue factor produced - produces prothrombin which induces thrombin
  6. Thrombin helps produce clots in micro-vasculture
  7. Platelets activated - to address endothelium injury
  8. Fibrinolysis
  9. Microvascular coagulopathy
Physiological Process