Postgraduate Student (Ph.D), Faculty of Science
Christopher completed his Master in Pharmacy (MPharm) degree at Keele University, United Kingdom (UK). Graduating top of his class, and with 1st Class Honours, he was awarded the Pharmaceutical Press Prize for Scholarship. His undergraduate research was supervised by Dr. Clare Hoskins and investigated the use of amphiphilic graft polymer formulations for propofol solubilisation. As an undergraduate, he also published his first three lead-author, peer-reviewed publications.
Christopher registered as a pharmacist in 2014, following a successful clinical pre-registration training year at Morriston Hospital, Swansea, UK. In September of 2014, he joined the EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines at UCL School of Pharmacy in order to undertake his Ph.D studies.
Title: Photochemical internalisation to improve the therapeutic indices of chemotherapy drugs
Photochemical internalisation (PCI) is a light-activated drug delivery technique that can achieve high drug concentrations in focal regions of therapeutic importance (e.g. cancerous tumours). PCI has been shown to be capable of enhancing cytosolic delivery of a diverse range of chemotherapeutic agents, particularly those that do not readily cross cellular membranes. My research will therefore explore the use of PCI to deliver a variety of chemotherapy drugs and will test these novel drug combinations in cancer cells. I will also utilise in vitro 3-D cell culture models and polymer formulations in my work.
CDT Training Project 1 Stemming the tide of resistance: in silico guided design of novel small molecule inhibitors of the carbapenemase KPC-2
University of NottinghamUniversity Park Nottingham, NG7 2RD
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