Physiological effects of sepsis
Select any of the terms to reveal further information about the physiological effects of sepsis.
Inflammatory Response and Coagulation Cascade
Capillary leak, resulting in:
- Loss of fluid from the blood stream (hypovolaemia)
- Drop in blood pressure (hypotension)
- Rise in heart rate (tachycardia) and respiratory rate (tachypnoea)
- Initially bounding pulse, becoming weaker
- Decreasing urine output
- Reduced renal blood flow
Hypovolaemia not only causes poor tissue perfusion but also anaerobic metabolism. This process releases oxygen for metabolism but also lactate causing metabolic acidosis.